Clinical Characteristics of Primary Thyroid Lymphoma in Koreans

HWANG, You-Cheol,KIM, Tae Yong,KIM, Won Bae,SHONG, Young Kee,YI, Ka Hee,SHONG, Minho,JO, Young Suk,KIM, Won Seog,CHUNG, Jae Hoon The Japan Endocrine Society 2009 Endocrine journal Vol.56 No.3

<P>Primary thyroid lymphoma is a very rare tumor and its prevalence is approximately 0.1% of all thyroid cancers in Korea. Its clinical experience is limited and not familiar to physicians. Therefore, we performed this study to investigate the clinical characteristics of primary thyroid lymphoma in Koreans. We retrospectively analyzed the medical records of the 44 patients with primary thyroid lymphoma from 1991 to 2006 at four major referral hospitals in Korea. Out of 44 patients, eight patients were male and 36 patients were female and their average age was 57 years. Fifty-six percent of patients had underlying Hashimoto′s thyroiditis. All but two patients had non-Hodgkin′s lymphoma with B cell origin, and eighty percent of patients presented with stage IE or IIE. Twenty-one of 44 patients (48%) had diffuse large B cell lymphoma (DLBCL) and 17 (39%) had MALT lymphoma. Malignancies originating from lymphoid cells were suspected in 10 of eighteen patients with DLBCL (56%) by using fine-needle aspiration cytology (FNAC), and no difference was noted compared with MALT lymphoma (64%). Compared with DLBCL, the patients with MALT lymphoma were more frequently presented with stage I disease (DLBCL vs. MALT lymphoma: 32% vs. 65%, P=0.04). Moreover, in contrast to DLBCL, most of the patients with MALT lymphoma achieved complete response with treatments (DLBCL vs. MALT lymphoma: 53% vs. 94%, P‹0.01). Because of the low diagnostic accuracy of FNAC, thyroid biopsy should be considered for the diagnosis of thyroid lymphomas in suspicious cases. The patients with MALT lymphoma were more frequently presented with early stage diseases and this might lead to the favorable outcome to treatments than those with DLBCL.</P>

Clinical Course of Patients with Ig A Nephropathy between Combined Treatment of Immunosuppressive Agents and ACE Inhibitor and ACE Inhibitor alone

(You Cheol Hwang),(Tae Won Lee),(Myung Jae Kim),(Moon Ho Yang),(Chun Gyoo Ihm) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2

N/A Background : It has not been clear whether immunosuppressive therapy favorably influences renal function and proteinuria in IgA nephropathy (IgAN). Angiotensin converting enzyme inhibitor (ACEi) has an anti-proteinuric effect in IgAN. A retrospective study was done to see whether the addition of immunosuppressive therapy to ACEi produces a more excellent anti-proteinuric effect and preserves better renal function than ACEi alone. Methods : A total of 49 patients with proteinuria>1.0 g/day and serum creatinine concentrations<1.5 mg/dL were followed-up from at least 1 year to 9 years. Among them, 25 patients were treated with the combination of cyclophosphamide, prednisolone and ACEi while the other 24 were treated with ACEi alone. Results : The combination therapy or ACEi alone both reduced proteinuria with significant value (the combination group: from 5.74±5.08 to 2.29±2.77 g/day, ACEi group: from 3.85±2.54 to 1.68±1.91 g/day), while no significant differences in reduction of proteinuria were noticed between the two groups. There was no significant elevation of serum creatinine in both groups during follow-up (the combination group: from 0.91±0.20 to 1.03±0.38 mg/dL, ACEi group: from 0.93±0.27 to 0.99±0.37 mg/dL). This study showed no significant differences in the change in slope of 1/serum creatinine levels during the follow-up period between the two groups. Conclusion : We conclude that immunosuppressive therapy may not be beneficial in patients with proteinuric IgAN. ACEi may be a valuable therapeutic agent avoiding serious side effects of immunosuppressive agents.

