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DO, Thi Thu Hien,NGUYEN, Thi Lan Anh,NGUYEN, Thi Hoai Phuong Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6
The study's goal is to determine the amount of climate change's impact on ethnic minority (EM) households' livelihoods, as well as their adaptability to climate change and long-term viability. The research was conducted in Vietnam's Northwestern Sub-region, where ethnic minorities account for more than half of the overall population. The study uses a combination of qualitative and quantitative methods based on a survey of 480 households in 04 provinces severely affected by climate change in the Northwest sub-region of Vietnam. The results show that: climate change (extreme weather events) occurs with increasing frequency, mainly affecting the life expectancy, health, and capital of households; Vulnerable groups (women, ethnic minorities) have a poor adaptive capacity and mainly suffer the consequences of shocks, are afraid to change their livelihoods; Microfinance plays an important role in enhancing the sustainability of livelihoods through increasing capital and financial assets and reducing the vulnerability of ethnic minority households. Finally, research has some solutions for microfinance - special credit specifically for ethnic minority households in the Northwest Sub-region: support for microfinance advice, home credit with transition orientations to adapt to climate change response and relieves its impact on the social lives.
Screening of Vietnamese Medicinal Plants for Cytotoxic Activity
Nguyen Bich Thu,Trinh Nam Trung,Do Thi Ha,Nguyen Minh Khoi,Tran Viet Hung,Tran Thi Hien,Yim Namhui,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.1
Thirty-two methanol extracts of thirty-one Vietnamese medicinal plants were evaluated for the cytotoxic activity against five human cancer cell lines, including A549, MCF-7, HT 1080, Huh-7, and HepG2. Of these, the nine extracts of Acanthopanax trifoliatus (4), Acanthopanax gracilistylus (5), Siegesbeckia orientalis (10), Betula alnoides (11), Passiflora edulis (18), Zanthoxylum simulans (leaf, 23), Adenosma caeruleum (26), Solanum verbascifolium (29), and Alpinia malaccensis (31), exhibited high potent cytotoxic activity showing a certain degree of selectivity against the different cell types, with IC50 values ranging from 2.1 to 3.8 mg/mL.
The Effect of Foreign Direct Investment Inflow on Exports: Evidence from Vietnam
Duc Anh DO,Yinghua SONG,Huu Tung DO,Thi Thu Hien TRAN,Thanh Thuy NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.2
Foreign direct investment (FDI) and export are now often regarded as two of the most important drivers of economic growth on a worldwide scale. The impact of foreign direct investment on Vietnam’s exports is investigated in this study. The data for the time period 1985–2020 was obtained from the World Bank and the Vietnam General Statistics Office. The years 1985 to 2020 were chosen to evaluate the evolution of macroeconomic parameters since 1986. The impact of the Covid-19 epidemic on renovation reform. The Johansen co-integration test proved that FDI and domestic investment (DI) had a long-term positive impact on Vietnam’s export growth. The Granger causality test revealed that there is a one-way relationship between FDI and export in the near term, but no such relationship exists between DI and export. The result of the variance decomposition study demonstrates that the FDI sector has a bigger impact on Vietnam’s export growth than the DI sector. Furthermore, export activities are vulnerable to FDI sector shocks. As a result, in recent years, FDI has been regarded as the most important factor of export growth in Vietnam.
Chien Minh Tran,Ngoc Thi‑Thanh Nguyen,Minh Hieu Ho,Vinh Khanh Doan,Khanh Loan Ly,Nhi Ngoc‑Thao Dang,Nam Minh‑Phuong Tran,Hoai Thi‑Thu Nguyen,Long Phuoc Truong,Thai Minh Do,Quyen Ngoc Tran,Hien Quoc Ng 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1
In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs)membrane fabrication process, in which SNPs were directly synthesized from silver nitrate (AgNO3) in PCL–acetone mixtureby gamma irradiation. The insolubility of AgNO3in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reductionagents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solventremoval, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation wasconfirmed by both UV–Visible spectrum (UV–Vis) and X-ray diffraction analysis. Scanning electron microscopy (SEM)revealed that the addition of SNPs significantly reduced the fiber diameter of PCL–Ag membranes compared to that of rawPCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy(TEM). The tensile test showed that the electrospun PCL–Ag membranes exhibited good mechanical characteristics. Moistureeasily penetrated the porous microstructure of PCL–Ag, facilitating wound humidity regulation. Inductively coupledplasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall,the PCL–Ag 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcusaureus strains and low in vitro cytotoxicity.
