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Set-Byul Moon(Set-Byul Moon) 건국대학교 아시아·디아스포라 연구소 2023 International Journal of Diaspora&Cultural Critici Vol.13 No.1
This article examines the literary representation of codeswitching and various accents between Korean and English in two minority women writers’ fictional territory portraying Korean American characters. Min-Jin Lee’s Free Food for Millionaires and Lisa See’s The Island of Sea Women center around the lives of Korean American women who speak English as a primary language and Korean as a home language or heritage language. The characters’ idea of Korea and “Koreanness” mostly manifests in their identity formation, rather than in their linguistic proficiency or a sense of belonging. Heavily related to the language proficiency and identity of Koreanness, the Korean American protagonists alternate between the languages and accents in linguistic repertoire deeply rooted in sociocultural practices that reflect the concept of diaspora and one’s diasporic identity. Their strategic code-switching signifies how one’s diasporic, immigrant identity affects one’s choice of speech that meticulously synthesizes social values, cultural norms, and ethnic/racial belief systems not only emblematic of mainstream American society but also of a minority community as well.
Exhaustivity, Genericity and vP-external Subjects
Han-byul Chung 한국생성문법학회 2017 생성문법연구 Vol.27 No.3
Chung, Han-byul. 2017. Exhaustivity, Genericity and vP-external Subjects. Studies in Generative Grammar. 27-3, 591-610. The source of exhaustivity observed in some i/ka-marked DPs in Korean has been a point of controversy among linguists (Schütze 1996, Yoon 2004, Choi 2005, among others). In this paper, I argue that the exhaustivity is a result of movement to a functional projection outside of the vP, presumably to [Spec, FP] (cf. Kiss 1998). The proposed movement is mostly not visible at the surface, due to Korean being a head-final language. However, subjects located outside of the vP show difference in their behaviors with regards to genericity and presuppositionality (Diesing 1992), and those behaviors are observed in exhaustive i/ka-marked DPs, but not in non-exhaustive i/ka-marked DPs. That exhaustivity in Korean is attained via movement is in accordance with observation made by Kiss (1998) that identificational focus in English and German are attained via movement.
Synergistic antitumor activity of sorafenib and MG149 in hepatocellular carcinoma cells
Byul Moon,Mijin Park,Seung-Hyun Cho,Kang Mo Kim,Haeng Ran Seo,김정훈,김정애 생화학분자생물학회 2022 BMB Reports Vol.55 No.10
Advanced hepatocellular carcinoma (HCC) is among the mostchallenging cancers to overcome, and there is a need for bettertherapeutic strategies. Among the different cancer drugs thathave been used in clinics, sorafenib is considered the standardfirst-line drug for advanced HCC. Here, to identify a chemicalcompound displaying a synergistic effect with sorafenib in HCC,we screened a focused chemical library and found that MG149,a histone acetyltransferase inhibitor targeting the MYST family,exhibited the most synergistic anticancer effect with sorafenibon HCC cells. The combination of sorafenib and MG149 exerteda synergistic anti-proliferation effect on HCC cells by inducingapoptotic cell death. We revealed that cotreatment with sorafeniband MG149 aggravated endoplasmic reticulum (ER) stressto promote the death of HCC cells rather than adaptive cellsurvival. In addition, combined treatment with sorafenib andMG149 significantly increased the intracellular levels of unfoldedproteins and reactive oxygen species, which upregulated ERstress. Collectively, these results suggest that MG149 has thepotential to improve the efficacy of sorafenib in advanced HCCvia the upregulation of cytotoxic ER stress.
