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곽우혁,최한고,박원우 金烏工科大學校 1998 論文集 Vol.19 No.-
This paper describes a nonlinear adaptive noise canceller using neural networks as the nonlinear adaptive filter, which is suitable for extracting periodic signals and nonstationary signals contaminated with broadband noise. Two neural networks. feedforward (FNN) and recurrent neural networks (RNN), are used as nonlinear adaptive filters. In this paper, it assumes that the noise of the primary input in the adaptive noise canceller is not the same characteristic as that of the reference input. Performance of the proposed noise canceller is evaluated using peripdic sawtooth signal and speech signal with white noise, and than compared with conventional adaptive noise canceller of linear structure. Experimental results show that the neural network based noise canceller outperforms the linear noise canceller. It is also verified that the RNN adaptive filer performs best with respect to noise rejection of mean square error.
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권혁록,한진우,이진호,최항문,박인우,이석근 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.3
Thirteen-year-old girl complaining of the swelling and pain on the left midface visited our dental hospital. On the radiogaphic examination, well-defined radiolucent lesion with hyperostotic border was found in the left maxilla accompanying with the external root resorption of the involved teeth and the displaced second molar. CT showed calcified bodies, thinning of hard palate, inferior orbital wall and lateral wall of nasal fossa, and thinning and perforation of the buccal plate of the maxilla. Enucleation and curettage of the lesion and nasoantrostomy was carried out and histopathologic examination mainly showed a solid tumor tissue composed of odontogenic epithelium and pulp tissues admixed with dentin and enamel formation. And some part of reduced follicular epithelium of tooth germ showed a change mimicking calcifying odontogenic cyst, Taken together, we concluded the lesion is an ameloblastic fibro-odontoma with a change of calcifying odontogenic cyst. (Korean J Oral Maxillofac Radiol 2001; 31 : 181-4)
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김남재,진성민,최혁재,주수만,송보완,김종우 한국병원약사회 2002 병원약사회지 Vol.19 No.4
The influence of single and repeated oral pretreatment of CHUNG-HYUL-DAN(CHD). a widely used Korean traditional herbal medicines prescribed for hypertension and hyperlipidemia, on the pharmacokinetics and pharmacodynamics of a calcium channel blocker, nicardipine after oral administration of nicardipine was investigated in rats. The single pretreatment of CHD significantly increased area under the plasma concentration-time curve(AUC_(0-8h), but did not influence the time to reach the maximum peak plasma concentration(T_(max)), the maximum peak plasma concentration(C_(max)), terminal elimination half-life(t_(1/2) or the elimination rate constant(λ) for nicardipine. And, C_(max) and AUC_(0-8h) for nicardipine were significantly increased by with 1-week repeated pretreatment with CHD, but the other parameters were not significantly different from those of control. Also, the extent of the lowering effect of nicardipine on blood pressure in rats was significantly increased after oral administration of nicardipine with single and repeated oral pretreatment with CHD. These results indicated that single and 1-week repeated oral pretreatment with CHD should inhibit the metabolism of nicardipine in rats.
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이현성,최우진,고영초,이채혁,박효일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Objectives : In this study, the author reviewed the clinical features of the patients with anaplastic oligodendroglioma and evaluated the efficacy of surgery, radiation therapy and chemotherapy as a treatment modality. The study was intended to provide the standardized treatment option for this rare disease. Methods : The author present ten cases of pathologically proven anaplastic oligodendrogliomas from 1988 to 2002. A retrospective analysis of clinical presentation. radiological and pathological features, and the effectiveness of treatment was performed and the factors affecting prognosis were investigated. Fesults : The ten patients comprised of four males and six females. The mean age at diagnosis was 34.4 (8-70). The mean follow-up duration was 40.5 months. and two patents died of tumor progression during the follow-up(70, 86 months, respectively). The most common presenting symptom was seizure(70%). All patients underwent surgery and the tumors were removed as much as possible. Postoperatively, Radiation therapy was applied to seven patients. and PCV(procarbazine CCNU-vincristine) based chemotherapeutic agent was administered to five patients. Total removal was achieved in five cases and subtotal removal was possible in the rest. In the group with PCV therapy, complete remission was observed in two, partial remission, stable disease, and disease progression to death in one, respectively. The patients well tolerated the toxicity of chemotherapy. During the follow-up, tumor recurrences were observed in four patients, and they were treated with additional operations and/or chemotherapy. Mixed anaplastic oligoastrocytoma showed earlier recurrence than anaplastic oligodendrogliomas in this study(P=0.014), but the other clinical factors and treatment modalities were not related to the time of recurrence of the tumor. Conclusions : In this study, the authors confirmed the good response of postoperative radiological treatment and chemotherapy in patients with anaplastic oligodendroglioma. PCV chemotherapy should be considered as primary treatment method for the patients with anaplastic oligodendroglioma.
