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Ahn, Sun Hee,Song, Ji-Eun,Kim, Suhee,Cho, Sung-Hyun,Lim, Yun Kyong,Kook, Joong-Ki,Kook, Min-Suk,Lee, Tae-Hoon Springer-Verlag 2016 Archives of microbiology Vol.198 No.6
<P>Periodontal diseases are infectious polymicrobial inflammatory diseases that lead to destruction of the periodontal ligament, gingiva, and alveolar bone. Sequential colonization of a broad range of bacteria, including Fusobacterium nucleatum and Porphyromonas gingivalis, is an important phenomenon in this disease model. F. nucleatum is a facultative anaerobic species thought to be a key mediator of dental plaque maturation due to its extensive coaggregation with other oral bacteria, while P. gingivalis is an obligate anaerobic species that induces gingival inflammation by secreting various virulence factors. The formation of a bacterial complex by these two species is central to the pathogenesis of periodontal disease. Reactive oxygen species (ROS) are produced during bacterial infections and are involved in intracellular signaling. However, the impact of oral bacteria-induced ROS on the ecology of F. nucleatum and P. gingivalis has yet to be clarified. In the present study, we investigated ROS production induced in primary human oral cells by F. nucleatum and P. gingivalis and its effect on the formation of their bacterial complexes and further host cell apoptosis. We found that in primary human gingival fibroblasts (GFs), two NADPH oxidase isoforms, NOX1 and NOX2, were activated in response to F. nucleatum infection but not P. gingivalis infection. Accordingly, increased NADPH oxidase activity and production of superoxide anion were observed in GFs after F. nucleatum infection, but not after P. gingivalis infection. Interestingly, in NOX1, NOX2, or NOX1/NOX2 knockdown cells, the number of P. gingivalis decreased when the cells were coinfected with F. nucleatum. A similar pattern of host cell apoptosis was observed. This implies that F. nucleatum contributes to attachment of P. gingivalis by triggering activation of NADPH oxidase in host cells, which may provide an environment more favorable to strict anaerobic bacteria and have a subsequent effect on apoptosis of host cells.</P>
안희국 ( Hee Kook Ahn ),한욱표 ( Uk Pyo Han ),신승호 ( Seung Ho Shin ),양동일 ( Dong Il Yang ),노희영 ( Hee Young Roh ) 한국항행학회 2011 韓國航行學會論文誌 Vol.15 No.2
전자메일은 사용의 편리성과 정보전달의 신속성 때문에 널리 사용되고 있지만, 광고목적이나 악의성을 갖는 스팸메일의 양도 증가하여 사회적 경제적으로 큰 문제를 야기한다. 스팸메일을 필터링하기 위한 방법은 수용 전 단계와 수용 후 단계로 나누어서 접근할 수 있는데, 수용 후 접근의 경우는 메시지로부터 단어나 문장 단위로 자질을 추출하고 그로부터 학습이나 매칭방법을 통하여 필터링을 하는 과정을 포함한다. 하지만, 필터링을 우회하기위해 스패머는 계속적으로 단어를 변형시켜 메일을 발송시키고 있다. 특히 한국어의 경우는 특성상 한 음절을 이루는 음소의 변화로부터 변형이 가능하기 때문에 그 변칙적 사용이 더 다양하다고 할 수 있다. 따라서, 기존의 정규식이나 학습알고리즘은 대처에 한계를 갖게 된다. 이에 본 논문에서는 한글의 변칙어를 인식할 수 있는 방법을 제안함으로서 스팸메일분류 시스템의 성능을 향상시키고자 한다. 이를 위해, 자소접근방법을 사용하고, Smith-Waterman알고리즘을 적용하였다. 메일서버로부터 추출한 필터키워드와 메일로부터 제안한 방법을 실험한 결과 유사도 수준에 따라 한글 변칙어들을 정확히 인지해 낼 수 있었다. 실험을 통해 소요 공간 및 시간은 허용될 수 있는 수준임을 확인하였다. As electronic mails are being widely used for facility and speedness of information communication, as the amount of spam mails which have malice and advertisement increase and cause lots of social and economic problem. A number of approaches have been proposed to alleviate the impact of spam. These approaches can be categorized into pre-acceptance and post-acceptance methods. Post-acceptance methods include bayesian filters, collaborative filtering and e-mail prioritization which are based on words or sentances. But, spammers are changing those characteristics and sending to avoid filtering system. In the case of Korean, the abnormal usages can be much more than other languages because syllable is composed of chosung, jungsung, and jongsung. Existing formal expressions and learning algorithms have the limits to meet with those changes promptly and efficiently. So, we present an methods for recognizing Korean abnormal language(Koral) to improve accuracy and efficiency of filtering system. The method is based on syllabic than word and Smith-waterman algorithm. Through the experiment on filter keyword and e-mail extracted from mail server, we confirmed that Koral is recognized exactly according to similarity level. The required time and space costs are within the permitted limit.
