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RISS 인기검색어
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- 저자 : Yufeng Zheng(Yufeng Zheng) (검색결과 6 건)
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Yufeng Zheng(Yufeng Zheng),Xue Liu(Xue Liu),Na Li(Na Li),Aimei Zhao(Aimei Zhao),Zhiqiang Sun(Zhiqiang Sun),Meihua Wang(Meihua Wang),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.
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THE INVESTIGATION OF ATOMIC STRUCTURE AND ELECTRIC PROPERTY OF POLYCRYSTALLINE CdS(Se) FILMS
Zheng, Zheng, Yufeng,Ma, Ma, Zhongquan,Deng, Deng, Rengping,Zha, Zha, Chaozheng 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1
The spray-sintering process and thermal evaporation technique were appliced to fabrication of polycrystalline CdS(Se) films on glass substrate respectively. Their atomic structure and surface morphology were analyzed by XRD and SEM spectrometers. It was found that films made in spraysintering process were of the zince-blende structure but the films evaporated in vacuum showed a two-dimensional layer structure of atom stacked along c axis with a lattice parameter of $3.351{\AA}$. A variation of the conductivity with annealing temperature in air and nitrogen for sintered films with impurities has been ascribed to the mobility and the concentration of majority carrier. A increase of the electric conductance with temperature in any ambience for evaporated films was resulted from forming a conductive layer which promoted the mobilization of eletron or hole. The absorption and desorption of oxygen in subsequent annealing process has alos been discussed.
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Yufeng Qi,Haodong Wu,Conghui Liu,Danni Zheng,Congzhi Yan,Wenjing Hu,Xiaohua Zhang,Xuanxuan Dai 한국유방암학회 2022 Journal of breast cancer Vol.25 No.4
Purpose: The incidence rate of breast cancer (BC) has increased annually. Downstream neighbor of son (DONSON) critically affects cell cycle progression and maintains stable genomic properties; however, its relevant effects on BC growth and progression require in-depth investigation. Methods: DONSON upregulation was validated in public databases. DONSON expression in matched BC and adjacent tissues and cell lines (MDA-MB-231, BT-549, and HS-578T) was determined using quantitative reverse transcription polymerase chain reaction. In vitro apoptosis, invasion, migration, and proliferation tests were performed to ascertain the functions of DONSON in BC cell lines. Then, using western blot analysis, the levels of DONSON downstream proteins were determined. Results: Compared to the control, DONSON was expressed at higher levels in BC tissues and cell lines. DONSON knockdown facilitated apoptosis and limited proliferation, migration, invasion, and S/G2 transition of BC cells in vitro. Furthermore, DONSON overexpression promoted BC cell proliferation and inhibited apoptosis in vitro. Moreover, DONSON knockdown reduced cyclin A1 and cyclin-dependent kinase 2 levels. Moreover, DONSON knockdown limited the progression of epithelial-mesenchymal transition. Conclusion: DONSON critically affects BC growth and serves as a possible target and marker for the efficacy of subsequent therapies.
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Forensic biogeographical ancestry inference: recent insights and current trends
Wen Yufeng,Liu Jing,Su Yonglin,Chen Xiacan,Hou Yiping,Liao Linchuan,Wang Zheng 한국유전학회 2023 Genes & Genomics Vol.45 No.10
Background As a powerful complement to the paradigmatic DNA profiling strategy, biogeographical ancestry inference (BGAI) plays a significant part in human forensic investigation especially when a database hit or eyewitness testimony are not available. It indicates one’s biogeographical profile based on known population-specific genetic variations, and thus is crucial for guiding authority investigations to find unknown individuals. Forensic biogeographical ancestry testing exploits much of the recent advances in the understanding of human genomic variation and improving of molecular biology. Objective In this review, recent development of prospective ancestry informative markers (AIMs) and the statistical approaches of inferring biogeographic ancestry from AIMs are elucidated and discussed. Methods We highlight the research progress of three potential AIMs (i.e., single nucleotide polymorphisms, microhaplotypes, and Y or mtDNA uniparental markers) and discuss the prospects and challenges of two methods that are commonly used in BGAI. Conclusion While BGAI for forensic purposes has been thriving in recent years, important challenges, such as ethics and responsibilities, data completeness, and ununified standards for evaluation, remain for the use of biogeographical ancestry information in human forensic investigations. To address these issues and fully realize the value of BGAI in forensic investigation, efforts should be made not only by labs/institutions around the world independently, but also by inter-lab/institution collaborations.
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Three-Dimensional Lock and Key Colloids
Wang, Yu,Wang, Yufeng,Zheng, Xiaolong,Yi, Gi-Ra,Sacanna, Stefano,Pine, David J.,Weck, Marcus American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.19
<P>Colloids with well-defined multicavities are synthesized through the hydrolytic removal of silica cluster templates from organo-silica hybrid patchy particles. The geometry of the cavities stems from the originally assembled cluster templates, displaying well-defined three-dimensional symmetries, ranging from spherical, linear, triangular, tetrahedral, trigonal dipyramidal, octahedral, to pentagonal dipyramidal. The concave surface of the cavities is smooth, and the cavity shallowness and size can be varied. These particles with multicavities can act as “lock” particles with multiple “key holes”. Up to <I>n</I> “key” particles can self-assemble into the lock particles via depletion interaction, resulting in multivalent, site-specific, reversible, and flexible bonding.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-19/ja502699p/production/images/medium/ja-2014-02699p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja502699p'>ACS Electronic Supporting Info</A></P>
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