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권광안 ( Kwang An Kwon ),김유경 ( Yu Kyung Kim ),정문기 ( Moon Gi Chung ),박동균 ( Dong Kyun Park ),권오상 ( Oh Sang Kwon ),김선숙 ( Sun Suk Kim ),김연석 ( Yeon Suk Kim ),권소영 ( So Young Kwon ),구양서 ( Yang Suh Ku ),최덕주 ( Du 대한장연구학회 2005 Intestinal Research Vol.3 No.2
목적: 최근 조기대장암의 내시경 치료의 가능성에 대한 관심이 높아지고 있다. 이에 저자들은 조기대장암의 임상양상 및 치료결과에 대하여 알아보고자 하였다. 대상 및 방법: 1999년 7월부터 2004년 6월까지 대장암으로 진단 받은 969명 중 117명(120병소)의 조기대장암 환자의 의무기록을 후향적으로 조사하였다. 결과: 전체 대장암 중 조기대장암의 빈도는 12.1%였고 점막암이 80예, 점막하층암이 40예였다. 조기대장암에서 병변의 평균크기는 1.8 cm, 암조직의 평균크기는 1.1 cm였다. 병변의 평균크기는 점막하층암이 2.2 cm로 점막암의 1.7 cm보다 컸다(p=0.03). 육안적 분류로 편평형에서 점막하층암이 30%로 점막암의 15%보다 높은 경향을 보였다(p=0.07). 조직학적 분화도는 고분화선암이 77.5%였으며, 중등도 분화를 보인 경우는 점막하층암에서 63%로 점막암의 3%보다 유의하게 높았다(p<0.001). 조기대장암에 대한 치료는 점막암 80예중 초치료로 10예에서 수술을 시행하였고, 70예에서 내시경 절제를 하였으며, 이 중 2예에서 추가 수술적 절제를 시행하였다. 점막하층암 40예에서는 초치료로 19예에서 수술을 시행하였으며, 21예가 내시경 절제를 받았고 이 중 13예에서 추가 수술적 절제를 받았다. 결론: 본 연구에서 조기대장암의 빈도는 12.1%로 국내 과거 보고보다 증가하고 있으며, 조기대장암에서 내시경 치료를 고려하는 경우 크기가 2 cm 이상이며 중등도 분화도를 보이는 편평형 조기대장암에서는 점막하층암일 가능성을 고려하는 것이 치료에 도움이 될 것으로 생각한다. Background/Aims: Recently, it has been more interested in the early colorectal cancer (ECC) with possibility of endoscopic treatment. We evaluated the clinicopathological characteristics and the treatment results of the ECC. Methods: 120 cases of ECC from 969 patients with colon cancer were analyzed. The cases of concomitant advanced colon cancer were excluded. Results: 12.1% of total colon cancer was ECC. 80 and 40 cases were mucosal (M) and submucosal (SM) cancer, respectively. The size of lesion and cancer tissue of SM cancer was significantly larger than that of M cancer (lesion size, 2.2 vs. 1.7 cm, p=0.03; cancer size, 1.7 vs. 0.7 cm, p<0.001). The prevalence of flat type in SM cancer was higher than that of M cancer (30% vs. 15%, p=0.07). Moderately-differentiated type was more common in SM cancer than M cancer (63% vs. 3%, p<0.001). 15 cases received the additional operation (M cancer; 2, SM cancer; 13). The metastasis of lymph nodes was verified in 2 cases of SM cancer. Conclusions: The ECC with flat type, more than 2 cm in size and moderately-differentiated type had the possibility of SM cancer. Therefore endoscopic treatment in patients with those characteristics should be considered with caution. (Intestinal Research 2005;3:133-139)
포스터 전시 : 간 15 ; 만성 간질환에서 혈중 gelatinase (Matrix metalloproteinase-2와 9)의 측정 의의
권오상 ( Oh Sang Kwon ),정혁상 ( Hyuk Sang Chung ),주기탁 ( Ki Tak Ju ),정문기 ( Moon Gi Chung ),박동균 ( Dong Kyun Park ),김선숙 ( Sun Suk Kim ),김연석 ( Yeon Suk Kim ),구양서 ( Yang Suh Koo ),김유경 ( Yu Kyung Kim ),최덕주 ( Duc 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-
HBsAg 음성, anti-HCV 음성인 알코올간경변증에서 anti-HBc 양성 혹은 B형간염바이러스 잠재감염이 간세포암종 발생에 미치는 영향
김민주 ( Min Ju Kim ),권오상 ( Oh Sang Kwon ),정낙소 ( Nak So Chung ),이서영 ( Seo Young Lee ),정혁상 ( Hyuk Sang Jung ),박동균 ( Dong Kyun Park ),구양서 ( Yang Suh Ku ),김유경 ( Yu Kyung Kim ),김연수 ( Yun Soo Kim ),김주현 ( Ju H 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.1
한국인에서 Mitochondrial Aldehyde Dehydrogenase ( ALDH2 ) 의 유전적 결핍이 알코올성 간질환 발생에 미치는 영향
변관수(Kwan Soo Byun),권소영(So Young Kwon),박상훈(Sang Hoon Park),구양서(Yang Suh Koo),연종은(Jong Eun Yeon),김재선(Jae Seon Kim),박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한내과학회 1993 대한내과학회지 Vol.45 No.3
Background: Deficiency of mitochondrial aldehyde dehydrogenase (ALDH2) is an inborn error of metabolism that is responsible for acute alcohol sensitivity (flushing response) observed only in Orientals of Mongoloid origin. The subjects with the mutant ALDH2 gene are at much lower risk than homozygotes of normal ALDH2 genes for alcoholic liver disease presumably because of their sensitivity to alcohol. However, the role of the mutant ALDH2 gene in the development of alcoholic liver disease had not yet been we11 analyzed. In this study, genotypes of ALDH2 were compared between normal controls and patients with alcoholic liver disease to clarify the role of ALDH2 deficiency in the development of alcoholic liver