Geometric Nonlinear Behavior Of Shallow Shells By Boundary Conditions

Park, Kanggeun,Lee, Dongwoo,Choe, Dongil,Park, Mijin SSNG Education Society 2017 International journal of latest trends in engineer Vol.8 No.4

<P> This paper investigates the mechanical characteristics of geometrical nonlinear behavior of shallow shells for boundary conditions of support. The shallow shells with a low rise-span ratio have a snap back and through behavior for a load condition or a support condition. The analytical models are a spherical shell, a cylindrical shell and a quadratic shell. The shells with all its edges hinged or fixed support condition are subjected to a concentrated load at the crown. The load is applied gradually by incrementing the deflection by displacement control. The objective of the study is to compare the load deflection curves according to support conditions or thicknesses. The element in the nonlinear analysis used 3-D four/eight nodes shell element and 3-D laminated composite shell element. In geometric nonlinear behavior of shallow shells, it will be observed for snap back and through behavior for a hinged and fixed support condition. The snap through phenomenon cannot be found in the load deflection curve of shells with the fixed support and the good results are observed for large deflection analysis of shells with hinged supports. </P>

Incidence, Management, and Prognosis of Graft Failure and Autologous Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

Park Jun-Hong,Lee Je-Hwan,Lee Jung-Hee,Park Han-Seung,Choi Eun-Ji,Kang Young-Ah,Kang Hyeran,Woo Ji Min,Lee Young-Shin,Jeon Mijin,Lee Kyoo-Hyung 대한의학회 2021 Journal of Korean medical science Vol.36 No.23

Background: This study presents outcomes of management in graft failure (GF) after allogeneic hematopoietic stem cell transplantation (HCT) and provides prognostic information including rare cases of autologous reconstitution (AR). Methods: We analyzed risk factors and outcomes of primary and secondary GF, and occurrence of AR in 1,630 HCT recipients transplanted over period of 18 years (January 2000– September 2017) at our center. Results: Primary and secondary GF occurred in 13 (0.80%), and 69 patients (10-year cumulative incidence, 4.5%) respectively. No peri-transplant variables predicted primary GF, whereas reduced intensity conditioning (RIC) regimen (relative risk [RR], 0.97–28.0, P < 0.001) and lower CD34+ cell dose (RR, 2.44–2.84, P = 0.002) were associated with higher risk of secondary GF in multivariate analysis. Primary GF demonstrated 100% mortality, in the secondary GF group, the 5-year Kaplan-Meier survival rate was 28.8%, relapse ensued in 18.8%, and AR was observed in 11.6% (n = 8). In survival analysis, diagnosis of aplastic anemia (AA), chronic myeloid leukemia and use of RIC had a positive impact. There were 8 patients who experienced AR, which was rarely reported after transplantation for acute leukemia. Patient shared common characteristics such as young age (median 25 years), use of RIC regimen, absence of profound neutropenia, and had advantageous survival rate of 100% during follow period without relapse. Conclusion: Primary GF exhibited high mortality rate. Secondary GF had 4.5% 10-year cumulative incidence, median onset of 3 months after HCT, and showed 5-year Kaplan-Meier survival of 28.8%. Diagnosis of severe AA and use of RIC was both associated with higher incidence and better survival rate in secondary GF group. AR occurred in 11.6% in secondary GF, exhibited excellent prognosis.

CDK9 inhibitors downregulate DKK1 expression to suppress the metastatic potential of HCC cells

Park Mijin,Cho Jin Hwa,Moon Byul,Kim Jeong-Hoon,Kim Jung-Ae 한국유전학회 2023 Genes & Genomics Vol.45 No.3

Background Elevated expression of Dickkopf-1 (DKK1) is frequently observed in hepatocellular carcinoma (HCC) patients with poor clinical outcomes. Several reports indicating the functional involvement of DKK1 in HCC progression have suggested DKK1 as a promising therapeutic target for HCC. Objective In this study, to develop an efficient way to target DKK1, we assessed the effect of CDK9 inhibitors on DKK1 expression linked to metastatic movement of HCC. Methods The expression of DKK1 in CDK9 inhibitor-treated HCC cells was measured by western blot, ELISA and quantitative real-time reverse transcription PCR. Wound healing assay, migration assay, invasion assay and western blot were examined to evaluate the functional role of DKK1 in CDK9 inhibitors-treated HCC. Results Inactivation of CDK9 either by a catalytic inhibitor being clinically evaluated or by a specific CDK9 protein degrader largely downregulated DKK1 expression at the transcript and protein levels. In addition, CDK9 inhibitors suppressed the migration and invasion of HCC cells. We observed that ectopic high expression of DKK1 at least partially reversed the defects in metastatic movement of HCC cells mediated by CDK9 inhibitors. We further discovered that the DKK1-nuclear β-catenin axis associated with the metastatic potential of HCC cells was impaired by CDK9 inhibitors. Conclusion Taken together, our findings suggest that CDK9 inhibitors are potent tools to target DKK1, which can suppress the metastatic progression of HCC.

