강원남부 폐광지역 개발기금 사업의 경제적 효과 : 2001~2021년간의 기금사업을 중심으로

유원근(Won Keun Yu),최호영(Ho-yeong Choi),김승렬(Seung-Leul Kim) 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.11

본 논문은 2001년부터 2021년 기간의 강원남부 폐광지역 4개 시군을 대상으로 전개된 폐광지역개발기금 투자의 경제적 파급효과를 실증적으로 분석함을 목적으로 한다. 이 기간 동안 연차별 투자 건수 1,220개로 구성된 691개의 재원 사업이 이행되었다. 분석대상 기간 동안 연차별로 투자된 재원의 합계는 총 1조 6,180.5억원이며, 지역산업연관분석을 통해 실증적으로 경제적 파급효과를 도출하는 것이 본고의 목적이다. 폐광지역개발기금의 투자금액의 면에서 보면, 대체로 생산유발효과가 상대적으로 낮은 3차산업 부문에 대한 재원의 비중이 큰 것으로 나타났다. 그러나 다른 한편으로 고려해야 할 점은 3차산업 부문의 취업유발효과가 이 지역에서 타 산업에 비해 높다는 점이다. 이러한 산업구조적 특성을 토대로 향후 폐광지역개발기금 사업의 경제적 효과를 최적화시키기 위해서는 유발계수 값의 분포를 고려한 재원의 배분 계획을 마련할 필요가 있다. 본고의 추정결과는 향후 폐광지역 개발기금의 합리적인 배분을 위한 실증적 기초 자료로서의 역할을 할 것으로 기대된다. This study aimed to analyze the economic effects of the closed mine area development fund on the southern part of the Gangwon provinces during the period 2001~2021. In this time frame, 691 financial projects comprising 1,220 items in the annual base were carried out and the total amount of investment was 1,618.05 billion Won. The main goal of this study was to derive empirical evidence about the economic effect of this fund through the regional industrial input-output tables. An analysis of the distribution of financial resources available to the specific fields revealed that the portion of funds invested in the tertiary industry sector has a low production inducement effect, which was not comparable with other industries. However, the movement of the employment inducement coefficient of tertiary industries led by the services sector in this area is comparatively high. Based on the regional character of the industrial structure, it is necessary to make a deliberate funds distribution plan taking the movement of the above inducement coefficients into consideration, to optimize the economic effect of the closed mine area development fund. The empirical output derived from this study would assist policymakers in establishing an effective distribution strategy for the closed mine area development fund in the future.

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

Sulforaphane protects against acetaminophen-induced hepatotoxicity

Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Kim, Kyoung-Shim,Oh, Won-Keun,Lee, Chul-Ho Elsevier 2015 Food and chemical toxicology Vol.80 No.-

<P><B>Abstract</B></P> <P>Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity <I>in vitro</I> and <I>in vivo</I>. Pretreatment of primary hepatocyte with SFN induced nuclear factor E2-factor related factor (Nrf2) target gene expression, especially HO-1 mRNA and protein expression, and suppressed APAP-induced glutathione (GSH) depletion and lipid peroxidation, which eventually leads to hepatocyte cell death. A comparable effect was observed in mice treated with APAP. Mice were treated with 300 mg/kg APAP 30 min after SFN (5 mg/kg) administration and were then sacrificed after 6 h. APAP alone caused severe liver injuries as characterized by increased plasma AST and ALT levels, GSH depletion, apoptosis, and 4-hydroxynonenal (4-HNE) formations. This APAP-induced liver damage was significantly attenuated by pretreatment with SFN. Furthermore, while hepatic reactive oxygen species (ROS) levels were increased by APAP exposure, pretreatment with SFN completely blocked ROS formation. These results suggest that SFN plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. SFN has preventive action in oxidative stress-mediated liver injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SFN pretreatment increases the cell viability against APAP-induced toxicity. </LI> <LI> SFN pretreatment protects depletion of cellular GSH after APAP treatment. </LI> <LI> SFN pretreatment enhances Nrf2 target gene expression, especially HO-1 after APAP treatment. </LI> <LI> SFN has protective effect against APAP overdose-induced liver injury <I>in vivo</I> model as well. </LI> </UL> </P>