Hoang Thai Hoa,Nguyen Thi Thu,Nguyen Thuong Dong,Tran Thi Oanh,Tran Thi Hien,Do Thi Ha 한국생약학회 2020 Natural Product Sciences Vol.26 No.3
The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.
고아라,위서리,Ji In Ryu,Hien Thi Thu Do,이연정,임수정,이인모,정대인,박진아,최정아,송만기,이나경 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.2
Adjuvants are essential vaccine componentsused to enhance, accelerate, and/or prolong adaptiveimmunity against specific vaccine antigens. In this study,we compared the adjuvanticity of two adjuvant formulationscontaining de-O-acylated lipooligosaccharide(dLOS), a toll-like receptor 4 agonist, on the Japaneseencephalitis (JE) vaccine in mice. Mice were immunizedonce or twice at a two-week interval with inactivated JEvaccine in the absence or presence of adjuvant. We foundthat both the alum- and the liposome-based formulationinduced significantly faster and higher serum IgG antibodyresponses as compared with the non-adjuvanted vaccineafter either one or two immunizations. The antibody titersof the mouse immune sera correlated with 50% plaquereduction neutralization test (PRNT50) antibody titers. Inaddition, the dLOS/liposome formulation was more effectivein inducing a Th1-type immune response than thedLOS/alum formulation, as suggested by a strong antigenspecificinterferon (IFN)-c response. Based on theseresults, we suggest that both alum- and liposome-basedadjuvant formulations containing dLOS may be used forthe development of JE vaccines with improvedimmunogenicity.
Duc Manh Hoang,Trinh Nam Trung,Phan Thi Thu Hien,Do Thi Ha,Hoang Van Luong,이명숙,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with IC50 values ranging from 3.4 mg/mL to 35.1 mg/mL; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with IC50 values less than 15.5 mg/mL; sixteen extracts (55.2%) could demonstrate PTP1B activity with IC50 values ranging from 15.5 mg/mL to 35.1 mg/mL. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
Wui, Seo Ri,Kim, Kwang Sung,Ryu, Ji In,Ko, Ara,Do, Hien Thi Thu,Lee, Yeon Jung,Kim, Hark Jun,Lim, Soo Jeong,Park, Shin Ae,Cho, Yang Je,Kim, Chang-Gyeom,Lee, Na Gyong Elsevier 2019 Vaccine Vol.37 No.15
<P><B>Abstract</B></P> <P>Varicella zoster virus (VZV) is a neurotropic and lymphotropic alpha herpesvirus that causes varicella and herpes zoster (HZ). At a primary infection, VZV causes varicella in young children. Reactivation of latent VZV in sensory ganglia causes painful HZ in elderly people, occasionally leading to a serious complication, postherpetic neuralgia (PHN). A live attenuated VZV vaccine, the first vaccine licensed for the prevention of HZ and PHN is not very effective, while a recombinant subunit vaccine provides higher and longer protection against HZ. In the present study, we developed a new adjuvant system CIA09A, which is composed of cationic liposomes, the Toll-like receptor 4 (TLR4) agonist de-<I>O</I>-acylated lipooligosaccharide, and <I>Quillaja</I> saponin fraction QS-21. We then determined its adjuvant activity for recombinant VZV glycoprotein E (gE) in mice. Co-lyophilization of the liposomal adjuvant formulation with gE did not abolish the immune-stimulating activity. In fact, the CIA09A-adjuvanted gE vaccine was highly effective in eliciting both humoral and cellular immune responses to the recombinant gE protein and VZV in a VZV-primed mouse model. Furthermore, the frequency of gE-specific polyfunctional CD4<SUP>+</SUP> T cells expressing interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-2 was significantly increased in mice immunized with the adjuvanted vaccine. These data indicate that co-lyophilization of protein antigens with CIA09A enables development of a liposome-adjuvanted vaccine in a single vial to induce strong cell-mediated immunity required for vaccine efficacy. Thus, the CIA09A-adjuvanted gE vaccine warrants further development as a new prophylactic vaccine against HZ.