Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect

Yufeng Zheng(Yufeng Zheng),Xue Liu(Xue Liu),Na Li(Na Li),Aimei Zhao(Aimei Zhao),Zhiqiang Sun(Zhiqiang Sun),Meihua Wang(Meihua Wang),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2

Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.

Distributed Fault Detection and Isolation Scheme for Abrupt and Incipient Faults in a Class of Nonlinear Systems

Zhiqiang Zheng,Yongxin Liu,Haiwen Yuan,Qiusheng Wang 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.3

This note developed a distributed fault detection and isolation scheme for a class of large-scale systems in discrete-time framework. The unstructured modeling uncertainty and abrupt and incipient faults are considered in this scheme. By using overlapping decompositions, the large-scale system is decomposed into a set of subsystems which are monitored by a network of local fault detectors (LFDs) and local fault isolation estimators (LFIEs). Specially, the LFIEs, corresponding the faults af-fecting the common components among different subsystems, may reach a cooperative (or consensus) isolation decision, based on the fact that they can exchange some knowledge about the local information of system by suitable communication links. As a result, for these LFIEs, the capability of isolating faults may be improved. Moreover, the derivation of rigorous analytical results for the detectability and isolability properties of the proposed scheme is given. Simulation results are provided to show the effectiveness of the presented scheme.

Detection Method of Weak Low-Frequency Electromagnetic Signal Based on Multi-layer Autocorrelation

Zheng Dou,Yu Tao,Yun Lin,Zhiqiang Wu,Dong Li,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.4

Low frequency electromagnetic signals play an important role in the detection of underground electrical structure. After propagation of long distance, signal will be attenuated to a certain extent and probably buried in noise, make it difficult to extract. In this paper, the method of multi-layer autocorrelation will be used to detect and extract the weak low frequency electromagnetic signal, and its performance will be compared with the narrow-band filter and the method of synchronous accumulation. Simulation results show that the correlation coefficient of signal obtained by multi-layer autocorrelation and source signal can achieve more than 0.8 when SNR is -18dB. However, the value of narrow-band filter and synchronous accumulation is lower than that mentioned above when SNR is only -14dB. Experimental verifies that multi-layer autocorrelation method can suppress noise more effectively and detect weak signals more accurately.

Study on the Influence of UHVDC Dynamic Response on Recovery Characteristic of Receiving End Power Grid

Zheng, Chao,Zhang, Kai,Sheng, Canhui,Lin, Junjie,Xue, Jinying,Chen, Dezhi,Zhang, Zhiqiang,Luo, Bangyun 대한전기학회 2014 The Journal of International Council on Electrical Vol.4 No.1

Aiming at the three UHVDC controller model in the electromechanical simulation software BPA which widely used in China, the structural features were analyzed. By the time-domain simulation, the influence of different simulation models and the key controller parameters on the recovery characteristics of the receiving end power system were studied. Simulation results show that the commutation failure simulated method impacts the recovery characteristic significantly for weak power grids, increasing the voltage measurement time constant of constant dc power control module and enhancing the start voltage threshold of voltage dependent current order limit (VDCOL) can decrease the reactive power consumption of inverter during the disturbance, and can help to improve the recovery characteristic of receiving end power grid.

Implementation of DSTFCs in MIMO MB-IR-UWB System

Zheng Dou,Zijing Jin,Yun Lin,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.3

This paper implements differential space-time-frequency codes (DSTFCS) to multiple-input multiple-output (MIMO), multi-band impulse radio ultra-wideband (MB-IR-UWB) system. Four scenarios of the system operating mode have been put forward and combination of DSTFCs and the system has been studied in this paper. Through simulation, a comparison of BER performance among different scenarios and channel statements is analyzed. In addition, considered inter-symbol interference (ISI), the simulation on system with ISI and without ISI is given. Finally the conclusion that scenario 3 is more suitable to the proposed MIMO MB-IR-UWB system for it being less sensitive to ISI has been drawn.

Self-Adaptive Power Flow Optimization Method for Multi-Terminal SNOP Considering the Difference of Risk of Node Voltage beyond Limit

Yiming Xu,Zhiqiang Wang,Zheng Fang,Sichao Xun,Guirong Hu,Yusheng Shen,Hongyi Xiao,Dongning Wu 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.5

Soft Normally Open Point (SNOP) is a power electronic device used widely in power distribution network. It can solve many problems by adjusting reactive power compensation and active power transmission. The uncertainty and fluctuation of distributed generation (DG) may cause many problems to the distribution network. In order to balance the safety and economy in power flow optimization better, a self-adaptive power flow optimization method for active distribution network with multi-terminal SNOP considering difference of the risk of node voltage beyond limit is put forward. It takes both weighted voltage deviation and the network loss into objective function to construct the optimal operation model and mainly has two improvements: one is considering initial voltage deviation and real-time penetration of the DG to establish the self-adaptive weight model of the sum of voltage deviation in the objective function; the other is putting forward the weighting strategy for node voltage deviation which decided by the electrical distance, DG position and correlation between source output and load. Then, taking three improved IEEE33 node feeders as an example to verify the validity of the strategy. The results validate that the self-adaptive strategy can reduce the loss and improve the regulation of voltage better and is useful in distribution network under different penetration

