한국 육군 일개 사단에서 군 복무 부적응자들의 정신의학적 평가 : 그린캠프 참가자들을 중심으로

김주현,강석훈,예병석,황현국,서재원,채공주,이환배,김찬형,Kim, Ju-Hyun,Kang, Suk-Hoon,Ye, Byoung-Seok,Hwang, Hyun-Kuk,Suh, Jae-Won,Chai, Gong-Ju,Lee, Hwan-Bae,Kim, Chan-Hyung 대한불안의학회 2010 대한불안의학회지 Vol.6 No.2

Objectives : In this study, we aimed to elucidate the demographic and psychological characteristics of maladaptive soldiers in the Republic of Korean Army. Methods : Study participants included 110 male conscripts who had participated in the Green camp, which was a form of group psychosocial treatment program for maladaptive soldiers. All participants were interviewed and diagnosed by a psychiatrist, and classified into two groups according to whether they left or rejoined the army. We analyzed the differences between these two groups in terms of demographic features, psychiatric diagnosis and the Minnesota Multiphasic Personality Inventory (MMPI) subscores. Results : Compared with soldiers who rejoined their units, those who left military service exhibited significantly lower educational level (p=0.041) and a higher rate in psychiatric treatment prior to enlistment (p=0.011). Among the 106 subjects, 63 (59.4%) and 23 (21.7%) were diagnosed with personality disorder and adjustment disorder, respectively. Further, those who left military service were diagnosed more frequently with mood disorder (p=0.001) and schizophrenia (p=0.014) than those who rejoined their units. Additionally, the MMPI scores of soldiers who left military service were significantly higher on the psychasthenia (p=0.028) and schizophrenia (p=0.039) scales than those of soldiers who rejoined their units. Conclusion : Most of the maladaptive soldiers were diagnosed with mental disorders. The results of this study suggest that systematic, consistent psychiatric evaluation and intervention for maladaptive male conscripts is crucial in the Republic of Korean army.

사례기반학습을 이용한 주식 데이터 예측 방법

김주현,전민수,정용규,Kim, Ju-Hyun,Jeon, Min-Soo,Jung, Yong-Gyu 서비스사이언스학회 2011 서비스연구 Vol.1 No.1

현재 국내에선 많은 수의 사람들이 주식관련업계에 종사하고 있으며 주식관련 정보와 관련 산업은 점점 발전해 가고 있다. 따라서, 주식을 예측하는 프로그램이 많이 나왔으며, 또한 정확한 수치화를 통해 주식을 예측하고자 하는 노력들이 더해지고 있다. 그러나 주식예측 결과는 아직 불안정하고, 근거가 없는 것이 현실이다. 본 논문에서는 방대한 량의 주식 데이터를 가지고, 주식의 변동 폭에 많은 영향을 끼치는 항목들을 조사하고, 가중치를 구하고자 한다. 이는 기존에 주식에 관련된 수치와 종목별의 분류와 다른 방법이다. 실험결과에 따른 체계적인 주식 데이터의 객관성 있는 분류를 제시하고자 한다. In recent years, a number of people are going more and more to develope and engage in stock and equity-related information and related industry. a lot of stock expection programs came out, but they are still unstable, especially predictions methods and reality is unfounded. In this paper, we have vast amounts of stock data, shares many of the changes affecting the width of the survey items, and should seek the weights. This is related to existing stock levels and categories and is another way. Results based on a systematic classification of the stock data that would like to introduce objectivity

준설매립지반에 대한 $\phi=0$ 해석의 적용성

김주현,정상국,심민보,이송,Kim, Ju-Hyun,Jeong, Sang-Kug,Shim, Min-Bo,Lee, Song 한국지반공학회 2004 한국지반공학회논문집 Vol.20 No.1

