편마비환자의 환측 하지 외회전 정도가 기립균형에 미치는 영향

이동욱,곽길환,배성수,Lee Dong-Wook,Kwak Kil-Hwan,Bae Sung-soo 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3

The two groups each consisting of 28 people who had an adult hemiplegia due to a brain injury received two different methods of exercises to reduce the angle to which the affected lower limb rotates externally. The comparisons between the two groups were made for the changes of the angle in external rotations measured between pre and post test. The static balance index values taken during pre and post tests were also compared. In addition, the correlations of the angle to which the affected lower limb rotates externally with static balance index values were analyzed. The result were as follows: 1. A statistical analysis indicated that in group one having taken simple R.O.M exercises, the angle to which the affected lower limb rotates externally and the static balance index values were both significantly different between pre and post test (P<.01). 2. A statistical analysis indicated that in group two having taken a pattern movement, both the angle to which the affected lower limb rotates externally and static balance index values were significantly different between pre and post test (P<.01). 3. A significant difference between simple R.O.M exercises group and pattern movement exercises groupwas shown only for the angle to which affected limb rotates externally not for static balance index values (P<.01), 4. Pearson correlation coefficient for the angle to which the affected limb rotates externally with static balance index values was found to be significant only in pattern movement exercises group (P < .05).

ATM-VP 전송망에서의 서비스 레벨 분류에 의한 Self-healing 방법

이동욱,홍충선,이대영,Lee, Dong-Wook,Hong, Choong-Seon,Lee, Dae-Young 한국정보처리학회 2000 정보처리논문지 Vol.7 No.11

ATM 네트워크에서 오류가 발생한 VP를 복원하기 위해 많은 자기치료 (Self-healing) 알고리즘이 이미 제안되어 왔다. 알고리즘 중 가장 많이 사용되는 것은 백업 VP를 이용하는 방법이다. 백업 VP를 이용한 알고리즘의 문제점은 백업 VP의 오류가 발생하였을 경우 심각한 문제가 발생하게 되며, 이를 보완하기 2차 백업 VP를 설정하는 알고리즘 제안되었다. 2차 백업 VP를 두는 알고리즘의 경우는 초기 계산량이 너무 많은 단점이 있다. 본 논문에서는 서비스 레벨에 따라 차등의 알고리즘을 두고 3가지 CASE별로 복구알고리즘을 적용하고 또한2차 백업으로 설정 알고리즘의 문제를 해결하여, 상대적으로 고가의 서비스가 되는 실시간 서비스 오류를 방지하는 자기치료 알고리즘을 제안한다. 또한 시뮬레이션을 통해 기존의 알고리즘과 비교하여 성능을 분석하였다. In is proposed that the algorithm for self-healing to restoration the backup-VP occurrence error in ATM network. Backup-VP used method is one of the most used algorithm. Most of the problem of backup-VP used algorithm occurts heavily when backup-VP is fault new algorithm is proposed to repair this problem which senup secondary backup-VP. The sccondary gackup-VP algorithm has many disadvantages in mitial setup. That is it requires too manyy calculation. To setile preseribed problem, this thesis proose quality of serviec algorithm to propose of the present problem. Analysis is adopted.

Purification and Properties of the Major Isozymic Form of NAD-linked ${\alpha}$-Glycerophosphate Dehydrogenase from Rat Kidney

이동욱,이희성,조성희,Lee, Dong-Wook,Lee, Hee-Sung,Cho, Sung-Hye 생화학분자생물학회 1988 한국생화학회지 Vol.21 No.3