Toxicities of Difenoconazole on the Development of Xenopus laevis

You-Hwa Lee,Jong-Woo Hwang,Da-Ra Park,Jun-Cheol Lee,Seon-Woo Cheong 한국생명과학회 2008 한국생명과학회 심포지움 Vol.49 No.-

Association between Second-hand Smoke Exposure and Urinary NNAL Level in Korean Adolescents

You Hyo-Sun,Lee Jae-woo,Kim Ye-seul,Kim Yonghwan,Lee Hyeong-Cheol,Hwang Jin Young,Yang Woojung,Kang Hee-Taik 대한의학회 2021 Journal of Korean medical science Vol.36 No.13

Background: The 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of tobacco-specific lung carcinogen that can be found in both smokers and non-smokers. Particularly, NNAL levels of children with a history of exposure to second-hand smoke (SHS) are higher than those of adults. Thus, we aimed to investigate the association between SHS exposure and urine NNAL levels in Korean adolescents. Methods: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey VII. Overall, 648 never-smoking adolescents (425 boys and 223 girls) aged 12 to 18 were included in this study. Logistic regression analyses identified the relationship between SHS exposure and elevated urine NNAL levels. Results: The mean urine NNAL levels of the no exposure and exposure group in boys were 1.39 and 2.26 ng/mL, respectively, whereas they were 1.01 and 2.45 ng/mL in girls, respectively (P < 0.001). Among the adolescents exposed to SHS, the confounder-adjusted odds ratio (95% confidence intervals) for elevated urine NNAL levels according to exposure area as overall, home, and public area were 2.68 (1.58–4.53), 31.02 (9.46–101.74), and 1.89 (1.12–3.17) in boys; and 6.50 (3.22–13.11), 20.09 (7.08–57.04), and 3.94 (1.98–7.77) in girls, respectively. Conclusion: SHS exposure was significantly associated with elevated urine NNAL levels in Korean adolescents, particularly in female adolescents and in those with home exposure. These findings remind us of the need to protect adolescents from SHS.

Regulation of $I{\kappa}B$ Kinase by $G{\beta}L$ through Recruitment of the Protein Phosphatases

You, Dong-Joo,Kim, You-Lim,Park, Cho-Rong,Kim, Dong-Kyu,Yeom, Jeong-Hun,Lee, Cheol-Ju,Ahn, Curie,Seong, Jae-Young,Hwang, Jong-Ik Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.6

G protein ${\beta}$-like ($G{\beta}L$) is a member of WD repeat-containing family which are involved in various intracellular signaling events. In our previous report, we demonstrated that $G{\beta}L$ regulates TNF${\alpha}$-stimulated NF-${\kappa}$B signaling by interacting with and inhibiting phosphorylation of $I{\kappa}B$ kinase. However, $G{\beta}L$ itself does not seem to regulate IKK directly, because it contains no functional domains except WD domains. Here, using immunoprecipitation and proteomic analyses, we identified protein phosphatase 4 as a new binding partner of $G{\beta}L$. We also found that $G{\beta}L$ interacts with PP2A and PP6, other members of the same phosphatase family. By interacting with protein phosphatases, which do not directly bind to IKK${\beta}$, $G{\beta}L$ mediates the association of phosphatases with IKK${\beta}$. Overexpression of protein phosphatases inhibited TNF${\kappa}$-induced activation of NF-${\kappa}$B signaling, which is an effect similar to that of $G{\beta}L$ overexpression. Down-regulation of $G{\beta}L$ by small interfering RNA diminished the inhibitory effect of phosphatases, resulting in restoration of NF-${\kappa}$B signaling. Thus, we propose that $G{\beta}L$ functions as a negative regulator of NF-${\kappa}$B signaling by recruiting protein phosphatases to the IKK complex.

Neuro-Fuzzy Gust Front Detection Algorithm With S-Band Polarimetric Radar

Hwang, Yunsung,Yu, Tian-You,Lakshmanan, Valliappa,Kingfield, Darrel M.,Lee, Dong-In,You, Cheol-Hwan IEEE 2017 IEEE transactions on geoscience and remote sensing Vol.55 No.3

<P>A gust front (GF) is the leading edge of the cold outflow from a thunderstorm. The upgrade of the S-band Weather Surveillance Radar-1988 Doppler (WSR-88D) to dual-polarization has been completed recently in the U.S. Therefore, it is timely to exploit the added benefits of polarimetric variables to identify GFs. In this paper, six signatures derived from polarimetric WSR-88D data are developed to characterize GFs, including medium reflectivity, apparent thin line feature in reflectivity, and the motion of reflectivity quantified by a line feature parameter, high differential reflectivity, low copolar cross-correlation coefficient, apparent convergence manifested by the large radial shear, and large standard deviation of differential phase. These signatures are fuzzy in nature, and therefore, a novel neuro-fuzzy GF detection algorithm (NFGDA) is developed using a fuzzy logic inference system, which is optimized by a training process using a neural network. WSR-88D data from 11 cases (totaling 121 volume scans) are used to evaluate the performance of NFGDA and compared to the operational machine intelligent GF algorithm (MIGFA) with single polarization data. The results show that NFGDA can provide improved performance with a higher probability of detection of 92% (versus 78% with MIGFA), lower false alarm ratio of 0% (versus 9%), and higher percentage correct of 93% (versus 74%). Additional length-based scoring schemes show that NFGDA can correctly detect 62% (41% with MIGFA) of the total length of GFs, and minimize falsely detected length to 7% (61%).</P>

