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증례 : 류마티스 ; Infliximab으로 치료한 건선 관절염 환자의 지염 1예
김담 ( Dam Kim ),손일웅 ( Il Woong Sohn ),김진주 ( Jin Ju Kim ),최윤영 ( Yun Young Choi ),정경희 ( Kyong Hee Jung ),김태환 ( Tae Hwan Kim ),성윤경 ( Yoon Kyoung Sung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
저자들은 건선 관절염으로 NSAIDs를 사용하던 환자에서 양측 엄지손가락의 지간 관절 및 말단과 양측 발의 지간 관절을 대칭적으로 침범한 건선 관절염에 의한 지염을 관찰하였고, infliximab을 투여하여 치료한 예를 경험하여 이런 예가 국내에서 보고가 없었으므로 이를 보고한다. 또한 본 환자에서는 단순 방사선 사진에서의 변화가 뚜렷하지 않아 bone scan 중 blood pool image로의 추적관찰이 유용했다. Dactylitis is a hallmark feature of psoriatic arthritis. It is usually managed with non-steroidal anti-inflammatory drugs and oral corticosteroids. Some cases have been treated successfully with intravenous corticosteroids or some disease-modifying antirheumatic drugs. Recently, inflximab has been reported as an effective treatment for dactylitis that is resistant to conventional treatment. This report describes a 37-year-old man with psoriatic arthritis who had multiple dactylitis on both thumbs and great toes. He was resistant to conventional treatment but was effectively treated with infliximab. This report highlights the effectiveness of infliximab for dactylitis, and the usefulness of blood pool imaging from bone scans as a method for determining treatment response. (Korean J Med 2011;80:S310-S313)
The Influence of Women Dental Hygienists’ Work-Family Balance on Happiness Level in Dental Clinics
( Ae-jung Im ),( Yun-woo Kim ),( Su-jung Kim ),( Seung-yeon Kim ),( Eo-jin Kim ),( So-dam Moon ),( Su-min Shin ),( Hae-in Jeong ),( Hee-ae Jeong ),( Hee-jung Lim ) 한국치위생과학회 2021 치위생과학회지 Vol.21 No.3
Background: To identify work-family balance and level of happiness among married women dental hygienists in Seoul and Gyeonggi Province. The goal of this study is to use the outcome as basic data to determine the compatibility of dental hygienists with work and family, systems, and improvement of happiness levels. Methods: From July 3 to August 10, 2020, 250 dental hygienists in Seoul and Gyeonggi Province were targeted. The questionnaire comprised 65 questions, including general characteristics (perception of work-family balance, perception of work-family balance system, job satisfaction, parenting type, happiness level) whether or not they were implemented. The results were obtained through a self-control questionnaire. Results: The perception of work-family balance was significantly different in job rank and average income, while that of the work-family balance system had significant differences in workplace type, total work experience, current job work experience, childcare system status, and parental leave period. Happiness level and job satisfaction were significantly different in job rank, average income, and childcare system status. Additionally, the perception of work-family balance and that of the work-family balance system showed a positive correlation with job satisfaction and happiness level. Finally, the perception of married women dental hygienists toward work-family compatibility was determined, where the higher the satisfaction with the job, the higher the level of happiness. Conclusion: To improve the work-family balance and job satisfaction of dental hygienists and their levels of happiness, changes in social perception and improvement of the working environment such as proper staffing, flexible work systems, and incentive systems should be considered.
창의적 문제 해결력 신장을 위한 중학교 과학 수업 전략의 개발 및 적용 효과(제III보)
윤현정,홍혜인,방담이,박지은,강순희,Yun, Hyun-Jung,Hong, Hye-In,Bang, Dam-I,Park, Ji-Eun,Kang, Soon-Hee 대한화학회 2011 대한화학회지 Vol.55 No.6
이 연구의 목적은 탐구 과정을 수행하는 동안 발산적 사고와 수렴적 사고를 경험할 수 있는 수업 전략을 개발하고 이를 적용함으로써 그 효과를 검증하는 것이다. 이를 위하여 발산하기 모형, 수렴하기 모형, 발산-수렴 함께하기 모형을 탐구의 각 단계에 활용할 수 있는 수업 전략을 개발하였다. 그리고 중학교 1학년을 대상으로 개발한 수업 전략을 실시한 후 이 수업 전략이 창의적 사고력, 비판적 사고력, 창의적 인성 및 학업 성취도에 미치는 효과를 알아보았다. 그 결과 문제 인식, 가설 설정, 변인 통제의 모든 영역에서 창의성의 하위 범주인 유창성과 융통성이 유의미하게 향상되었다. 독창성에 대해서는 실험 집단의 교정 평균이 통제 집단에 비해 높게 나타났으나 통계적으로는 유의미하지 않았다. 비판적 사고력에 대해서는 문제 인식, 결론 도출 및 일반화 과정에서 유의미한 신장을 나타냈다. 또한, 본 연구의 수업 전략은 학업 성취도에도 긍정적인 영향을 미치는 것으로 나타났다. 그러나 창의적 인성에 대해서는 모든 하위영역에 대하여 유의미한 차이가 나타나지 않았다. The purpose of this study was to develop teaching materials using Pyramid model of divergent thinking, Inverse pyramid model of convergent thinking and Diamond model of divergent-convergent thinking. And the teaching materials was implemented to 120 students in middle school over 10 weeks. Results indicated that the experimental group presented statistically meaningful improvement in creative thinking skills, especially in fluency and flexibility(p<.05). Also the teaching materials contributed to improve critical thinking skills, especially in inquiry process of recognizing problems, making conclusion and generalization(p<.05). Moreover, academic achievement was improved(p<.05). But, there was no significant improvement in creative personality(p<.05).
