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김시중,장호찬 우송대학교 부설 산업연구원 1999 산업연구 Vol.1 No.1
The purpose of this research was to analyze the sexual discrimination level of woman employee in hotel industry. This research was based on a survey. The survey was conducted on 130 individuals who were working in hotels in Seoul. With collected data, regression analysis, T-Test and analysis of variances were utilized using SAS program. The results showed that there were no evidences of sexual disrimination among the individuals' educatination, sexual harassment, discrimination against employment, and workload among the position levels within a corporation. Finally, the analysis showed that there were sexual discrimination in a promotion policy, retirement policy, workload, and employment during employment period. However, there were no evidences of sexual discfrimination in other areas.
Pseudomonas sp. 로부터 생산되는 phytase에 관한 연구
김대영,양시용,권문남,김찬길 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.2
Phytase (myo-inositol hexakisphosphate phosphohyrolase) is found naturally in plants and microorganisms. It catalyses pydrolysis of phytate to release inorganic phosphate, which would decrease the addition of phosphorus to feedstuffs for monogastric animals and thus reduce environmental pollution. this study was carried out for examination of characteristic of phytase from Pseudomonas sp. The phytase from Pseudomonas sp. was partially purified by DEAE-Sepharose chromatography and its molecular weight was estimated to 45kDa by SDS-PAGE Partially purified phytase was stable at pH values ranging from 5.0~7.0, and it was stable to 40℃.
Hyperinsulinemia, Hyperreninemia 및 Hypokalemia를 동반한 공황장애 1례
박시성,김호찬 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.1
요 약 공황장애의 다양한 원인적 가설이 제시되었음에도 불구하고, 그 병태생리적 기전은 불분명하다. 검사소견 또한 다양하고 일관되지 않아 공황장애에 특이적이라고 할 수 없다. 따라서 검사소견 은 진단을 위해 응용될 수 없으며, 공황장애의 진단은 주로 임상적 소견에 의해서 이루어 진다. 반면 공황장애는 여러가지 의학적 상태와 감별을 필요로 한다. 특히 검사소견상의 이상이 동반 될 경우에는 공황발작과의 관계를 살펴보아야 한다. 본 증례는 검사소견상 혈청 K+의 저하, 혈장 insulin과 renin의 상승을 동반한 공황장애이다. 우선 이들 이상소견을 나타낼 수 있는 의학적 질환을 배제하였다. 공황발작과 별도로 환자가 호소하는 사지마비감은 저칼륨혈증에 의한 증상이라고 판단된다. 저칼륨혈증은 증가된 혈장 insulin과 renin에 의해 초래되었을 가능성이 높다. Insulin과 renin의 상승은 공황장애의 -아 드레날린성 기전 및 세로토닌성 기전과 연관될 것이라고 생각된다. Although various etiological hypotheses of panic disorder have been proposed, the pathophysiological mechanism is still unclear. It also has been suggested that some pathology and laboratory findings were useful to diagnose a panic disorder, however, these findings were not specific to panic disorder. On the other hand, several medical conditions have similar symptoms of panic attacks. So, the differential diagnosis must be done between panic disorder and a certain medical condition especially when some abnormal laboratory findings are found in a patient with panic attacks. The authors report a case of panic disorder with abnormal laboratory findings of hypokalemia, hyper- insulinemia and hyperreninemia. The patient complained not only panic attacks with anticipatory anxiety, but tingling and paralyzed sensation on extremities without panic attack. The possible relationships between these abnormal laboratory findings and pathophysiological processes of -adrenergic, serotonergic mechanism of panic disorder are discussed.
남성진,이동욱,박찬규,정시욱,김추성,조성래,구본천,양사규,이일웅,박정자 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2
Castleman' s disease is a rare, reactive lymphoid proliferation of unknown cause and pathogenesis. Depending on histololgic findings, it has been divided into two distinct histologic subtypes that include hyaline-vascular type(90%) and plasmacell type(10%). This disease occurs most commonly in mediastinal lymph nodes and cervical lymph nodes, inguinal lymph nodes respectively. But occurs rarely in retroperitoneum. We report a case of hyaline-vascular type asymptomatic Castleman' s disease of the retroperitoneum in a 47-year-old man.