Byul Lyu,황규연,김선영,김수영,나경선 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.6
Purpose: The purpose of this multi-institute, single-group clinical trial was to evaluate the effectiveness andsafety of toric orthokeratology lenses for the treatment of patients with combined myopia and astigmatism. Methods: A total of 44 patients were included in this clinical trial. The patients ranged in age from 7 to 49 years,with myopia of -0.75 to -6.0 diopters (D) and astigmatism of 1.25 to 4.0 D. After excluding 21 subjects, 23 subjects(39 eyes) were analyzed after toric orthokeratology lens use. The subjects underwent ophthalmologicexamination after 1 day and 1, 2, 3, and 4 weeks of wearing overnight toric orthokeratology lenses. Results: A total of 19 subjects (31 eyes) completed the trial after five subjects (eight eyes) dropped out. In thepatients who completed the study by wearing lenses for 4 weeks, the myopic refractive error decreasedsignificantly by 2.60 ± 2.21 D (p < 0.001), from -3.65 ± 1.62 to -1.05 ± 1.64 D. The astigmatic refractive errorwere also significantly decreased by 0.63 ± 0.98 D (p = 0.001), from 2.07 ± 0.83 to 1.44 ± 0.99 D. The meanuncorrected and corrected visual acuities before wearing the lenses were 2.14 ± 0.80 logarithm of the logMAR(logMAR) and 0.05 ± 0.13 logMAR, respectively, which changed to 0.12 ± 0.30 logarithm of the logMAR (p <0.001) and 0.01 ± 0.04 logMAR (p = 0.156) after 4 weeks. No serious adverse reactions were reported duringthe clinical trial. Conclusions: Our results suggest that toric orthokeratology is an effective and safe treatment for correcting visualacuity in patients with combined myopia and astigmatism.
Byul-Ha-Na Lee(이별하나),Yong-Hee Kwon(권용희),Kyoung-Hee Shin(신경희),Hee-Seung Park(박희승) 한국원예학회 2010 원예과학기술지 Vol.28 No.3
‘Merlot’ 포도 품종의 수확전 ethyl oleate 처리는 외표피와 아표피의 두께를 감소시키며 착색을 현저히 향상시킨다. 무처리구의 과피 두께는 126-189㎛인데 반하여 처리 과실의 과피두께는 90-107㎛로 조사되었으며, 이러한 외표피와 아표피층의 두께 감소는 처리 후 외표피와 아표피를 구성하는 세포의 빠른 노화에 의하여 세포가 죽거나 탈수가 나타나기 때문인 것으로 조사되었다. 처리 후에 빠르게 과피 표면의 왁스층이 녹은 듯한 형태를 보이며 이는 착색을 증진시키는 것으로 관찰되었으며, 전체적인 안토시아닌 함량 역시 증가하는 것으로 조사되었다. 반면에 각각의 안토시아닌 함량에 있어서는 메톡시기와 결합하거나 유기산과 결합한 안토시아닌이 증가한 반면 수산기와 결합한 안토시아닌은 감소하는 경향이었다. Preharvest treatment with 4% ethyl oleate on ‘Merlot’ (Vitis vinifera L.) grape reduced the thickness of the epidermal and hypodermal layers with significantly enhanced pigmentation. Thickness of the skin in treated berries was 90-107 ㎛, whereas those in control berries were 126-189 ㎛. Decreases in the thickness of epidermal and hypodermal cell layers seemed to be due to cellular death or dehydration by rapid senescence after the treatment. Immediate change observed in treated berries was the deformation of the wax that appeared melted resulting in color improvement. Total anthocyanin was also increased by ethyl oleate treatment. Separate forms of anthocyanins, acylated and methoxylated anthocyanins increased, whereas hydroxylated anthocyanins tended to decrease.
( Byul Bo Ra Choi ),( Gyoo Cheon Kim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.4
Osteosarcoma is a malignant bone tumor that develops in the osteoblast cells that form the outer covering of bone. It is the most frequent malignant bone tumor found at 10-14 years and at >65 years of age. Atmospheric pressure plasma has advantages of high density and rich chemical agents without elevation of the substrate temperature. These non-equilibrium characteristics show promising applications in the biomedical field, opening a new research area called “Plasma Medicine”, which includes sterilization, coagulation, wound healing, and cancer treatment. However, the mechanism of apoptosis caused by plasma treatment in osteosarcoma is not well understood. In this study, the researchers show that microwave plasma causes selective cell cycle arrest and apoptosis in osteosarcoma cells in vitro. An inhabitation of cell growth of microwave plasma showed that this plasma has selective cytotoxic effects on MG-63 cells in comparison to hFOB 1.19 cells. Also, the resesearchers observed that microwave plasma treatmenst significantly showed disruption and aggregation of F-actin. The results demonstrated that treatment of MG-63 cells with microwave plasma induced cell cycle arrest in the G2/M phase, using flow cytometry and western blot assay. To detect PARP and DFF-45 cleavage or a decrease as a result of caspase-3 activation, MG-63 cells were treated either with various times of microwave plasma. The research studies demonstrated that microwave plasma induced G2/M cell phase arrest and triggered apoptosis.