지진에 대한 재해위험도 평가 모형에 관한 연구 - 청주시 사례 중심으로 -
정의담,신창호,황희연,Jeong. Eui-Dam,Shin. Chang-Ho,Hwang. Hee-Yun 한국방재학회 2010 한국방재학회논문집 Vol.10 No.5
많은 기회요소와 편의성이 존재하기 때문에 도시에는 많은 인구와 건물이 집중되어 있다. 이러한 이유로 인하여 재해 발생 가능성이 높고 재해가 발생하면 그 피해는 치명적이다. 본 연구는 우리나라 도시특성에 맞는 실용적인 재해 위험도 평가방법을 제시하는데 있으며, 사례지역으로 충청북도 청주시를 대상으로 평가하였다. 화재위험도, 건물붕괴위험도, 대피위험도, 가스폭발 위험도를 포함한 종합위험도를 분석하고 적용한 결과, 현재 도심공동화 현상이 나타나는 북문로 일대가 위험성이 가장 높게 나타나는 것으로 분석되었다. 이 일대는 구시가지로 재난의 대책 및 정비가 이루어지지 않았음을 예상할 수 있으며 시급한 정비가 이루어져야 된다고 판단된다. Relatively high density of population and buildings exists in urban area mainly because of broad job opportunities and conveniences available. In other words, if happened, there might be high possibility of disaster which can not be easily recovered. The purpose of this study is to show evaluation approach of the risk degree resulted from the disaster, which considers the attributes of urban area. Cheongju-city in Chungcheongbuk-do is selected as sample district to be estimated. The degree of overall risk including fire risk, building collapse risk, evacuation risk and gas explosion risk etc. is analyzed in the designated area. The analysis suggests the highest risk degree in Bukmun-ro district which also shows CBD decline phenomenon. Therefore, it can be not only predicted that this area as old downtown has not been provided with disaster prevention operation and urban renewal project, but also judged that administrative assistances for the disaster are required possibly soon.
사람 내피세포에서 염증 전구사이토카인이 VCAM - 1의 발현에 미치는 영향
조영주,박수길,이재담,황온유,문희범,장윤혜,김승후,홍혜남 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.2
Background: The expression of adhesion molecules contribute to development of systemic diseases. Vascular cell adhesion molecule-l(VCAM-1) is an endothelial cell membrane glycoprotein that has been implicated in leukocyte/endothelial cell interactions in inflammation. Ojective: The aim of this study was to characterize the surface expression and regulation of VCAM-1 on two different endothelial cells. Methods: We examined the effects of the expression of VCAM-1 in two different endothelial cells, isolated from human umbilical cords and human glomerulus. Expression of VCAM-1 was measured by enzyme-linked immunosorbent assay(ELISA) and flow cytometry. Results: In human umbilical cord endothelial cells(HUVECs), both interleukin-lβ(IL-lβ) and tumor necrosis factor-α(TNF-α) increased VCAM-1 expression. VCAM-1 expression increased by TNF-αwas higher than that increased by IL-lβ. In human glomerular endothelial cells(HGECs), IL-lβand TNF-αmarkedly increased VCAM-1 expression. Conclusion. The regulation of VCAM-1 appears to be somewhat different in HGECs compared with HUVECs. These differences between the responsiveness of the two cells may possibly indicate inherent differences in endothelial cell derived from different vascular beds.
Effects of Saenghyul-dan (SHD) on the Myelosuppression Induced by 5-Fluorouracil
Lee, Gi-Joon,Son, Chang-Gue,Lee, Yeon-Weol,Lee, Nam-Heon,Yun, Dam-Hee,Yoo, Hwa-Seung,Cho, Chong-Kwan,Cho, Jung-Hyo The Society of Korean Medicine 2006 대한한의학회지 Vol.27 No.4
Objective : This study aimed to investigate the effect of SHD on myelosuppression using an animal model for therapeutic evidence supporting clinical positive results. Methods : After determining the optimal concentration of 5-FU as 300 mg/kg for developing the mouse model, ICR mice or BALB/c mice were administered with SHD, and several blood parameters, including hematopoietic cytokines, colony forming activity and histological findings, were examined to evaluate the effects. Results : SHD restored the WBC and hemoglobin, and showed effects on maintaining body weight, producing GM-CSF and IL-3 and stem cell colony forming activity in accordance with histological relative entirety on bone marrow. Conclusion : SHD is an herbal drug having therapeutic effects on myelosuppression. Thus, it could be prescribed to cancer patients undergoing chemo-therapies or radio-therapies in the process of cancer treatment.