뇌졸중 위험인자를 가진 어지럼 환자에서의 확산강조 자기공명영상

강형구,윤유상,이진희,박인철,이경룡,정상원,구홍두,김승호 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: The management of vertiginous patients is a great challenge to emergency physicians. We evaluated the diagnostic value of a diffusion-weighted image(DWI) in differentiating central vertigo from the peripheral vertigo in patients who presented no neurological symptoms other than risk factors for stroke. Methods: From March 2000 to February 2001, we retrospectively analyzed the cases of 68 patients who visited the emergency department with symptoms of isolated vertigo and who had risk factors for stroke. DWIs, computed tomograms(CT), and medical records were reviewed, and the final diagnose, the DWIs and the CT readings, the risk factors for stroke, and the time it took waiting for a DWI or CT scan were analyzed. Results: Of the 68 patients, 21(30.8%) had central vertigo: 15 vertebrobasilar transient ischemic attacks(VB-TIA), 4 brain stem infarctions, 1 cerebellar infarction, and 1 cerebellopeduncular infarction. The DWI showed a 28.6% sensitivity, a 97.9% specificity, and an 85.7% positive predictive value in diagnosing central vertigo. It also had a 100% sensitivity in detecting infarctions. Conclusion: A DWI had a comparable sensitivity to MRI in detecting central vertigo and small, but potentially, lethal infarctions in our patient population. We recommend clinical application of DWI in the emergency department evaluation of isolated vertigo patients with risk factors for stroke.

고혈압 환자들의 건강행태

김석범,강복수,윤성호,황정희,이경수 韓國保健敎育.健康增進學會 2000 보건교육건강증진학회지 Vol.17 No.1

This study was conducted to examine health behaviors in hypertensive patients and the factors that would affect these healthy life-styles, and to provide basic data for effective and continuous hypertension control in private medical facilities. Among those patients diagnosed as hypertension who had visited the Department of Internal Medicine of Yeungnam University Hospital during the two month period from August 2 to September 30, 1999, the present study included 222 patients who were in more than one month after the initial diagnosis of hypertension and those who had hypertension for less than 10 years. Using a structured questionnaire, the present study was conducted by a self-administered survey method, and the obtained data were analyzed with t-test, χ2-test and one-way analysis of variance using the SPSS statistical program. The scores on knowledge related to hypertension were higher as the education level of a patient was higher(p〈0.05). As for occupation, those who performed office or management jobs showed higher scores than those who were into manufacturing jobs, and as for economic status, although those patients who were in middle class showed highest scores, however, no statistical significance was observed. The scores of knowledge on hypertension was higher when the family history hypertension was present(p〈0.05). The scores of health-related behaviors were higher with higher education level and higher economic status, higher in those with family history of hypertension, and higher in those with office or management jobs than those who had manufacturing jobs(p〈0.05). Blood pressure measurement on regular basis was performed most frequently in those who were between 50∼59 years old with 83.3% and was least frequent in those who were older than 70 years old with 50%(p〈0.05). The frequency of regular blood pressure measurement was higher with higher education level, higher economic status, higher in those with family history of hypertension, and the highest in those with management position with 93.5%, however, on statistical significance was observed. Changes in health-relaxed behaviors after hypertension diagnosis were higher with higher education level, higher economic status, and in those patients performed office or management work. In particular, diet change was observed in female and higher economic status and smoking cessation was observed in 60∼69 years old. Housewives and office workers or managers have taken exercise more regularly and those who had management jobs and had high scores on knowledge related to hypertension would participate health education program more actively. Thus, for improving health-related behaviors for continuous management of hypertension, changes in health-related behaviors can be followed through conduction health education to improve understanding of knowledge related to hypertension as the method of helping to improve changes in health life-styles in those with little education and those in low economic status.

HL-60 세포주를 이용한 결핵균항원의 세포성면역반응의 분석

박정규,강윤중,김운옥,임재현,송창화,조은경,김화중 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Most persons who become infected with M. tuberculosis mount a protective immune response and remain clinically well, the only evidence of infection being development of a positive tuberculin skin test. Five to 10% develop tuberculosis disease within the first 2 years after infection (primary tuberculosis) or thereafter (reactivation tuberculosis). Acquired resistance against tuberculosis paradigmatically rests on cell-mediated immunity, with the major factors being mononuclear phagocytes and T Lymphocytes. While the former cells act as the principal effectors, the latter ones serve as the predominant inducers of protection. The usefulness of the single dose of BCG routinely given in childhood in many developing countries in preventing far more commonly occurring tuberculosis in adults is in doubt. An effective and safe vaccine against tuberculosis is sorely needed. A subunit vaccine are capable of inducing protective immunity and could have substantial advantages over BCG or other whole-bacterium vaccines. The human promyelocytic cell line HL-60 adopted characteristic macrophage-like properties, including adherence and CD14 expression after a period of continuous culture at high ambient CO_(2) concentration. When HL-60 cells were cultured with 1,25-dihydroxyvitamin D_(3) for 4 days, the cells acquired the activity to potentiate T cell proliferation by the 30 kDa or 38 kDa antigen of Mycobacterium tuberculosis H37Rv Therefore, vitamin D-treated HL-60 cells showed the function of the antigen presenting cells.

