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박찬수,이강현,김명구,강수일,유재우 대한골절학회 1990 대한골절학회지 Vol.3 No.1
Clacaneal fractures involving subtalar joint can be associated with prolonged and severe disability, Many different methods have been tried for the treatment in order to search for better results. From October 1987 to October 1989, five cases of calcaneal fractures involving subtalar joint were treated by open reduction and internal fixation, and the results were as follows: 1. The causes of fractures of the calcaneus were fall from a height in all five cases. 2. The medial approach was used usually and, when the anatomical reduction was impossible by medial approach only, the lateral approach was combined. 3. The average Bohler's angle was 4.6' before reduction and 24.6 after open reduction. The Bohler's angle was increased to average 20' 4, Satisfactory results were obtained in all but one, who was not followed up for over 1 year. 5. The open reduction and internal fixation through the medial approach was valuable treatment method of the intraarticular calcaneal fracture.
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Inflammatory bowel disease pathogenesis mediated by Th17 cells: cytokines, microbiota, and therapies
박찬수,박지현,이민혁 충북대학교 동물의학연구소 2024 Journal of Biomedical and Translational Research Vol.25 No.2
Inflammatory bowel disease (IBD) is a chronic condition characterized by continuous inflammation of the gastrointestinal tract that varies in intensity over time. IBD is caused by several factors including aberrant gut flora, immunological dysregulation, altered environmental conditions, and genetic variations. However, the pathogenesis of IBD remains unclear. Studies have indicated that an imbalance between T helper 17 (Th17) and regulatory T (Treg) cells contributes significantly to the development of IBD. Intestinal Tregs suppress inflammation and are critical for maintaining tissue homeostasis. Th17 cells are known to play an important role in the development and pathogenesis of IBD and provide non-inflammatory support for the integrity of the intestinal barrier against bacterial and fungal infections. Therefore, the Th17/Treg cell balance is crucial in the pathogenesis of IBD and gut integrity. The microenvironment of the intestinal mucosal immunity is regulated by the secretion of cytokines associated with Th17 cells and Tregs. Several studies have indicated that the gut bacteria contribute to the control of the immune milieu and play a key role in the regulation of Th17 cell development. Intestinal bacteria and cytokines control Th17 cell development. Th17 cells secrete cytokines that regulate the immune microenvironment in the gut mucosa. This review provides an overview of Th17 cells and examines the strategies for treating patients with IBD using Th17 cell-targeted drugs.
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사이버전의 역량평가 개선과 역량 강화 방안에 관한 연구
박찬수,박용석,Park, Chan-soo,Park, Yongsuk 한국정보통신학회 2015 한국정보통신학회논문지 Vol.19 No.5
Recently, as the development of cyber weapons, the threat of cyber warfare has been increasing. Nations, which experienced cyber warfare already, have been damaged not only in the cyber space as well as in real war field. Therefore, each nation is constantly making efforts to prepare for cyber warfare. First of all, to prepare for cyber warfare, each nation's capability of cyber warfare should be understood. A plan of reaction of cyber warfare should be searched by comparison and analysis of capability of cyber warfare. This paper compares and analyzes established methodology of capability assessment about cyber warfare, and this paper finds a better point to suggest the improvement of capability assessment about cyber warfare. This paper applies capability assessment of cyber warfare to nations, which can influence on Korea with improved capability assessment of cyber warfare. Comparing and analyzing the result of assessment, this paper deducts complementary point of Korean cyber warfare to suggest the plan to enhancing capability of cyber warfare. 최근 사이버 무기의 발전으로 사이버전의 위협이 점점 더 증가되고 있다. 이미 사이버전을 경험한 국가들은 피해가 사이버상에서만 국한 되는 것이 아니라 물리적인 피해까지 영향을 받게 되어 피해가 상당하다. 이렇기 때문에 각국은 사이버전에 대비하기 위해 끊임없이 노력을 하고 있다. 먼저, 사이버전을 대비하기 위해서는 각국의 사이버전 역량이 파악되어야 하며, 비교 / 분석을 통해 사이버전 대응방안을 모색해야 한다. 본 논문에서는 기존 사이버전의 역량평가 방법에 대해서 비교 / 분석해보고, 향상점을 도출하여 사이버전 역량 평가 개선안을 연구하였다. 개선된 사이버전 역량 평가를 통해서 한국에 영향을 줄 수 있는 국가들을 대상으로 사이버전 역량 평가를 실시하였으며, 평가 결과를 비교 / 분석함으로 한국의 사이버전 역량의 보완점을 도출하여 사이버전 역량 강화 방안을 제시하였다.
