The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection

Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.

선박수리업무에 종사하는 군무원들의 작업환경에 대한 인식이 직업만족도에 미치는 영향

오경재,모영하,윤한,김명선,이정미,권근상 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was carried out to evaluate the relations among working environments, health behaviors and satisfaction with their duty in a group of 200 ship-repair workers in the ROK navy. The results were as following; Age of workers was 40 years and over(83%) and working duration was 10 years and over (71.5%). Most of them were married and had studied beyond high school. The 69.5% of workers satisfied with their job, whereas. about 59.5% of workers had satisfaction with their working condition. There were current drinkers, 78.5%, current exercising workers, 43.5%, obese workers, 28.0%, and salted food intakers, 18.5% in the workers. The major harmful environmental factors in the ship-repair workplace are noise, vibration, dust and chemicals. Most of workers are exposed to above harmful factors and complained about exposure of noise and dust. The consumption of cigarette or alcohol in people who exposed to noise was much higher than in people who did not, but the difference was not statistically significant. Prevalence of obesity and hypertension were not significantly different between the exposure with noise and dust. Noise or dust exposure was significant relation to satisfaction with their duty and working condition. The affective factors for satisfaction with their duty were people who worked for 10 years or more(OR= 4.53), exercisers(OR=4.78) and dust(OR=3.05) in Logistic regression analysis.

내생적 성장이론 접근법에 의한 성장과 분배의 관계

오상근 東亞大學校 1997 東亞論叢 Vol.34 No.-

경제발전 내지 성장과 분배의 관계에 관한 고전적 연구인 쿠즈네츠 가설에 대한 최근의 새로운 접근을 이론적, 실증적으로 정리하여 향후 우리나라의 성장정책 및 분배정책에 필요한 시사점을 찾아보고자 한다. 솔로우 모형으로 대표되는 신고전적 성장이론에 따르면 성장촉진정책은 무용하지만, 최근에 새로이 전개되고 있는 내성적 성장이론에 따르면 경제주체들의 주관적 선호, 경제의 객관적인 기술주준뿐만 아니라 조세정책 등 성장촉진정책이 유효함을 논증하고있다. 이런 입장에서 본다면 재분배정책 등은 경제성장을 위해 필요하다는 유추를 해볼수 있다. 그러나 이를 위해서는 먼저 (애초의)분배의 불평등의 경제성장에 유해함을 입증하여야 한다. 현단계에서는 아직 최종적으로 합의점에 도달하지는 못하였다. 이 논문에서는 지금까지의 다양한 연구결과를 이론적 실증적으로 정리하였다.

자본자유화의 장단기적 효과

오상근 東亞大學校 2002 東亞論叢 Vol.39 No.-

The aim of this paper is to review critically the literature on the theoretical and empirical effect of capital account liberalization. The research is stimulated by the recent financial turmoils in East Asian countries during 1996-1997. Traditional theories have emphasized that financial in opening may promote economic growth and efficiency without financial and economic stability as do the trade opening. However many casual empirical studies have shown that it is not he case in many emerging economies. I argue that the capital account liberalization may enhance efficiency in financial intermediaries and thus economic growth in the long-run even though it may cause some short-run instability with pain. So there is in some sense inter-temporal trade off between short run stability and long-run growth. I also suggest some policy options to reduce costs and to increase benefits from capital account liberalization.