纖維强化 Plastics의 切削加工에 관한 硏究

金元鎰,李允景,姜渭民 慶南大學校 附設 工業技術硏究所 1991 硏究論文集 Vol.9 No.-

本 硏究에서는 유리纖維 强化樹脂의 旋消時 각 切削 條件에 따른 超音波 振動切削과 常用切削時 나타나는 加工特性을 考察하기 위하여 眞圓度, 表面粗度을 中心으로 比較, 檢討한 結果 다음과 같은 結論을 얻을 수 있었다. 1. 眞圓度의 값은 切削條件 및 振幅에는 많은 影響을 받지 않고, 纖維角이 60˚인 경우 V=60m/min, f=0.08mm/rev, t=0.05mm일때 眞圓度 값이 10㎛로 가장 良好하였고, 纖維角이 90˚인 경우에는 振動切削에서는 19㎛, 常用切削에서는 37㎛로 가장 높은 값이 나타났으며, 振動切削이 常用切削 보다 약 2배 改善되었다. 2. 表面眺度는 纖維角이 60˚인 경우가 가장 良好하고, V=20m/min에서는 振動切削과 常用切削의 값은 거의 變化가 없으며 V=30m/min이상에서는 振動切削이 顯著하게 改善되었다. 3. 工具傾斜角은 眞圓度에는 많은 影響을 미치지 않지만 表面粗度는 0˚보다 6˚가 약간 改善됨을 알 수 있다. 4. 振動切削은 硏削에서 얻을 수 있는 加工精度를 旋削에서도 쉽게 얻을 수 있어 精密度와 生産性을 向上시키는 加工法이라 할 수 있다. In this paper, under different cutting condition on G.F.R.P, ultrasonic vibration cutting and the characteristics in conventional cutting have been studied. So the following conclusion centered on comparison, examination of roundess, surface roughness has been reached. 1. The value of surface roundess doesn't get much effect from amplitude as well as cutting conditions. With 60˚of fiber angle, v=60m/min, f=0.08mm/rev, t=0.05mm, the value of surface roundess, 10㎛, was the best. In case of 90˚, the highest value was 19㎛ in vibration cutting and 37㎛ in conventional cutting vibration cutting has improved about twice as high as conventional cutting. 2. In case the fiber angle was 60˚, surface roundess was little difference between vibeation and conventional cutting. Under v=30m/min and above, vibration cutting has remarkably improved. 3. Even if the tool rake angle doesn't affect the roundess, surface roughness has improved a little more at 6˚than at 0˚. 4. Vibration cutting helps to gain as lathe turing working precision as in grinding, Consequently, it's considered a good working method to improve precision and productivity.

Evaluation of enteral formulas for nutrition, health, and quality of life among stroke patients

Kang, Yun-Kyeong,Lee, Ho-Sun,Paik, Nam-Jong,Kim, Woo-Sub,Yang, Mi-Hi The Korean Nutrition Society 2010 Nutrition Research and Practice Vol. No.

Enteral nutritional support has been used via tube feeding for dysphagic stroke patients. We performed long and short term trials to evaluate the effects of commercial enteral nutritional supports on nutrition and health in stroke patients (mRS = 3~5) and quality of life in their caregivers. For a long term study, we recruited chronic (${\geq}$ 1 yrs) stroke patients (n = 6) and administered them 6 cans/day (1,200 kcal) of the commercial enteral formula N for 6 months according to IRB-approved protocol. We collected peripheral blood at 0, 2, 4 and 6 months. For a short term study, we recruited acute (${\leq}$ 3 months) stroke patients (n = 12) and randomly administered them two different commercial enteral formulas, N or J, for 2 weeks. We collected their blood at 0, 4, 7 and 14 day of the administration. Blood samples were analyzed to quantify 19 health and nutritional biomarkers and an oxidative stress biomarker, malondialdehyde (MDA). In order to evaluate quality of life, we also obtained the sense of competence questionnaire (SCQ) from all caregivers at 'before' and 'after trials'. As results, the enteral formula, N, improved hemoglobin and hematocrit levels in the long term trial and maintained most of biomarkers within normal ranges. The SCQ levels of caregivers were improved in the long term treatment (P < 0.05). In a case of the short term study, both of enteral formulas were helpful to maintain nutritional status of the patients. In addition, MDA levels were decreased in the acute patients following formula consumption (0.05 < P < 0.1). Most of health and nutrition outcomes were not different, even though there is a big difference in price of the two products. Thus, we evaluate the formula N has equal nutritional efficacy compared to the formula J. In addition, long term use of enteral formula N can be useful to health and nutrition of stroke patients, and the quality of life for their caregivers.

