Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

모기계대세포에서의 러시아 춘하뇌염의 증식

李淵台,金敬淑,李潤日,金明淑,李種訓 최신의학사 1973 最新醫學 Vol.16 No.9

Growth of Russian spring-summer encephalitis virus in established line of mosquito (Sigh's Aedes albopictus) cells was studied by infectivity ' titration of mouse lethal doses and observation of morphological changes on the infected cell monolayers. The cell line could support the multiplication of Russian spring summer encephalitis virus. The maximum virus titer of 10''0 mice LD50 was reached in 3 days after virus inoculation. Cytopathic effect was found on the whole monolayer from second post infective day and large round spherical cell aggregates were observed theereafter.

폐 내 병변으로 인한 소아 급성 호흡부전의 원인 질환과 예후

이혜영,박지숙,최희라,서지현,김점수,임재영,최명범,박찬후,우향옥,윤희상 대한소아과학회 2004 小兒科 Vol.47 No.5

민주주의를 위한 교육의 철학적 기초

이명숙 全北大學校 哲學科 1996 饗宴 Vol.3 No.-

세대별 가족자원 및 가족관계 인지에 관한 연구 : 모녀간의 차이를 중심으로 between mother and daughter

이명숙 안성산업대학교 1998 論文集 Vol.30 No.-

This study examines the perceptions of family resources and family relations between mother and daughter. The Major findings of the study are summarized as follows. 1) The perceived future environment have no differencies significantly according to generation gap. All of the mothers and daughters perceived the family life and their health as the most future value. 2) The group of mothers prerceived more satisfactory their family resources than the group of daughters. 3) The group of mothers perceived heigher quality of family relation than the group of daughters.

생활양식 변화에 대한 고찰

이명숙 안성산업대학교 1998 論文集 Vol.30 No.2

In this rapidly-changing social environments, as various information, stimulations and resources are acting on family life in diverse ways. The purposes of this study are to consider the changes of the general lifestyle. For these aims, this study has applied reviewing literatures and researches. As a results, lifestyle should be analysed as totality of the living activities which have an organic relationship with each other and the concept of the "change" of mode of living should be grasped as one of the "formation"of the mode of living.

大單位 아파트團地의 配電方式의 改善에 關한 硏究

權錫兜,李明鎬 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.1

This paper presents an improved extra-high voltage distribution system on the large scale apartment site. In this paper, we are attempting to step up feeder voltage to 22.9KV from the established voltage, 6.6KV between distribution lines. For this application, the third Panpo Apartment Site is sampled as a case. Amount of power distribution loss and its construction cost are calculated by digital computer. The results showed that amount of power distribution loss was reduced by 0.73%, from 4.62% to 3.8%, and construction cost by the reduction of facilities was curtailed by 0.7% less than that of the existing system. From these results, we suggest strongly that the improved distribution system may be used to reduce distribution loss and construction cost on the large scale apartment area in the near future.

디자인 정보 시스템 구축에 관한 연구 : 제품디자인 프로세스를 중심으로 Focused on the Product Design Process

최명식,이종석 慶熙大學校 1998 論文集 Vol.27 No.-

The role of information can not be more emphasized in these times of globalization and digitalization. Establishing an efficient and accurate information system to maintain information effectively with easy access is needed in design. This will bring innovation to product design development. Standardizing all design data is also needed for easily establishing the design information system and making better quality design development and management. Expected results of establishing design information system are : 1. more efficient design development in less time by sharing the same data and process. 2. compiling data will develope good design history as a tool to support future product development. 3. by using the information system we can easily acquire global market information and respond with the most appropriate designs. 4. sharing standardized data and knowhow will create better communication and efficient use of time and finance. Design information system may help designers to focus on more creative works and to develop better quality of products.