본 연구에서는 $\phi=0$ 조건에서 준설매립지반에 대한 지지력 산정의 문제점과 적용범위를 파악하기 위하여 2차 원모형재하시험을 실시하였고 기존의 제안식과 재하시험결과를 비교분석하여 다음과 같은 결과를 얻었다. 재하판폭의에 해당되는 깊이까지의 평균비배수전단강도와 깊이 이내의 임의의 깊이에서 측정된 전단강도 값의 차이가 $\pm50%$ 이상일 경우에는 $\phi=0$ 해석을 단일층으로 고려할 경우 사용되는 지지력계수, Nc는 적용성이 떨어지는 것으로 나타났다. 또한, 특별한 제안사항없이 포화된 점토에 적용하는 것으로 되어있는 $\phi=0$ 해석에 이용되는 지지력 계수, Nc=5.7, 5.14에 의한 준설매립지반의 지지력 산정은 불안전측의 값을 도출하여 적용성이 떨어지므로, 일축압축시험이 가능한 약 75% 이하의 함수비에서 적용이 가능할 것으로 판단된다. In this test, there was two-dimensional model loading test implemented for analysis with respect to the problem of evaluating bearing capacity and the application range on the dredged and reclaimed ground, so it was possible to get the following result by comparing a result of loading test and an equation proposed previously. When the difference between average undrained shea. strength by (equation omitted)B of loading board width and the strength under. (equation omitted)B is mere than $\pm50%$, the applicability of Nc(coefficient of bearing capacity where $\phi=0$ analysis is considered in the single layer) was declined. As well, using Nc=5.7, 5.14(coeffcient of bearing capacity where $\phi=0$ analysis is applicable to saturated clay without special limit) for evaluating bearing capacity on the dredged and reclaimed ground causes poor applicability, therefore that seem to be applicable when water content is less than about 75% which makes the unconfined compression test possible.

입자론의 관점에서 본 확산과 용해 개념에 관련된 과학 교과서 및 인터넷 자료 분석과 컴퓨터 수업 보조자료의 개발

김주현,이동준,김선경,강성주,백성혜,Kim, Ju Hyun,Lee, Dong Jun,Kim, Sun Kyoung,Kang, Seong Joo,Paik, Seong Hey 대한화학회 2000 대한화학회지 Vol.44 No.6

이 연구에서는 확산과 용해에 관련된 3~12학년의 과학교과서와 여러 문헌 자료들, 인터넷 사이트들을 분석하였다. 이 자료들로부터, 교과서에 제시된 확산과 관련된 설명들이 용해, 상태변화, 분출과 혼동되어 사용되고 있었으며 매질과의 충돌 또한 고려되고 있지 않았다는 것을 알았다. 그리고 용해와 관련된 거의 모든 자료도 용해의 원리를 인력에 의한 영향으로 설명하지 못하고 있었으며, 거의 대부분 용해에 관한 설명이 개념의 이해보다는 계산 문제 풀이에 초점이 맞추어져 있었다. 또한, 각종 인터넷 사이트들도 단편적인 교과서의 나열 수준에서 벗어나지 못하였고 단지 시청각적인 효과에 치중하고 있었다. 화학이 입자론적 관점에서 자연현상을 이해해야 함에도 불구하고 대부분의 교과서와 인터넷 사이트들은 그것을 충분히 반영하지 못하고 있었다. 이에 이 연구에서는 올바른 과학적 개념을 형성하고 입자론적인 관점에서 미시세계를 거시적 자연현상과 연결시키고자 했다. 그 방법으로 움직이는 물체를 표현할 수 있는 컴퓨터의 장점을 최대한 활용하여 입자이동의 관점으로 확산과 용해와 관련된 수업보조자료를 개발하였다. In this study we analysed 3-12 grade science textbooks, many literatures and internet sites related to diffusion and dissolution concepts. From these data, we discovered that the explanations of diffusion that used in textbooks are not considered the site of collision with mediums, and confused with dissolution, state transition and effusion. In the case of dissolution, almost analysis data were short of the explanations of interaction effect. Most of all, the focus of dissolution explanations was to solve the calculation problems rather than to understand the concept. Every internet site was poor, just as the level of showing textbook contents with computer, so the only effect of using computer was the sense of sight and hearing. Chemistry must be understood nature phenomena with a view point of particle theory, but many textbooks and Internet sites didn't represent it sufficiently. We set up the correct scientific concept and linked micro world of particle theory with macro world of nature phenomena. With a use of computer which have the advantage of representing moving things, we developed the computer-assisted instruction programs related to diffusion and dissolution with the viewpoint of particle movement.