Yoo, Keon Hee,Lee, Soo Hyun,Sung, Ki Woong,Koo, Hong Hoe,Chung, Nak Gyun,Cho, Bin,Kim, Hack Ki,Kang, Hyoung Jin,Shin, Hee Young,Ahn, Hyo Seop,Baek, Hee Jo,Han, Dong Kyun,Kook, Hoon,Hwang, Tai Ju,Kim, Wiley Subscription Services, Inc., A Wiley Company 2011 American journal of hematology Vol.86 No.1
<P><B>Abstract</B></P><P>We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (<I>n</I> = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (<I>n</I> = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 10<SUP>7</SUP>/kg and 2.00 × 10<SUP>5</SUP>/kg, respectively. The median times to neutrophil (>0.5 × 10<SUP>9</SUP>/L) and platelet recovery (>20 × 10<SUP>9</SUP>/L) were 18 and 45 days, respectively. Grade 2–4 acute graft‐versus‐host‐disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty‐five patients developed CMV disease. The 5‐year overall and event‐free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation‐based conditioning (<I>P</I> = 0.007), salvage transplant (<I>P</I> = 0.001), failure to achieve early complete chimerism (<I>P</I> < 0.0005), and CMV disease (<I>P</I> = 0.001). The outcomes of the single‐ and double‐unit UCBT (<I>n</I> = 64) were similar, while double‐unit recipients were heavier (<I>P</I> < 0.0005) and older (<I>P</I> < 0.0005). We conclude that double‐unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%. Am. J. Hematol., 2011. © 2010 Wiley‐Liss, Inc.</P>
Structural Behavior of KSTAR CS Magnet During Plasma Operation
Ahn, Hee-Jae,Park, Hyun-Ki,Kim, Jinsub,Kim, YoungOk,Kim, Kwang Pyo,Chu, Yong,Kim, Hyun-Seok,Park, Kaprai,Oh, Yeong-Kook,Lee, Sudo,Kim, Yong Hwan Institute of Electrical and Electronics Engineers 2018 IEEE transactions on applied superconductivity Vol.28 No.3
<P>The finite element model of KSTAR central solenoid (CS) magnet has been developed with new smeared orthotropic material properties of CS coils and the effective coefficient of thermal expansion of the magnet structures. The accuracy of structural analysis for assembly and cool-down processes is higher than in previous studies. Electromagnetic analysis was performed to evaluate Lorentz forces of poloidal field (PF) coils during a long pulse discharge. The analyzed structural behavior of the CS magnet was clearly consistent with the measured data and calculated Electromagnetic (EM) forces during the plasma operation. The current of PF4 coil had a significant effect on axial compression and the minimum preloading was maintained at 2.0 MN in the end of plasma. Equivalent EM force can easily predict the axial compression of CS magnet without complicated structural analysis. The study on the structural behavior of CS magnet is expected to provide the optimal combination of PF coil current limits for large plasma current and long pulse discharges.</P>
만성 B형간염에서 간 조직내 TGF-p1과 a-SMA 단백질의 발현정도와 인터페론 치료효과와의 상관관계
국진환,김경철,황성규,최유정,홍성표,정은미,박필원,안희정,김배영,오성욱,임규성 대한간학회 1998 Clinical and Molecular Hepatology(대한간학회지) Vol.4 No.4
Backg round/Aims : The aim of this study was to evaluate the effect of α- interferon (IFN) on liver histology as well as on activation of hepatic stellate cell ( HSC) and trans for ming growth fact or β- 1 (TGF -β1) expression. We had also investigated the clinical usefulness of TGF-β1 and α- smooth muscle actin (α-SMA) expression in liver tissue for predicting a response toα- IFN therapy in chronic hepat it is B. Methods : We studied the expression of TGF-β1 and α- SMA in liver biopsys pecimens from 51 chronic hepatitis B pat ients . Using immunohistochemical staining and a semiquant it ative scoring met hod, we also evaluated TGF- β1 and α- SMA expression in liver stellate cells before and after α- IFN therapy in liver tissue from rebiopsys pecimen of the 12 chronic hepatitis B pat ients . Recombinant IFN α- 2b (Intron A) in doses of 6 MU/ d was given to patients intramus cularly three times per week for 6 months ( total doses , 432 MU). The patients were divided into two groups accordinanine aminotransferase levels as well as HBV- DNA and HBeAg s eroconversion stat e. Histological grading and staging scores were according to modified Histological Activity Index (HAI) gradingsys tems of Ishak ( 1995). Results : The index of portal inflammation and total scores of HAI grading significantly decreased in biopsies afterα - IFN t reat ment, but the scores of fibrosis staging showed no significant change in biopsies after IFN t reat ment. A significant decrease in α- SMA expression, especially in periportal area, was found, but the change of TGFβ- 1 expression was not significant. The immunoreactivity of α- S MA was significantly lower in responders than in non-res ponders , whereas the diffference of immun or eactivity of TGFβ - 1 between these two groups was not found. Conclusions : These findings suggest that α- IFN therapy may reduce the necroinflammatory activity in liver tissues of chronic B viral hepatitis and that the degree of - S MA ex pression before treatment may be employedpottent predicting indicat or for the therapeutic efficacy of IFN- alfa.(Korean J Hepatol 1998;4:317 329)