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조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1
The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.
Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis
Seoung Wan Chae,Jin Hee Sohn,Hyung Sik Shin,Young Euy Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.4
Purpose: The increased expression of cyclooxygenase(COX)-2 has been implicated in the development and progressionof human cancers. We investigated COX-2 expressionin normal, gastric adenomas and adenocarcinomas.Materials and Methods: COX-2 protein was assayed ingastrectomy and biopsy specimens, from 68 gastric adenocarcinomas,40 gastric adenomas and 35 normal gastrictissues, by immunohistochemistry, and 32 specimensof normal and adenocarcinomas by western blot analysis.Correlation between COX-2 expression and various clinicopathologicalfactors were studied in the gastric adenocarcinoma.Results: COX-2 protein expression in epithelial cells wasincreased in 6/40 (15%) of the adenomas and 55/68 (80.9%) of the adenocarcinomas, while normal mucosa wasnot expressed. COX-2 expression was increased in differentiatedgastric carcinomas compared with those in theundifferentiated group (p〈0.05). The expression of COX-2protein was unrelated to tumor size, depth of tumor invasionand the presence of lymphatic or vascular invasions.Western blot analysis showed the enhanced expressionof the COX-2 protein (23 out of 32)(71%) in gastric carcinomascompared to that of normal gastric mucosal epithelium.Conclusion: The above results indicated that the expressionof COX-2 protein occurs in dysplastic epithelium andgastric carcinomas, which suggests COX-2 expressionmay contribute to tumor formation. (Cancer Res Treat. 2002;34:252-257)
Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer
Seoung Wan Chae,손진희,Eo Jin Kim,Eun Yoon Cho,Bong Hwa Lee 대한암학회 2003 Cancer Research and Treatment Vol.35 No.5
Purpose: The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of human cancer. This study investigated the COX-2 expression in colorectal cancer, and its relationships with tumor angiogenesis and the clinicopathological factors.Materials and Methods: The expression of the COX-2 protein and microvessel density were evaluated, using immunohistochemical methods, in 21 normal colonic mucosa and 190 human colorectal carcinomas. Correlations between COX-2 expression and microvessel density, as well as various clinicopathological factors, were studied in colorectal carcinomas.Results: The COX-2 protein expression in epithelial cells was increased in 169 of the 190 adenocarcinoma cases (88.9%), but in only 1 of the 21 (4.8%) normal mucosa cases. The COX-2 expression was significantly increased in the differentiated compared with the undifferentiated colorectal carcinomas (p〈0.05), and significantly correlated with the depth of invasion and microvessel density (p〈0.05). Rectal cancers had more COX-2 positive cases than the colon cancers (p〈0.05). However, there were no significant differences in the tumor size and the presence of lymphatic or vascular invasion.Conclusion: The overexpression of cyclooxygenase-2 in colorectal carcinomas seems to play a role in the invasion and angiogenesis of the tumors, so may be a useful marker of the prognosis. The prominent expression was also demonstrated in differentiated colorectal cancers. (Cancer Res Treat. 2003;35:400-406)
Park, Seoung Ju,Lee, Kyung Sun,Kim, So Ri,Min, Kyung Hoon,Choe, Yeong Hun,Moon, Hee,Chae, Han Jung,Yoo, Wan Hee,Lee, Yong Chul Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.5
<P>Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a critical role in the control of airway inflammation. Recently, IL-17 has been found to be implicated in many immune and inflammatory responses, including airway inflammation. However, no data are available concerning the effect of PPARgamma on IL-17 production in airway inflammatory diseases. In this study, we used a mouse model of asthma to evaluate the effect of two PPARgamma agonists, rosiglitazone or pioglitazone, on IL-17 expression in allergic airway disease. After OVA inhalation, mice developed the typical pathophysiological features of asthma, and the expression of IL-17 protein and mRNA in the lungs was increased. Administration of rosiglitazone or pioglitazone reduced the pathophysiological features of