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- 검색키워드
- 저자 : ( Moon-jeoung Kim ) (검색결과 151 건)
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김문열,정희연 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2
This study was conducted on 18 insomniac patients who had visited neuro-psychiatric department of Eulji General Hospital from September 1, 1984 to December 31, 1984. The subjects were 11 males and 7 females with a mean age of 37.9 years. All had a diagnosis of primary insomnia. Patients with other psychiatric disorders or organic diseases were eliminated. Each patient was first studied for two to three preliminary baseline nights prior to the main study, and then for four to six complete main study nights. The drug and placebo nights were randomly distributed for each patients. 30 minutes before retiring to bed on a study night, each patient received 2mg of L-tryptophan with 100mg of nicotinamide, 10mg of pyridoxine and 500mg of ascorbic acid at drug nights or same amount of placebo at placebo nights. Sleep was investigated by means of behavioral observations every 15 minutes throuhgout the night and by a brief interview and questionnaire the morning after each study night. All data analyses were done separately for the entire group of 18 patients and also for this group of 14 "objectively insomniac" patients. Results of the objective observations were tabulated and analyzed for three variables. The result indicate that 2mg of L-tryptophan had a significant effect in the direction of better sleep on total sleep and sleep latency but no significant effect on number of awakenings. Overall, the results were somewhat more marked in the 14 "objectively insomniac" group than in entire sample of 18 patients. Data from questionnaires given in the morning after sleep study nights indicate that tryptophan nights were rated significantly higher than both baseline nights and placebo nights on subjective estimate of sleep but the difference between tryptophan and placebo did not reach statistical significance and tryptophan nights were rated significantly higher than only baseline nights on subjective estimate of feeling state in the morning..
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( Moon Kyung Joo ),( Hyo Soon Yoo ),( Jong Jae Park ),( Jungwan Choe ),( Yong Jeoung ),( Jiwon Kim ),( Ho Kim ),( Beom Jae Lee ),( Jae Seon Kim ),( Young Tae Bak ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a plant-drived natural agent extracted from the root of Plumbago zeylanic. A recent study reported that plumbagin down-regulated the activity of Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway to show various anti-tumor effects. We aimed in this in vitro study to demonstrate the inhibition of JAK2-STAT3 pathway by plumbagin through inducing SH2-containing protein tyrosine phosphatase 1 (SHP-1) expression in gastric cancer cell line. Methods: We performed Wetern blot to measure SHP-1, phospho-JAK2/STAT3 level, and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate target gene expression of STAT3. Several functional studies such as water soluble tetrazolium-1 (WST-1) assay, wound closure assay and matrigel invasion assay were also performed. Results: Plumbagin induced SHP-1 expression and simultaneously down-regulated phospho-JAK2/STAT3 level via dose-and time-dependant manner in MKN28 cell, a gastric carcinoma cell line which has negative SHP-1 expression. This effect was consistent when JAK2-STAT3 signaling was activated by interleukin-6, and ameliorated when cells were treated with prevanadate, a protein tyrosin phosphatase inhibitor. Furthermore, plumbagin signifi cantly reduced gene expression of cyclin D1, VEGF1, survivin, MMP9, which are known target products of STAT3 activation in gastric cancinogenesis. The functional effect of plumbagin could be validated as inhibition of cell proliferation, migration and invasion, which are the results of activation of JAK2- STAT3 pathway in gastric cancer cell lines. Conclusions: Plumbagin is a potential negative regulator of cellular growth, migration and invasion by inhibiting both constitutive and inducible STAT3 activity through induction of SHP-1 in gastric cancer cell line.
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Kim, Nam-Hee,Park, You-Mie,Jeong, Eun-Sook,Kim, Chang-Soo,Jeoung, Min-Kyo,Kim, Kyoung-Soon,Hong, Seung-Hwa,Son, Jong-Keun,Hong, Jin-Tae,Park, Il-Young,Moon, Dong-Cheul 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.10
An immunoglobulin (IgG) preparation with micro-amount of histamine fixed on the active protein fraction has been used to increase the resistance to allergic reactions. However, excessive histamine may cause hypo- or hypertension, headache, or anaphylactic shock and so the histamine content of the drug is strictly controlled by a regulation: $0.15{\mu}g$ of histamine dihydrochloride is allowed for 12 mg of immunoglobulin. In this study, a liquid chromatographic method to determine micro-amount of histamine in the pharmaceutical was developed and validated. This method include a sample cleanup by a solid phase extraction (SPE) using a polystyrenedivinyl benzene (PS-DVB) polymeric sorbent and high-performance liquid chromatography after precolumn fluorescent labeling of the histamine with o-phthaldialdehyde. The drug sample was loaded to the SPE cartridge after adjusting to pH 9.5. After successive washings of the cartridge with water and 30% aqueous methanol, histamine was then eluted with 100 mM sodium acetate (pH 9.5)-methanol (20:80, v/v). An aliquot from the eluate was labeled with 0phthaldialdehyde-mercaptoethanol (OPA-ME) for fluorescence detection at the excitation maximum of 340 nm and emission maximum of 450 nm. HPLC analysis was performed on a phenyl-hexyl column with an acetonitrile-phosphate buffer (pH 6.8; $50{\mu}M$) (35:65, v/v) as the mobile phase. The retention times of histamine and 3-methylhistamine (IS) were approximately 7.2 and 9.5 min, respectively. The quantitation range was between 0.01-0.2 mg/mL of histamine showing good linearity (r=0.9996). This analytical method would provide a potential mean for the strict control of histamine content in the pharmaceutical product.