Priming 처리종자의 저장기간에 따른 발아력 전당함량 및 α-amylase 활력

김재현,이석순,박성태,정명근 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.3

벼 종자의 priming처리 후 저장성을 검토하기 위하여 저장기간과 저장온도에 따라서 종자의 발아력과 저장양분 및 발아에 관여하는 주요 효소활력의 변화를 조사한 결과를 요약하면 다음과 같다. 1. Priming한 종자를 6개월간 저장하여도 어느 저장온도에서나 발아율의 차이가 없었다. 2. Priming한 종자에서 발아속도(T_50)가 2∼3일 빨랐으며 3개월 동안은 변화가 없었고 3개월 이후 발아속도가 약간 감소하였으나 priming 처리하지 않은 종자에 비해서 빨랐다. 3. 발아균일도는 priming 처리효과가 6개월간 계속 유지되었으며 25℃보다 저온인 17℃에서 효과가 더 크게 나타났다. 4. α-amylase 활력은 저장기간이 길수록 높았고 전당함량의 경우 3개월 이상 저장하였을때 감소하였으나 발아력에는 영향을 미치지 않았다. 5. 종자 수확후 6개월 동안은 어느 시기에 priming 처리하여 저장하여도 발아력 및 종자의 활력은 유지되었다. This experiment was carried out to determine changes of seed germination ability, total sugar, and α-amylase activity to different storage period, and temperature after seed priming treatment. In the storage during the six months, final germination rate and speed were similar to the untreated control seeds and the uniformity was continuously preserved. Germination speed(T_50) was faster than the control seeds by 2∼3 days. T_50 was a little decreased to priming effect after three months but faster than the control seeds. In the case of germination temperature 25℃, germination uniformity was decreased to long term storage periods. Total sugar content was increased to compare with the control seed during the one months at -10, 5 and 20℃ and total sugar content was decreased after two months. α-amylase activity was increased to storage of long term period and seed of storage temperature 5℃ was increased compared with -10 and 20℃. Germination ability and α-amylase activity was preserved continuously during six months after priming treatment.

항생제 대체제(앤타시드-100)의 급여가 젖소 송아지 육성에 미친 영향

명윤아,박덕섭,이인덕,남명수,이형석,김용국 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

This study was carried out to develope an antibiotic substitute with some feed additive ingredients; activated charcoal, microbial products( Saccharomyces cerevisiae), sodium bentonite and pyroligneous. Sixty Holstein male calves(control 30 and tested 30 calves) were assigned to one of two diets, control(containing commercial antibiotic) and treatment diet (containing antibiotic substitute) with three replicates(10 calves each). The experiment were carried out for 30 days. The daily weight gains were similar between control(1.01kg/d) and treatment groups(1.01kg/d), however feed requirement were lower for treatment calves (2.80kg) than control calves (3.24kg) (P<0.05). Also calves were more health for treatment calves than control calves for diarrhea and respiratory diseases occurrences. The ammonia concentration of feces were lower for treatment calves(2.67 ppm) than for control calves(6.33 ppm) (P<0.05). No statistical difference were found in blood substances between control and treatment calves(P>0.05). In conclusion, the calve performances were improved by substitute without commercial antibiotic additive. 본 연구는 항생제를 대체할 목적으로 동물체의 활성을 가져오는 원료로 알려져 있는 활성탄과 목초액, sodium bentonite, 홍삼박, 생균제를 선별하여 이들 원료로 구성된 항생물질 대체제를 개발하여 홀스타인 수송아지에 급여하였을 때 생산성에 미치는 효과를 규명하고자 수행하였다. 송아지의 일당증체량은 대조구(1.011kg), 처리구(l.0lkg)간에 유의적인 차이가 없었고(P>0.05), 사료 요구율은 대조구 3.24에 비하여 처리구 2.80로 처리구에서 유의적인 개선효과를 나타냈다(P<0.05). 설사 발생률은 동일하였으나 분 상태는 처리구가 양호하였고, 호흡기 질병은 처리구에서는 발생하지 않았다. 분 중 NH₃ 농도는 대조구(6.33 ppm)에 비하여 처리구(2.67 ppm)에서 뚜렷한 개선 효과를 보였고(P<0.05), 혈액 수치는 대조구와 처리구가 유사하였다. 항생물질 대체제를 급여한 처리구가 시판 항생제 첨가사료급여군(대조구)에 비하여 증체에서는 다소 낮은 성적을 나타냈지만 질병 발생 없이 유사한 성적을 낸 것은 대체물질이 가축 소화기관의 활성화, 사료의 소화율 증진 등에 영향을 나타내어 동물의 활력이 증진되므로 항생제의 사용 없이도 양질의 축산물을 생산할 수 있는 결과를 얻었다.