disease. Method: Genotyping of ALDH2 was performed in 33 normal controls and 30 patients with alcoholic liver disease using the polymerase chain reaction and Southern blot hybridization by allele-specific oligonucleotide probes. Result: In 33 normal controls, 19 cases (57.6%) were homozygotic for the normal ALDH2 gene, 13 cases (39.4%) were heterozygotic for the normal and mutant ALDH2 genes and 1 caw (3.0%) was homozygotic for the mutant ALDH2 gene. All normal controls who had the mutant ALDH2 gene experienced facial flushing response after drinking. Amount of alcohol intake each time in controls who had the mutant ALDH2 gene was much smaller than that in normal ALDH2 homozygotes (p<0.001). All patients with alcoholic liver disease were homozygotic for the normal ALOH2 gene. The frequency of ALDH2 deficiency in patients with alcoholic liver disease was significantly lower than that in normal controls (p<0.001). Conclusion: These results suggest that ALDH2 deficiency is one of the important genetic factors in regulating alcohol consumption and plays a protective role against alcoholism and alcoholic liver diseases.
급성간염 환자에서 발생한 용혈성빈혈이 동반된 순수적혈구형성부전증 1 예
신상원(Sang Won Shin),연종은(Jong Eun Yeon),이영호(Young Ho Lee),구양서(Yang Suh Goo),권소영(So Young Kwon),변관수(Kwan Soo Byun),박영태(Young Tae Bak),김준석(Jun Suk Kim),김진호(Jin Ho Kim),이창홍(Chang Hong Lee),박현진(Hyun Jin Par 대한내과학회 1994 대한내과학회지 Vol.46 No.4
We report a case of pure red cell aplasia with hemolytic anemia which was associated with acute hepatitis. A 60-year-old housewife was admitted to the hospital because of progressive jaundice. Initially, she was diagnosed as acute hepatitis of unknown origin because hepatitis B surface antigen was negative and antibodies to hepatitis B, C, and E virus were negative. On the 16th hospital day, sudden fall of hemoblobin and reticulocytopenia developed. High fever and deepening of jaundice followed. On the 34th hospital day, there were findings of pure red cell aplasia in the bone marrow, and many acanthocytes with hemolysis in the peripheral blood. She was treated with methyplrednisolone 1.0 g i.v. for 3 days and then, with prednisone 60 mg per oral with slowely tapering. After steroid treatment, the fever subsided, and hemoglobin gradually increased. After improvement of pure red cell aplasia, follow-up bone marrow biopsy showed normal erythropoiesis and liver biopsy showed acute hepatitis with confluent hepatic necrosis.
감염과 관련된 위점막 조직의 Glutathione에 관한 연구
박동균 ( Dong Kyun Park ),김은수 ( Eun Soo Kim ),홍순홍 ( Soon Hong Hong ),정문기 ( Moon Gi Chun ),권오상 ( Oh Sang Kwon ),김선숙 ( Sun Suk Kim ),구양서 ( Yang Suh Kwon ),김유경 ( Yu Kyun Kim ),최덕주 ( Duck Joo Choi ),박현철 ( Hy 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> Helicobacter pylori(H. pylori)에 의한 위점막 손상은 H. pylori에 의해 활성화된 염증세포의 산소 유리기 생성 및 자극과 관련이 있다고 알려져 왔고 최근에는 H. pylori 자체에서도 산소 유리기가 발생한다는 연구가 있다. 본 연구에서는 updated Sydney system을 이용한 grading 과 산소 유리기를 간접적으로 측정할 수 있는 glutathione(GSH)의 농도를 분석하여 위점막의 산소유리기와 H
고주파 열치료술로 성공적으로 치료된 간세포암종의 폐전이 1예
박재찬 ( Jae Chan Park ),김연수 ( Yun Soo Kim ),정영걸 ( Young Kul Jung ),강명희 ( Myung Hee Kang ),권오상 ( Oh Sang Kwon ),최덕주 ( Duck Joo Choi ),구양서 ( Yang Suh Ku ),김주현 ( Ju Hyun Kim ) 대한간암학회 2013 대한간암학회지 Vol.13 No.1
Surgical resection or liver transplantation is a main curative modality for hepatocellular carcinoma (HCC). But nowadays local ablation therapy is being accepted as a useful option for local control therapy for HCC. Here we present a case of 59 years old male with hepatitis B virus related liver cirrhosis, who underwent surgery for HCC at S6 two years ago. He had received percutaneous ethanol injection (PEI), radiofrequency ablation (RFA) and multiple sessions of transarterial chemoembolization (TACE) for intrahepatic recurrences of HCC after surgery. A small radio-opaque lesion occurred at the left upper lobe of lung. Metastatic HCC was confirmed by CT-guided percutaneous needle core biopsy. CT-guided RFA for pulmonary metastasis was performed. Now it is been 11 months after the treatment without any recurrence.