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Jeoung, Min,Kim, Kyoung,Kim, Chang,Kim, Nam,Chung, Youn‐,Bok,Hong, Jin,Moon, Dong‐,Cheul Taylor Francis 2005 JOURNAL OF LIQUID CHROMATOGRAPHY AND RELATED TECHN Vol.28 No.9
<P>Trimetazidine dihydrochloride has been used as an antianginal drug that possess protective properties against ischemia-induced damage to heart. A simple and sensitive analytical method of trimetazidine dihydrochloride in human plasma by using high performance liquid chromatography (HPLC) was developed. The method employs a liquid-liquid extraction for isolation and sample concentration, followed by reversed-phase liquid chromatography (RPLC) analysis using ultraviolet (UV) detection at 207 nm. Analytes were extracted from plasma samples that previously were mixed with 300 µL saturated K 2 CO 3 solution into an ethyl acetate phase. HPLC separation was accomplished at 40°C on a reversed-phase column using a mobile phase, 15% acetonitrile in 50 mM potassium dihydrogen phosphate and phosphoric acid (pH=4.0), at a flow-rate of 1.0 mL/min. The linear range of the method was between 10- and 150 ng/mL of tirmetazidine dihydrochloride in human plasma and the quantification limit was 10 ng/mL. The intra- and inter-day relative standard deviation (RSD) were less than 7.6% and the accuracy was in the range of 98–107%. Extraction recoveries ranged from 71.5 to 84.6% and the C.V. values showed between 1.7 and 10.4% in the same concentration range. This method has been sought for carrying out pharmacokinetic studies and for assessing bioavailabiltiy. Such a method would be ideally suitable for pharmacokinetic studies in human volunteers after oral administration of different types of dosages of the drug.</P>
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Effects of Shoulder Abduction on Muscle Activities During Pilates Breathing
( Moon-jeoung Kim ),( Sung-hyun Park ),( Il-hun Baek ) 대한물리의학회 2018 대한물리의학회지 Vol.13 No.1
PURPOSE: This Study compared the level of activation of the muscles around the shoulder at the time of abduction through Pilates breathing and regular breathing by using quantified biofeedback. METHODS: Experiment was conducted on 25 healthy males and females in the age bracket of 20’s~30’s as the subjects. The level of activation of muscles displayed at the time of Pilates breathing were measured at intercostal (InC) muscle, transverse abdominis (TrA) muscle, internal oblique (IO) muscle and external oblique (EO) muscle by using surface electromyogram (EMG) and were provided as biofeedback. Moreover, the changes in the level of muscular activation at sternocleidomastoid (SCM) muscle, upper trapezius (UT) muscle and Deltoid (Del) muscle, which are the muscles around the shoulder, at the time of abduction of shoulder during Pilates breathing and regular breathing were measured. RESULTS: When abduction of shoulder is executed through Pilates breathing, the level of muscular activation of UT muscle was 11.56±7.10% at the time of exhaling of Pilates breathing and 17.54±9.57% at the time of exhaling of regular breathing. Del muscle also displayed lowered level of muscular activation at the time of Pilates breathing with 12.88±5.80% during inhaling and 15.14±5.49% during exhaling. CONCLUSION: In conclusion, the results could be interpreted as indicating that the muscle activities of upper trapezius and deltoid muscle were decreased based on Pilates breathing more than those on regular breathing.