Improvement of Employee Health through a Tailored Health Promotion Program in a Multinational Manufacturing Workplace in Korea

Mijin Park,Chungsik Yoon,Gyuseok Hwang 서울대학교 보건환경연구소 2012 보건학논집 Vol.49 No.1

The association between idiopathic scoliosis and growth hormone treatment in short children

Park Mijin,Kim Yu Jin,Oh Kyeong Eun,Kang Eungu,남효경,Rhie Young-Jun,Lee Kee-Hyoung 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.3

Purpose: Idiopathic scoliosis is the most common form of scoliosis, and the risk of onset and progression has been found to correlate with growth spurts. Therefore, treatment with recombinant human growth hormone (GH) treatment in short children may initiate and/or aggravate scoliosis. The aim of this study was to investigate the relationship between idiopathic scoliosis and GH treatment in short children. Methods: The medical records of 113 subjects seen at the participating institution between January 2010 and December 2020 and who were diagnosed with GH deficiency and small for gestational age, had idiopathic short stature, and were treated with GH for at least one year were reviewed. Scoliosis was defined as a Cobb angle greater than 10 degrees as assessed using a spine x-ray. Clinical data and laboratory findings before and 12 months after GH treatment were compared. Results: There was significant increase in height, height-standard deviation score, insulin-like growth factor 1, and insulin-like growth factor binding protein 3 (P<0.001) with GH treatment. However, there were no significant differences in the average Cobb angle (6.2°±3.3° vs. 6.1°±3.5°, P=0.842) and the prevalence of scoliosis (9.7% vs. 13.3%, P=0.481) before and after one year of GH treatment. A comparative analysis of both initial Cobb angle and change in Cobb angle during GH treatment showed no relationship with other factors. Conclusion: Although GH treatment in short children increased height and growth velocity, it was not associated with development or aggravation of idiopathic scoliosis.

Shape Transformation of Gold Nanoparticles from Octahedron to Cube Depending on in situ Seed-Growth Time

Kim, Mijin,Park, Hyung Ju,Han, Sang Woo,Park, Jimin,Yun, Wan Soo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.8

지역사회복지관 조직풍토와 사회복지사의 자원연계기술과의 관계: 성찰적 사고의 매개효과

박미진 ( Park Mijin ),현안나 ( Hyun Anna ) 한국사회복지연구회 2017 사회복지연구 Vol.48 No.2

본 연구는 지역사회복지관에 근무하는 사회복지사들의 자원연계기술에 지역사회복지관 조직풍토가 미치는 영향을 확인하고, 이들의 관계에서 성찰적 사고의 매개효과를 검증하고자 하였다. 이를 위해 지역사회복지관의 조직풍토, 자원연계기술, 성찰적 사고에 대한 선행연구를 토대로 연구모형을 설정하여 매개효과를 검증하였다. 본 연구의 대상은 부산광역시 소재의 종합사회복지관, 노인복지관, 장애인복지관 전수를 대상으로 이들 기관에 근무하는 사회복지사들을 대상으로 하였다. 자료수집은 우편설문조사방법으로 실시하였고, 526명의 자료를 최종분석에 활용하였다. 주요연구결과는 다음과 같다. 첫째, 지역사회복지관의 조직풍토는 사회복지사의 자원연계기술에 통계적으로 유의미한 정적 영향을 미치는 것으로 나타났다. 즉, 사회복지사들이 조직풍토에 대해 긍정적으로 인식할수록 자원연계기술의 활용정도가 증가함을 의미한다. 둘째, 지역사회복지관의 조직풍토와 사회복지사의 자원연계기술과의 관계에서 성찰적 사고의 매개효과는 통계적으로 유의한 것으로 나타났다. 연구결과를 토대로 지역사회복지관 사회복지사들의 자원연계기술향상과 성찰적 사고의 실천적 방안들을 제언하고, 실천적 함의 및 추후연구과제에 대해 제시하였다 The purpose of this study is to examine the impact of organizational climate on the resource linking skills of social workers working in community welfare centers as well as the mediating effects of reflective thinking in these relationships. To test the mediating effects, we set up a research model based on previous studies on the organizational climate, resource linkage skills, and reflective thinking of social workers. The subjects of this study were social workers in community welfare centers in the Busan metropolitan city. Data were collected using mail surveys, and data from 526 respondents were used for the final analysis. The main results are as follows. First, the organizational climate of community welfare centers has a statistically significant impact on social workers` resource linkage skills. In other words, the more the social workers recognize positively about the organizational climate, the more the utilization of resource linkage skills increases. Second, reflective thinking has a mediating effect in the relationship between the organizational climate and resource linkage skills of social workers in community welfare centers. Based on the study results, practical suggestions for improved resource linkage skills and reflective thinking of social workers in community welfare centers were suggested, and practical implications and future research were discussed.