Modularization and economic analysis of bioethanol production facilities using lignocellulosic biomass

Kyeong Eop KANG,Minhee HAN,Jun-seong JEONG,Yule KIM,Se Yun LEE,Kyung Woo KANG,Jin Ho CHUNG,Se-Kwon MOON,Hee Jong LEE 한국생물공학회 2016 한국생물공학회 학술대회 Vol.2016 No.4

Characteristics of Structure and Expression Pattern of ADSF/resistin Gene in Korean Native Cattle

Kang, Hye Kyeong,Park, Ji Ae,Seo, Kang Seok,Kim, Sang Hoon,Choi, Yun Jai,Moon, Yang Soo Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.3

Adipocyte-specific secretory factor (ADSF)/resistin, a hormone, is a small cysteine-rich protein secreted from adipose tissue and has been implicated in modulating adipogenesis in humans and rodents. The objective of this study was to clone a gene encoding ADSF/resistin and to characterize its function in Korean Native Cattle (Hanwoo). The coding sequence was 330 base pairs and it encoded a protein of 109 amino acids. An NCBI BLAST-search revealed the cloned cDNA fragment shared significant homology (82%) with the cDNA encoding the human ADSF/resistin. The nucleotide sequence homology of the Hanwoo sequence was 73% and 64% for the rat and mouse, respectively. A 654 bp ADSF/resistin gene promoter was cloned and putative binding sites of transcription factors were identified. Tissue distribution of ADSF mRNA was examined in liver, skeletal muscles (tenderloin, biceps femoris), subcutaneous fat, and perirenal fat by RT-PCR. ADSF mRNAs were detected in fat tissues but not in liver and muscles, suggesting that ADSF/resistin expression may be induced during adipogenesis. Although, the physiological function of ADSF/resistin in the cow remains to be determined, these data indicate ADSF is related to the adipocyte phenotype and may have a possibly regulatory role in adipocyte function.

뇌졸중환자를 중심한 산화적 손상지표의 양상

강윤경,양미희 숙명여자대학교 약학연구소 2010 약학논문집-숙명여자대학교 Vol.25 No.-

Oxidative stress has been emphasized as a molecular etiology for degenerative disease and various biomarkers to measure oxidative stress have been developed. Among them, hyperhomocysteinemia has been focused as a risk factor for stroke. However, there are still discrepancies for the roles of homocysteine on stroke. In the present study, we analyzed oxidative stress levels with malondialdehyde (MDA) and homocysteine levels in chronic male stroke patients (N=7; age, 65.5 ± 6.0 yrs) due to progress of stroke (for 6 months). In addition, vitamin B12, a chemopreventive candidate, has been analyzed to study its effects on MDA or homocysteine. As results, MDA levels were increased due to time period (0.05<p<0.1) and were positively associated with homocysteine levels (p<0.001). However, vitamin B12 did not show any negative association with MDA or homocysteine. In conclusion, we found increased oxidative stress due to stroke progress. Based on positive association with MDA, homocysteine may be involved in oxidative damage during stroke progress. This finding provides a useful mechanism to develop anti oxidative materials to protect stroke.

Analyses of Atmospheric Rivers in East Asia

Yun Seob Moon,Da Bin Kim,Woo Kyeong Kang,Young Ji,Ok Jin Jeong 한국기상학회 2018 한국기상학회 학술대회 논문집 Vol.2018 No.10

Analsysis of Process Parameters to Improve In-Chip Linewidth Variation

Yun-Kyeong Jang,Doo-Youl Lee,Sung-Woo Lee,Eun-Mi Lee,Soo-Han Choi,Yool Kang,Gi-Sung Yeo,Sang-Gyun Woo,Han-Ku Cho,Jong-Rak Park 대한전자공학회 2004 Journal of semiconductor technology and science Vol.4 No.2

The influencing factors on the OPC (optical proximity correction) results are quantitatively analyzed using OPCed L/S patterns. 3cr values of proximity variations are measured to be 9.3 nm and 15.2 nm for PR-A and PR-B, respectively. The effect of post exposure bake condition is assessed. 16.2 nm and 13.8 nm of variations are observed. Proximity variations of 11.6 nm and 15.2 nm are measured by changing the illumination condition. In order not to seriously deteriorate the OPC, these factors should be fixed after the OPC rules are extracted. Proximity variations of 11.4, 13.9, and 15.2 nm are observed for the mask mean-to-targets of 0, 2 and 4 nm, respectively. The decrease the OPC grid size from I nm to 0.5 nm enhances the correction resolution and the OCV is reduced from 14.6 nm to 11.4 nm. The enhancement amount of proximity variations are 9.2 nm corresponding to 39% improvement. The critical dimension (CD) uniformity improvement for adopting the small grid size is confirmed by measuring the CD uniformity on real SRAM pattern. CD uniformities are measured 9.9 nm and 8.7 nm for grid size of I nm and 0.5 nm, respectively. 22% improvement of the CD uniformity is achieved. The decrease of OPC grid size is shown to improve not only the proximity correction, hut also the uniformity.<br/>