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Determination of Eperisone in Human Plasma by Liquid Chromatography-ESI-Tandem Mass Spectrometry
Jeoung, Min-Kyo,Jeong, Eun-Sook,Kim, Nam-Hee,Kim, Chang-Soo,Chung, Youn-Bok,Lee, Yong-Moon,Ahn, Su-Youn,Cho, Hwang-Eui,Lee, Yong-Hwa,Hong, Jin-Tae,Moon, Dong-Cheul 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
A sensitive and selective method for the determination of 4’-ethyl-3-methyl-3-piperidinopropiophenone hydrochloride (eperisone hydrochloride) in human plasma was developed and validated The procedure employed an internal standard and a solvent extraction step followed by chromatography on a Xterra $C_{18}$ minibore column. Detection was by electrospray ionization tandem mass spectrometry with multiple reaction monitoring. The mass transitions of eperisone and tolperisone (IS) were m/z 260 ${\rightarrow}$ 98 and m/z 246 ${\rightarrow}$ 98, respectively. The method has a limit of detection of 0.1 pg/mL for eperisone based on the three times signal-tonoise value with a linear range from 0.01 to 10.0 ng/mL for the analyte. Extraction recovery was on average 98.6${\pm}$7.2% (SD) for eperisone. The Intra- and inter-day assay accuracy ranged from 93 to 114% and precision (RSD) was better than 8.5%. The method was successfully employed to analyze plasma samples and evaluate pharmacokinetics of eperisone in healthy male volunteers.
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( Yong Jeoung ),( Hyo Jung Kim ),( Ji Won Kim ),( Ho Kim ),( Jin Sung Koh ),( Jung Wan Choe ),( Moon Kyung Joo ),( Beom Jae Lee ),( Jong Jae Park ),( Jae Seon Kim ),( Young Tae Bak ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: In acute pancreatitis (AP), fever is observed frequently and related to the infi ammatory process. It is suggested that obese patients express a more intense infi ammatory response. Antibiotics are frequently initiated in AP without proven infection. We studied the relation obesity and characteristics of AP including fever.Methods: Data from 305 patients diagnosed to AP between January 2011 and December 2013 were collected and 145 patients were excluded due to the past history of pancreatitis or pancreatic disease, malignancy, immunodefi ciency. Body mass index (BMI) was classifi ed into three groups, normal (BMI1), overweight (BMI2, 23-24.9) and obese (BMI3). Results: Of the enrolled 160 patients (male 117, mean age 55.04 years), 36.9% (59/160) were BMI1, 38.1% (61/160) BMI2 and 25% (40/160) BMI3. The mean BMI according to cause of AP was 24.4 in alcoholic (40), 24.8 in idiopathic (19), 31.4 in hyper-TG (4), 23.4 in gallstone (60) and 23.1 in recurrent alcoholic (37). Fever was observed frequently in gallstone pancreatitis (55%, 33/60) but more common in alcoholic, idiopathic and hyper-TG pancreatitis (64%, 40/63). In analysis of 63 patients excluded gallstone cause, fever incidence was higher in patients with higher BMI; 53% (10/19)in BMI1, 63% (12/19) in BMI2 and 72% (18/25) in BMI3. Also fever duration was longer in higher BMI 1.94, 2.25 and 4.88 days respectively (p<0.05). Total hospital stay and serum CRP were higher in patients with higher BMI but did not show signifi cant difference. Broad spectrum antibiotics were used in 38 of 40 patients with fever but infectious cause was not proved in all febrile patients. PCD was done in one patient and one patient expired due to septic shock related with atherosclerosis.e Conclusions: Obesity is related with fever in AP and antibiotics would be used for inappropriate indications.
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시연교육이 언어치료학과 학생들의 문제해결과정 및 실습자신감에 미치는 효과
김문정(Moon Jeoung Kim),오희라(Hee Ra Oh) 한국언어치료학회 2016 한국언어치료학회 학술발표대회 논문집 Vol.2016 No.12
Purpose: The purpose fo this paper was to assess if there is a relationship between Kolb learning style and learner variables including age, gender and simulation education among speech - language pathology students. This is a one group design with pretest and posttest for evaluation of effectiveness of an simulation education among sophomore speech-language pathology students according to their learning styles. Methods: Participants were 31 sophomore speech-language pathology students. The Kolb Learning Style Inventory (LSI) is used at many educational levels to determine the learning preferences of students and clinicians. The students’ learning styles were analyzed for associations with learner variables. They were categorized based on learning variables. Problem solving process, self-confidence were significantly enhanced by simulation education. Results: Learning style and educational effectiveness(problem solving process, self-confidence with practice) were measured. Learning styles of sopomore Speech-language pathology students were converger 15.6 %, assimilator 34.4%, accommodator 18.7%, and diverger 28.3%. Conclusion: Base on the results, devising stratagem to maximize and educational effectiveness will be needed through re-evaluation of relationship between learning style and effectiveness of simulation education.
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