만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

Preventive effects of mycobacteria and their culture supernatants against asthma development in BALB/c mice

Han, Eui-Ryoung,Choi, Inseon S.,Eom, Sun-Ho,Kim, Hwa-Jung The Korean Academy of Asthma, Allergy and Clinical 2010 Allergy, Asthma & Immunology Research Vol.2 No.1

<P><B>Purpose</B></P><P>Live <I>Mycobacterium bovis</I> Bacille Calmette-Guérin (BCG) has a suppressive effect on asthma, but its use in clinical practice may be limited due to adverse reactions. To develop a product that is effective for suppressing asthma with minimal adverse reactions, we investigated whether the heat-killed body or culture supernatants of mycobacteria could also prevent asthma development.</P><P><B>Methods</B></P><P>Female BALB/c mice were treated with live BCG, the heat-killed body, or culture supernatants of BCG or <I>Mycobacterium tuberculosis</I> intraperitoneally, while sensitizing and provoking with ovalbumin. Then they underwent a methacholine bronchoprovocation test, and the peribronchial inflammatory cell numbers and cytokine levels in splenocyte culture supernatants were assessed.</P><P><B>Results</B></P><P>The airway sensitivity to methacholine decreased significantly after treatment with not only live BCG (30.8 versus 10.0 mg/mL, <I>P</I><0.001) but also with the culture supernatant (BCG, 23.0 mg/mL, <I>P</I><0.05; <I>M. tuberculosis</I>, 20.5 mg/mL, <I>P</I><0.05). In contrast, heat-killed mycobacteria did not effectively decrease airway sensitivity. The peribronchial eosinophil counts and the goblet cell proportions in total epithelial cells decreased significantly in most of the groups. The interferon-γ/interleukin-5 ratios increased significantly in most of the treatment groups except for the heat-killed groups, and were significantly related to airway sensitivity (<I>r</I>=0.312, <I>P</I><0.01) and peribronchial eosinophil counts (<I>r</I>=-0.416, <I>P</I><0.001). Interleukin-17A level was inversely related to airway sensitivity (<I>r</I>=-0.212, <I>P</I><0.05) and was significantly lower in the live BCG group than in the control (137±20 versus 308±57 pg/mL, <I>P</I><0.05).</P><P><B>Conclusions</B></P><P>BCG and mycobacteria culture supernatants may effectively prevent the development of asthma associated with altered Th1/Th2 cytokines and interleukin-17A levels.</P>

천식 의심환자에서 기도과민성과 관련된 공기 매개성 알레르겐

한의령 ( Eui Ryoung Han ),최인선 ( Inseon S. Choi ),이석 ( Seok Lee ),조영욱 ( Yeong Wook Cho ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2

Background: House dust mites and cats are major allergens causing asthma, and grass pollens are more closely related to allergic rhinitis. Objective: To investigate which aeroallergens are related to airway hyperresponsiveness (AHR), a characteristic feature of asthma, in Korean patients. Method: Medical records of suspected asthmatics, who performed both skin prick tests using common aeroallergens and the methacholine bronchoprovocation test between 2001 and 2007, were reviewed. A positive response to an allergen was defined as allergen/histamine wheal ratio of ≥1. A positive and a ≥moderate AHR were defined as 20% fall in FEV1 to ≤25 and ≤2 mg/mL of methacholine, respectively. The relative risks (adjusted odds ratio) for AHR compared to non-atopy were determined by a multivariate logistic regression analysis. Result: House dust mites were the most prevalent allergens in both asthma (n=238) and non-asthma (n=149) patients. The AHR severity was significantly related to the sensitization rates to house dust mites in asthmatics. The relative risks for ≥moderate AHR of subjects sensitized to Dermato-phagoides farinae and hazel were 1.21 (P<0.01) and 0.72 (P<0.05), respectively. Conclusion: Sensitization to a house dust mite, D. farinae, might be a significant risk factor for AHR, but hazel sensitization was protective and might be related to allergic rhinitis. (Korean J Asthma Allergy Clin Immunol 2007;27:105-110)

전남대학교 의과대학 졸업 후 진로지도 프로그램 설계와 운영

한의령,정은경,Eui-Ryoung Han,Eun-Kyung Chung 연세대학교 의과대학 2024 의학교육논단 Vol.26 No.1

Chonnam National University Medical School has designed and implemented two career planning programs: a three-phase curriculum-based program and a longitudinal non-curricular program over the course of 6 academic years. The three phases of the curriculum-based career planning program are self-assessment, career exploration, and field experience. The non-curricular career counseling program operates through a faculty advisor system, with each faculty member guiding a group of students from each academic year, and students in each year forming a mentor-mentee relationship. The non-curricular career exploration program consists of a student research support program, an international practice program in basic and clinical medicine, and a specialty exploration fair. A survey conducted among 38 graduates (54.3%) working as interns at Chonnam National University Hospital revealed that graduates preferred autonomous elective subjects within the curriculum-based program. They also responded positively to the faculty advisor system, through which they maintained close relationships. A focus group interview with three interns indicated that subjects providing direct experience in fields of interest and courses that students could choose freely were helpful in career decisions. Through follow-up research, it is necessary to design and operate a systematic career planning program based on an analysis of the needs of graduates taking part in a residency training program after selecting a medical specialty.

