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HyunKyoung Kim,HeeSook Kim,SeogJu Kim 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-North Korean women defectors have suffered from anxiety, depression, and somatization after defection. Also they have had many menstrual problems like amenorrhea. This study was done to identify the correlations of anxiety, depression, and somatization to menstrual problems among North Korean woman defectors in South Korea. Methods-The participants in this study were 126 women from 5 government resettlement centers throughout South Korea. Questionnaires which included State-Trait Anxiety Inventory (STAI), Center for Epidemiological studies-Depression Scale (CED-S), and Symptom Checklist-90-Revised (SCL-90-R) were used to identify anxiety and somatization. Data were collected between June and September, 2012. Results-The women reported the following problems; amenorrhea (9.5%), hypomenorrhea (13.6%), menorrhagia (19.8%), polymenorrhea (13.5%), oligomenorrhea (4.8%), changes in amount of menstrual discharge (4.0%), and changes in amount of blood clot (9.5%). Anxiety (r=0.20, p=0.002), depression (r=0.25, p=0.005), and Somatization (r=0.35, p<0.001) were correlated with number of menstrual problems. Conclusion-The results of this study indicate that mental health services need to be taken into account in interventions for North Korean woman defectors to improve their reproductive health including addressing menstrual problems.
Molecular Surveillance for Tick-Borne Rickettsial and Protozoal Infectious Diseases of Dog in Korea
Keun-Ho Kim(Keun-Ho Kim),Mi-Sun Yoo(Mi-Sun Yoo),Hyun-Ji Seo(Hyun-Ji Seo),Kyu-Won Kwak(Kyu-Won Kwak),Hyunkyoung Lee(Hyunkyoung Lee),Jung-Won Park(Jung-Won Park),Seunghee Lee(Seunghee Lee),Soon-Seek Yoo 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Kim, Jongho,Kim, Gyeongyeob,Lee, Hyunkyoung,Moon, Bo-Youn,Lee, Kichan,Byun, Jae-Won,Park, Ji-Young,Lee, Kyoung-Ki,Jeoung, Hye-Young,Ko, Mi-Kyeong,Ku, Bok-Kyung,Chung, Yun Soo,Bae, You-Chan The Korean Society of Veterinary Science 2022 大韓獸醫學會誌 Vol.62 No.2
Salmonella enterica serotype Choleraesuis causes swine paratyphoid, with clinical findings of enterocolitis and septicemia. However, the clinicopathological features of S. Choleraesuis infections in pigs have not been reported in Korea. We describe the pathological findings of two weaned pigs with S. Choleraesuis infections, presenting with diarrhea, cough, and sudden death. Pathological examination indicated severe necrotic colitis in pig 1 and septicemic lesions in pig 2. Multidrug-resistant S. Choleraesuis was isolated from the pigs' lungs and intestinal contents. Further research is required for the surveillance of S. Choleraesuis infections in pigs and the virulence estimation in the S. Choleraesuis isolates.
Kim, Hangun,Han, Jeong-Ran,Park, Jaejun,Oh, Minsoo,James, Sarah E,Chang, Sunghoe,Lu, Qun,Lee, Kwang Youl,Ki, Hyunkyoung,Song, Woo-Joo,Kim, Kwonseop American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.2
<P>Delta-catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin promotes dendritic morphogenesis were unclear. In this study, we demonstrated delta-catenin interaction with p190RhoGEF, and the importance of Akt1-mediated phosphorylation at Thr-454 residue of delta-catenin in this interaction. We have also found that delta-catenin overexpression decreased the binding between p190RhoGEF and RhoA, and significantly lowered the levels of GTP-RhoA but not those of GTP-Rac1 and -Cdc42. Delta-catenin T454A, a defective form in p190RhoGEF binding, did not decrease the binding between p190RhoGEF and RhoA. Delta-catenin T454A also did not lower GTP-RhoA levels and failed to induce dendrite-like process formation in NIH 3T3 fibroblasts. Furthermore, delta-catenin T454A significantly reduced the length and number of mature mushroom shaped spines in primary hippocampal neurons. These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis.</P>
Kim, Hangun,Ki, Hyunkyoung,Park, Hee-Sae,Kim, Kwonseop American Society for Biochemistry and Molecular Bi 2005 The Journal of biological chemistry Vol.280 No.23
