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Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1
Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.
Radio Resource Management of CoMP System in HetNet under Power and Backhaul Constraints
( Jia Yu ),( Shaohua Wu ),( Xiaodong Lin ),( Qinyu Zhang ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.11
Recently, Heterogeneous Network (HetNet) with Coordinated Multi-Point (CoMP) scheme is introduced into Long Term Evolution-Advanced (LTE-A) systems to improve digital services for User Equipments (UEs), especially for cell-edge UEs. However, Radio Resource Management (RRM), including Resource Block (RB) scheduling and Power Allocation (PA), in this scenario becomes challenging, due to the intercell cooperation. In this paper, we investigate the RRM problem for downlink transmission of HetNet system with Joint Processing (JP) CoMP (both joint transmission and dynamic cell selection schemes), aiming at maximizing weighted sum data rate under the constraints of both transmission power and backhaul capacity. First, joint RB scheduling and PA problem is formulated as a constrained Mixed Integer Programming (MIP) which is NP-hard. To simplify the formulation problem, we decompose it into two problems of RB scheduling and PA. For RB scheduling, we propose an algorithm with less computational complexity to achieve a suboptimal solution. Then, according to the obtained scheduling results, we present an iterative Karush-Kuhn- Tucker (KKT) method to solve the PA problem. Extensive simulations are conducted to verify the effectiveness and efficiency of the proposed algorithms. Two kinds of JP CoMP schemes are compared with a non-CoMP greedy scheme (max capacity scheme). Simulation results prove that the CoMP schemes with the proposed RRM algorithms dramatically enhance data rate of cell-edge UEs, thereby improving UEs` fairness of data rate. Also, it is shown that the proposed PA algorithms can decrease power consumption of transmission antennas without loss of transmission performance.
Effect of Light with Different Wavelengths on Nostoc flagelliforme Cells in Liquid Culture
( Yu Jie Dai ),( Jing Li ),( Shu Mei Wei ),( Nan Chen ),( Yu Peng Xiao ),( Zhi Lei Tan ),( Shi Ru Jia ),( Nan Nan Yuan ),( Ning Tan ),( Yi Jie Song ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.4
The effects of lights with different wavelengths on the growth and the yield of extracellular polysaccharides of Nostoc flagelliforme cells were investigated in a liquid cultivation. N. flagelliforme cells were cultured for 16 days in 500 ml conical flasks containing BG11 culture medium under 27 μmol·m-2·s-1 of light intensity and 25oC on a rotary shaker (140 rpm). The chlorophyll a, phycocyanin, allophycocyanin, and phycoerythrin contents in N. flagelliforme cells under the lights of different wavelengths were also measured. It was found that the cell biomass and the yield of polysaccharide changed with different wavelengths of light. The biomass and the yield of extracellular polysaccharides under the red or violet light were higher than those under other light colors. Chlorophyll a, phycocyanin, and allophycocyanin are the main pigments in N. flagelliforme cells. The results showed that N. flagelliforme, like other cyanobacteria, has the ability of adjusting the contents and relative ratio of its pigments with the light quality. As a conclusion, N. flagelliforme cells favor red and violet lights and perform the complementary chromatic adaptation ability to acclimate to the changes of the light quality in the environment.
Jia-Jia Lin,Young-Hyun Han,Jung-Woo Kwon,Yong-Nan Xu,Yi-Bo Luo,Yu-Jin Jo,Chang-Eun Park,Jung-Kyu Baang,Suk Namgoong,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2014 Reproductive & Developmental Biology(Supplement) Vol.38 No.2s
In meiosis, Emi2 plays important role as CSF (Cytostatic Factor) to make the oocyte arrested in mII stage by the inhibition of APC/C (anaphase promoting complex/cyclosome). Once the oocyte fertilized, Emi2 was destabilized and degraded. For the degradation of Emi2, calcium signaling activate calmodulin-dependent protein kinase (CaMK) and phosphorylate emi2. Phosphorylated emi2 is recognized by polo-box domain of polo-like kinase 1 (Plk1) and further degradated by ubiquitin-dependent proteolysis. But recognition of Plk1 and emi2 is unknown. In this works, we determined the high-resolution crystal structure of polo-box domain of Plk1 and phosphorylated emi2 peptide at 1.90Å. Determined structure revealed that several unique features, including binding of Phe169 in the tyrosin-rich hydrophobic pocket. This is the first report of crystallization that Plk1-emi2 complex. Based on the complex structure, we designed the peptide analogs which pontentially inhibits recognition of Emi2 by Plk1 and assessed its biological activity in oocyte maturation and pathernogenetic activation. Injection of AB103-8, the inhibitor of Plk1 Polo-box domain, in mouse oocytes, induced the maturation arrest in GV stage and the delay in mII parthenogenetic activation. Further investigations of the mechanism that Plk1 involved into the Emi2 mII arrest are underway.