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전두엽 상내측 신경교종의 수술 수 발생하는 운동보조영역 증후군
김재현,고영초,이채혁,권오기,최우진,박효일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2
Objective : This retrospective study was aimed to correlate characteristic neurologic deficits of transient contralateral motor weakness with or without speech disturbance(Supplementary Motor Area, SMA syndrome) after the resection of the gliomas in the superior frontal gyrus, especially with the extent of resection of the tumors. Method : Ten patients with medial superior frontal glioma, who underwent gross total or subtotal resection of the tumor, as well as, partial or complete resection of the spolementary motor area were studied. The following parameters were evaluate 1) tumor location 2) extent of resection 3) degree and duration of postoperative deficits. Result : Postoperative neurologic deficits were transient contralateral motor weakness with or without motor dysphasia. As a whole, postsurgical SMA syndrome occurred in 3 patients out of 10 patients with medial superior frontal gliomas(30%), who underwent gross total or subtotal resection of the tumors. Motor deficits were present in 3 out of 10 patients and speech disturbances in 2 out of 3 left frontal gliomas. Recovery of neurological dysfunction was rapid occurring between the 5th 14th POD and their neurological function returned almost normal in two patients. In the remaining one patient, who had preoperative mild motor weakness showed incomplete recovery of the worsened motor weakness and newly developed speech disturbance till 1yr postoperatively. Conclusion : The postsurgical SMA syndrome in patients with glioma in the medial superior frontal gyrus was not so uncommon phenomenon and well correlated with the extent of surgical resection of the supplementary motor area. Thus, preoperative awareness and warning about the possibility of the development of this charicteristic SMA syndrome is necessary.
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Ribosomal Intergenic Spacer 1 Based Characterization of Button Mushroom (Agaricus bisporus) Strains
( Hyuk Woo Kwon ),( Min Ah Choi ),( Dae Wook Kim ),( Youn-lee Oh ),( Min Woo Hyun ),( Won-sik Kong ),( Seong Hwan Kim ) 한국균학회 2016 Mycobiology Vol.44 No.4
Breeding the button mushroom requires genetic information about its strains. This study was undertaken to genetically characterize four domestically bred button mushroom strains (Saea, Saejung, Saedo, Saeyeon cultivars) and to assess the possibility of using the intergenic spacer 1 (IGS1) region of rDNA as a genetically variable region in the genetic characterization. For the experiment, 34 strains of Agaricus bisporus, two strains of A. bitorquis, and one strain of A. silvaticus, from 17 countries were used. Nucleotide sequence analysis of IGS1 rDNA in these 37 Agaricus strains confirmed that genetic variations exist, not only among the four domestic strains, but also between the four domestic strains and foreign strains. Crossing two different haploid strains of A. bisporus seems to generate genetic variation in the IGS1 region in their off-spring haploid strains. Phylogenetic analysis based on the IGS1 sequence revealed all A. bisporus strains could be differentiated from A. silvaticus and A. bitorquis strains. Five genetic groups were resolved among A. bisporus strains. Saejung and Saeyeon cultivars formed a separate genetic group. Our results suggest that IGS1 could be complementarily applied in the polymorphism analysis of button mushroom.
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Woo Sang Hyun,Kim Young Woo,Cheon Ho-Jun,Jang SungHo,Do Jun-Young,Choi Joon Hyuk,Kang Dong Ho,Nam Hyun Jae,Yoo Myung Jae,Lee Young Seok,Choi Jin-Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.2
Background: On February 2, 2017, the surgical team of ten board-certified hand specialists of W Hospital in Korea successfully performed the nation's first hand transplantation at Yeungnam University Medical Center (YUMC). This paper reports on the legal, financial, and cultural hurdles that were overcome to open the way for hand transplantation and its functional outcomes at 36 months after the operation. Methods: W Hospital formed a memorandum of understanding with Daegu city and YUMC to comply with government regulations regarding hand transplantation. Campaigns were initiated in the media to increase public awareness and understanding. With the city's financial and legal support and the university's medical cooperation, a surgical team performed a left distal forearm hand transplantation from a brain-dead 48-year-old man to a 35-year-old left-handed man. Results: With this successful allotransplantation, the Korean Act on Organ Transplantation has now been amended to include hand transplantation. Korean national health insurance has also begun covering hand transplantation. Functional outcome at 36 months after the operation showed satisfactory progress in both motor and sensory functions. The disabilities of the arm, shoulder, and hand score were 23. The final Hand Transplantation Score was 90 points. Functional brain magnetic resonance imaging shows significant cortical reorganization of the corticospinal tract, and reinnervation of intrinsic muscle is observed. Conclusions: Hand transplantation at the distal forearm shows very satisfactory outcomes in functional, aesthetical, and psychological aspects. Legal and financial barriers against hand transplantation have long been the most burdensome issues. Despite this momentous success, there have been no other clinical applications of vascularized composite allotransplantation due to the limited acceptance by Korean doctors and people. Further public education campaigns for vascularized composite allotransplantation are needed to increase awareness and acceptance.
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