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Effect of Highly Pressurized Hydrogen Gas Charging on the Hydrogen Embrittlement of API X70 Steel
Dong-Su Bae,Chi-Eun Sung1,Hyun-Ju Bang,Sang-Pill Lee,Jin-Kyung Lee,In-Soo Son,조영래,Un-Bong Baek,Seung-HoonNahm 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.4
During the use of API X70 steel as a pipeline structural material for the transportation of natural gas,hydrogen embrittlement can occur due to the hydrogen contained in natural gas. The aim of this study is toinvestigate the effects of the hydrogen content under high-pressure hydrogen gas conditions on the hydrogenembrittlement of air-cooled API X70 steel. The air-cooled API X70 steel was manufactured by hot rollingand was then air-cooled to room temperature. Tensile test specimens were held for 0 h, 1000 h, and 2000 hwithin a pressure vessel filled with 100% hydrogen gas at a gas pressure of 10 MPa, with the tensile teststhen performed at room temperature. The microstructure of the API X70 steel consists of coarse polygonalferrite, coarse pearlite, and fine acicular ferrite. The yield and tensile strength increased and elongationdecreased considerably after a holding time of 2000 h compared to those of 0 h and 1000 h within the pressurevessel. The morphology of the fracture surface changed from ductile to brittle upon hydrogen gas charging. Secondary cracks were observed in both of the hydrogen-gas-charged specimens. No external cracks wereformed on the surface of the tensile-tested specimen with a 0 h holding time; however, many external crackswere observed on the specimen surface subjected to hydrogen gas charging.
Genotoxicity Studies on Geranti Bio-Ge Yeast<SUP>Ⓡ</SUP>, an Organic Germanium Synthesized in Yeasts
Soo-Jin Min,Mei-Shu Zheng,Jong-Il Park,Jong-Sung Lee,Yun-Bae Kim,Jong-Koo Kang,Tsang-Uk Sohn,Cheol-Beom Park 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
The objective of this study was to determine genotoxic potential of Geranti Bio-Ge Yeast<SUP>Ⓡ</SUP>, an organic germanium naturally synthesized in yeasts. For the in vitro reverse mutation test, we set the treatment levels of Geranti Bio-Ge Yeast<SUP>Ⓡ</SUP> at 312.5, 625, 1,250, 2,500 and 5,000 ㎍/plate using Salmonella typhimurium strains (TA1535, TA1537, TA98 and TA100) and Escherichia coli WP2uvrA (pKM101). No significant mutagenic activity was observed both in the presence and absence of S9 mix with all Salmonella and Escherichia strains used. For the in vitro chromosomal aberration test using Chinese hamster lung fibroblasts, we set the treatment levels of Geranti Bio-Ge Yeast<SUP>®</SUP> at 1,250, 2,500 and 5,000 ㎍/㎖, No significant increase in the structural and numerical chromosome aberration was observed in both the presence and absence of S9 mix. In the micronucleus test, mice were orally administered with 125, 250, 500, 1,000, 2,000 or 5,000 ㎎/㎏ of Geranti Bio-Ge Yeast<SUP>®</SUP>, or intraperitoneally with mitomycin C as a positive control. The mice were sacrificed 24 hours later, and bone marrow was collected and stained with Giemsa solution. There was no evidence that Geranti Bio-Ge Yeast<SUP>®</SUP> significantly induced micronucleated polychromatic erythrocytes. In conclusion, it is suggested that Geranti Bio-Ge Yeast<SUP>®</SUP> do not have a genotoxic potential under the conditions of this study.