실크단백질 효소 가수분해물이 2형 당뇨 마우스의 혈당 및 혈청지질에 미치는 영향

신미진(Mijin Shin),박민정(Minjeong Park),윤명섭(Myungsub Youn),이영숙(Youngsook Lee),남문석(Moonsuk Nam),박인선(Insun Park),정윤화(Yoonhwa Jeong) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.10

This study was performed to investigate the effects of silk protein enzyme hydrolysates on blood glucose and serum lipid in db/db diabetic mice. Twelve week-old-male C57BL/KsJ db/db mice were divided into two groups: diabetic control group and 0.25% silk protein hydrolysates solution group, which were fed for 8 weeks. Body weight increased in the silk protein hydrolysates group compared with the diabetic control group. There were no differences in food and water intake between the diabetic control and the silk protein hydrolysates groups. The weight of liver increased in the silk protein hydrolysates group while that of kidney increased in the diabetic control group. The blood glucose level increased about 18.0% in the diabetic control group after 8 weeks while that in the silk protein hydrolysates group increased about 5.8%. Also, silk protein hydrolysates improved the glucose tolerance in C57BL/KsJ db/db mice. There was no difference in total cholesterol and non-HDL cholesterol concentration between the diabetic control and the silk protein hydrolysates group. Triglyceride concentration were lower in the silk protein hydrolysates group than in the diabetic control group (p<0.05) while HDL-cholesterol concentration were higher in the silk protein hydrolysates group than in the diabetic control group (p<0.05). This results suggest that administration of silk protein enzyme hydrolysates reduces significantly an increasing rate of blood glucose, decreases triglyceride, and increases HDL-cholesterol in C57BL/KsJ db/db mice.

부성휴가제도가 남성 돌봄시간에 미치는 영향 - 노동시간의 조절효과를 중심으로 -

박미진(Park, Mijin) 한국사회복지학회 2020 한국사회복지학회 학술대회 자료집 Vol.2020 No.10

본 연구는 부성휴가제도와 남성의 돌봄시간 간에 어떠한 관계가 있는지 검토하고, 노동시간이 그 관계를 조절하는지 규명하는 데 목적이 있다. 일 · 가족양립을 다룬 대다수의 선행연구들은 일 · 가족양립의 주체로 여성만을 상정하여 분석한 한계를 드러내었고, 일부 남성을 대상으로 한 연구들에서도 미시적인 가구 내 역할분담에만 초점을 두어, 보다 거시적인 관점에서 남성의 일 · 가족양립 문제를 파악할 필요성이 제기된다. 본 연구는 한국과 유럽의 2015년 근로환경조사를 활용하여 25개국의 7,169명을 대상으로 다수준 분석을 실시함으로써, 남성돌봄시간의 결정요인을 다차원적으로 규명하고자 하였다. 연구결과, 노동시간이 짧은 남성들에게는 제도의 발달이 돌봄시간을 증가시키는 정적 효과를 나타낸 반면, 장시간 노동을 하는 남성들에게는 제도의 발달이 오히려 돌봄시간을 큰 폭으로 낮추는 기제로 작동되었다. 따라서 남성의 일 · 가족양립을 확보하기 위해서는 일 · 가족양립정책의 발달뿐만 아니라 노동시간단축 등 노동환경의 변화가 동시에 뒷받침될 필요가 있음을 제언하였다. This study examines the relationship between paternity leave and paternal childcare time, while considering any moderating effects of working hour. Empirical evidence on the aspects of paternal childcare time from a broader perspective is sparse. This study used multilevel modeling and data were obtained from the 2015 European Working Condition Survey. This study found that paternity leave had no significant association with paternal childcare time. Conversely, this study found that longer work hours were strongly associated with lower paternal childcare time, supporting the time availability theory. Finally, the length of working hours was found to moderate the relationship between paternity leave and paternal childcare time. The findings of this study suggest that paternity leave policies alone may not be sufficient to improve paternal childcare time. The moderating effect suggests that working hour needs to be also considered. To be specific, reducing working hours may not only help male caregivers extend their childcare time directly, but also reinforce the impact of paternity leave. These findings shed light on the new role of men for balancing work and family.

지역사회거주 노인의 사회적 고립 예측요인에 관한 연구

박미진(Mijin Park) 한국지역사회학회 2013 지역사회연구 Vol.21 No.3

This study examines the effects of control factors (age, gender, education, public assistance status), personal factors (perceived health, depression, cognitive function, housing ownership, type of housing), community factors (the number of people over 65 in a community, neighborhood poverty, the number of social services agencies for older adults, the incidence of elderly abuse) on social isolation among the elderly. Towards this end, this study uses panel data, Korean Longitudinal Study of Ageing(KLoSA). The data of 3,831 respondents aged over 65 are used to this analysis by the SPSS 19.0 software. The results of this study are as follows. Lower cognitive function, non-ownership of housing, and housing type result in higher social isolation among respondents. However, community factors results in greater social isolation than personal factors, and are more significantly predictive of social isolation in adults over 65. Lastly, we discuss implications of the findings and offer suggestions for further research.