Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts

Chuan-Te Tsai,Yung-Ming Chang,Shu-Luan Lin,Yueh-Sheng Chen,Yu-Lan Yeh,Viswanadha Vijaya Padma,Chin-Chuan Tsai,Ray-Jade Chen,Tsung-Jung Ho,Chih-Yang Huang 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.3

Angiotensin II (Ang II) is a very important cardiovascular disease inducer and may cause cardiac pathological hypertrophy and remodeling. We evaluated a Chinese traditional medicine, alpinate oxyphyllae fructus (AOF), for therapeutic efficacy for treating Ang II-induced cardiac hypertrophy. AOF has been used to treat patients with various symptoms accompanying hypertension and cerebrovascular disorders in Korea. We investigated its protective effect against Ang II-induced cytoskeletal change and hypertrophy in H9c2 cells. The results showed that treating cells with Ang II resulted in pathological hypertrophy, such as increased expression of transcription factors NFAT-3/p-NFAT-3, hypertrophic response genes (atrial natriuretic peptide [ANP] and b-type natriuretic peptide [BNP]), and Gαq down-stream effectors (PLCβ3 and calcineurin). Pretreatment with AOF (60–100 μg/mL) led to significantly reduced hypertrophy. We also found that AOF pretreatment significantly suppressed the cardiac remodeling proteins, metalloproteinase (MMP9 and MMP2), and plasminogen activator, induced by Ang II challenge. In conclusion, we provide evidence that AOF protects against Ang II-induced pathological hypertrophy by specifically inhibiting the insulin-like growth factor (IGF) II/IIR-related signaling pathway in H9c2 cells. AOF might be a candidate for cardiac hypertrophy and ventricular remodeling prevention in chronic cardiovascular diseases.

New Permeable Structure for Controlling Debris Flows in the Wenjiagou Gully

Yu-feng Liang,Chuan Liang,Hongwei Zhou,Feng-rong Yang,Miao Huo,Jia-wen Zhou 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11

Aimed to control debris flows more effectively, we attempt to develop a new structure called a “sloping roof grill dam”, which consists of guidance walls, separation grills and lateral deposit areas. A series of flume tests were performed to verify the function of this new structure, focusing on the trapping efficiency (β ), deceleration efficiency (μ) and coarse-fine sediment separation extents (η) under different conditions of structure and debris flows. Experimental results show that both the trapping and deceleration efficiency increase with a decrease in permeability, whereas the separation extent shown the opposite effect. Multiple regression analysis indicates that β and η are linearly dependent on the permeability, deceleration efficiency and magnitudes of debris flow. In addition, an increase in beam gap can lead to an increase in the impact area downstream for the debris flow after the control of the structure. Finally, a two-level installation of the structure is tested to determine whether there is an enhancement of the debris control, which indicated that although the trapping effect of the two-level structure is considerably greater than that of a single-level structure (2.11 times at maximum), the separation extent of the two-level structure is not distinct and may be even lower.

Performance Analysis of Permanent Magnet Brushless Motors for Mobility Scooters

Yu-Chuan Lu,Ming-Yang Cheng,Chun-Hsien Wu,Wei-Chih Chen,Cheng-Hu Chen 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

Most modern commercial electric scooters are still equipped with the DC brush motor. This type of motor has mechanical structures such as permanent magnet, brush, and commutator. Therefore, it has attractive features, e.g., large start-up torque and easy to control. However, this kind of mechanical commutation often leads to drawbacks such as low power density, low reliability, and poor heat dissipation. In contrast, the Permanent Magnet Brushless Motors (PMBLMs) have advantages such as high efficiency and maintenance free, etc. Hence, the PMBLMs have great potential in becoming the actuators for electric scooters. In this paper, the performance of the PMBLMs with trapezoidal and sinusoidal back-emf waveforms driven by square wave commutation and sinusoidal commutation is investigated. To reduce the cost, low-resolution Hall sensors are used to implement sinusoidal commutation.