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We determined the adjuvanticity of CIA09A (cationic liposomes with a TLR4 ligand and QS-21) for VZV gE. </LI> <LI> Co-lyophilization of CIA09A with gE did not abolish the immune-stimulating activity for VZV gE. </LI> <LI> The CIA09A-adjuvanted gE vaccine effectively elicited humoral and CMI responses to gE and VZV. </LI> <LI> The adjuvanted vaccine induced gE-specific CD4<SUP>+</SUP> T cells expressing IFN-γ, TNF-α, and IL-2. </LI> <LI> Co-lyophilization of VZV gE with CIA09A enables manufacture of a subunit vaccine in a single vial. </LI> </UL> </P>
( Ara Ko ),( Seo Ri Wui ),( Ji In Ryu ),( Yeon Jeong Lee ),( Do Thi Thu Hien ),( Inmoo Rhee ),( Sung Jae Shin ),( Shin Ae Park ),( Kwang Sung Kim ),( Yang Je Cho ),( Na Gyong Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.1
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guerin (BCG) vaccine is the only TB vaccine currently available, but it is not sufficiently effective in preventing active pulmonary TB or adult infection. With the purpose of developing an improved vaccine against TB that can overcome the limitations of the current BCG vaccine, we investigated whether adjuvant formulations containing de-O-acylated lipooligosaccharide (dLOS) are capable of enhancing the immunogenicity and protective efficacy of TB subunit vaccines. The results revealed that the dLOS/dimethyl dioctadecyl ammonium bromide (DDA) adjuvant formulation significantly increased both humoral and Th1-type cellular responses to TB subunit vaccine that are composed of three antigens, Ag85A, ESAT-6, and HspX. The adjuvanted TB vaccine also effectively induced the Th1-type response in a BCG-primed mouse model, suggesting a potential as a booster vaccine. Finally, the dLOS/DDA-adjuvanted TB vaccine showed protective efficacy against M. tuberculosis infection in vitro and in vivo. These data indicate that the dLOS/DDA adjuvant enhances the Th1-type immunity and protective efficacy of the TB subunit vaccine, suggesting that it would be a promising adjuvant candidate for the development of a booster vaccine.
( Ji In Ryu ),( Seo Ri Wui ),( Ara Ko ),( Hien Thi Thu Do ),( Yeon Jeong Lee ),( Hark Jun Kim ),( Inmoo Rhee ),( Shin Ae Park ),( Kwang Sung Kim ),( Yang Je Cho ),( Na Gyong Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.8
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that commonly causes fatal infections in cystic fibrosis and burn patients as well as in patients who are hospitalized or have impaired immune systems. P. aeruginosa infections are difficult to treat owing to the high resistance of the pathogen to conventional antibiotics. Despite several efforts, no effective prophylactic vaccines against P. aeruginosa are currently available. In this study, we investigated the activity of the CIA06 adjuvant system, which is composed of alum and de-Oacylated lipooligosaccharide, on a P. aeruginosa outer membrane protein (OMP) antigen vaccine in mice. The results indicated that CIA06 significantly increased the antigen-specific IgG titers and opsonophagocytic activity of immune sera against P. aeruginosa. In addition, the antibodies induced by the CIA06-adjuvanted vaccine exhibited higher cross-reactivity with heterologous P. aeruginosa strains. Finally, mice immunized with the CIA06-adjuvanted vaccine were effectively protected from lethal P. aeruginosa challenge. Based on these data, we suggest that the CIA06 adjuvant system might be used to promote the immunogenicity and protective efficacy of the P. aeruginosa OMP vaccine.