asthma and decreased the increased IL-17 protein and mRNA expression after OVA inhalation. In addition, the attenuating effect of PPARgamma agonist on allergic airway inflammation and bronchial hyperresponsiveness is abrogated by coadministration of rIL-17. This study also showed that the inhibition of IL-17 activity with anti-IL-17 Ab remarkably reduced the increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, and the increased levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and OVA-specific IgE in serum. In addition, we found that administration of rosiglitazone or pioglitazone decreased the increased NF-kappaB activity and that a NF-kappaB inhibitor, BAY 11-7085, substantially reduced the increased IL-17 protein levels in the lung tissues after OVA inhalation. These findings suggest that the therapeutic effect of PPARgamma in asthma is partly mediated by regulation of IL-17 expression via NF-kappaB pathway.</P>
Park, Seoung Ju,Lee, Kyung Sun,Kim, So Ri,Chae, Han Jung,Yoo, Wan Hee,Kim, Dong Im,Jeon, Myoung Shin,Lee, Yong Chul Birkhäuser 2012 Inflammation research Vol.61 No.10
<P>Occupational asthma is characterized by airway inflammation and hyperresponsiveness associated with increased vascular permeability. AMP-activated protein kinase (AMPK) has been suggested to be a novel signaling molecule modulating inflammatory responses.</P>
김성훈,김지연,김현영,신채희,김동완,김기환,박현용,박무인,박선자,구자영 고신대학교 의학부 2002 高神大學校 醫學部 論文集 Vol.17 No.1
Primary small cell carcinoma of the stomach is a very rare cell type in gastric cancer and an extremely aggressive tumor with grave prognosis. Because of the highly malignant potency, chemotherapy for the primary therapy of small cell carcinoma is accepted generally. We report a 44-year-old man with primary advanced gastric small cell carcinoma who respond to cisplatin and etoposide combination chemotherapy.
Han-Jung Chae,Jang-Sook Kang,Byung-Gwan Bang,Seoung-Bum Cho,Jo-IL Han,Joo-Young Choi,Hyung-Min Kim,Soo-Wan Chae,Hyung Ryong Kim 대한생리학회-대한약리학회 1999 The Korean Journal of Physiology & Pharmacology Vol.3 No.6
<P> Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly responsible for bone remodeling. Periodontal disease represents example of abnormal bone remodeling. Osteoclasts are multinucleated cells present only in bone. It is believed that osteoclast progenitors are hematopoietic origin, and they are recruited from hematopoietic tissues such as bone marrow and circulating blood to bone. Cells present in the osteoclast microenvironment include marrow stromal cells, osteoblasts, macrophages, T-lymphocytes, and marrow cells. These cells produce cytokines that can affect osteoclast formation. In vitro model systems using bone marrow cultures have demonstrated that IL-1β, IL-3, TNF-α, bFGF can stimulate the formation of osteoclasts. In contrast, IL-4 inhibits osteoclast formation. Knowledge of cytokines and bFGF that affect osteoclast formation and their capacity to modulate the bone-resorbing process should provide critical insights into normal calcium homeostasis and disorders of bone turnover such as periodontal disease, osteoporosis and Paget s disease.
Unsupervised Segmentation of Overlapped Nuclei Using Bayesian Classification
Jung, Chanho,Kim, Changick,Chae, Seoung Wan,Oh, Sukjoong IEEE 2010 IEEE Transactions on Biomedical Engineering Vol.57 No.12
<P>In a fully automatic cell extraction process, one of the main issues to overcome is the problem related to extracting overlapped nuclei since such nuclei will often affect the quantitative analysis of cell images. In this paper, we present an unsupervised Bayesian classification scheme for separating overlapped nuclei. The proposed approach first involves applying the distance transform to overlapped nuclei. The topographic surface generated by distance transform is viewed as a mixture of Gaussians in the proposed algorithm. In order to learn the distribution of the topographic surface, the parametric expectation-maximization (EM) algorithm is employed. Cluster validation is performed to determine how many nuclei are overlapped. Our segmentation approach incorporates a priori knowledge about the regular shape of clumped nuclei to yield more accurate segmentation results. Experimental results show that the proposed method yields superior segmentation performance, compared to those produced by conventional schemes.</P>