Top-down 방식의 열분해질량분석 스펙트라 분석 및 Gram-type 세균 분류

김주현,Kim, Ju-Hyun 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.4

To apply TMAH-based Py-MS to a field biological detection system for real-time classification of cell-type, reproducible patterns of the TMAH-based Py-MS spectra was known as a critical factor for classification but was seriously disturbed by quantity of cells injected into pyro-tube. This factor is an exterior variable that could not be complemented by improving the performance of the TMAH-based Py-MS instrument. One of idea to solve the knotty problem has been flashed from "Top-down proteomics for identification of intact microoganisms". That is, biomarker peaks are selected from complicate Py-MS spectra for intact microoganisms by tracing out their origins, based on Py-MS spectra for the featured components of different cell-types, in Top-down approach. This idea has been tested in classification of different Gram-type microoganisms. Through the analyses of spectra for the featured components - peptidoglycan and lipoteichoic acid for Gram-positive cells and lipopolysaccharide and lipid A for Gram-negative cells - with comparing to the spectra the corresponding Gram-type cells in the Top-down approach, biomarker peaks were selected to carry out PCA(Principal Component Analysis) in order to see classification of different Gram-types, resulting in significant improvement of their classification. Furthermore, weighting biomarker peaks on intact cell's spectra, based on the data for the featured components of the Gram-types, contributed to elevate classification performance.

TMAH에 기반한 열분해 질량분석법의 생물 탐지체계 적용

김주현,Kim, Ju-Hyun 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.2

TMAH-based Py-MS has been investigated to apply for a real-time classification of biological agents in the field. Acquiring reproducible data from mass spectrometry is a key to biological detection in the field. Nevertheless, it has been little studied on what factors could affect to the reproducibility of the TMAH-based Py-MS spectrum patterns. Given the TMAH-based Py-MS applied to the field system, several factors which could affect to the reproducible pattern of TMAH-based Py-MS spectra are needed to be examined, including changes in TMAH injection volume, growth temperature for microorganism, and number of cells collected in pyrolyzer, and implication of stabilizer used for lyophilization. This study showed that the reproducibility of the spectrum patterns was significantly hindered by changes in TMAH concentration and cell number, and stabilizer implication but not by growth temperature. Among those at low TMAH concentration(0.015m) was not observed the significant alterations of the spectrum pattern even when its injection volume was changed, yet was in different cell numbers and stabilizer implication.

기도내 이물의 외과적 처치에 관한 연구

김주현,김삼현,Kim, Ju-Hyeon,Kim, Sam-Hyun 대한흉부심장혈관외과학회 1981 Journal of Chest Surgery (J Chest Surg) Vol.14 No.4

The inhalation of a foreign body into the tracheobronchial tree is a child is a life-threatening accident. Forgotten foreign bodies In the airways cause chronic pulmonary infections, allergic asthma, bronchiectatic changes, and lung abscess Foreign bodies that cannot be grasped by bronchoscopic forceps should be removed by thoracotomy and bronchotomy. This report describes our experience In 16 patients who were treated to remove inhaled foreign bodies from the airways after repeated bronchoscopies had been unsuccessful from 1963 to 1981 at the department thoracic surgery of Seoul National University Hospital. The surgical procedures are as follows: 12 patients bronchotomy, 2 patient pneumonectomy, 2 patients lobectomy. In these cases, the foreign bodies are 8 metallic material, 3 plastic material, 1 bean, 1 black snail, and 3 cases of no records. Bronchotomy must be performed as soon as possible in order to avoid more advanced pathologic changes In the Involved lung, such as bronchiectasis, fibrosis or abscess.

C형 간염바이러스(HCV) 유전체를 특이적으로 변형할 수 있는 Trans-Splicing Aptazyme 발굴

김주현,이창호,장선영,이성욱,Kim, Ju-Hyun,Lee, Chang-Ho,Jang, Sun-Young,Lee, Seong-Wook 한국미생물학회 2008 미생물학회지 Vol.44 No.3

