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Chien Minh Tran,Ngoc Thi‑Thanh Nguyen,Minh Hieu Ho,Vinh Khanh Doan,Khanh Loan Ly,Nhi Ngoc‑Thao Dang,Nam Minh‑Phuong Tran,Hoai Thi‑Thu Nguyen,Long Phuoc Truong,Thai Minh Do,Quyen Ngoc Tran,Hien Quoc Ng 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1
In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs)membrane fabrication process, in which SNPs were directly synthesized from silver nitrate (AgNO3) in PCL–acetone mixtureby gamma irradiation. The insolubility of AgNO3in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reductionagents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solventremoval, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation wasconfirmed by both UV–Visible spectrum (UV–Vis) and X-ray diffraction analysis. Scanning electron microscopy (SEM)revealed that the addition of SNPs significantly reduced the fiber diameter of PCL–Ag membranes compared to that of rawPCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy(TEM). The tensile test showed that the electrospun PCL–Ag membranes exhibited good mechanical characteristics. Moistureeasily penetrated the porous microstructure of PCL–Ag, facilitating wound humidity regulation. Inductively coupledplasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall,the PCL–Ag 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcusaureus strains and low in vitro cytotoxicity.
Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,주성호,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,권영인,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Medicinal plants constitute an important sourceof potential therapeutic agents for diabetes. The purpose ofpresent study is to investigate the effect of root extract ofRosa rugosa Thunb. on inhibition of sucrase related todiabetes mellitus (DM). Bioassay-guided fractionation ofthe methanol extract led to the identification of 13 triterpenoidsaponins (1–13). Their structures were elucidatedon the basis of extensive spectroscopic analysis, including1D, 2D NMR, and MS. The n-butanol fraction showedpotent rat intestinal sucrase inhibitory activity with value of87.62 ± 5.84 % inhibition compared to the positive controlacarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11–13 (1.0 mM) exhibited significantsucrase inhibitory activity, with inhibition percentagevalues of 41.17 ± 3.52, 46.80 ± 4.00, and39.39 ± 4.19 %, respectively. Whereas, compounds 2–6,8, and 10 showed moderate sucrase inhibitory activity(ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition)at a same concentration. The data provide a starting pointfor creating new sucrase inhibitors, which may be usefulfor the development of effective therapies for the treatmentof DM.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Nguyen Bich Thu,Trinh Nam Trung,Do Thi Ha,Nguyen Minh Khoi,Nguyen Viet Than,Thipthaviphone Soulinho,Nguyen Hai Nam,Tran Thi Phuong,배기환 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
The methanol extract of Zanthoxylum rhetsa (MZRR) were evaluated for its ability to suppress the formation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. MZRR presented an inhibition of LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that MZRR significantly inhibited the protein and mRNA expressions of iNOS and COX-2 in LPS-activated macrophages in a dose-dependent manner. LPS-induced COX-2, iNOS, and nuclear factor kappa beta (NF-kB) activity were also decreased in the presence of MZRR. The production of tumor necrosis factor-a (TNF-a), the mRNA expression levels of pro-inflammatory cytokines, including TNF-a and IL-1b, were reduced after MZRR administration in a dose dependent-manner. These results suggest that the MZRR extract involved in the inhibition of iNOS and COX-2 via the NF-kB pathway, revealing a partial molecular basis for anti-inflammatory properties of the MZRR extract.
Xuan Truong NGUYEN,Thai Ha NGUYEN,Huynh Phuong DANG,Thi Lan Phuong PHAM,Thi Thanh BUI,Nhat Minh TRAN,Tri An HUYNH,Nam Phong NGUYEN 한국유통과학회 2022 유통과학연구 Vol.20 No.2
Purpose: This study aims to identify factors affecting the adoption of e-commerce by household businesses in Vietnam s food and beverage industry. Research design, data and methodology: The integrated TAM and TOE frameworks and ten hypotheses were developed to test the relationship between relevant factors. A cross-sectional survey was conducted to collect valid data from 992 respondents who run F&B household businesses in Vietnam. Results: The empirical research results confirm all proposed hypotheses that e-commerce adoption is affected by the perceived usefulness, the perceived ease of use, vendor support partners, social expectancy, competitive pressure, subjective norm, and household resources. Meanwhile, technical readiness, environment readiness, and organization readiness are intermediate variables that influence the implementation of e-commerce in food and beverage distribution. Conclusions: The findings suggest effective orientations to foster the food and beverage e-trading practice for household businesses in developing countries. Accordingly, to encourage private household businesses to adopt e-commerce, it is necessary to focus on improving business resources, technology readiness, environment readiness, and organization readiness through raising awareness of usefulness, benefits, perceived ease of use, and increased support of vendor partners. Future research can focus on improving the efficiency of e-commerce applications in F&B distribution for both household businesses and larger-scale enterprises.