The relationship between medical students’ epistemological beliefs and achievement on a clinical performance examination

Sun-A Oh,Eun-Kyung Chung,Eui-Ryoung Han,Young-Jong Woo,Deiter Kevin 한국의학교육학회 2016 Korean journal of medical education Vol.28 No.1

Purpose: This study was to explore the relationship between clinical performance examination (CPX) achievement and epistemological beliefs to investigate the potentials of epistemological beliefs in ill-structured medical problem solving tasks. Methods: We administered the epistemological beliefs questionnaire (EBQ) to fourth-year medical students and correlated the results with their CPX scores. The EBQ comprised 61 items reflecting five belief systems: certainty of knowledge, source of knowledge, rigidity of learning, ability to learn, and speed of knowledge acquisition. The CPX included scores for history taking, physical examination, and patient-physician interaction. Results: The higher epistemological beliefs group obtained significantly higher scores on the CPX with regard to history taking and patient-physician interaction. The epistemological beliefs scores on certainty of knowledge and source of knowledge were significantly positively correlated with patient-physician interaction. The epistemological beliefs scores for ability to learn were significantly positively correlated with those for history taking, physical examination, and patient-physician interaction. Conclusion: Students with more sophisticated and advanced epistemological beliefs stances used more comprehensive and varied approaches in the patient-physician interaction. Therefore, educational efforts that encourage discussions pertaining to epistemological views should be considered to improve clinical reasoning and problem-solving competence in the clinic setting.

얼굴 및 눈 위치 추적을 통한 IPTV 화면 인터페이스 제어에 관한 연구

이원오(Won Oh Lee),이의철(Eui Chul Lee),박강령(Kang Ryoung Park),이희경(HeeKyung Lee),박민식(Minsik Park),이한규(Han-Kyu Lee),홍진우(Jin Woo Hong) 한국통신학회 2010 韓國通信學會論文誌 Vol.35 No.6b

최근 HCI 분야에서 사용자의 시선 추적을 통해 보다 편리한 입력 장치를 개발하려는 연구가 활발히 진행되고 있다. 하지만 기존의 시선 추적 방법들은 부가적인 사용자 착용형 장비를 필요로 하거나 원거리에서 작동되지 않는 문제 등으로 인해 IPTV 환경에서 적용하기 어려운 실정이다. 이에 본 연구에서는 사용자 착용없이 고정된 하나의 카메라를 이용하여 얼굴을 취득하고, 취득된 얼굴 영역 내에서 눈의 위치를 검출하여 IPTV의 화면 인터페이스를 제어할 수 있는 새로운 방법을 제안한다. 또한, Adaboost 방법으로 얼굴이나 눈이 성공적으로 검출되지 못했을 경우에도, 계층적 KLT (Kanade-Lucas-Tomasi)특징 추적 방법을 통해 구해진 모션 벡터를 이용하여 화면 인터페이스를 제어할 수 있는 방법을 제안한다. 이처럼, 본 논문의 방법은 기존의 방법과는 달리 실제 IPTV의 시청거리인 2m 정도의 원거리에서도 사용가능하며, 카메라 이외에 별도의 장치를 착용할 필요가 없으므로 편의성이 높고 얼굴 움직임의 제약이 없다는 장점이 있다. 실험결과, 입력되는 얼굴 영상을 초당 15프레임의 속도로 실시간 처리함을 확인할 수 있었으며, 기존 입력 장치의 역할을 충분히 대신할 수 있음을 알 수 있었다. Recently, many researches for making more comfortable input device based on gaze detection have been vigorously performed in human computer interaction. However, these previous researches are difficult to be used in IPTV environment because these methods need additional wearing devices or do not work at a distance. To overcome these problems, we propose a new way of controlling IPTV interface by using a detected face and eye positions in single static camera. And although face or eyes are not detected successfully by using Adaboost algorithm, we can control IPTV interface by using motion vectors calculated by pyramidal KLT (Kanade-Lucas-Tomasi) feature tracker. These are two novelties of our research compared to previous works.

