Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Tae Kyeong Shin,Mi Sun Kang,Ho Youn Lee,Moo Sang Seo,Si Geun Kim,Chi Dae Kim,Won Suk Lee 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1Ձ (HIF-1Ձ) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1Ձ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin, Tae-Kyeong,Kang, Mi-Sun,Lee, Ho-Youn,Seo, Moo-Sang,Kim, Si-Geun,Kim, Chi-Dae,Lee, Won-Suk The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1 ${\alpha}$ (HIF-1 ${\alpha}$) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1 ${\alpha}$ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

키넥트 센서를 이용한 고령자 대상의 선자세 균형능력 평가

양승태(Seung-Tae Yang),강동원(Dong-Won Kang),서정우(Jeong-Woo Seo),김대혁(Dae-Hyeok Kim),김태호(Tae-Ho Kim),최진승(Jin-Seung Choi),탁계래(Gye-Rae Tack) 대한전기학회 2017 전기학회논문지 Vol.66 No.2

Portable low-cost Kinect sensor was used to analyze standing balance ability of the elderly. Eighty subjects who can walk alone and have a normal cognitive level participated in this experiment. Based on Berg Balance scale (BBS) test with 52 points, subjects were divided into Healthy older (HO: 46 persons, BBS: 53.80 ± 1.19) and Impaired older (IO: 34 persons, BBS: 49.06 ± 2.03) group. Each subject performed 30 seconds four different standing balance tests (EO: Eyes Open, EC: Eyes Close, EOf: Eyes Open on foam, ECf: Eyes Close on foam). Five variables (Mean distance, Range of distance, Root mean square, Mean velocity, 95% ellipse area) were calculated from the hip joint center movement of Kinect sensor. Results showed that there were significant differences between groups for four different standing tests. Calculated variables from kinect sensor showed significant correlation with BBS score. Especially, mediolateral mean distance, mediolateral root mean square, mediolateral range of distance and 95% ellipse area showed discriminative ability for all tests. Mean values of variables of IO were higher than those of HO, which means the decreased balance ability in IO compared with HO. Therefore, it was possible to estimate simple balance assessment of the elderly using portable low-cost Kinect sensor.

두부 못총상의 치험례

서면,김영태,하호균 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

The authors report a rare case of gunshot injury to the head by a nail-gun which was treated by stereotactic surgery. The patient was arrived at our emergency room by 119 rescue. He was 23 years old with semicomatose mentality and decerebrated rigidity. On simple skull series and Brain CT scan, the large nail was located in the 3rd ventricular area in the mid-line with vertical stature. The entry point was identified 1 cm anterior to the coronal suture line and just lateral to the sagittal suture line. We planned stereotactic removal and the stereotactic frame was introduced to the patient. The foreign body was removed stereotactically with the guidance of C-arm fluoroscope. The # 8 L EVD drain was placed into the 3rd ventricle. Intensive care was performed to the young patient, but he died due to initial severe brain damage at # POD 6.

초등학교 과학 수행평가에 대한 교사의 인식

서승조,조태호,백남권,박강은,김성규,박장서 晋州敎育大學校 科學敎育硏究所 2001 科學敎育硏究 Vol.27 No.-

The purposes of this study are to examine how Science Performance Assesment is being well conducted in elementary schools and to check the teachers' awareness through surveying the actual condition. To achieve this purpose, the author, in this study, distributed questionnaire developed by researcher under supervision of academic advisor to the elementary school teachers in Gyeongnam province. Based on the data. the research results were mainly analyzed by the statistical method using Chi-square test. The survey was consisted of questions which was designed to perceive teachers' awareness about elementary school science performance assessment. The main findings of this study are summarized as follows', 1. Elementary teacher's are doing affirmative estimation about induction of performance assessment. 2. Most teacher are recognizing performance assessment right and teachers' understanding appeared high. 3. Material development of performance assessment is recognizing that people who have opinion which is special must develop. 4. The biggest problem of performance assessment fixing is recognizing that number of persons per class are many and amount of training courses is much also with the tribe during time. 5. It was recognizing positively whether it is in class improvement of performance assessment effect. 6. Teachers had awareness that confirm studies accomplishment degree through performance assessment, or will utilize to improvement material of teaching-learning method.

양극성 장애의 우세삽화와 임상양상 간의 연관성 : 예비연구

서호준,우영섭,채정호,전태연,김광수,박원명 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objective : This study was performed to fmd clinical implications ofdistinctive pattems in bipolar patients with predominance of depressive episodes or manic episodes and to find possibilities to predict predominant episodes in bipolar disorder. Methods : The recmitment period was between 2002 and 2004, among inpatients who had received psychiatric treatment for bipolar disorder. The data about the number and the polarity of the past episodes were collected through medical records, and Sub-jects were divided into depressive or manic episode predominant groups. The two groups were compared regarding Sociodemo-graphic and clinical variables. Results : 74 patients met the inclusion criteria during the study period. 21 subjects were classified as depressive episode Pre-dominant group (depressive episode group), and 53 subjects as manic episode predominant group (manic episode group). There were no differences in sociodemographic data, the number of total episodes and hypomanic episodes, and onset age. However, 90.5% (n=19) subjects of depressive episode group showed depressive episode as first episode, and 88.7% (n=47) of manicepisode group experienced manic episode as first episode (χ²=42.13, df=1, P<0.00l). Psychotic symptomswere significantly more prominent in the manic episode group (χ²=6.85, df=1, P=0.009), and the number ofsubjects who had suicide attempt experience was higher in the depressive episode group (χ²=7.39, df=1, P=0.007). In the comparison of highest GAF scores during the past year, significant difference was found between the two group (p=0.046), as the mean scores of depressive epi-sode group was 68.337±7.47 and manic episode groupwas 71.51±5.42. Conclusion : The results ofthis study show that there are differences in clinical features according to predominant episodes in bipolar disorder. The type of onset episode appears to be related to predominant episode in this study, and it would be a valid Pa-rameter with therapeutic implication in bipolar patients.

