신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Dimethyl Phthalate와 Ethylene Glycol간의 에스테르 교환반응에서 염화물 촉매의 영향

박근호 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

Transesterification reaction between dimethyl phthalate and ethylene glycol was kinetically investigated in the presense of various metal chloride catalysts at 140-170℃. The reaction rates measured by the amount of distilled methanol from the reaction vessel. The transesterification reaction was carried out under the first order conditions respect to the concentration of reactants, respectively. The overall reaction order was 2nd. The linear relationship was shown between apparent rate constant and reciprocal absolute temperature. By the Arrhenius plot the activation energy have been calculated as 19.9 kcal/mole under zinc chloride catalyst and also apparent rate constant, k' was found to obey first kinetic with respect to the concentration of catalyst.

社會淨化運動과 意識改革敎育의 發展方向

朴瑾浩 동국대학교 행정대학원 1984 행정논집 Vol.14 No.-

地方公企業의 組織行態에 관한 調査硏究

朴瑾浩 동국대학교 행정대학원 1983 행정논집 Vol.13 No.-

디메틸 프탈레이트와 에틸렌 글리콜의 에스테르 交換反應에서의 觸媒活性에 關한 硏究

朴根浩 國立 昌原大學校 産業技術硏究所 1991 産技硏論文集 Vol.5 No.-

Transesterification reaction between dimethly phthalate and ethylene glycol was kinetically investigated in the presense of various metal acetate catalysts at 185℃. The reaction rates measured by the amount of distilled methanol from the reaction vessel. The transesterification reaction was carried out under the first order conditions respect to the concentration of dimethyl phthalate, ethylene glycol and catalyst, respectively. The over-all order was 3rd. Maximum reaction rate was appeared at the range of 1.2 to 1.7 in electronegativity of metal ions and maximum catalytic activity was appeared at the range of 1.4 to 1.6 in instability constant of metal acetates.

人間行態의 分析模型

朴瑾浩 동국대학교 행정대학원 1978 행정논집 Vol.8 No.-

다형성 교모세포종에서 광범위 전적출술후 단기 재발된 치험 1예

박호권,강중식,조준,문창택,장상근,임정애 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Glioblasty/ma Multiforme(GBM) is the one of the most common malignant tumors in central nervous system(CNS). The incidence of the tumor is about 12% of all CNS tumors and about 50% of all intracranial tumors. Though the development of the microsurgical technique, radiosurgical technique, and chemotherapy works effectively, complete cure of the GBM has not been achieved. It has been known that the prognosis of GBM depends on the extent of surgical tumor removal, remained tumor volume, radiation dose, and chemotherapy. Not only patient's age but also tumor characteristics such as MRI enhancement, angiogenesis and necrosis are also very important prognostic factors. Authors experienced very aggressive GBM in aged woman, who received gross total tumor removal, but refused other therapeutic motalities postoperatively. Very rapid recurrence of GBM and global cerebral edema in aged woman should be considered fatal. This case demonstrates the effectiveness of aggressive removal and the limited usefulness of neurosurgical tools in GBM recurrence. Authors would suggest that the early diagnostic effort and the verified neurosurgical therapy for malignant tumor are still strongly requested to make better prognosis.

호주의 쌀 산업 동향과 생산비 분석

박평식,박준근,정호근 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.1

본고는 호주의 쌀 생산동향과 변화추이, 재배기술 및 생산비 구조를 분석하여, 우리나라 쌀 산업의 경쟁력 제고를 위한 시사점을 모색코자 하였다. 이를 위해 호주의 주요 쌀 생산지를 방문하여 생산농가와 연구기관 등 관련자 접촉을 통해 현지자료를 수집분석하였다. 호주의 쌀 품종 및 재배기술 개발, 경지정리 및 수자원 관리기법, 생산자조합의 체계적인 활동과 저장가공 시설의 적재적소배치 등을 통한 생산비 절감노력 등을 벤치마킹해야 할 것이다. 경영규모의 영세성은 우리 쌀 농업이 지니고 있는 가장 큰 한계점이고, 그 결과 높은 생산비가 우리 농산물의 대외적인 경쟁력을 약화시키고 있다. 쌀을 수출하는 호주 등 주요 국가의 생산비는 우리나라의 10∼45% 수준에 불과한 실정이다. 이러한 상황하에서 자연증가에 의한 호당 경영면적의 확대는 현실적으로 매우 어려운 것으로 나타나고 있다. 우리나라 쌀 산업 발전을 위해서는 무엇보다도 생산비 절감이 매우 절실하고 그 방향은 구조개혁에서 찾아야 할 것이다. 특히, 생산기반의 구조조정 차원에서 경지정리, 교환분합, 임대차 확대, 농지집단화 노력의 배가가 시급하다고 할 수 있다. 이러한 규모화 사업이 품질향상과 더불어 우선적인 정책방향으로 추진되어야 한다. 동시에 선진국에서 막대한 예산을 투입해서 시행하고 있는 직불제도는 우리나라에서도 필요한 것이 사실이다. 다만 구조조정에 역행하거나 모순되는 직불제의 시행보다는 구조조정을 최대한 촉진시킬 수 있는 직불제가 더 현실화된 금액으로 시행되는 것이 바람직하다. 쌀 농민들의 수직적 통합이 보다 적극적으로 진행되어 농업인들의 자생적 경쟁력이 강화되어야 하며, 불합리하게 많이 설치된 RPC를 비롯한 방만한 유통조직도 재정비되어야 할 시점에 있다. This study aims to analyze the trend of Australian rice economy and production cost. Rice cultivating region is Riverina plain area in New South Wales, Australia. In recent years(1998-2000), about 1,291 thousand tonnes(paddy rice base) of rece produced on the 135,000 ha in the country. About 85% of Australian rice production exports to more than 40 countries. That makes Australia is the main exporter of Japonicatype rice in the international market. The current situation and trend of Australian rice industry and structure of production cost are described in this paper.

Mitomycin-C 적용시간에 따른 누낭비강연결술의 수술결과

박근성,임진호,민병무,최시환,김창식,김용백 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

To determine the usefulness of application of Mitomycin-C (MMC) and effectiveness of different concentration of MMC in external DCR. A total of 100 eyes of 87 patients diagnosed with primary acquired nasolacrimal duct obstruction were assigned randomly to either a MMC group or control group. The surgical procedures in both groups were same. In MMC group, a piece of neurosurgical cottonoid soaked with 0.4 mg/ml MMC was applied to the osteotomy site and then was removed after 5 and 10 minutes differently. Nasoendoscopic examination was performed at 1 month, 3 months, and 6 months after surgery for all patients. The causes of epiphora as trauma (20 cases), failed DCR (1 case), sinus surgery (2 cases), unknown (77 cases). The overall anatomical success rate of the procedure was 88% and functional success rate was 79%. Obstruction site was related to anatomical surgical results. Anatomical surgical outcome at lower lacrimal sac level group of patients showed a statistically significant success rate, but functional surgical outcome showed no significant difference between the two groups. The anatomical success rate was 87.7% and the functional success rate was 84.2% in MMC group. The anatomical success rate was 88.3% and the functional success rate was 74.4% in control group. Application of MMC and it's application time were not related to surgical results.