S-아데노실-L-메치오닌-설페이트-P-톨루엔설페이트(SAMET)의 만성관절염(류마치스성 관절염 및 퇴행성 관절염)에 대한 치료효과

오상근 최신의학사 1987 最新醫學 Vol.30 No.7

Sandblasted large grit, acid etched 표면처리에 따른 교정용 미니 임플랜트의 제거회전력에 관한 연구

오남희,김성훈,국윤아,이근혜,강윤구,모성서 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.5

Sandblasted large grit, acid etched(SLA) 표면처리 된 교정용 미니 임플랜트와 평활면을 가진 교정용 미니 임플랜트 사이에 제거회전력과 조직학적 소견을 통해 표면처리된 교정용 임플랜트의 임상적 가능성에 대하여 알아보고자 하였다. 실험재료로는 길이가 9.5 mm, 외경이 1.8 mm인 custom made, screw shaped, titanium implants가 사용되었다. 미니 임플랜트는 두개의 군으로 분류되었는데 SLA군은 20개의 SLA 표면처리된 미니 임플랜트이었고, 평활면군은 크기와 형태가 같지만 SLA처리공정이 생략되어 제작된 20개의 미니 임플랜트로 구성되었다. 이들은 10마리 가토의 경골에 식립되었다. 각각의 가토의 우측 경골에는 SLA군의 미니 임플랜트 2개가 식립되었고, 좌측 경골에는 평활면군의 미니 임플랜트 2개가 식립되었다. 각 군에는 식립 직후 Ni-Ti coil spring에 의해 약 150 g의 지속적인 견인력이 주어졌다. 식립 6주 후에 10마리의 가토를 희생하였고, 안정된 상태에서 Ni-Ti coil spring을 제거하였으며 digital torque gauge를 이용하여 제거 회전력을 측정하였다. 식립 6주 후에 SLA군의 경우 (8.29 Ncm) 평활면군 (3.34 Ncm)에 비해 더 높은 평균 제거회전력을 나타내었고 조직학적 소견에서도 screw 하방에서의 신생골 형성이 관찰되었다. SLA 표면처리된 미니 임플랜트는 평활면 미니 임플랜트에 비해 좀 더 강한 교정력에 저항할 수 있을 것으로 예상되었다. Objective: The purposes of this study were to evaluate the differences between sand blasted, large grit and acid-etched (SLA) treated mini-implants and smooth surface orthodontic mini-implants in relation to the removal torque as well as the histologic analysis. Methods: Custom-made, screw-shaped, titanium implants with a length of 9.5 mm and an outer diameter of 1.8 mm were divided into 2 groups; the SLA group (20 SLA treated orthodontic mini-implants) and the smooth surface group (20 smooth surface mini-implants), and placed in the tibia metaphysis of 10 rabbits. Each rabbit had 4 mini-implants placed, 2 in each tibia. The right tibia were implanted with the SLA group mini-implants and the left tibia had the smooth group mini-implants placed. Each mini-implant group were immediately applied with a continuous traction force of 150 g using a Ni-Ti coil spring. The rabbits were sacrificed 6 weeks post-surgically. Subsequently, the legs were stabilized, the Ni-Ti coil springs were removed and the mini-implants were removed under reverse torque rotation with a digital torque gauge. Results: 6 weeks after placement, the SLA group presented a higher mean removal torque value (8.29 Ncm) than the smooth group (3.34 Ncm) and histologic analysis revealed a higher new bone formation aspect along the screw in the SLA group. Conclusion: Results of this study indicates that SLA treated mini-implants may endure higher orthodontic forces without loosening.

금융위기: 원인과 결과

오상근 東亞大學校 大學院 1998 大學院論文集 Vol.23 No.-

Financial crises hit economies from diverse sources. I explore their causes and consequences. Capital market liberalization and excessive foreign borrowing render financial fragility from optimistic investors and lenders resulting moral hazard. The debt structure is a crucial factor:short-term, unhedged foreign-currency-denominated borrowings are very vulnerale to exchange rate hike. Abrupt hyge capital outflow precipitates foreign exchange market collapse. A self-fulfilling expectations is easily realized under weak financial market. Costs of financial crises are estimated about 30% of GDP. A reconstruction of sound financial structure is urgently required.