증례 : 알레르기 ; 만성 호산구성 폐렴의 임상양상을 동반한 급성 호산구성 폐렴 1예

김성수 ( Sung Soo Kim ),고영일 ( Young Il Koh ),한의령 ( Eui Ryoung Han ),위정욱 ( Jeong Ook Wi ) 대한내과학회 2010 대한내과학회지 Vol.79 No.6

본 증례를 통하여 급성 호산구성 폐렴은 아토피질환 존재등의 만성 호산구성 폐렴의 임상양상을 일부 동반할 수 있으며, 만성 호산구성 폐렴과의 감별이 어려운 경우 기관지폐 포세척술을 시행하여 세척액내 호산구뿐만 아니라 림프구 및 호중구의 증가 소견을 증명하면 급성 호산구성 폐렴의 진단에 도움이 될 수 있을 것으로 생각된다. Acute eosinophilic pneumonia (AEP) represents a clinical entity distinct from chronic eosinophilic pneumonia (CEP). In contrast with CEP, AEP is characterized by duration of symptoms less than 5 days, hypoxemic respiratory failure, no blood eosinophilia at presentation, no atopic background or history of asthma, and no recurrence. However, we report a case of AEP with some features of CEP. A 33-year-old man presented with respiratory symptoms for 4 days. He was diagnosed with AEP based on hypoxemic respiratory failure, diffuse alveolar-interstitial chest X-ray infiltrates, and eosinophilia, lymphocytosis and neutrophilia from bronchoalveolar lavages. However, he had two atopic diseases, asthma and atopic dermatitis. In addition, he presented with blood eosinophilia, which are all features of CEP. Thus, there might be some overlap of clinical features between AEP and CEP. The presence of increased lymphocytes and neutrophils in the bronchoalveolar lavage can be an important finding to help distinguish between AEP versus CEP in difficult cases. (Korean J Med 79:724-728, 2010)

혈관염을 동반한 DRESS증후군

위정욱 ( Jeong Ook Wi ),진남철 ( Nam Chul Jin ),한의령 ( Eui Ryoung Han ),윤병조 ( Byung Jo Yoon ),박상훈 ( Sang Hun Park ),고영일 ( Young Ll Koh ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.4

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a drug hypersensitivity syndrome characterized by fever, skin rash, blood eosinophilia and multiple organ involvements including liver and kidney developed following drug administration. Vasculitis could be infrequent one of manifestations of DRESS syndrome. Mortality rate of DRESS syndrome is at least 10%. Here, we reported a case of DRESS syndrome with vasculitis. A 67-year-old man with essential hypertension presented with fever and maculopapular rash after being given allopurinol over 2 weeks for gout. He had severe oral mucositis. He had peripheral blood eosinophilia and abnormal hepatic and renal functions. A skin biopsy showed leukocytoclastic vasculitis. Gastroduodenoscopy showed spontaneous mucosal oozing in mid-to-lower esophagus. He was diagnosed as having DRESS syndrome with vasulitis. Allopurinol was stopped and systemic corticosteroid was administrated. His clinical manifestations improved gradually. However, he died of sudden onset of massive intracranial hemorrhage. The case suggests that DRESS syndrome could sometimes present manifestations of vasculitis, which might be fatal. (Korean J Asthma Allergy Clin Immunol 2010;30:320- 324)

소세포폐암에서 Etoposide 투여 후 발생한 아나필락시스

김영일 ( Young Il Kim ),김규식 ( Kyu Sik Kim ),한의령 ( Eui Ryoung Han ),권용수 ( Yong Soo Kwan ),오인재 ( In Jae Oh ),임성철 ( Sung Chul Lim ),김영철 ( Young Chul Kim ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.2

Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.

Airway Responsiveness to Inhaled Aspirin is Influenced by Airway Hyperresponsiveness in Asthmatic Patients

( Sung Soo Kim ),( Inseon S. Choi ),( Yeon Joo Kim ),( Chang Seong Kim ),( Eui Ryoung Han ),( Dong Jin Park ),( Dae Eun Kim ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.3

Background/Aims: Many patients with aspirin-induced asthma have severe methacholine airway hyperresponsiveness (AHR), suggesting a relationship between aspirin and methacholine in airway response. This study was performed to determine whether methacholine AHR affects the response of asthmatics to inhaled aspirin. Methods: The clinical records of 207 asthmatic patients who underwent inhalation challenges with both aspirin and methacholine were reviewed retrospectively. An oral aspirin challenge was performed in patients with a negative inhalation response. The bronchial reactivity index (BRindex) was calculated from the percent decrease in lung function divided by the last dose of the stimulus. Results: Forty-one (20.9%) and 14 (7.1%) patients showed a positive response to aspirin following an inhalation and oral challenge, respectively. Only 24.3 and 14.3% of the responders had a history of aspirin intolerance, respectively. The methacholine BRindex was significantly higher in the inhalation responders (1.46±0.02) than in the oral responders (1.36±0.03, p<0.01) and in non-responders (n=141, 1.37±0.01, p<0.001). The aspirin BRindex was significantly correlated with the methacholine BRindex (r=0.270, p<0.001). Three of four patients who received the oral challenge, despite a positive inhalation test, showed negative responses to the oral challenge. Two of these patients had severe AHR. Conclusions: A considerable number of asthmatic patients with no history of aspirin intolerance responded to the inhalation aspirin challenge. The airway response to aspirin was significantly correlated with methacholine-AHR, and a false-positive response to aspirin inhalation test seemed to occur primarily in patients with severe AHR. (Korean J Intern Med 2010;25:309-316)