비모형화 특성 및 외란을 갖는 비선형 시스템에 대한 강인한 적응 제어기 설계에 관한 연구

현근호,양해원 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

In this paper we present a robust adaptive backstepping output-feedback controller for nonlinear systems perturbed by unmodelled dynamics and disturbances. The adaptive backstepping controller has been extremely successful in the last several years for nominal nonlinear and linear systems. However, the systems perturbed by unmodelled dynamics and disturbances have not been well studied in case of the adaptive backstepping controller. We will use "Switching-σ Modification" in the update law which has been used in the conventional robust adaptive controller and a modified control law to attenuate the effects of unmodelled dynamics and disturbances for nonlinear systems. The plant dynamics that ale represented by an output-feedback form will be transformed to the adaptive observer form by the recently developed Marino-Tomei (MT) filter. We analyze convergence, stability and transient characteristics of the resulting closed-loop system. The feasibility of the proposed controller and its performance are demonstrated by some suitable simulations.

골다공증 진단에 피부 두께의 임상적 유용성 평가

박원근,최민주,김호찬,조성제,박전홍 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The study was carried out to examine how much clinically useful was the skin thickness in diagnosis of osteoporosis. The project was to look into not only the presumption that patients with osteoporosis have the skin loss at the similar rate of the reduction in the collagen content of the bone but also the correlation between the collagen content and the skin thickness. The skin thickness was measured on the dorsal hand(right) of the patients using an ultrasonic technique with a 20 MHz focused ultrasonic transducer. Measurements of the bone density of the patients were made on both the lumbar spine (L2-4) and the femoral neck using Dual­Energy X­ray Absorptionmeter(DEXA, Norland). An ultrasonic bone densitometer(Mark 6000, Medison Co. Korea) was taken to measure the speed of sound (SOS) on the calcaneus. It was observed that there were some degrees of correlation between the bone density obtained by the DEXA and the SOS of the calcaneous (P<0.01). There was no evidence that the skin thickness was correlated with the DEXA produced bone density and ultrasonically measured SOS.

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

우리나라 미혼여성들의 신부화에 대한 선호도

이원영,조근호,박천호 한국화훼연구회 1999 화훼연구 Vol.8 No.1

This paper was to survey preferences of bridal wedding bouquet by young women at the age of marriage and outdoor-wedding bouquet. The accessive results showed necessity of the bouquet for their purposes of just taking photography outdoors (71%). The most preferred main materials belong robes (46%) and orchids (21%) in that order. Gypsophilas (32%) were found to be the most preferred secondary material for the floral design, and miniature roses (28%) were the second most preferred. Ivies (45%) were the most foliage material preferred and asparagus (22%) in the next. 45% of the subjects preferred were one or two kinds of materials put in bridal bouquet. In outdoor-used bouquet, 47% of participants joined in the survey indicated their preferences to use three to four kinds of floral material, while 13% of the subjects preferred five to six kinds of material in them. 79.8% of the participants responded to prefer white or cream colors in bridal bouquet, while 47.9% preferred pink and red colors when in outdoors. The survey results indicated that Korean women at the marriage age seem to prefer mixtures of variety and yet colorful ones for the outdoor bouquet. They preferred cascade (43%) and round shape (31%) varied of bridal bouquet. Free style (38%) and round shape (27%) bouquet were likened by the people.

교사가 지각한 교감의 역할수행이 교장의 지도성에 미치는 영향

조남근,원호태 고려대학교 교육문제연구소 1999 敎育問題硏究 Vol.11 No.-

TRIGA Mark-Ⅱ 原子爐의 爐雜音 解析

李源根,尹浩鎭 慶熙大學校 材料科學技術硏究所 1991 材料科學技術硏究論集 Vol.4 No.-

For the purpose of measurement of reactor kinetic paramter, rossi-α experiment In TRIGA Mark-Ⅱ reactor are performed. The past neutron noise measurement which is using HARDWARE have had defects of inaccuracy. In this study, I developed SOFTWARE to betterment of these defects and using it investigated α which is reciprocal of prompt period. To collect neutron pulses, developed data acquisition system using 16 bit personal computer (IBM-AT) and developed pascal languge program to analysis neutron pulses. As a result of experiment, α is 103, 5, 155.6, 172.7 238.7, 266.5 (1/Sec) at -1, -20, -40, -60, -80, (cent) respectively, and compare it with other experiment data convinced accurate, know S/B ratio must be larger then 10% and in case of thermal reactor, low power reactor such as AGN-201 is needed to neutron noise analysis.