시상 뇌졸중 후에 발생되는 중추성 동통 : 임상적-방사선학적 특징에 대한 연구

오상근,이애영,김건익,김제,김재문 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

一部 運動選手(體操와 排球)들의 一側優位性 (左右差 : 手, 足, 體, 眼)에 관한 硏究

吳尙勳,柳根林,朴淳永 慶熙大學校 1989 論文集 Vol.18 No.-

This study is from March 1st. of 1988 to September 31, 1988. The subjects of study consists of sports man who are in attendance at high school and college and all samples are selected at random. The total number of subjects counts to 92 ( male ; 56, female ; 36 ). Gymnestic ; 30 ( male ; 20 female ; 10), volley ball ; 62 ( male ; 36, female ; 26) and the researcher measures and analyses the subjects, physique, physical fitness, the test of dominance eye, the functional tests of hand, foot, body and eye. The results as follows ; 1. Physical growth and development Mean values of body height are 177.19±5.01㎝ (G : 164.51±4.55㎝, V : 184.24±5.25㎝) for male and 168.23±3.31㎝ (G : 158.00±3.12㎝, V : 172.17±3.38㎝) for female and superior to standard values of Korean. Mean values of body weight are 69.56±6.17㎏ ( G : 60.03±4.81㎏, V : 74.85±6.81㎏) for male and 58.82±4.24㎏ ( G : 49.15±5.21㎏, V : 62.54±3.80㎏) for female , and the mean values of chest girth are 91.86±4.83㎝ ( G : 89.48±5.10㎝, V : 93.18±4.67㎝ ) for male and 84.55±3.49㎝ ( G : 80.39±4.07㎝, V : 86.15±3.24㎝ ) for female. Mean values of sitting height are 93.88±4.28㎝ ( G : 86.13±5.68㎝, V : 98.19±3.26㎝ ) for male and 91.32±3.09㎝ ( G : 82.55±3.00㎝, V : 94.69±3.12㎝) for female. 2. Physical fitness Mean values of grip strength are 41.60±4.30 for right side and 44.03±6.00 for left side in male and 32.63±3.42 for right and 34.89±4.72 for left in female. Mean values of arm strength are 29.66±3.91 for right and 31.84±2.95 for left in male and 21.42±3.14 for right and 22.54±2.68 for left in female. Mean values of leg strength are 38.36±5.79 for right and 43.80±6.09 for left in male and 25.97±3.09 for right 29.39±3.03 for left in female. 3. Tests of dominance eye As considered according to tests of dominance eye, the results of right eve, left eye in both of male and female, the results are each of 62.5%, 37.5%, for male and 55.6%, 44.4% for female and 59.8%, 40.2% for both sexes, respectively. 4. Functional rate of foot, thrunk, eye and hand As considered according to its functions the rates of right foot, left foot, both of feet in both of male and female, the total rates are each of 78.4% ( M : 83.3 % ane F : 68.1%), 26.1% (16.7% and 28.0%.), 2.9% ( 2.4% and 3.9% ). The rates of right sidedness, left sidedness, both of sidedness in both of male and female, the total rates are each of 53.3%, 37.4%, 6.7% for male and 55.7%, 32.1%, 4.8% for female and 54.0%, 35.7%, 3.1% for both sexes, respectively. The rates of right eye, left eye, both of eyes in both of male and female, the rates are each of 45.3%, 27.6%, 3.2% for male and 49.5%, 33.3%, 17.2% for female and 46.1%, 28.7%, 5.8% for both sexes, respectively. The rates of right handedness, left handedness, both of handedness in both of male and female, the total rates are each of 67.5%, 21.8%, 5.2% for male and 86.4%, 12.0%, 1.5% for female and 78.5%, 16.1%, 3.1% for both sexes, respectively.

변형된 미끄럼 탐색 기법을 이용한 고속 프랙탈 영상압축

오우진,권상근 金烏工科大學校 1998 論文集 Vol.19 No.-

Fractal image coding applies the self-similarity of image. But it takes long time to search for the self-similarity block. To shorten the searching time. we proposed the modified sliding search algorithm which employs the classification of variance of range and domain blocks. For some blocks which have small variance, only mean value of range block is transmitted without searching. Compared with sliding search algorithm, our algorithm shows 15% lower in bit rate and 21% gain in searching time, but PSNR decreases only 0.05 dB.