American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc^Min/+ mice

Yu, Chunhao,Wen, Xiao-Dong,Zhang, Zhiyu,Zhang, Chun-Feng,Wu, Xiaohui,He, Xin,Liao, Yang,Wu, Ningning,Wang, Chong-Zhi,Du, Wei,He, Tong-Chuan,Yuan, Chun-Su The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.3

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered $Apc^{Min/+}$ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10-20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p < 0.01). This tumor number reduction was more obvious in those mice treated with a low dose of ginseng. The tumor multiplicity data were supported by body weight changes and gut tissue histology examinations. In addition, quantitative real-time polymerase chain reaction analysis showed that compared with the untreated group, ginseng very significantly reduced the gene expression of inflammatory cytokines, including interleukin-$1{\alpha}$ (IL-$1{\alpha}$), IL-$1{\beta}$, IL-6, tumor necrosis factor-${\alpha}$, granulocyte-colony stimulating factor, and granulocyte-macrophage colony-stimulating factor in both the small intestine and the colon (all p < 0.01). Conclusion: Further studies are needed to link our observed effects to the actions of the gut microbiome in converting the parent ginsenosides to bioactive ginseng metabolites. Our data suggest that American ginseng may have potential value in CRC chemoprevention.

American ginseng significantly reduced the progression of high-fatdiet-enhanced colon carcinogenesis in ApcMin/þmice

Chunhao Yu,Xiao-Dong Wen,Zhiyu Zhang,Chun-Feng Zhang,Xiaohui Wu,Xin He,Yang Liao,Ningning Wu,Chong-Zhi Wang,Wei Du,Tong-Chuan He,Chun-Su Yuan 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.3

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered ApcMin/þ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10e20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p < 0.01). This tumor number reduction was more obvious in those mice treated with a low dose of ginseng. The tumor multiplicity data were supported by body weight changes and gut tissue histology examinations. In addition, quantitative real-time polymerase chain reaction analysis showed that compared with the untreated group, ginseng very significantly reduced the gene expression of inflammatory cytokines, including interleukin-1a (IL-1a), IL-1b, IL-6, tumor necrosis factor-a, granulocyte-colony stimulating factor, and granulocyte-macrophage colony-stimulating factor in both the small intestine and the colon (all p < 0.01). Conclusion: Further studies are needed to link our observed effects to the actions of the gut microbiome in converting the parent ginsenosides to bioactive ginseng metabolites. Our data suggest that American ginseng may have potential value in CRC chemoprevention.

Evaluation of the YOLO models for discrimination of the alfalfa pollinating bee species

Zhang Chuan-Jie,Liu Teng,Wang Jinxu,Zhai Danlan,Zhang Youxin,Gao Yang,Wu Hui-Zhen,Yu Jialin,Chen Min 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1

Identifying insect pollinators and their roles in mediating pollen flow is critical to understand the potential gene flow risks of insect pollination-dependent crop species, such as alfalfa. This study was conducted to evaluate and compare the feasibility of You Only Look Once (YOLO) version 3 (YOLOv3), YOLOv5, YOLOv7, and YOLO Representation (YOLOR) to discriminate the three most common alfalfa pollinating bee species, including honeybee, bumblebee, and leafcutting bee. The metrics comparison results showed YOLOv3 and YOLOv5 out performed YOLOv7 and YOLOR regarding model precision, recall, F 1 score, and mAP50 values. YOLOv3 and YOLOv5 could successfully discriminate the three different bee species with an accuracy of almost 100% (99.9%, 99.8%, and 100% accuracy for honeybee, bumblebee, and leafcutting bee for the two models, respectively). Comparatively, YOLOv7 could discriminate honeybee with an accuracy of 95% but was more likely to mistakenly discriminate bumblebee and leafcutting bee due to the relatively lower discriminating accuracy (87.3% and 66.2%, respectively). While the values of determined parameters for YOLOR were lower than YOLOv3 and YOLOv5, the higher precision (0.99680) along with recall (0.98721), F 1 (0.99198), mAP50 (0.99323), and mAP50-100 (0.89076) values indicate that this model could be able to obtain a favorable performance in discriminating the three bee species. In summary, the proposed method in this study has the potential for identifying the alfalfa pollinating bee species, studying the bees’ flower-visiting behaviors, evaluating the risks of insect-mediated pollen flow, and thus contributing to the management of genetically engineered (GE) alfalfa transgene flow.

Formulation and Evaluation of Irinotecan Suppository for Rectal Administration

( Hai Yang Feng ),( Yu Ping Zhu ),( De Chuan Li ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.1

Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using HPLC. The pharmacokinetics of intravenous administered and rectal administered in rabbits was investigated. Following a single intravenous dose of irinotecan (50 mg/kg), the plasma irinotecan concentration demonstrated a bi-exponential decay, with a rapid decline over 15 min. Cmax, t1/2, AUC0-30h and AUC0-∞ were 16.1 ± 2.7 g/ml, 7.6 ± 1.2 h, 71.3 ± 8.8 μg·h/μl and 82.3 ± 9.5 μg·h/ml, respectively. Following rectal administration of 100 mg/kg irinotecan, the plasma irinotecan concentration reached a peak of 5.3 ± 2.5 μg/ml at 4 h. The AUC0-30h and AUC0-∞ were 32.2 ± 6.2 μg·h/ml and 41.6 ± 7.2 μg·h/ml, respectively. It representing ~50.6% of the absolute bioavailability.

외국문헌초록(外國文獻草綠) : UASB와 MBR의 결합에서 손쉬운 질산화, 탈질화 및 메탄형성의 통합

Ying Yu An,Feng Lin Yang,Hwee Chuan Chua,Fook Sin Wong,Bing Wu 한국수처리학회 2009 한국수처리학회지 Vol.17 No.2

Hydrophobic modification of silica/exfoliated graphite nanoplatelets aerogel and its application as supporting material for form-stable phase change materials

Ni Tan,Yang Feng,Ping Hu,QiLin Ding,Chuan-Huang Lin,Yu-Hao Ning,Hao-Nan Zhou,Linping Yu,Zhong Cao,Ju-Lan Zeng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-

Hydrophobic modified silica/exfoliated graphite nanoplatelets aerogel (M-SiO2/xGnP) were successfullyprepared via surface modification of silica/xGnP alcogel and followed by ambient pressure drying. Afterwards, form-stable PCMs in which capric–palmitic acids eutectic (CA–PA) was confined in theprepared aerogels were obtained by vacuum infiltration. Characterization of the prepared form-stablePCMs revealed that both the hydrophobic modification and the doping of xGnP could effectively improvethe loading of CA–PA in the aerogel. The unmodified silica aerogel could not adsorb CA–PA, while theloading of CA–PA in the surface modified pure silica aerogel supported form-stable PCM and theunmodified silica/xGnP aerogel supported form-stable PCM were 24.2 wt% and 44.4 wt%, respectively. Besides, the hydrophobic modification and the doping of xGnP showed significant synergistic effect. Theloading of CA–PA in the M-SiO2/xGnP supported form-stable PCM (FPCM/xGnP-20-48) could attain78.9 wt% when the M-SiO2/xGnP was obtained by modifying the alcogel with 20 vol% trimethylchlorosilane for 48 h. The FPCM/xGnP-20-48 not only had high latent heat and good thermal reliability,but also exhibited significantly improved thermal conductivity and alleviated supercooling due to theeffective thermal conductive network formed by xGnP and the promoted heterogeneous nucleation ofCA–PA at interfaces with aerogel.

Green and sustainable applications of energetic plasmon-activated water

Chih-Ping Yang,Shih-Hao Yu,Yu-Chuan Liu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

This review describes the use of bulk deionized water (DIW) treatment to become plasmon-activatedwater (PAW) with reduced hydrogen bonds (HBs). PAW with special properties can be used in innovativeapplications and development of environmental protection science and sustainable energy management. PAW is a natural water solvent, but PAW subverts the public’s idea that hydrophobic solutes are difficultto dissolve in water. PAW can dissolve more-hydrophobic solutes than ordinary water, and can also interactwith water-soluble alcohol molecules to form stronger HBs. Moreover, in the application of certainreduction reactions, no chemical reducing agent is needed, and the catalytic reduction effect can beachieved using natural PAW. A characteristic application of PAW can also be extended to seawater desalination. Due to weak HBs among PAW molecules, high water evaporation rates can be produced, and ahigher chemical potential can also be applied to the innovative development of solar energy storage. In electrochemical applications, PAW itself can promote water oxidation, oxygen reduction reactions,hydrogen and oxygen evolution reactions, and the efficient capacitor production of H2O2. Furthermore,PAW can delay the melting of sea ice in the habitat of polar bears, so it may be applied to the issue ofsaving polar bears.