소신 소비 척도 개발 및 타당성 검증

고경아 한국PR학회 2023 한국PR학회 학술대회 Vol.2023 No.11

노년층 소비자의 디지털 역량이 삶의 만족에 미치는 영향: 우울감의 매개효과와 자아존중감의 조절된 매개효과를 중심으로

고경아 동국대학교 사회과학연구원 2024 사회과학연구 Vol.31 No.2

본 연구는 2021년 미디어 패널조사 데이터를 활용하여 노년층 소비자의 디지털 역량이 우울감을 매개로 삶의 만족에 미치는 영향을 살펴보고, 이러한 관계에서 자아존중감의 조절된 매개효과를 검증하였다. 연구 결과 노년층 소비자들의 디지털 역량이 삶의 만족에 직접적인 영향을미쳤을 뿐만 아니라 우울감을 매개로 삶의 만족에 영향을 미치는 관계인 부분 매개모형을 지지하는 것으로 나타났으며, 노년층 소비자의 우울감은 자아존중감에 따라 삶의 만족에 미치는 영향이 다르게 나타나 자아존중감의 조절효과가 입증되었다. 그러므로 노년층 소비자의 디지털역량을 강화하고 자아존중감을 높이는 것은 노년층의 우울감을 완화하고 삶의 만족감을 향상시킬 수 있다고 볼 수 있다. 이러한 노년층 소비자의 삶의 만족감이 어떠한 요인에 의해 매개되고 조절되는지에 대한 통합적인 접근 방식은 노년층 소비자의 삶의 질을 향상시킬 수 있는 다양한 방법과 함의를 제시하는 데 중요한 역할을 할 수 있을 것으로 기대한다. Using data from the 2021 media panel survey, this study examined the impact of digital capabilities of elderly consumers on life satisfaction mediated by depression, and verified the moderated mediating effect of self-esteem in this relationship. It was found that the digital capabilities of elderly consumers not only directly affected life satisfaction, but also supported the partial mediating model, a relationship that affects life satisfaction through depression. Depression of elderly consumers showed different effects on life satisfaction depending on self-esteem, proving the moderating effect of self-esteem. Therefore, it can be seen that strengthening the digital capacity of the elderly can alleviate depression and improve life satisfaction. It is expected that this integrated approach to what factors mediate and control the life satisfaction of elderly consumers will play an important role in suggesting various methods and implications that can improve the quality of life of elderly consumers.

제주지역 고등학생의 제주4・3 인식과 평화・인권교육 방안

고경아 제주4.3연구소 2020 4.3과 역사 Vol.20 No.-

Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway

고경아,김소미 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1

Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in α-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase. Ethyl linoleate inhibited the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase related protein 1 (TRP1) in governing melanin pigment synthesis. We observed that ethyl linoleate inhibited phosphorylation of Akt and glycogen synthase kinase 3β (GSK3β) and reduced the level of β-catenin, suggesting that ethyl linoleate inhibits melanogenesis through Akt/GSK3β/β-catenin signal pathway. Therefore, we propose that ethyl linoleate may be useful as a safe whitening agent in cosmetic and a potential therapeutic agent for reducing skin hyperpigmentation in clinics.

Comparative evaluation of free radical scavenging activities and cytotoxicity of various solvent fractions of Sandong Sageretia thea (Osbeck) M.C. Johnst. branches

고경아,손모아,김소미 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

Sageretia thea (Osbeck) M.C.Johnst., an evergreen tender shrub of the Rhamnaceae, has been used as folk medicine and in traditional tea. To the best of our knowledge, this is the first study that investigates the free radical scavenging activity and cell cytotoxicity of S. thea branches. The ethyl acetate fraction and n-butanol fraction were identified to be rich in phenolic compounds exhibiting impressive antioxidant activity after stepwise partitioning of solvent fractions of the methanol extracts of S. thea branches (MB). Among the different human cancer cells tested, maximum cytotoxicity was found in MDA-MB-231 human breast cancer cells with MB, chloroform, ethyl acetate, n-butanol and water fraction. A significant (p<0.05) correlation between antioxidant activities and cytotoxicity exists in each fraction. These results suggest the branches of S. thea can be a valuable source of antioxidants, and they can serve as natural anticancer constituents in nutraceutical and pharmaceutical applications.