흰쥐 신장의 NAD 의존성 ${\alpha}$-glycerophosphate 탈수소 효소는 4종의 isozyme으로 존재하였고 그들의 등전점은 pH6.9, 6.6, 6.4 및 6.2였다. 이들중 등전점 6.6인 major isozyme을 blue dextran-Sepharose 4B, DEAE-cellulose, Sephadex G-100 chromatography를 통하여 1,078배 정제하였다. Major isozyme의 분자량은 62,000이고, 반응 최적온도와 pH는 각각 55도 및 10.0이었고, 최적온도에서 쉽게 불활성화 되었다. 이 효소는 일가 및 이가 양이온의 첨가에 의해 활성화 되었으며 p-HMB와 iodoacetamide에 의해 활성이 크게 억제되었고, glycerophosphate와 NAD에 대한 Km값은 각각 3.22 및 0.31 mM 이었다. 이들 결과로부터 이 효소의 isozyme pattern은 조직에 따라 다를지라도 major isozyme의 이화학적 성상은 서로 비슷함을 알 수 있었다. NAD-linked ${\alpha}$-glycerophosphate dehydrogenase(EC 1.1.1.8) in rat kidney existed as four different isozymic forms with an isoelectric point at pH 6.9, 6.6, 6.4 and 6.2, respectively. The major isozymic form(PI 6.6) was purified using several chromatographic procedures involving an ion exchange and two affinity chromatography steps. The 1,078 fold purified enzyme was homogeneous, nucleotide free protein. The molecular weight of the major isozyme was 62,000 daltons, the optimal pH and temperature for its catalytic activity were 10.0 and $55^{\circ}C$, respectively. At the optimal temperature this enzyme was rapidly inactivated$(t_{1/2}=1.5min)$. The major isozyme was activated by the addition of cations such as $K^+$, $Na^+$, $Mg^{++}$ or $Ca^{++}$, and was strongly inhibited by alkylating agents such as P-hydroxymercurybenzoate or iodoacetamide. Glycerophosphate oxidation reaction obeyed the Michaelis-Menton behavior with Km values of 3.22 and 0.31 mM for glycerophosphate and NAD, respectively. The data suggest that although the isozyme pattern of NAD-linked ${\alpha}$-glycerophosphate dehydrogenase is quite different by tissue or species of the animal the physico-chemical properties of the major isozymic form are very similar each other except the affinity for substrate and coenzyme.

고주파 SAW Filter 의 제작과 Filter 특성

이동욱,김동수,강성건,류근걸,남효덕,이만형 ( Dong Uk Lee,Dong Su Kim,Sung Gun Kang,Kun Kul Ryoo,Hyo Duk Nam,Man Hyeong Lee ) 한국전기전자재료학회 1997 한국전기전자재료학회 추계학술대회논문집 Vol.1997 No.1

Food Restriction as An Effective Modulator of Free Radical Metabolism in Aging Rats

이동욱,유병팔 ( Dong Wook Lee,Byung Pal Yu ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.2

Chronic dietary restiction without malnutrition extends both the mean and maximum life span of all laboratory organisms so far tested. This life-extension is attributed to numerous beneficial effects of well-maintained physiological systems, and the retardation of chronic diseases. Although the biological mechanisms of these anti-aging actions by dietary restriction are not known, recent evidence indicated that modulation of free radical activity might play important roles in such beneficial action. Our present study with SPF male Fischer 344 rats provides further data that the anti-radical action of dietary restriction suppresses the formation of reactive oxygen species, enhances the antioxidant capacity, and increases the membrane resistance against oxidative stress. Based on these results we propose that dietary restriction is an effective modulator of free radical activity.

NEWS FOCUS - GMT 적응광학(Adaptive Optics) 소개

이동욱,Lee, Dong-Uk 한국천문연구원 2009 KASI news letter Vol.88 No.-

비마토프로스트 점안 후 눈 주변 피부 색소침착이 발생한 환자에서 약물중단 후 경과

이동욱,Dong Wook Lee,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.8

Purpose: To evaluate the demographic and clinical characteristics of bimatoprost-induced periocular skin hyperpigmentation. Methods: The chart analyses of 16 patients in whom cosmetically noticeable periocular skin hyperpigmentation developed after starting bimatoprost therapy were reviewed. Data collated included age, medication history, dates of starting and stopping bimatoprost treatment, and the subjective assessment of the periocular hyperpigmentation at initial detection as well as follow-up visits. Periocular hyperpigmentation was graded using an arbitrary scale from 0 to 3. The number of days to the onset of hyperpigmentation and to pigment resolution was determined and their associations to demographic and other clinical parameters were analyzed. Results: Patients had variable grades of periocular hyperpigmentation at presentation (mean, 1.53±0.66). Bimatoprost-induced periocular hyperpigmentation appeared 1-10 (mean, 4.3±2.6) months after initiation of bimatoprost therapy. Resolution of skin hyperpigmentation was noted 2-10(mean 6.8±1.9) months after stopping bimatoprost treatment. There was a minor correlation(R=+0.19) between the number of days to resolution of hyperpigmentation and the number of days when bimatoprost was used. At 12 months after stopping bimatoprost treatment, 12 of the 13 patients had complete resolution of periocular hyperpigmentation. However, weak hyperpigmentation remained in one patient. Conclusions: Bimatoprost-induced hyperpigmentation is benign and reversible.