Yu Jia 아시아사회과학학회 2022 Jornal of Asia Social Science Vol.8 No.2
The initial intention of education is to cultivate people with virtue, and career planning in colleges and universities is the most important basic course for college students. Under the background of ideological and political education, it is an important task for colleges and universities to build a career planning curriculum system. The purpose of this paper is to construct the curriculum system of career planning from the aspects of curriculum objectives, curriculum contents, teaching staff construction and curriculum evaluation under the guidance of ideological and political spirit.
A hybrid strategy for comprehensive annotation of the protein coding genes in prokaryotic genome
Jia-Feng Yu,Jing Guo,Qing-Bin Liu,Yue Hou,Ke Xiao,Qing-Li Chen,Ji-Hua Wang,Xiao Sun 한국유전학회 2015 Genes & Genomics Vol.37 No.4
Protein coding gene annotation errors in prokaryotic genomes are accumulating continually in bioinformatics databases, while the update rate of genome annotation can not keep up with the explosive increasing genome sequences in most cases. Hence it is critical to manually rectify the genome annotation errors. In this paper, a hybrid strategy by combing the gene ab initio predicting programs and the over annotated gene re-annotation programs is proposed for re-annotation of the protein coding genes in prokaryotic genomes. Based on this strategy, the protein coding genes in Geobacter sulfurreducens PCA is comprehensively re-annotated. As a consequence, 16 hypothetical genes are annotated as non-coding sequences and 104 missing genes are retrieved as protein coding genes. Subsequent function analysis and sequences analysis show that the predicting results are much reliable and robust. Further application to other genomes show that this work can provide alternative tools for later post-process of prokaryotic genome annotations.
( Jia Yi Yu ),( Xiao Fei Zhou ),( Mi Kyoung Chang ),( Mako Nakaya ),( Jae Hoon Chang ),( Yi Chuan Xiao ),( J. William Lindsey ),( Stephanie Dorta Estremera ),( Wei Cao ),( Anna Zal ),( Tomasz Zal ),( 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-cell activation but causes retention of effector T cells in the draininglumph node in a neuroinflammatory autoimmunity model,experimental autoimmune encephalomyelitis (EAE).Atolder ager,the T-cell-conditional TBK1-knockout mice also spontaneously accumulate T cells with activated phenotype.TBK1 contrlos the activation of AKT and its downsream kinase m TIORC1 by a mechanism involving TBK1-stimulated AKT ubiquitination and degradation. The deregulated AKT-mTORC1 signalling in turn contributes to enhanced T-cell activation and impaired effector T-cell egress from draining lymph nodes. Treatment of mice with a small-molecule inhibitor fo TBK1 inhibits EAE induction. These results suggest a role for TBK1 in regulating T-cell migration and establish TBK1 as a regulator of the AKT-mTORC1 signalling axis.
Jia-Ci Jhang,Ting Ru Lin,Yu-Chun Chuang,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.3
It is trendy to use polymers with different forms in a diversity of fields. This study uses nylon fibers and lowmelting-point polyester (LMPET) fibers or low melting point polylactic acid (LMPLA) fibers to fabricate three-dimensionalnylon/LMPET and nylon/LMPLA cushioning composite fabrics employing the nonwoven manufacturing. The employmentof needle punching process and thermal treatment reinforce the cushioning composite fabrics, and the subsequent thermalbonding points strengthen the mechanical properties effectively. In comparison to pure nylon nonwoven fabrics, the nyloncushioning composite fabrics exhibit higher tensile strength by 2.3 times regardless of whether it is a nylon/LMPET or nylon/LMPLA cushioning composite fabric. Similarly, based on the hammer rebound rate measurement, when the 3D cushioningcomposite fabrics are composed of 20 wt% of LMPLA fibers or 80 wt% of LMPET fibers, the hammer rebound rate reaches20 %, which is 1.4 times greater than that of the control group. Additionally, the composite fabrics that are composed of80 wt% of LMPLA fibers or 40 wt% of LMPET fibers also demonstrate higher compression recovery than the control group.