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12부위 확장생검법에 의해 발견된 전립선암의 임상적 의의
박찬수,이상은,정현 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.1
Purpose: Twelve-core biopsy improves the detection rate of prostate cancer; however,the clinical significance of these additionally detected tumors has not been established. We retrospectively evaluated the clinical difference between prostate cancers detected by only the 12 core biopsy and by the 6 core biopsy from patients underwent radical prostatectomy. Materials and Methods: Between February 2000 and April 2005, 124 men underwent radical prostatectomy after 12-core biopsy at Seoul National University College of Medicine, Bundang Seoul National University Hospital, Seoul National University Boramae Hospital. Among the 12-core biopsy group, we compared the subset with standard sextant cores(Group A) and the subset with lateral sextant cores(Group B). The low-risk group was defined as patients with a serum prostate-specific antigen(PSA) level less than 10.0ng/ml, a Gleason score of the final pathologic findings≤6, no pelvic lymph node metastasis and no lymphadenectomy performed, and a T stage≤T2a. Results: There was no statistically significant difference between low-risk patients in group A and group B(p=0.0814). Groups A and B were then divided into three groups according to preoperative PSA levels of less than 10.0ng/ml, 10.0ng/ml to less than 20.0ng/ml, and greater than 20.0ng/ml. The results of the subset analysis were the same for all three PSA categories. There was no statistically significant difference when we performed the analysis between group A and group B according to the Gleason score of the final pathologic findings and the TNM stage(p=0.0814), and there was also no statistically significant difference when we performed the analysis between group A and group B according to only the Gleason score of the final pathologic findings(p=0.5026). Conclusions: The prostate cancers diagnosed by means of 12-core biopsy did not appear to be of a clinically lower risk than those detected with 6-core biopsy. We have firmly shown that 12-core biopsy is a more clinically effective procedure than 6-core biopsy. Purpose: Twelve-core biopsy improves the detection rate of prostate cancer; however,the clinical significance of these additionally detected tumors has not been established. We retrospectively evaluated the clinical difference between prostate cancers detected by only the 12 core biopsy and by the 6 core biopsy from patients underwent radical prostatectomy. Materials and Methods: Between February 2000 and April 2005, 124 men underwent radical prostatectomy after 12-core biopsy at Seoul National University College of Medicine, Bundang Seoul National University Hospital, Seoul National University Boramae Hospital. Among the 12-core biopsy group, we compared the subset with standard sextant cores(Group A) and the subset with lateral sextant cores(Group B). The low-risk group was defined as patients with a serum prostate-specific antigen(PSA) level less than 10.0ng/ml, a Gleason score of the final pathologic findings≤6, no pelvic lymph node metastasis and no lymphadenectomy performed, and a T stage≤T2a. Results: There was no statistically significant difference between low-risk patients in group A and group B(p=0.0814). Groups A and B were then divided into three groups according to preoperative PSA levels of less than 10.0ng/ml, 10.0ng/ml to less than 20.0ng/ml, and greater than 20.0ng/ml. The results of the subset analysis were the same for all three PSA categories. There was no statistically significant difference when we performed the analysis between group A and group B according to the Gleason score of the final pathologic findings and the TNM stage(p=0.0814), and there was also no statistically significant difference when we performed the analysis between group A and group B according to only the Gleason score of the final pathologic findings(p=0.5026). Conclusions: The prostate cancers diagnosed by means of 12-core biopsy did not appear to be of a clinically lower risk than those detected with 6-core biopsy. We have firmly shown that 12-core biopsy is a more clinically effective procedure than 6-core biopsy.
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박찬수 한국기계기술학회 2014 한국기계기술학회지 Vol.16 No.5
We have performed CFD simulation and analyzed flow and concentration fields for the basic data of the ventilation system for removing pollutants which were produced in a lecture room. The flow patterns indicated differently according to the arrangement of openings and the concentration distribution of pollutants were showed higher and lower because of the effect of that flow patterns. In the case of arranging the openings to the upper and lower side, the stagnation appearance of flow formed in the interested space. In the case of arranging the openings to the right and left side, the stagnation of high concentration pollutants appeared in the middle area of the interested space. On the increasing exhaust velocity, the distribution of pollutants appeared similar to the normal case, but the concentration of pollutants were lower.
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