Bae, Hyo Sook,Kim, Yeon-Joo,Lim, Myong Cheol,Seo, Sang-Soo,Park, Sang-yoon,Kang, Sokbom,Kim, Sun Ho,Kim, Joo-Young Blackwell Scientific Publications 2016 International journal of gynecological cancer Vol.26 No.4
<B>Purpose</B><P>We identified the predictive factors for locoregional failure after definitive chemoradiation in patients with locally advanced cervical cancer.</P><B>Methods</B><P>Altogether, 397 patients with locally advanced cervical cancer (stage IB2-IVA) were treated with definitive chemoradiation between June 2001 and February 2010. Platinum-based concurrent chemotherapy was given to all patients with median radiation dose of external beam radiotherapy 50.4 Gy in 28 fractions and intracavitary radiotherapy 30 Gy in 6 fractions. Competing risk regression analysis was used to reveal the predictive factors for locoregional failure.</P><B>Results</B><P>During the median follow-up of 7.2 years, locoregional failure occurred in 51 (12.9%) patients. The estimated 3-year rate of locoregional control was 89%, whereas the overall survival rate was 82%. After univariate and multivariate analyses, large tumor size (>5 cm), young age (≤40 years), nonsquamous histology, positive lymph node on magnetic resonance imaging, and advanced stage (III-IV) were identified as risk factors for locoregional failure (<I>P</I> = 0.003, <I>P</I> = 0.075, <I>P</I> = 0.005, <I>P</I> = 0.055, and <I>P</I> < 0.001, respectively). After risk grouping according to the coefficients from the multivariate model, we identified a high-risk group for locoregional failure after treatment with definitive chemoradiation as follows: (1) tumor size larger than 5 cm, and at least 1 other risk factor or (2) tumor size 5 cm or less, and at least 3 other risk factors. The cumulated estimated 3-year rate of locoregional failure of the high-risk group was 26%, which was significantly higher than that of the low-risk group (7%, <I>P</I> < 0.001). The 3-year overall survival rates of the 2 groups were also significantly different (57% vs 86%, <I>P</I> < 0.001).</P><B>Conclusions</B><P>Large tumor size (>5 cm), young age (≤40 years), nonsquamous histology, positive lymph node on magnetic resonance imaging, and advanced stage are all risk factors for locoregional failure after definitive platinum-based chemoradiation in patients with locally advanced cervical cancer. In the high-risk group, further clinical trials are warranted to improve the locoregional control rate.</P>
A Linear-Logarithmic CMOS Image Sensor With Adjustable Dynamic Range
Bae, Myunghan,Choi, Byoung-Soo,Jo, Sung-Hyun,Lee, Hee-Ho,Choi, Pyung,Shin, Jang-Kyoo IEEE 2016 IEEE SENSORS JOURNAL Vol.16 No.13
<P>A new pixel structure is proposed for wide dynamic range CMOS image sensors. A pixel based on a three-transistor active pixel sensor has two linear responses and a logarithmic response using additional circuits. The photogate surrounding the n(+)/p-sub photodiode exists for the second linear response. The logarithmic response is due to the biased MOS cascode. The proposed pixel was designed and fabricated using a 0.35-mu m 2-poly 4-metal standard CMOS process. The dynamic range of the pixel is higher than 106 dB. A test chip with a pixel pitch of 10 x 10 mu m(2) and a 160 x 120 pixel array is evaluated.</P>
Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis
Sung, Hye-Jin,Ahn, Jung-Mo,Yoon, Yeon-Hee,Na, Sang-Su,Choi, Young-Jin,Kim, Yong-In,Lee, Soo-Youn,Lee, Eung-Bae,Cho, Sukki,Cho, Je-Yoel MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10
<P>As lung cancer shows the highest mortality in cancer-related death, serum biomarkers are demanded for lung cancer diagnosis and its treatment. To discover lung cancer protein biomarkers, secreted proteins from primary cultured lung cancer and adjacent normal tissues from patients were subjected to LC/MS–MS proteomic analysis. Quiescin sulfhydryl oxidase (QSOX1) was selected as a biomarker candidate from the enriched proteins in the secretion of lung cancer cells. QSOX1 levels were higher in 82% (51 of 62 tissues) of lung cancer tissues compared to adjacent normal tissues. Importantly, QSOX1 serum levels were significantly higher in cancer patients (<I>p</I> < 0.05, Area Under curve (AUC) = 0.89) when measured by multiple reaction monitoring (MRM). Higher levels of QSOX1 were also uniquely detected in lung cancer tissues, among several other solid cancers, by immunohistochemistry. QSOX1-knock-downed Lewis lung cancer (LLC) cells were less viable from oxidative stress and reduced migration and invasion. In addition, LLC mouse models with QSOX1 knock-down also proved that QSOX1 functions in promoting cancer metastasis. In conclusion, QSOX1 might be a lung cancer tissue-derived biomarker and be involved in the promotion of lung cancers, and thus can be a therapeutic target for lung cancers.</P>