EFFECT OF CODONOPSIS PILOSULA AND ASTRAGALUS ON THE TREATMENT OF CORONARY HEART DISEASE

Liao, Jiazhen,Yang, Qinfel,Chen, Wenwei 경희대학교 동서의학연구소 1991 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1991 No.3

The theory of traditional Chinese medicine (TCM) holds that the main pathogenesis of coronary heart disease (CHD) is qi-dcficiency and blood stasis. Therefore, the drugs for replenishing qi are often used for treatment of CHD. The present study is to explore the effects of Codonopsis pilosula and Astragalus (CP-A) on CHD by means of modern scientific methods. The results showed that the principal therapeutic actions of CP-A on CHD are as follows: 1. To reduce the frequency and severity of angina pectoris, decrease the depression of the ischemic ST-T and total ischemic burden during Holter Moniting. 2. To strengthen the left ventricular function, the mechanism responsible for inotropic effect of CP-A relating to inhibit the activity of PDE and increase the cAMP levels in the myocardial cells; 3. To inhibit the activity of PDE and increase the cAMP levels in the platelets resulting in the inhibition of platelet aggregation; 4. To increase the levels of ATP, glucogen, SDH and LDH in the myocardial cells and strengthen the energy metabolism in myocardiac cells. 5. To increase the volume of nutritious blood flow in the myocardium; 6. To prolong the action potential duration of myocardial cell and the activation time of sinus node; 7. Te reduce the plasma TXB2 level and increase or don't affect 6-keto-PGF1α level. 8. To strengthen the immunofunction and increase the level of OKT4 and OKT4/OKT8 ratio.

Effect of Heat Treatment on the Microstructure and Properties of High Strain Rate Rolled 7050 Aluminum Alloy

Yang Liao,Hongge Yan,Weijun Xia,Jihua Chen,Bin Su,Xinyu Li,Lu Zhao 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.4

High strain rate rolling (HSRR) is developed to improve the strength, plasticity and stress corrosion resistance of 7050 aluminumalloy simultaneously. The volume fraction of the small-angle grain boundary in the HSRRed alloy sheet is 89.9%. TEM shows that the presence of dislocations and sub-grains promotes the precipitation of the second phase. The alloy inthe T6 state has the highest strength (622 MPa) and the biggest elongation to rupture (20.6%), but poor corrosion resistance. The over-aged state shows the best corrosion resistance. The RRA state can achieve the tensile strength equivalent to T6 of614 MPa, the highest yield strength of 561 MPa and corrosion resistance comparable to the over-aged state. TEM observationshows the existence of sub-grains and dislocations plays an important role in the nucleation of the second phase. Thehigh strength can be attributed to the higher volume fraction of the precipitates, and the high plasticity can be attributed tothe higher work hardening rate. The better corrosion resistance can be ascribe to the wider precipitate-free zones at the grainboundary and the presence of the larger size second phase particles.

CNC Corner Milling Parameters Optimization Based on Variable-Fidelity Metamodel and Improved MOPSO Regarding Energy Consumption

Yang Yang,Yuan Wang,Qianfeng Liao,Jiongliang Pan,Junyu Meng,Hao Huang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.4

In the corner milling process, processing energy consumption is a very important objective, since the energy efficiency of CNC machine is barely above 14.8%. Meanwhile, the excessive processing temperature will increase the thermal deformation of the product and leads to quality decline. Improper process parameters will lead to unnecessary high temperature and energy consumption. By optimizing the process parameters, the appropriate temperature and Specific Energy Consumption can be obtained. This study investigated into modeling Specific Energy Consumption and temperature in corner milling process using variable-fidelity metamodels. The adopted variable-fidelity metamodels are constructed by Hierarchical Kriging, in which 48 sets of low-fidelity data obtained from the AdvantEdge software simulation are used to reflect the trends of the metamodels, and 16 sets of high-precision data obtained from physical experiments are used to calibrate the trends. The experimental cost is reduced and the prediction accuracy is increased by making full use of both sets of data. An improved K-means Multi-objective Particle Swarm Optimization algorithm was adopted and applied on the multi-objective corner milling parameters optimization problem to find satisfactory specific energy consumption and temperature. The obtained Pareto solutions can provide guidance for selecting process parameters according to different requirements, such as reducing energy consumption or temperature.

Backbone Coplanarity Tuning of 1,4-Di(3-alkoxy-2-thienyl)-2,5-difluorophenylene-Based Wide Bandgap Polymers for Efficient Organic Solar Cells Processed from Nonhalogenated Solvent

Liao, Qiaogan,Yang, Kun,Chen, Jianhua,Koh, Chang Woo,Tang, Yumin,Su, Mengyao,Wang, Yang,Yang, Yinhua,Feng, Xiyuan,He, Zhubing,Woo, Han Young,Guo, Xugang American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.34

<P>Halogenated solvents are prevailingly used in the fabrication of nonfullerene organic solar cells (NF-OSCs) at the current stage, imposing significant restraints on their practical applications. By copolymerizing phthalimide or thieno[3,4-<I>c</I>]pyrrole-4,6-dione (TPD) with 1,4-di(3-alkoxy-2-thienyl)-2,5-difluorophenylene (DOTFP), which features intramolecular noncovalent interactions, the backbone planarity of the resulting DOTFP-based polymers can be effectively tuned, yielding distinct solubilities, aggregation characters, and chain packing properties. Polymer DOTFP-PhI with a more twisted backbone showed a lower degree of aggregation in solution but an increased film crystallinity than polymer DOTFP-TPD. An organic thin-film transistor and NF-OSC based on DOTFP-PhI, processed with a nonhalogenated solvent, exhibited a high hole mobility up to 1.20 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP> and a promising power conversion efficiency up to 10.65%, respectively. The results demonstrate that DOTFP is a promising building block for constructing wide bandgap polymers and backbone coplanarity tuning is an effective strategy to develop high-performance organic semiconductors processable with a nonhalogenated solvent.</P> [FIG OMISSION]</BR>

The Typical Symbol and Cultural Identity of Hakka NiangTofu in the Perspective of Food Anthropology

Yang Liao,Shao-di Ho 한국식생활문화학회 2017 한국식생활문화학회학술대회논문집 Vol.2017 No.11

Research on the Influence of Corporate Social Responsibility on Organizational Performance based on Structural Equation Model

Yang Liao 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.5

With the economic and social transformation, corporate social responsibility has become an important factor affecting the enterprises performance. In this paper, we make an empirical analysis of the relationship between corporate social responsibility and organizational performance by using structural equation model. The result shows that CRS has an impact on the human resource management practice and organizational performance, at the same time, the HRM system has played an intermediary role. Enterprises to fulfill corporate social responsibility will significantly enhance the efficiency of human resource management, and obtain recognition of employees. So that it is necessary for enterprises to undertake the social responsibility in the long-term, and CRS will provide potential value for enterprises’ competitive advantage.

ENVIRONMENTAL POLICY INSTRUMENTS, SUSTAINABLE CONSUMPTION ATTITUDE AND SUSTAINABLE CONSUMPTION BEHAVIOR: THE MODERATING ROLE OF LONG-TERM ORIENTATION

Zhongju Liao,Yang Sun 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

With the ecological environment deteriorating and rapid growth of world population, sustainable issue becomes a hot issue all over the world. All the state, industry and consumer levels pay more attention to the sustainable filed. Even Kotler (2011) in his study mentioned that the need for sustainable issue means new challenges to the scholars and practitioners. This research aim to the sustainable consumption filed in China. Based on the previous studies, sustainable consumption can be summarized including clothing, food, housing and travelling is an important way to cope with the deteriorating ecological environment and the rapid growth of world population. The Chinese government attaches great importance to sustainable consumption, at the same time the government has issued many sustainable policies to promote the development of sustainable consumption concept. Environmental policies consists of three kinds of instruments (regulation instrument, economic instrument, and information instrument), but which instrument is more effective to promote people’s sustainable consumption attitude and behavior, and whether these effects will be changed or not in different context, previous studies have no clear answer. Based on the literature view, this study organized and established the concept research model. Following the logic of policy-attitude-behavior, the researchers examined the relationship among environmental policy instruments, sustainable consumption attitude and sustainable consumption behavior. Meanwhile, due to long-term orientation was an important variable to explain attitude and behavior, based on time orientation theory, this research also tested the moderating role of long-term orientation between environmental policy instruments and sustainable consumption attitude. Data were collected from Chinese residents in the medium size city, after excluding 67 invalid questionnaires, 325 questionnaires were used to analysis. Through exploratory factor analysis and confirmatory factor analysis, this study confirmed that the scales of main variables had good reliability and validity. Researchers adopted SPSS19.0 to conduct multiple regression analysis. Results showed that regulation instrument and economic instrument had significant effects on sustainable consumption attitude, but the effect of information instrument was not significant. Long-term orientation played the positive moderating role between economic instrument and sustainable consumption attitude; consumers’ sustainable consumption attitude was correlated with sustainable consumption behavior, and was as a mediator between regulation instrument, economic instrument and sustainable consumption behavior. Finally, based on the research results we give some suggestions and contributions to both academy and practice. The conclusions of this study can contribute to the enrichment of environment policy theory,time orientation theory and sustainable consumption,and can provide a certain theoretical guidance and reference for the issue of government on how to promote the development of sustainable consumption. We also point out the limitations of this study and some suggestions for further researches.

Synthesis and application of zirconium phosphate mesoporous coordination polymer for effective removal of Co(II) from aqueous solutions

Zeng Yang,Yuan Guoyuan,Lan Tu,Li Feize,Yang Jijun,Liao Jiali,Yang Yuanyou,Liu Ning 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.11

A kind of zirconium phosphate mesoporous coordination polymer Zr-EDTMPA was successfully synthesized and characterized using XRD, FTIR, TGA, EA, SEMeEDS, and N2 sorption-desorption measurements. The prepared Zr-EDTMPA was first employed for the removal of Co(II) from an aqueous solution, and the effects of pH, contact time, temperature, initial Co(II) concentration, reusability, and sorption mechanism were systematically investigated. The results showed that the Zr-EDTMPA is a zirconium phosphate complex formed by the coordination of EDTMPA to Zr in a molar ratio of 1:1. The sorption of Co(II) by Zr-EDTMPA was a pH-dependent, spontaneous and endothermic process, which was better fitted to the pseudo-second-order kinetic model and Langmuir isotherm model. The Zr-EDTMPA was demonstrated to have excellent reusability and presented a high sorption capacity of 73.0 mgg-1 for Co(II) at pH 8.0. The sorption mechanism was mainly attributed to the strong coordination between cobalt and the untapped hydroxyl functional groups on Zr-EDTMPA, which was confirmed by XPS spectra. Therefore, as a candidate sorbent with high sorption capacity and excellent reusability, ZrEDTMPA has a great potential for the removal of Co(II) from aqueous solutions.

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

Cao Yang,Xinghuo Wu,Zhiwei Liao,Kun Wang,Wenbin Hua,Xianzhe Liu,Yu Song,Yukun Zhang,Shuhua Yang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Intervertebral disc degeneration (IDD) is characterized by excessive apoptosis of nucleus pulposus (NP) cells and hyperactive extracellular matrix (ECM) catabolism. Our previous studies revealed the relationship between human islet amyloid polypeptide (hIAPP) and NP cell apoptosis. However, the role of hIAPP aggregates in IDD has not yet been investigated. This study aimed to determine whether the accumulation of hIAPP aggregates promotes IDD progression. The aggregation of hIAPP increased in human NP tissues during IDD. The deposition of hIAPP aggravated the compression-induced IDD that promoted NP cell apoptosis and ECM degradation via IL-1β/IL-1Ra signaling in an ex vivo rat disc model. Moreover, neutralizing IL-1β augmented the protective effects of hIAPP overexpression by decreasing hIAPP aggregation in human NP cells. These results suggest that the aggregation of hIAPP promotes NP cell apoptosis and ECM degradation ex vivo and in vitro by disrupting the balance of IL-1β/IL-1Ra signaling.

Bioinformatic and integrated analysis identifies an lncRNA–miRNA–mRNA interaction mechanism in gastric adenocarcinoma

Yong Liao,Wen Cao,Kunpeng Zhang,Yang Zhou,Xin Xu,Xiaoling Zhao,Xu Yang,Jitao Wang,Shouwen Zhao,Shiyu Zhang,Longfei Yang,Dengxiang Liu,Yanpeng Tian,Weizhong Wu 한국유전학회 2021 Genes & Genomics Vol.43 No.6

Background lncRNAs–miRNAs–mRNAs networks play an important role in Gastric adenocarcinoma (GA). Identifcation of these networks provide new insight into the role of these RNAs in gastric cancer. Objectives Biological information databases were screened to characterize and examine the regulatory networks and to further investigate the potential prognostic relationship this regulation has in GA. Methods By mining The Cancer Genome Atlas (TCGA) database, we gathered information on GA-related lncRNAs, miRNAs, and mRNAs. We identifed diferentially expressed (DE) lncRNAs, miRNAs, and mRNAs using R software. The lncRNA–miRNA–mRNA interaction network was constructed and subsequent survival examination was performed. Representative genes were selected out using The Biological Networks Gene Ontology plug-in tool on Cytoscape. Additional analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms were used to screen representative genes for functional enrichment. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) were used to identify the expression of fve candidate diferential expressed RNAs. Results Information of samples from 375 cases of gastric cancer and 32 healthy cases (normal tissues) were downloaded from the TCGA database. A total of 1632 DE-mRNAs, 1008 DE-lncRNAs and 104 DE-miRNAs were identifed and screened. Among them, 65 DE-lncRNAs, 10 DE-miRNAs, and 10 DE-mRNAs form lncRNAs–miRNAs–mRNAs regulatory network. Additionally, 10 lncRNAs and 2 mRNAs were associated with the prognosis of GA. Multivariable COX analysis revealed that AC018781.1 and VCAN-AS1 were independent risk factors for GA. GO functional enrichment analysis found DE-mRNA was signifcantly enriched TERM (P<0.05). The KEGG signal regulatory network analysis found 11 signifcantly enrichment networks, the most prevailing was for the AGE-RAGE signaling pathway associated with Diabetic complications. Results of RT-qPCR was consistent with the in silico results. Conclusions The results of the present study represent a view of GA from a analysis of lncRNA, miRNA and mRNA. The network of lncRNA–miRNA–mRNA interactions revealed here may potentially further experimental studies and may help biomarker development for GA.