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카테킨 섭취와 운동수행에 따른 obese Zucker rat 골격근의 GLUT-4 VAMP-2와 Syntaxin-4 단백질 발현의 변화
김철현,임예현,조인호,김성찬,방상식,조준용,이규성 한국운동과학회 2003 운동과학 Vol.12 No.4
김철현, 임예현, 조인호, 김성찬, 방상식, 조준용, 이규성, 카테킨 섭취와 운동수행에 따른 obese Zucker rat 골격근의 GLUT-4, VAMP-2와 Syntaxin-4 단백질 발현의 변화. 운동과학, 제12권 제4호, 663-678, 2003. 골격근에서 인슐린의 자극은 GLUT4를 세포막으로 전좌하도록 활성화하여 세포내로 글루코스를 공급할 수 있도록 한다. GLUT4의 전좌는 특이적인 액포(vesicle)결합 단백질인 v-SNARE가 표적 세포막에 위치한 상동성이 큰 t-SNAHE(Syntaxin-4)단백질을 특이적으로 인식하고 상호작용하여 GLUT-4를 세포막 표면으로 가역적 전좌(translocation)를 시켜 글루코스 섭취 능력을 증가시킨다. 본 연구는 v-와 t-SNARE 단백질의 상호 신호전달 작용 및 GLUT-4 작용 기전을 규명하고, 운동과 녹차 성분인 카테킨 섭취에 따른 골격근의 인슐린 저항성에 미치는 영향을 구명하는데 그 목적이 있다. 이를 위해, 본 연구는 비만동물로 확립된 obese Zucker rat(fa/fa)를 사용하여 실험을 수행하였다. 집단은 비교집단, 카테킨 섭취, 운동집단, 운동과 카테킨 섭취 집단(4집단)으로 구분하여 8주간 실험을 실시하였다. 실험결과 카테킨 섭취는 운동수행은 독립적으로 obese Zucker rat의 골격근내 인슐린 조절 단백질인 GLUT-4와 Vamp-2, Syntaxin-4 단백질 발현을 증가시킨 것으로 나타났다. 이는 운동 혹은 카테킨은 각각 독립적으로 골격근의 글루코스 섭취 능력 및 인슐린 저항성을 개선시키는데 도움이 되는 것을 확인할 수 있었다. 즉, 운동 영양학 측면에서 카테킨과 같은 항당뇨 관련 보조물 섭취는 운동과 함께 비만과 당뇨병 개선 효과를 극대화시키는데 도움이 될 것으로 나타났다. 그러나 운동에 의한 GLUT-4의 세포막 이동 외에 카테킨 섭취가 GLUT-4의 세포막으로 이동에 있어서 또 다른 기전에 관여할 가능성이 있어 카테킨 섭취에 따른 GLUT-4 이동의 기전을 다시 확인하기 위한 후속 연구가 필요하다. Kim, C.H., Leem, Y.H., Cho, I.H., Kim, S.C., Bang, S.S., Cho, J.Y.,Lee, K.S. The effect of exercise training and catechins supplementation on skeletal muscle GLUT-4, VAMP-2 and Syntaxin-4 protein expression in obese Zucker rats. Exercise Science, 12(4): 653-670, 2003. Studies have suggested an important role for synaptobrevin and syntaxin homologues in this event, particularly the v-soluble N-ethylmaleimide attachment protein receptors(SNAREs)cellubrevin and vesicle-associated memo r ane protein-2(VAMP-2) and the syntaxin-4(t-SNARE) but the expression of these proteins has not been studied in insulin resistant tissues. There fore, we examined SNARE protein content in skeletal muscle from obese Zucker rats and determined the effect of exorcise and/or catechin treatment on these proteins. GLUT4 levels in skeletal muscle from exorcise and/or catechin treatments were elevated compared with control group. VAMP-2, and syntaxin 4 protein levels were elevated in skeletal muscle from obese Zuker rats compared with controls Restoration of normo-glycemia and normo-insulinemia in exorcised obese Zuker rats improved VAMP-2, and syntaxin-4 protein to levels approaching normal in lean animals. These data show that elevated v- and t-SNARE protein levels are associated with insulin resistance in skeletal muscle and that these increase may be achieved by exorcise and/or catechin treatments concomitant with a restoration of glycemic control. in summary, we have demonstratedthat v- and 1- SNAHE concentration as well as muscle GLUT-4 protein and mRNA can increase significantly after prolonged exorcise and/or catechin, and confirmed that this increase in GLUT-4 protein is controlled at both the pre-translational and translational levels. The observation that improved glucose storage suggests that the increased expression of GLUT-4 protein expression can serve as a molecular yardstick for exorcise-dependent glycogen deposition.
유산균체와 유단백질 유래 Peptide의 면역조절 기능 연구 동향
김철현 한국유가공기술과학회 2008 추계 학술대회 Vol.2008 No.-
The immune system of mammals includes a complex array of cells and molecules, which interact to provide protection from pathogenic microorganisms. The beneficial role played by lactic acid bacteria and milk-derived peptide in the humans, including the effects on the immune system, has been extensively reported. They are present in dairy products and are frequently used as nutraceuticals to some improve some biological functions in the host. The activation of the systemic and secretory immune response by lactic acid bacteria and milk-derived peptide requires many complex interactions among th different constituents of the intestinal ecosystem. The aim of this review was to make the point about the immunological potential of lactic acid bacteria and milk-derived peptide.
김철현,김재혁,김익곤,황룡 대한골절학회 1998 대한골절학회지 Vol.11 No.2
Clavicle fracture is one of the most common fracture, which had been managed via conservative methods with some exceptions such as nonunion. Operative treatment had been regarded as an important cause of nonunion and poor outcome. Nowadays, however, the goal of fracture treatment has become anatomical reduction, rigid fixation and early rehabilitation for better final results. We managed 43 clavicular shaft fracture which was displaced above 11 mm, with conservative treatment (23 cases) and operative treatment (20 cases) since 1990 to 1995. All patients achieved good union in both group, except 5 nonunions of conservative treatment and no significant difference in union time. By functional evaluation of shoulder by Weitzman 23), final results were excellent in 17, good in 2 case., fair in 1 case with operative treatment and excellent in 12, good in 4, fair in 3 and poor in 4 cases with conservative treatment. It was concluded that early operative treatment of clavicular shaft fracture showed better result than conserative treatment, especially in displaced and comminuted ones.