Maillard 反應에 關한 硏究 : Ⅴ. 反應溫度 및 時間이 skim milk의 Maillard reaction에 미치는 영향 Ⅴ. Effects of reaction temperature and time on the Maillard reaction by heating skim milk

李乙熙,朴玉潤,徐珠銖,高鏡畢 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

The color intersities of melanoidins and the contents of HMF in skim milk by heat treatment. The contents of HMF in skim milk were detected in all heat-treated skim milk by colormetrical method and HPLC method. The color intensities of melanoidins showed significant dependence on reaction temperature and time. The contents of HMF in skim milk were detected in all heat treated skim milk by colormetrical method. While they were not detected by HPLC method when skim milk was heated at the temperature 70℃ for 30, 50 and 70 minutes. It showed significant dependence of reaction temperature and time.

순·구개열 환자의 두부규격방사선사진상을 이용한 친자간의 유사성에 관한 연구

이언경,나승목,고광준,조수범 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to determine whether any similarity existed in craniofacial morphology between parents and offspring in cleft lip with or without cleft palate. Thirty three measurements of the various regions of cranium and face were obtained from lateral cephalometric radiograms in 28 families comprising 28 fathers, 28 mothers and 28 cleft patients. The measurements of cleft patients were compared with those of their fathers, mothers and midparents. The obtained results were as follows: 1. There were similar measurements between the cleft patients and their father; ramal height(Ar-Go), mandibular angle(∠MP-RP). 2. There were similar measurements between the cleft patients and their mothers; cranial base angle(∠NSBa), relation of maxilla to the cranial base(∠SNA), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), angle of inferior border of mandible(∠SNL-MP) and convexity of nose apex(soft tissue:N"PrnPog"). 3. There were similar measurements between the cleft patients and their mdparents; ramal height (Ar-Go), cranical base angle(∠NSBa), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), Y axis angle(∠NSGn) and mandibular angle(∠MP-RP). 4. There was no similar measurements between the cleft patients and their fathers and mothers simultaneously.

담배식물의 생장에 따른 Holocellulose와 Lignin 함량의 변화

이학수,이경훈,오지훈 충북대학교 연초연구소 2009 煙草硏究 Vol.22 No.-

본 연구는 담배식물의 바이오에타놀 생산원료서의 가능성을 타진하기 위하여 온실에서 pot재배를 통하여 이식 후 25일부터 80일까지 5일 간격으로 잎과 줄기의 holocellulose와 lignin함량 변화를 조사해 보았다. 생육이 진행됨에 따라 건물 g당 holocellulose와 lignin의 함량도 증가하여 성숙 및노화기로 갈수록 높았다. 건물 g당 holocellulose함량은 잎보다 줄기가 높았고, 줄기의 lignin함량은 최대생장기에 급격히 증가했다. 담배 1주당 총 함량은 이식 후 70일에 최대였는데, holocellulose함량은 건물중의 60%이었고 lignin을 합할 경우에는 67%가 되었다. Changes in holocellulose and lignin contents of tobacco p1ants(var. NC 82) were determined from 25 days after transplanting in a pot to senescence stage at 5 days interval in green house. The amount of holocellulose and lignin per g of dry matters were increased from growing to senescence stage. The hollocellulose content of dry stalk was higher than of leaf, and lignin content of stalk was increased rapidly during the maximal growing stage of tobacco plant. The total amounts of holocellulose and lignin per a tobacco plant were reached maximum at the around 70 days after transplanting. At that time, the ratio of holocellulose only and holocellulose with lignin to dry matter was about 60% and 67%, respectively.

간호사의 셀프리더십과 간호업무성과간의 관계

서문경애,장성옥,조경희,김인아,이수정 대한간호학회 간호행정학회 2006 간호행정학회지 Vol.12 No.1

Purpose: This study was undertaken in order to suggest self-leadership as a way to promote organization efficiency of nursing organization. So the relation between self-leadership and outcome of nursing practice inorganization was studied. Method: The subjects of study were nurses as a population who were working for the 2 of university hospitals which have over 500 beds in Kyong Ki Province as well as who have been working for over 6 months. The data was collected by questionnaires from 215 nurses and analyzed using descriptive statistics, perason correlation coefficient, t-test and ANOVA on SAS Program. Results: Self-leadership of nurse got 3.51 grade out of 5 as a mean point. Each of the segments got 3.74 in self-compensation, 3.57 in self-expectation, 3.53 in goal-setting, 3.45 in rehearsal, 3.37 in self-criticism and 3.30 in constructive thinking in order. Independent performance of nursing practice at each items of outcome of nursing practice showed the highest correlations with the self-expectation among self-leadership segments. Constructive thinking, self-compensation, rehearsal, goal-setting were related like this in order, but self-criticism was related just a little. Dependent nursing practice has the highest correlation with the self-expectation, goal-setting, rehearsal, constructive thinking, self-compensation were similar as aboves in order, but self-criticism didn't show any similar correlations. Relationship practice has the highest correlation with the self-expectation, and goal-setting, constructive thinking, self-compensation, rehearsal were similar, while self-criticism did not show any correlations. Conclusion: In conclusion the result was obtained that self-leadership is much correlated with outcome of nursing practice. Therefore, as a way to promote efficiency of nursing organization, the constant study about self-leadership with the various aspects is needed focusing on self-management and inner motivation as a new leadership paradigm.