중추 신경계를 침범한 전신성 홍반성 낭창의 임상적 연구
정윤석,박석원,이돈행,김시찬,박중원,홍천수 대한내과학회 1992 대한내과학회지 Vol.42 No.1
1987년 7월부터 1990년 6월까지 연세의대 세브란스 병원에 입원한 전신성 흉반성 낭창 환자 103예를 대상으로 조사하여 신경학적 증상과 징후가 있거나 뇌 전산화 단층 촬영상 또는 뇌파 검사상 이상이 있는 경우, 또는 정신병적 증상과 징후가 나타난 경우를 중추 신경계 낭창이라고 정의하였을때 다음과 같은 결과를 얻었다. 1) 전체 103예중 43예(41.7%)에서 중추 신경계 침범을 보였다. 2) 중추 신경계 낭창군은 비 중추 신경계 낭창군에 비하여 높은 초기 사망률을 나타내었다. 3) 중추 신경계 낭창군은 비 중추 신경계 낭창군에 비하여 신장 기능이 의의 있게 저하되어 있었다. 4) 중추 신경계 낭창군과 비 중추 신경계 낭창군 사이에 유병기간, 침범된 장기, 자가면역 항체 등에 있어서는 유의한 차이를 보이지 않았다. 결론적으로 전신성 홍반성 낭창환자, 특히 신장 기능이 저하되어 있는 환자는 중추 신경계 침범 여부를 조심스럽게 관찰하여 조기에 진단하고, 중추 신경계 침범이 확인된 경우는 사망률을 저하시키기 위하여 보다 적극적인 치료를 요할 것으로 사료된다. Central nervous system involvement in systemic lupus erythematosus (CNS lupus) is characterized by difficulty in it's proper diagnosis, treatment, and poor prognosis. We analyzed 103 systemic lupus erythematosus patients who have admitted to Severance Hospital, Yonsei University, from July 1987 to June 1990. The results were as followed: 1) 43 cases out of 103 systemic lupus erythematosus patients had central nervous system involvement. 2) Immediate mortality in CNS lupus was significantly higher than non-CNS lupus group. 3) Renal functions in CNS lupus were more significantly impaired than non-CNS lupus group. 4) There was no significant difference in duration of disease, number of organ involved, autoantibodies between CNS and non-CNS lupus group. These results suggest that patients with imparied renal function should be carefully followed up for early detection of central nervous system involvement. And, if central nervous system involvement is suspected, then more aggressive treatment may be required to reduce high mortality rate.
Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation
Kim, Juewon,Cho, Si Young,Kim, Su Hwan,Cho, Donghyun,Kim, Sunmi,Park, Chan-Woong,Shimizu, Takahiko,Cho, Jae Youl,Seo, Dae Bang,Shin, Song Seok The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3
Background: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging. Methods: The human melanoma MNT1 cell line was treated with ginseng root extract, ginseng berry extract, or syringaresinol. Then, the cells were analyzed using a melanin assay, and the tyrosinase activity was estimated. The Caenorhabditis elegans wild type N2 strain was used for the life span assay to analyze the antiaging effects of the samples. A lipofuscin fluorescence assay was performed during 10 passages with the syringaresinol treatment. Results: A 7-d treatment with ginseng berry extract reduced melanin accumulation and tyrosinase activity more than ginseng root extract. These results may be due to the active compound of the ginseng berry, syringaresinol. The antimelanogenic activity was strongly coordinated with the activation of the longevity gene foxo3a. Moreover, the ginseng berry extract had more potent antiaging effects, caused a life span extension, and reduced lipofuscin accumulation. Conclusion: Taken together, our results suggest that these antimelanogenic effects and antiaging effects of ginseng berry mediate the activation of antioxidation-FoxO3a signaling.
Kim, Hee Man,Kim, Hyun Ki,Lee, Sang Kil,Cho, Jae Hee,Pak, Kyung Ho,Hyung, Woo Jin,Noh, Sung Hoon,Kim, Choong Bai,Lee, Yong Chan,Song, Si Young,Youn, Young Hoon Raven Press 2012 Annals of surgical oncology Vol.19 No.4
<P>The multifocality rate of EGC ranges from 4 to 20%, but there are few data regarding both lymph node metastasis and feasibility of the endoscopic treatment. We investigated the risk of lymph node metastasis with the purpose to evaluate the potential for endoscopic treatment in patients with multifocal EGC.</P>