만성 간질환에서 혈중 Gelatinase (Matrix Metalloproteinase-2와 9)의 측정 의의
권오상,임도윤,권광안,정문기,박동균,김선숙,김연석,권소영,구양서,김유경,최덕주,김주현,황유진,변관수,이창홍 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3
목적: Gelatinase (MMP-2와 9)는 기저막의 주구성요인 type IV collagen을 분해하는 효소로, MMP-2는 간경변과 MMP-0은 간세포암의 진행과 연관이 있는 것으로 알려져 있다. 본 연구에서는 만성 간질환과 MMP-2와 9의 관계를 알아보고자 하였다. 대상과 방법: 간기능이 정상이고 간질환이 없는 건강 대조군 10예, 만성 간염 15예, 간경변 18예, 그리고 간세포암 25예를 대상으로 혈장을 채취하여 MMP-2와 9의 활성을 보기 위해 zymography를 시행하였다. 결과: 혈장 MMP-2의 활성은 간경변군에서 건강 대조군(p=0.009)과 만성 간염군(p=0.011)에 비해 증가되어 있었으나 간세포암군과는 차이가 없었다. 혈장 MMP-9의 활성은 간경변군에서 건강 대조군에 비해 증가되어 있었으나(p=0.035), 만성 간염군과 간세포암군과는 차이가 없었다. 간세포함이 없는 간경변군 15예와 간세포암을 동반한 간경변군 23예를 합친 총 간경변군 38예에서 MMP-2의 활성은 total bilirubin이 높을수록 (r=0.323, p=0.048) 그리고 Child-Pugh 점수가 높을수록(r=0.414, p=0.012) 증가되어 있었다. 총 간경변군에서 MMP-2와 MMP-9의 활성은 알코올 성 간경변군에서 HBV에 의한 간경변군 보다 현저히 증가되어 있었다(각각 p=0.009, p=0.002). 결론: 혈장 MMP-2의 활성은 간경변의 진단과 중증도에 유용한 표지자로 사용될 수 있을 것이다. 혈장 MMP-9의 활성은 간세포암에서의 유용성은 적으리라 생각되나 알코올성 간경변의 진단적 표지자로는 유용하리라 생각된다. MMP-2와 MMP-9의 활성은 간경변의 원인 별로 차이가 나는 것으로 생각되며 그 이유에 대한 연구가 필요하리라 생각된다. Background/Aims: Gelatinase (matrix metalloproteinase (MMP) -2 and 9) has an important role in the pathogenesis of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). In this study, we evaluated the relationship of gelatinase to chronic liver disease. Methods: Four groups of subjects were examined; healthy control (10 cases), chronic hepatitis (18 cases), LC (15 cases), and HCC (28 cases). The plasma of each subject was obtained, and the equal quantification of plasma protein was done. The plasma activities of MMP-2 and 9 were measured by zymography. Results: The activities of plasma MMP-2 in patients with LC were significantly higher than those in controls (p=0.009) and in patients with chronic hepatitis (p=0.011), but not different from those in patients with HCC. The activities of plasma MMP-9 in patients with LC were significantly higher than those in controls, but not different from those in patients with chronic hepatitis or HCC. In patients with LC (regardless of having HCC), the activities of MMP-2 correlated with total bilirubin (r=0.323, p=0.048) and Child-Pugh score (r=0.414, p=0.012). The activities of MMP-2 and 0 were higher in patients with LC (regardless of having HCC) caused by alcohol than caused by HBV (p=0.009 and 0.0002 for each one). Conclusions: The plasma activity of MMP-2 may be a useful marker for the diagnosis and determination of the severity of LC. The plasma activity of MMP-9 was not useful for HCC, but may be a marker for alcoholic LC. Further study is needed to determine why the plasma activity of gelatinase was higher in patients with LC caused by alcohol than by HBV.(Korean J Hepatol 2003;9:222-230)