신장 이식 후 발생한 골수 이형성 증후군 1예

이철우,이현아,박민선,김진국,김원배,이희발,황승덕,이유경,강문수,추원석 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1

A 44-year-old man treated with azathioprine, cyclosporine and prednisolone for 7.5 years after allogeneic renal transplantation was admitted because of exertional dyspnea, fatigue and pancytopenia which were found 3 months ago. He had been on hemodialysis for renal failure of unknown cause for 8 months before the renal transplantation. Bone marrow examination showed hypercellularity, erythroid hyperplasia and 7% of myeloblast, consistent with the diagnosis of myelodysplastic syndrome. Cytogenetic study showed chromosomal abnormalities:deletion of chromosome 5, monosomy 7, trisomy 8, monosomy 14 and deletion of chromosome 17. Immunosuppressive agents were discontinued and he was treated with transfusion, G-CSF, and combination chemotherapy including topotecan and Ara-C. Graft kidney function was normal before and after the treatment, but the clinical course was fatal because of leukemic transformation and eventually sepsis. Although therapy induced myelodysplastic syndrome was rare in renal allograft recipients, thorough evaluations including bone marrow biopsy and cytogenetic study are recommended in patients with anemia of unknown etiology.

도로 낙석방지울타리의 낙석지지능력 평가

황영철(Hwang Young Cheol),유병옥(You Byung Ok),이승호(Lee Seung Ho) 대한토목학회 2002 대한토목학회 학술대회 Vol.2002 No.11

토사사면에서의 FRP보강 그라우팅 공법 적용성 평가

황영철(Hwang Young Cheol),김낙영(Kim Nak Young),유병옥(You Byung Ok),김성환(Kim Sung Hwan),최용기(Choi Yong Ki) 대한토목학회 2000 대한토목학회 학술발표회 논문집 Vol.2000 No.2

Long-term Clinical Outcomes of Radiofrequency Catheter Ablation versus Permanent Pacemaker Implantation in Patients with Tachycardia-Bradycardia Syndrome

Sang-Cheol Cho,Eun-Sun Jin,Sang Yong Om,Ki Won Hwang,최형오,Ki-Hun Kim,Sung-Hwan Kim,Kyoung-Min Park,Jun Kim,Ki-Joon Choi,You-Ho Kim,Gi-Byoung Nam 대한심장학회 2020 Korean Circulation Journal Vol.50 No.11

Background and Objectives: Pacemaker (PM) implantation is a well-accepted treatment option for patients with paroxysmal atrial fibrillation (AF) and related tachycardia-bradycardia syndrome (TBS). Data on the long-term clinical outcomes after radiofrequency catheter ablation (RFCA) or PM implantation are sparse. Methods: The medical records of 217 patients with TBS were retrospectively assessed. Outcomes in patients who underwent RFCA (n=108, 49.8%) were compared to those with PM implantation (n=109, 50.2%). The clinical outcomes were sinus rhythm maintenance, conversion to persistent AF, additional procedure or crossover, and the composite of cardiovascular hospitalization and death. Results: During the follow-up period (mean 3.5±2.0 years), the RFCA group, compared to the PM group, showed better sinus rhythm maintenance (adjusted hazard ratio [aHR], 0.27; 95% confidence interval [CI], 0.15–0.46; p=0.002) and less progression to persistent AF (aHR, 0.20; 95% CI, 0.06–0.63; p=0.006). Additional procedure or crossover did not differ significantly between the groups (aHR, 2.07; 95% CI, 0.71–6.06; p=0.185 and aHR, 0.69; 95% CI, 10.8–2.67; p=0.590, respectively). Most RFCA patients (92.6%) did not require pacemaker implantation during long term follow-up period (>3.5 years). The composite endpoint of cardiovascular rehospitalization and death was not significantly different between the groups (aHR, 0.92; 95% CI, 0.50–1.66; p=0.769). Conclusions: RFCA is an effective alternative to PM implantation in patients with TBS. In these patients, successful RF ablation of AF is related to a higher rate of sinus rhythm maintenance compared to PM implantation, and the composite outcome of cardiovascular rehospitalization and death is similar.