화상처리에 의한 주행 차선인식 알고리즘

서경호,김태효,박영석 경남대학교 정보통신연구소 1999 연구논문집 Vol.1 No.-

본 논문에서는 화상처리를 이용하여 고속도로에 그어진 차선을 정확하게 검출할 수 있는 알고리즘을 제안하고 이를 시험하였다. 본 알고리즘은 전 처리과정이 없이 원화상을 제안한 경사형 마스크에 의해 처리된다. 실험은 고속도로를 주행하면서 비데오 카메라로 영상을 녹화하였고, 이 영상을 Capture Board로 디지털영상으로 변환하여 본 알고리즘에 적용하였다. 차선검출 과정에서 좌측 및 우측 차선을 검출하기 위한 2개의 경사형 마스크를 사용하므로서 부분적 그림자 및 조도의 변화로 인한 경계선이 희미한 차선의 경우도 효과적으로 검출할 수 있음을 확인할 수 있었다. In this paper, we proposed and tested an algorithm which the road lane on express way can exactly be detected and recognized using image processing. This algorithm has no use for pre-processing, and the original image is directly processed by the two RAMP MASKs. In the experiment, we recorded the test images by a video camera while we were in driving. The recorded images were converted to digital images by the image capture board and applied the algorithm. In order to detect the left and right lanes, the two RAMP MASKs were used respectively. In the result, we confirmed that this algorithm can effectively detect the road lanes although the boundary line of both lanes have no clear due to partial shadows or variation of light.

무첨가 및 첨가제 윤활유에 따른 마멸입자 형태해석

서영백,옥철호,김동호,박흥식,전태옥 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

This paper was undertaken to do morphological analysis of wear debris on no additive and additive lubricating oil. The lubricating wear test was performed under different experimental conditions using the wear test device was made in our laboratory and wear specimens of the pin on disk type was rubbed in paraffine series base oil by materials, varying applied load, sliding distance, oil additives such as stearine acid, DBDS, TCP. Morphologic character of wear debris is easily distinguished by four shape parameter(50% volumetric diameter, aspect, roundness and reflectivity). As the applied load sliding distance increase, size and shape of wear debris was complexed, but reflectivity was decreased, a large wear debris was apt to be oxidezed.

협동학습이 자연과 학업성취 및 과학태도에 미치는 효과

서승조,백남권,조태호,김용진 晋州敎育大學校 科學敎育硏究所 1999 科學敎育硏究 Vol.25 No.-

The purpose of this study is to manifest the effect of STAD cooperative learning which has not yet been explained in cooperative learning of an elementary school, on the academic achievement in science and science related attitudes. Therefore, in order to achieve that purpose, I established the following issues of study. First: What effect does STAD cooperative learning have on the elementary school students' academic achievement in science? Second: What effect does STAD cooperative learning have on the elementary school students' science related attitudes? The results of the study are as follows. First, while it was proven that the effect of STAD cooperative learning on academic achievement in science had no significant difference in pre·post achievement levels for both the experimental group and the control group, the experimental group showed larger changes in the mean value than control group; it can be inferred that classes to which cooperative learning is applied is more effective than traditional science classes. Second, in regard with the effect of STAD cooperative learnign on science related attitudes, while there was a significant difference between the experimental group and control group in pre examination, there was no significant difference, which means STAD cooperative learning does have effect on science related attitudes. In conclusion, the results of this study manifest that STAD cooperative learning is effective for science related attitudes in elementary school science classes, and assume that it can be effective for academic achievement.

초등학교 과학과 에너지영역의 STS 내용 변천

서승조,조태호,백남권,김성규,박강은,정인재 晋州敎育大學校 科學敎育硏究所 2001 科學敎育硏究 Vol.27 No.-

This research compared and analyzed the content ratio of the STS (Science-Technology-Society) Education and subjects and types of learning activities to determine the characteristics of STS education in science classes of elementary schools. In the 5th curriculum, the STS-related content on energy section took up 6.6% , in the 6th curriculum, compared with that of the 5th, the STS content ratio on the energy section increased 7.9% and the STS content on the energy section in the 7th curriculum showed an increased 20.8% proportion. Comparing the main subjects of the STS in the energy section for the science class according to curriculum in the 5th, they obviously have influenced technological development, energy, the development of space studies, and sociology of science, in that order. In the 6th curriculum. compared with that of the 5th, the energy section decreased and the sociology of science increased much. There were no significant changes in other subjects. In the 7th, the STS elements were distributed evenly but the extent of the STS main subjects reduced compared to that of the 6th. The STS education activities represented in science textbooks of elementary schools were mainly executed through discussion, research activities, and actual activities. Other activities such as role-playing, simulation tests, problem solving and decision making, data analysis, research design, case studies, etc. were hardly made.