양극성 장애에서 표피성장인자의 유전적 다형성에 대한 연합연구

김수경,이규영,주은정,강웅구,안용민,김용식 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Epidermal growth factor (EGF) is a neurotrophic factor which regulates the intracellular signaling molecules. These molecules are also affected by mood stabilizers such as lithium and valproate. In addition, epidermal growth factor enhances neuronal survival, maturation and differentiation especially in midbrain dopaminergic neurons of which dysfimction may play a role in pathophysiology of bipolar disorders. Bipolar disorder has some genetic commonalities with schizophrenia, and several association studies of EGF have been done with schizophrenia. In this study, we tried to investigate the geneticassociation between EGF A61G polymorphism and bipolar disorder. Methods : Total of 189 patients and 347 nonnal control were included. All patients satisfied the diagnostic criteria of DSM-IV for bipolar disorder type I (BPDI, N= 146) and bipolar disorder type II (BPDII, N=43). Genomic DNA was extracted from the peripheral blood, and genotyping was performed by TaqMan™ method. Genotype and allele frequency of EGF A61G polymorphism between the patients and the control were compared by contingency chi-square test or the Fisher's exact test. Results : No association was found between EGF A61G polymorphism and susceptibility of BPDI, BPDII and bipolar disorder (all patients). Female patients with BPDII showed overexpression of AG genotype compared to that ofcontrol group (p=0.03). However, this association was not significant after correction of multiple testing. Conclusion : In conclusion, EGF A61G polymorphism has no association with susceptibility of bipolar disorder. However, the disease modifying role of EGF gene polymorphism for bipolar disorder remains to be elucidated in respect to factors such as gender difference or diagnostic subtype.

하악골 절제술후 재이식된 돌결자가골 재이식 : 치험 3례

김 식,김수관,김운규,김수민,류종희,이준길,조경안,김수흥,정태영,여환호 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

We described three cases of immediate reimplantation of a frozen-thawed autogenous mandible composed of a mixture of iliac bone, marrow, and particulate hydroxyapatite in tumors of the mandible. Acceptable outcomes were obtained in three patients who underwent immediate autogenous mandibular graft reconstruction. The conditions leading to successful outcome of the procedure are also discussed. Reimplantation of frozen autogenous lesioned mandible was performed in three patients with mandibular tumors. Two reimplanted grafts survived without complications following surgery. One case had postoperative infection that resolved with appropriate antibiotic treatment. There were no recurrences of the primary lesions. Satisfactory facial contour after surgery was achieved. These results are most promising, and we believe that, with further refinement, this technique will offer a new and acceptable modality for facial reconstruction in patients with cancer.

Ecological characteristics and trap plant attraction effect of Metcalfa pruinosa in red pepper cultivation area of Korea

Hwa-Young Seo,Gyeong-Ju Lee,In-Su Hwang,Mi-Sook Na,Yong-Seok Choi 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

Metcalfa pruinosa is the agricultural pest, first reported in Seoul, Gyeong-gi, Gyeongnam, Korea in 2009. This pests are difficult to control due to the wide range of hosts such as beans, apples, ginseng, pears, persimmon, and peaches. This study was carried out to investigate the ecological characteristics of M. pruinosa in pepper cultivation area. As a result of the density of M. pruinosa survey in Chungnam, Korea in 2018, the density of wintering-eggs, nymph, adult was the largest in Dang-jin area. And the results of the ecological characteristcs survey of M. pruinosa in red pepper cultivation area of Korea, M. pruinosa didn’t enter a red pepper field. In addition, the possibility of using three kinds of plants as attraction plants was examined in order to control environmentally friendly M. pruinosa. Among them, the greatest number of M. pruinosa nymph were attracted to Sunflower and Green perilla during nymph stage.

Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

Lee, Su Yeon,Ju, Min Kyung,Jeon, Hyun Min,Lee, Yig Ji,Kim, Cho Hee,Park, Hye Gyeong,Han, Song Iy,Kang, Ho Sung Hindawi 2018 Oxidative medicine and cellular longevity Vol.2018 No.-

<P>Metastasis is a major obstacle to the efficient and successful treatment of cancer. Initiation of metastasis requires epithelial-mesenchymal transition (EMT) that is regulated by several transcription factors, including Snail and ZEB1/2. EMT is closely linked to the acquisition of cancer stem cell (CSC) properties and chemoresistance, which contribute to tumor malignancy. Tumor suppressor p53 inhibits EMT and metastasis by negatively regulating several EMT-inducing transcription factors and regulatory molecules; thus, its inhibition is crucial in EMT, invasion, metastasis, and stemness. Metabolic alterations are another hallmark of cancer. Most cancer cells are more dependent on glycolysis than on mitochondrial oxidative phosphorylation for their energy production, even in the presence of oxygen. Cancer cells enhance other oncogenic metabolic pathways, such as glutamine metabolism, pentose phosphate pathway, and the synthesis of fatty acids and cholesterol. Metabolic reprogramming in cancer is regulated by the activation of oncogenes or loss of tumor suppressors that contribute to tumor progression. Oncogenic metabolism has been recently linked closely with the induction of EMT or CSC phenotypes by the induction of several metabolic enzyme genes. In addition, several transcription factors and molecules involved in EMT or CSCs, including Snail, Dlx-2, HIF-1<I>α</I>, STAT3, TGF-<I>β</I>, Wnt, and Akt, regulate oncogenic metabolism. Moreover, p53 induces metabolic change by directly regulating several metabolic enzymes. The collective data indicate the importance of oncogenic metabolism in the regulation of EMT, cell invasion and metastasis, and adoption of the CSC phenotype, which all contribute to malignant transformation and tumor development. In this review, we highlight the oncogenic metabolism as a key regulator of EMT and CSC, which is related with tumor progression involving metastasis and chemoresistance. Targeting oncometabolism might be a promising strategy for the development of effective anticancer therapy.</P>

Regulation of Tumor Progression by Programmed Necrosis

Lee, Su Yeon,Ju, Min Kyung,Jeon, Hyun Min,Jeong, Eui Kyong,Lee, Yig Ji,Kim, Cho Hee,Park, Hye Gyeong,Han, Song Iy,Kang, Ho Sung Hindawi 2018 Oxidative medicine and cellular longevity Vol.2018 No.-

<P>Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (e.g., glucose) deprivation, which occurs because of insufficient blood supply. This results in necrotic cell death in the core region of solid tumors. Necrotic cells release their cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1), which is a nonhistone nuclear protein, but acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells. These released molecules recruit immune and inflammatory cells, which exert tumor-promoting activity by inducing angiogenesis, proliferation, and invasion. Development of a necrotic core in cancer patients is also associated with poor prognosis. Conventionally, necrosis has been thought of as an unregulated process, unlike programmed cell death processes like apoptosis and autophagy. Recently, necrosis has been recognized as a programmed cell death, encompassing processes such as oncosis, necroptosis, and others. Metabolic stress-induced necrosis and its regulatory mechanisms have been poorly investigated until recently. Snail and Dlx-2, EMT-inducing transcription factors, are responsible for metabolic stress-induced necrosis in tumors. Snail and Dlx-2 contribute to tumor progression by promoting necrosis and inducing EMT and oncogenic metabolism. Oncogenic metabolism has been shown to play a role(s) in initiating necrosis. Here, we discuss the molecular mechanisms underlying metabolic stress-induced programmed necrosis that promote tumor progression and aggressiveness.</P>

Growth of carbon nanotubes by microwave plasma-enhanced chemical vapor deposition at low temperature

Lee,Young Hee,Bae,Dong Jae,Choi,Young Chul,Lee,Byung Soo,Park,Gyeong-Su,Choi,Won Bong,Lee,Nae Sung,Kim,Jong Min 국립경상대학교 공과대학 부설 첨단소재연구소 1999 尖端素材 Vol.9 No.-

Carbon nanotubes have been grown on Ni-coated Si substrates by microwave plasma-enhanced chemical vapor deposition with a mixture of methane and hydrogen gases at temperatures ranging from 520 to 700℃. The density and the length of carbon nanotubes increased with increasing growth temperature. At growth temperature of 520℃, carbon nanotubes were curly, whereas the nanotubes were straight and self-aligned upward at temperatures above 600℃. Images of high-resolution transmission electron microscope showed that nanotubes were multiwalled with a few wall-structures. The graphitized structures were also confirmed by Raman spectra. We show that the size of Ni domains on Si substrates is correlated to the diameters of the grown carbon nanotubes.