C형 간염바이러스(hepatitis C virus; HCV) 복제를 효과적이며 특이적으로 제어할 수 있는 유전산물을 개발하기 위하여 특정 리간드 존재에 의해 allosteric하게 그 활성이 조절될 수 있는 HCV 유전체 표적 trans-splicing 리보자임(trans-splicing aptazyme)을 발굴하였다. 이러한 trans-splicing aptazyme은 특정 리간드와 특이적으로 결합하는 RNA aptamer 부위, aptamer와 리간드와의 결합에 의해 리보자임 활성을 유도할 수 있도록 구조적 변이를 전달할 수 있는 communication module부위 및 HCV IRES의 +199 nt를 인지하는trans-splicing리보자임 등으로 구성되도록 설계하였다. 특히 trans-splicing 리보자임의 catalytic core의 P6과 P8 부위에 aptamer와 communication module을 삽입하였을 때 가장 allosteric하게 리보자임 활성이 유도되었다. 이러한 리보자임은 리간드가 없거나 대조 리간드가 존재할 때에는 trans-splicing 반응을 유도하지 못하였으나 특정 리간드가 존재할 때에만 효과적이며 특이적으로 trans-splicing 반응을 유도하여 표적 RNA를 변형시킬 수 있음을 관찰하였다. 이러한 aptazyme은 HCV 증식에 대해 특이적이며 효과적인 억제를 위한 선도물질로 이용 가능할 뿐 아니라 HCV 치료선도 물질의 스크리닝용 도구로서도 활용될 수 있을 것이다. For the development of specific and effective basic genetic materials to inhibit replication of hepatitis C virus (HCV), HCV genome-targeting trans-splicing aptazyme, which activity is allosterically regulated by a specific ligand, was developed. The aptazyme was designed to be comprised of sequence of RNA aptamer to the ligand, communication module sequence which can transfer structural transition for inducing ribozyme activity upon binding the ligand to the aptamer, and trans-splicing ribozyme targeting +199 nt of HCV IRES. Especially, when the aptamer and the communication module was inserted at both P6 and P8 catalytic domain of the specific ribozyme, allosteric activity of the aptazyme was the most induced. The aptazyme was shown to induce activity of trans-splicing reaction specifically and efficiently only in the presence of the specific ligand, but neither in the absence of any ligand nor in the presence of control ligand. This aptazyme can be used as a specific and effective genetic agent against HCV, and a tool for the isolation of anti-HCV lead compounds.

한국인에서의 사이트린 결핍증의 경험

김주현,김구환,유한욱,Kim, Ju-Hyun,Kim, Gu-Hwan,Yoo, Han-Wook 대한유전성대사질환학회 2006 대한유전성대사질환학회지 Vol.6 No.1

Citrin deficiency resulting from mutations of SLC25A13is associated with two major clinical phenotypes; neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and adult-onset type 2 citrullinemia (CTLN2). In Korea, 7 cases of citrin deficiency have been diagnosed based on biochemical and molecular findings. Four NICCD cases were identified by newborn screening using MS/MS or presenting symptoms like cholestatic jaundice. They are all males, presenting with conjugated hyperbilirubinemia, elevated liver enzymes, hypoalbuminemia, mild hyperammonemia, elevated citrullin, methionine and threonine. All of them have been spontaneously recovered from hepatic manifestation by the age of 6-8 months. Mutation analysis has been performed using their genomic & cDNAs obtained from skin fibroblasts. They turned out to be compound heterozygotes carrying each of 851del4, IVS11+1G>A, and IVS13+1G>A. Three CTLN2 patients were identified. Two adult male patients presented with a sudden loss of consciousness, seizure, vomiting, hyperammonemia and citrullinemia in their twenties. They carried an IVS13+1G>A, 851del4, and IVS11+1G>A mutant alleles. The other CTLN2 patient was 52 year old female patient, manifesting lethargy, altered consciousness, irritability and hyperammonemia. Similar clinical symptoms had recurred at the delivery of first and second babies in her past medical history. She was managed by hemodialysis and survived with neurological sequellae. Also, we screened the presence of 9 common mutations in 500 Korean newborns using dried blood spot of filter papers. Only a allele carried 854del4 mutation. In conclusion, the entire picture of citrin deficiency in Korea including incidence, genotype, clinical features and natural courses, is still vague at the present time.

김정일 시대 《조선문학》에 나타난 북한문학의 특질

김주현(Kim Ju-hyun) 중앙어문학회 2008 語文論集 Vol.38 No.-

North Korea's literary policies have been carried out through the frame of ‘Juche realism’ without any significant changes since it was accomplished in the 1970s. However, there have been subtle changes from time to time. Discarding literary autonomy in the 80s, North Korean literature in the Kim Jong-il era shows an aspect that ideology has been consolidated again. This paper classifies the characteristics of North Korean literature into three categories, described in《Chosun Literature》in the Kim Jong-il era until the year of 2000 . Right after Kim Jong-il's succession, the literature of embodying the successor focused on depicting Kim Jong-il as an affectionate mother as it did when shaping Kim Il-sung. But, in the late 90's when economic hardship got worse, the two ideologies in the Kim Jong-il era, ‘the Red Flag Spirit’ and ‘the March of Hardship’, were emphasized. Furthermore, highlighting tradition and reaffirming the legitimacy of Kim Jong-il government are also distinctive features of the literature in his era. This literary tendency is a significant evidence that the North Korean literature in the era of Kim Jong-il recognizes reality as ‘a whole crisis’.