A case of disappeared Rasmussen’s aneurysm after the treatment of pulmonary tuberculosis

고경아,한민수 대한내과학회 2021 대한내과학회 추계학술발표논문집 Vol.2021 No.1

생태교통 수원 2013을 통해 본 환경문제 인식과 실천

고경아 한국환경사회학회 2015 한국환경사회학회 학술대회 자료집 Vol.2015 No.4

The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

고경아,박진영,이중석,예병석,정의원,최성호,차재국 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.8

Purpose: The aim of this study was to investigate the association between the changes in masticatory function and cognitive im pairment by analyzing longitudinal data of older Korean patients. Materials and Methods: Patients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020(follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified intotwo groups, the dementia group (n=122) and the control group (n=366). Changes in masticatory function were calculated using thetotal functional tooth unit (T-FTU) in both groups. The incidence of tooth extraction (%) and the subsequent rehabilitation duringthe observation period were also evaluated. Results: In the dementia group, T-FTU significantly decreased from T1 to T2 (9.81±2.78 to 9.11±3.16, respectively, p=0.008), whileno significant change was observed in the control group. During the mean observation period of 9 years, significantly more teethwere extracted and neglected to be prosthetically restored in the dementia group than in the control group. Regression analysis re vealed that the number of missing teeth neglected [odds ratio (OR)=1.195, 95% confidence interval (CI)=1.025–1.393, p=0.023] andprevious alcohol consumption (OR=4.445, 95% CI=1.831–1.795, p=0.001) were the most significant risk factors of dementia. Conclusion: There might be a causative relationship between the neglected missing dentition and the onset of dementia.

추출조건에 따른 블루베리 열수추출물의 항산화 활성 비교

고경아,손모아,강혜림,임지희,임근형,김소미 한국식품저장유통학회 2015 한국식품저장유통학회지 Vol.22 No.3

Five extraction conditions (AE, autoclave extraction; OE, oven extraction; HWSE, hot water and sonication extraction; HWASE, hot water acidified with 0.5% (v/v) acetic acid and sonication extraction; and BE, boiling extraction) were examined to compare the effects of different hot water extraction methods on the antioxidant properties of blueberries. The extraction yields of the AE, OE, HWSE, HWASE, and BE were 7.94%, 8.35%, 8.55% 9.15%, and 8.50%, respectively. The polyphenol and flavonoid contents of AE were 3.47 mg GAE/g and 1.59 mg RE/g, respectively, which were highest centents among others. Those of OE were ranked second to the highest. The total anthocyanin content of HWSE (5.29 mg/g) was significantly higher than that of others whereas that of AE showed the lowest content (0.96 mg/g). The order of ABTS radical and alkyl radical scavenging activities was as follows: AE > BE > OE > HWSE > HWASE. The antioxidant properties were considerably correspondent with the total polyphenol and flavonoid content. DPPH radical scavenging activity was quite high in HWSE, AE, and BE extraction, however, there were no significant differences among the five extraction methods in the aspect of Fe2+ ion chelating activities. Moreover, AE showed the highest SOD activity, and protected the dermal fibroblast the best against H2O2-induced cytotoxicity. In conclusion, it was suggested that the autoclave extraction (AE) would be the most effective method for preparing blueberry hot water extracts with relatively high antioxidant activities.

금융시장의 불확실성이 수출에 미치는 영향에 관한 연구

고경일,최돈승 한국경영컨설팅학회 2013 경영컨설팅연구 Vol.13 No.4

본 연구는 금융시장의 불확실성이 수출에 미치는 영향을 분석하였다. 금융시장은 채권시장, 외환시장, 주식시 장을 선정하였으며 각 시장의 불확실성 변수는 CD(91일)금리, 원/달러 환율, 코스피지수의 변동성으로 측정하 였다. 특히 기업규모에 따라 수출에 대한 금융시장의 영향이 다르게 나타날 것을 고려하여 대기업 수출금액과 중소기업 수출금액의 증가율을 구분하여 금융시장의 불확실성이 미치는 효과를 분석한 후 각각의 결과를 비 교하였다. 분석 방법으로는 그랜저 인과관계 검정과 VAR모형에 기초한 충격반응함수와 예측오차 분산분해를 사용하였다. 그랜저 인과관계 검정 결과에 따르면 금융시장의 불확실성과 수출 사이에는 통계적으로 유의한 인과관계가 존재하였다. 뿐만 아니라 VAR모형을 사용한 충격반응함수의 결과에 따르면 금융시장의 불확실성은 단기적으 로 수출 증가율에 부정적인 영향을 미치고 있음을 확인할 수 있었다. 그리고 예측오차의 분산분해를 사용하여 수출 증가율에 대한 개별 변수들의 상대적인 설명력의 크기를 비교한 결과 금융시장 중에서는 외환시장의 불 확실성이 수출에 가장 큰 영향을 미치고 있었다. 끝으로 중소기업보다 대기업의 수출이 오히려 금융시장의 영 향을 더 받고 있는 것으로 나타났다.