Hieu, Doan Thanh,Anh, Duong Tien,Tuan, Nguyen Minh,Hai, Pham-The,Huong, Le-Thi-Thu,Kim, Jisung,Kang, Jong Soon,Vu, Tran Khac,Dung, Phan Thi Phuong,Han, Sang-Bae,Nam, Nguyen-Hai,Hoa, Nguyen-Dang Elsevier 2018 Bioorganic chemistry Vol.76 No.-
<P><B>Abstract</B></P> <P>In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized several series of novel <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinazolin-4(3<I>H</I>)-ones (<B>4a-h</B>, <B>8a-d, 10a-d)</B>. Biological evaluation showed that these hydroxamic acids were generally cytotoxic against three human cancer cell lines (SW620, colon; <I>PC</I>-3, prostate; NCI-H23, lung cancer). It was found that the <I>N</I>-hydroxypropenamides (<B>10a-d)</B> were the most potent, both in term of HDAC inhibition and cytotoxicity. Several compounds, e.g. <B>4e</B>, <B>8b-c</B>, and <B>10a-c</B>, displayed up to 4-fold more potent than SAHA (suberoylanilide hydroxamic acid, vorinostat) in term of cytotoxicity. These compounds also comparably inhibited HDACs with IC<SUB>50</SUB> values in sub-micromolar range. Docking experiments on HDAC2 isozyme revealed some important features contributing to the inhibitory activity of synthesized compounds, especially for propenamide analogues. Importantly, the free binding energy computed was found to have high quantitative correlation (<I>R</I> <SUP>2</SUP> ∼ 95%) with experimental results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel quinazolin-4(3H)-one-based <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides were synthesized. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited potent HDAC inhibition. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited good cytotoxicity. </LI> <LI> Docking studies and ADMET estimation were carried out. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Two series of novel, simple <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinolin-4(3H)-one (<B>4a-h</B>, <B>8a-d, 10a-d</B>) were designed and synthesized. Biological evaluation showed that these benzamides/propenamides potently inhibited HDAC with IC<SUB>50</SUB> values in sub-micromolar range. A number of compounds also exhibited cytotoxicity up to 4-fold more potent than SAHA, a positive control.</P> <P>[DISPLAY OMISSION]</P>
NGUYEN, Xuan Truong,NGUYEN, Thai Ha,DANG, Huynh Phuong,PHAM, Thi Lan Phuong,BUI, Thi Thanh,TRAN, Nhat Minh,HUYNH, Tri An,NGUYEN, Nam Phong Korea Distribution Science Association 2022 유통과학연구 Vol.20 No.2
Purpose: This study aims to identify factors affecting the adoption of e-commerce by household businesses in Vietnam's food and beverage industry. Research design, data and methodology: The integrated TAM and TOE frameworks and ten hypotheses were developed to test the relationship between relevant factors. A cross-sectional survey was conducted to collect valid data from 992 respondents who run F&B household businesses in Vietnam. Results: The empirical research results confirm all proposed hypotheses that e-commerce adoption is affected by the perceived usefulness, the perceived ease of use, vendor support partners, social expectancy, competitive pressure, subjective norm, and household resources. Meanwhile, technical readiness, environment readiness, and organization readiness are intermediate variables that influence the implementation of e-commerce in food and beverage distribution. Conclusions: The findings suggest effective orientations to foster the food and beverage e-trading practice for household businesses in developing countries. Accordingly, to encourage private household businesses to adopt e-commerce, it is necessary to focus on improving business resources, technology readiness, environment readiness, and organization readiness through raising awareness of usefulness, benefits, perceived ease of use, and increased support of vendor partners. Future research can focus on improving the efficiency of e-commerce applications in F&B distribution for both household businesses and larger-scale enterprises.