Assay of Cytochrome P-450-dependent Testosterone Hydroxylases in Liver Microsomes of Rats

이동욱,박기현,Lee, Dong-Wook,Park, Ki-Hyun 생화학분자생물학회 1988 한국생화학회지 Vol.21 No.3

흰쥐 간 마이크로좀의 cytochrome P-450(P-450)에 의해 생성된 testosterone의 monohydroxy 대사물을 동시에 쉽게 정량할 수 있는 TLC 방법을 정립하였다. 이 방법을 이용하여 phenobarbital(PB)로 유도된 흰쥐 간 마이크로좀의 P-450에 의한 testosterone의 대사를 관찰하였다. 생성된 14종의 대사물이 확인되었고 그중 6종의 monohydroxy 대사물($2{\alpha}-$, $2{\beta}-$, $6{\alpha}-$, $6{\beta}-$, $7{\alpha}-$ 그리고 $16{\alpha}$-monohydroxytestosterone)을 정량하였다. 설정한 반응조건에서 이들 대사물의 생성은 P-450의 농도(1nmol/0.5ml 반응액 이하)에 따라 양호한 직선 관계 (r=0.9687-0.9999)와 재현성(C.V=$1.8{\pm}1.0%$)을 나타내었다. 또한 PB로 유도된 P-450에 의한 $2{\beta}$-monohydroxytestosterone의 생성은 대조군에 비해 2배로 증가된 반면$2{\alpha}-$와 $7{\alpha}$-monohydroxytestosterone의 생성은 오히려 48, 32%로 각각 감소되었다. 그러나 확인된 대사물의 총함량은 서로 비슷하였다. A rapid and one time determinable TLC method for the monohydroxytestosterones formed by microsomal cytochrome P-450(P-450) was established, and applying this method the activity of P-450-dependent testosterone hydroxylases was observed in liver microsomes of rats pretreated with phenobarbital(PB). The 14 testosterone metabolites were found on the TLC plate. The amounts of 6-monohydroxytestosterones ($2{\alpha}-$, $2{\beta}-$, $6{\alpha}-$, $6{\beta}$, $-7{\alpha}$-and $16{\alpha}$-OH-T) were determined. The formation of these metabolites showed a good linearity(r = 0.9687-0.9999) corresponding to the concentration of P-450 added up to about 1.0 nmol/min/reaction mixture, and an excellent reproducibility (C.V.=$1.8{\pm}1.0%$) when determined with 0.5 nmol P-450 in this assay system. The hydroxylation of testosterone to its $2{\beta}$-OH-T by PB-inducible P-450 was increased (2 fold), while $2{\alpha}-$ and $7{\alpha}$-OH-T was rather decreased to 48 and 32%, respectively, compared with those of uninduced one. The $6{\beta}$-OH-T was predominantly formed by uninducible and PB-inducible P-450, especially PB-inducible P-450 hydroxylated stereospecifically onto the C2-position of testosterone $(2{\alpha}/2{\beta}=1:3.8)$. However, the oxidation rates of testosterone to its $6{\alpha}-$, $6{\beta}-$ and $16{\alpha}$-OH-T, and the total amount of testosterone metabolites identified were not changed significantly by the administration of PB.

탄성표면파 콘벌버를 이용한 직접 시퀀스 대역 확산 통신에서의 DPSK 복조에 관한 연구

이동욱,조관,황금찬,Lee, Dong-Wook,Cho, Kwan,Whang, Keum-Chan 한국통신학회 1990 韓國通信學會論文誌 Vol.15 No.6

This paper reports on the development of a DPSK demodulator of DS spread spectrum communications that use one SAW convolver. The spreading code chip pattern is changed from bit to bit in data portion of packet. And code chip is PSK modulated. Compared with simulation, experiment shows that the DPSK signal spreaded can be demodulated by using only one SAW convolver. And the theoretical performance of this DPSK demudulator is equal to CSK demodulator wich uses two SAW convolvers. 본 논문에서는 한 개의 탄성표면파 콘벌버를 사용한 직접 시퀀스 대역 확산 통신시스템에서의 DPSK 복조기를 제작, 실험을 하고, 이론적인 고찰을 하였따. 제작한 DPSK 복조 시스템은 SSMA를 위하여 각 데이터 마다 다른 코드로 대역 확산시켰으며, 코드 칩은 PSK로 변조하였다. 본 논문에서 제안한 복조 시스템의 출력은 시뮬레이션 파형과 같음을 확인하였으며, 이론적인 고찰 결과 두개의 콘벌버를 사용한 CSK 복조 시스템과 같은 성능을 보였다.

이대덕목

이동욱,Lee, Dong-Uk 한국IT전문가협회 1987 소프트웨어세계 Vol.1 No.-