A Case Study of Cutting Performance by a Transverse Cutting Head Based on Three-Dimensional Particle Flow Model

Kangjian Zhang,Zheng Liu,Zhiqiang Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5

Roadheaders have been increasingly used in a variety of tunnel cross-sections and roadway excavations. The appropriate setting of key construction parameters of the roadheader can maintain the excellent cutting performance of the roadheader during excavation. In this respect, this paper reviews in detail the previous studies on various experiments and numerical simulations affecting the cutting performance parameters of roadheader. A method for simulating the breaking process during the mechanical cutting of rock was then introduced using the Particle Flow Code in 3 Dimensions (PFC3D). In the numerical simulations, we used the parallel bond model to simulate the studied rock material and completed the calibration of the mesoscopic parameters by numerical simulation tests. In the simulations, we set different cutting modes, cutting depths and cutting thicknesses to study the rock breaking process of the transverse cutter head in a highly weathered granite environment from a microscopic perspective. The simulations indicated that the cutting mode, cutting depth and cutting thickness have significant effects on the cutting force and specific energy consumption. It is feasible to use the available space to the fullest and effectively reduce the wear of the picks by adopting the undercutting mode. The cutting efficiency can be improved and the specific energy consumption of cutting can be significantly decreased by increasing the cutting depth. The optimal cutting depth for highly weathered granite is 13 cm. As the cutting thickness increases, the cutting head’s normal and rolling forces increase linearly, and the cutting efficiency improves. Under the condition of highly weathered granite, the maximum cutting thickness of the Erkat ER1500 transverse cutting head is 12.5 cm. Overall, the results indicate that the discrete element method is a powerful tool for simulating rock cutting process.

Identification of MicroRNAs as potential biomarkers for detecting ischemic stroke

Li Kexin,Shen Li,Zheng Pingping,Wang Yanjun,Wang Lijuan,Meng Xiaoli,Lv Yaogai,Xue Zhiqiang,Guo Xin,Zhang Anning,Pan Pan,Bi Chunli,Chen Yang,Feng Tianyu,Li Bo,Jin Lina,Yao Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Increasing epidemic of ischemic stroke (IS) makes it urgent to understand the pathogenesis and regulatory mechanism, previous studies have described microRNAs (miRNAs) is part of the brain's response to ischemia. Objective: The aim of this study was to screen potential biomarkers for the prediction and novel treatment of IS. Methods: Differentially expressed miRNAs were screened from three newly diagnosed IS patients and three controls by RNA sequencing technology. Furthermore, target prediction databases were then used to analysis the target genes of different expressed miRNAs, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database were used to identify the functions and the main biochemical and signal pathways of differentially expressed target genes. Results: Our results revealed that 27 miRNAs were differentially expressed in IS, among which, hsa-miR-659-5p was the most highly increased and was first found to be associated with IS. In addition, KEGG pathway analyses showed that differentially expressed miRNAs were mainly significantly enriched in lysosome pathway, cytokine-cytokine receptor interaction pathway, spliceosome pathway, base excision repair pathway. Conclusions: miRNAs were involved in IS pathogenesis, and hsa-miR-659-5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study.

Melting and Casting Processes : EMC TECHNOLOGY STUDY OF ALUMINUM ALLOY BILLETS

Jin JunZe,Cao ZhiQiang,Zhang XingGuo,Zheng XianShu 대한금속재료학회 ( 구 대한금속학회 ) 1995 Advanced Material and Processing Vol.1 No.-

Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration Renshen-Yuanzhi compatibility through liquid chromatography-tandem mass spectrometry

Sun, Yufei,Feng, Guifang,Zheng, Yan,Liu, Shu,Zhang, Yan,Pi, Zifeng,Song, Fengrui,Liu, Zhiqiang The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.1

Background: Exploring the pharmacokinetic (PK) changes of various active components of single herbs and their combinations is necessary to elucidate the compatibility mechanism. However, the lack of chemical standards and low concentrations of multiple active ingredients in the biological matrix restrict PK studies. Methods: A putative multiple reaction monitoring strategy based on liquid chromatography coupled with mass spectrometry (LC-MS) was developed to extend the PK scopes of quantification without resorting to the use of chemical standards. First, the compounds studied, including components with available reference standard (ARS) and components lacking reference standard (LRS), were preclassified to several groups according to their chemical structures. Herb decoctions were then subjected to ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis with appropriate collision energy (CE) in MS² mode. Finally, multiple reaction monitoring transitions transformed from MS² of ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were used for ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry to obtain the mass responses of LRS components. LRS components quantification was further performed by developing an assistive group-dependent semiquantitative method. Results: The developed method was exemplified by the comparative PK process of single herbs Radix Ginseng (RG), Radix Polygala (RP), and their combinations (RG-RP). Significant changes in PK parameters were observed before and after combination. Conclusion: Results indicated that Traditional Chinese Medicine combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies.