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김유진,박미경,박이랑,이보람,이혜림,전선미,양난영,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38
The results of this Study are as follows:33.6% of all participants have insomnia; 22.5% of those who have insomnia are DIS(difficulty in initiating sleep), 17.3% are DMS(difficulty returning to sleep once awakened) and 7.0% awakened too early. 3 4.8% experience sleepiness during daytime. Type 1, experiencing insomnia and sleepi ness during daytime together, is 12.0%, Type 2, with insomnia only, is 21.6%, Type 3, with sleepiness during daytime only, is 22.8% and 43.5% experience no sleeping disturbances. After studying only those with 3 types of sleeping disturbances, it is found that the most common cause of such disturbance is stress 88.4%, anxiety 56.0%, no apparent reason 33.8%, anxiety/fear/terror 29.3%, hurry 23.6%, alcohol/caffeine 16.9%, bedroom tem perature 11.1%, urination during nighttime and persons living together 10.7%, noise from inside 8.9%, illumination 8.0%, and pain/itch 5.8%. The one group revealed significant differences in residential environment(p=0.003). Sex, age, education level, medicine, monthly earning revealed no meaningful differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), whether taking enough sleep(p=0.029), whether taking regular sleep(p=0.005) showed significant differences depending on whether or not having insomnia, and mean duration of sleep time, time to sleep, time of rising, whether taking naps did not reveal significant differences. Of sleep behavior, time to sleep(p=0.000), whether taking naps(p=0.000), indicated significant differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), and whether taking enough sleep(p=0.000), time of going to bed (p=0.002), whether or not taking nap(p=0.000), whether or not taking regular sleep(p=0.010) indicated significant differences among the sleeping disturbance types.
Yu Rim Lee,Soo Young Park,Won Young Tak 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4
Background/Aims: The treatment outcomes and prognostic markers of acute variceal bleeding (AVB) in hepatocellular carcinoma (HCC) patients remain unclear. Therefore, we evaluated the clinical outcomes and prognostic factors of AVB in HCC patients. Methods: Cirrhotic patients with endoscopically confirmed AVB between 2007 and 2013 were enrolled in this prospective study. Prognostic factors were identified by multivariate Cox proportional hazards regression analysis. Results: Among the 329 enrolled patients, 125 patients (38.0%) were diagnosed with HCC. The 6-week mortality rates of all enrolled AVB patients and the HCC subgroup were 14.9% and 26.4%. The 5-day treatment failure, 6-week mortality, cirrhosis-related complications, and duration of hospitalization were greater in HCC patients than in non-HCC patients (all p<0.05). In the HCC subgroup, the Model for End-Stage Liver Disease (MELD) score (hazard ratio [HR], 1.145; p=0.001) and Barcelona Clinic Liver Cancer (BCLC) stage (C–D vs 0–B) (HR, 3.096; p=0.019) were independent predictors of 6-week mortality. Our study revealed that 85% of HCC patients with both a MELD score ≥15.5 and BCLC stage C–D died within 6 weeks, and the 6-week mortality risk was 21-fold higher in this group than in the group with a lower MELD score and earlier HCC stage (p<0.001). Conclusions: The 5-day treatment failure and 6-week mortality rates were significantly higher among AVB patients with HCC than those without HCC. The MELD score and the presence and stage of HCC are strong predictors of 6-week mortality in patients with AVB.
Lee, Yu-Jin,Kang, Yeong-Rim,Lee, So Young,Jin, Yena,Han, Dong Cho,Kwon, Byoung-Mog Lychnia 2017 International journal of oncology Vol.51 No.4
<P>Ginkgetin has been reported to display antitumor activity. However, the relevant pathway integrating cell cycle regulation and signaling pathways involved in growth inhibition in CRC cells remains to be identified. In this study, ginkgetin-treated HCT116 CRC cells exhibited significant dose-dependent growth inhibition with a GI(50) value of 4.0 mu M for 48-h treatment, together with apoptosis, via G(2)-phase cell cycle arrest. When HCT116 cells were treated with 10 mu M ginkgetin for 48 h, the percentage of cells in G(2)/M phase increased by 2.2-fold (43.25%) versus the untreated control (19.69%). Ginkgetin regulated the expression of genes that are critically involved in G(2) phase arrest cells, such as b-Myb, CDC2 and cyclin B1. Furthermore, we found that the suppression of b-Myb expression by ginkgetin was rescued similar to 5.1-fold by treatment with a miR-34a inhibitor (500 nM) and b-Myb was downregulated by >80% by 100 nM miR-34a mimic. These data suggest that the miRNA34a/b-Myb/cyclin B1 cascade plays a critical role in ginkgetin-induced G(2) cell cycle arrest, as well as in the inhibition of HCT116 cell proliferation. Moreover, the administration of ginkgetin (10 mg/kg) reduced tumor volumes by 36.5% and tumor weight by 37.6% in the mice xenografted with HCT116 cells relative to their vehicle-treated counterparts. Therefore, ginkgetin is the first compound shown to regulate b-Myb by modulating miR-34a, and we suggest the use of ginkgetin as an inducer of G(2) arrest for the treatment of CRC.</P>
Quality Characteristics and Antioxidant Activity of Malt Made with domestic Oats
Yu-Rim Lee,Seung-Hyun Sim,Da-Bin Kim,Kang-Hyun Chung,Jeung Hee An 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was conducted to investigate the quality characteristics and antioxidant activity of malt made from oats. The moisture content of the oat malt was contained 7.33%. The pH, total sugar content, and soluble solid of the oat malt was at 6.05, 119.95 mg/g, and 2°Brix, respectively. The color values of the malt were 56.37 at the L(lightness) value, 2.27 at a(redness) value, and 18.08 at the b(yellowness) value. The protein contents of oat were contained 13.83%. Also, the oat malts higher increased to 14.95% than the barley. The diastatic power was showed at oat malt (163.39 W.K), and higher increased than other malts. The domestic oat malt showed the highest total polyphenol, flavonoid content, and tannic acid. In addition, in the DPPH and ABTS radical-scavenging activity of domestic oat malt extract was increased in a dose-dependent manner and it showed a higher content than other malts. The domestic oat malt contained a higher reducing power than ascorbic acid at 700∼1000 μg/mL concentration. Therefore, these results suggest that domestic malts can be used effectively as functional foods with antioxidant activity or free radical scavenging activity.
Neuro anti-inflammatory effect of Green Tea on MPTP induced oxidative damage
Yu-Rim Lee,Gyo-Ha Moon,Kang-Hyun Chung,Kwon-Jai Lee,Jeong Hee Hong,Jeung Hee An 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The present study, the antioxidant capacities of 7 green teas were evaluated. Also, The Green tea protected againist MPTP-induced dopaminergic neurotoxicity in SH-SY5Y cells. Green tea noticeably alleviated the enhanced expression of pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, macrophage-1, and phosphorylated iκB-α. In addition, green tea reduced MPTP-induced oxidative damage by increasing the expression of anti-oxidant defense enzymes such as superoxide dismutase and glutathione S-transferase. Our results suggest that green tea are valuable for treating PD and other disorders associated with neuro-inflammatory and neuro-oxidative damage.
The functional properties of semi-femented tea
Yu-Rim Lee,Gyo-Ha Moon,Kang-Hyun Chung,Kwon-Jai Lee,Jeong Hee Hong,Jeung Hee An 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study investigated the antioxidant and anti-inflammatory effects of 7 semi-fermented tea from Korea and China. In the DPPH radical-scavenging activity (IC50), domestic oolong tea (Hadong) was 9.99 μg/mL, white tea was 10.44 μg/mL. In the evaluation of ABTS radical-scavenging activities, except Seogwihuang cha (Jeju) and Da Hong Pao tea, other samples showed a higher ABTS radical-scavenging effect compared to the ascorbic acid control group. White tea (Hadong) with a concentration of 100 μg/mL showed a significant nitric oxide (NO) inhibition activity compared to all the other samples by decreasing NO production to 46%. In the analysis of MPTP-induced dopaminergic neurotoxicity in SH-SY5Y cells, domestic white tea (Hadong), Da Hong Pao tea, and Junsan Yinchen tea at a concentration of 100 μg/mL showed results of 68.16%, 69.96%, and 69.14%, respectively. These results indicated 20% higher anti-inflammatory effects compared to the MPTP treatment group. Therefore, our results suggest that domestic semi-fermented tea has good antioxidant and anti-inflammatory effects and is expected to have high utility value as a functional food material.