<P>The enzyme γ-secretase is involved in the cleavage of several type I membrane proteins, such as Notch 1 and amyloid precursor protein. Presenilin-1 (PS-1) is one of the critical integral membrane protein components of the γ-secretase complex and is processed endoproteolytically, generating N- and C-terminal fragments (NTF and CTF, respectively). PS-1 is also known to incorporate into a high molecular weight complex by binding to other γ-secretase components such as Nicastrin, Aph-1, and Pen-2. Mutations on PS-1 can alter the effects of γ-secretase on its many substrates to different extents. Here, we showed that PS-1 mutants have a different activity for Notch cleavage, which depended on the PS-1 mutation site. We demonstrated that defective PS-1 mutants located in CTF, <I>i.e.</I> D385A and C410Y, could restore their γ-secretase activities with the compensatory overexpression of wild type CTF or of minimal deleted CTF (amino acids 349-467). However, the defective PS-1 D257A mutant could not restore their γ-secretase activities with the compensatory overexpression of wild type NTF. In comparison, both D257A NTF and D385A CTF could abolish the γ-secretase activity of wild type and pathogenic PS-1 mutants. We also showed that PS-1 NTF but not CTF forms strong high molecular weight aggregates in SDS-PAGE. Taken together, results have shown that NTF and CTF integrate differently into high molecular weight aggregates and that PS-1 Asp-257 and Asp-385 have different accessibilities in their unendoproteolyzed conformation.</P>
Improved Therapeutic Profiles of PLA₂-Free Bee Venom Prepared by Ultrafiltration Method
Hyunkyoung Lee,Min-Jung Pyo,Seong Kyeong Bae,Yunwi Heo,Choul Goo Kim,Changkeun Kang,Euikyung Kim 한국독성학회 2015 Toxicological Research Vol.31 No.1
Bee venom (BV) has long been used in traditional Eastern and Western medicine for chronic inflammation, pain and skin therapy. Human exposure to BV, however, often causes unwanted adverse effects and is even fatal in some cases. Phospholipase A₂ (PLA₂) of BV is now suspected to play a key role in these adverse effects. We investigated the potential use of PLA₂-free bee venom (PBV) as a replacement for BV in cosmetic products. PBV prepared by molecular weight cut-off ultrafiltration exhibits a superior profile in comparison with regular BV, by inhibiting elastase activity and suppressing the induction of nitric oxide (NO) and metalloproteinase-9 (MMP-9), while retaining the effects of cell proliferation and protection against ultraviolet B (UVB)-induced damage in human dermal fibroblast cells. PBV thus appears to be more promising than BV as a cosmetic ingredient with a reduced potential for adverse reactions in the recipient.
Anti-wrinkle Effect of PLA2-free Bee Venom against UVB-irradiated Human Skin Cells
Hyunkyoung Lee,Seong Kyeong Bae,Min-Jung Pyo,Yunwi Heo,Choul Goo Kim,Changkeun Kang,Euikyung Kim 경상대학교 농업생명과학연구원 2015 농업생명과학연구 Vol.49 No.1
The use of bee venom (Apis mellifera L., BV) occasionally causes side effects such as inflammation and allergic reactions in the recipients. Several case reports also suggested the treatment of BV has some limitations in its clinical uses, due to the occurrence of dermal necrosis and anaphylatic reactions. It is generally understood that bee venom allergy is mainly the result of its allergic component, phospholipase A2 (PLA2). The present study was aimed to generate PLA2-free bee venom (PBV) and evaluate its efficacy as skin care and cosmetic preparation, comparing with original bee venom (BV). Our results showed that both BV and PBV exhibited significant protective effects in UVB-irradiated human keratinocyte (HaCaT) and human dermal fibroblast (HDF) cells and they also induced type I collagen synthesis in UVB-irradiated HDF cells except BV at 3 μg/ml. Furthermore, BV and PBV showed the inhibition of UVB-stimulated matrix metalloproteinase-1 (MMP-1), a major collagen degrading enzyme in skin. However, BV, unlike PBV, exhibited strong cytotoxicities in skin cells (both HaCaT and HDF) at its working concentrations of anti-wrinkle effect. The underlying cell signaling mechanisms of anti-wrinkle effects of BV and PBV were demonstrated by the activation of ERK1/2, and p38. Conclusively, PBV appears to be the bee venom of choice with less cytotoxicity and higher efficacy on UVB-irradiated skin cells in comparison with original bee venom (BV). Therefore, PBV can better be used as a cosmetic ingredient exhibiting excellent anti-wrinkle effect against photoaging than original BV.