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아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성
조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.
변유량,최홍식,조형용,권윤중,김주봉 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.1
The vertical column batch dryer which is suitable to Korean farm was constructed and dryer performance was investigated through field test. The effect of a drying air temperature and an airflow rate on the drying rate was studied, and an empirical drying equation was established. The average drying rate of paddy were 1.6-1.8%/hr at the air temperature of 43℃ and the airflow rates of 19.4 - 24.5 CFM/ft². The differences of grain moisture content between the inner and outer layer of vertical paddy bed were 0.5 - 0.9% The effect of a drying air temperature was larger at high airflow rate. At constant temperature, the drying rate was increased as an airflow rate was increased. The empirical drying equation could be expressed as followed: ??=0.9exp(??) Where K=3.22×?? The average whitening ratio of brown rice which was dried with column batch dryer was higher 0.6% than that of sun dried rice.
陸相元,李光揆,愈閏朝 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2
Young Chou Pyeong In Jul Gok deals with in Chapter 1 the size of stomach and the volume that contains water and food, and in Chapter 2, deals with the size of small intestine, large intestine, and anus, and also volume that contains water and food, and in Chapter 3, deals with the biological function of stomach and provides the reason that an ordinary man ought to die if he does not eat anything for seven days. Therefore this point is a very valuable material through which one can realize the degree of anatomical recognition about body of old oriental. The following result is gotten from the study of this remarks. 1. It is considered that 7 lit(three mals and five measures) is based upon the body alive not dead. 2. The whole length ,of small and large intestine-about 13m(five jang and five chuk and eight chi is calculated according to a tradition that I chuk is taken for 23.1cm during West Han dynasty) is about 3.55-5.6m longer than 8.40-9.45m in contemporary anatomy. 3. Small intestine includes a part of the duodenum, jejunum, large intestine, and large intestine is from the middle to descending colon, and anus is considered to include sigmoid colon and rectum. 4. It is not considered true that an ordinary man ought to die if he doesn't eat anything for seven days because in fact there are cases around that a few people have survived after fast for over 40 days.
排出物診斷에서 "諸病水液 澄澈淸冷 皆屬干寒"의 임상적 價値에 대한 文獻的 考察 : 鼻流, 喀痰, 구토를 중심으로
李光揆,姜昌洙,愈潤朝 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2
There are many ways to differentiate symptoms and signs in clinic, and among them are the ways to distinguish various symptoms and signs by comparing them without using natural philosophy and chemistry and tools in differentiating cold syndrome or hot syndrome, especially how to make the nature of illness clear by examining various abnormal condition of the secretion or dejecta is very useful in treatment. Here I report some findings about differential diagnosis of cold symptoms through the secretion or dejecta based on "Chebyeongsuaek Chingcheolcheongnaeng Kaesokuhan" of 'The Yellow Emperor's Canon of Internal Medicine·Chijinyodaeron, by literal study on the books about clinic. As a conclusion, the ejection seems to be trifling, but, in fact, it plays very important part in differentiating cold symptoms and hot symptoms. Though a medical examination using natural philosophy and chemistry is important, the ejection itself is much more important because it is very decisive in diagnosis of cold symptoms and hot symptoms.
(+)-Chromen 유도체의 합성 및 이들의 Wnt/β-catenin pathway 억제 활성 평가
이지현,조수현,윤은주,오유석,송규용 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
(+)-Decursin and GCK062, which is decursin derivative, showed strong inhibitory activity for Wnt/β-catenin signaling and suppressed concentration-dependently PC3 cell growth. These compounds have pyranocoumarin ring as backbone and acryloyl group as side chain. In this study, we introduced (+)-chromen ring as backbond, that is more simplified than pyranocoumarin, and synthesized (+)-chromen derivatives. As a results, in most cases, (+)-chromen derivatives disappeared or lowered the inhibitory activities for Wnt/β -catenin signaling. However (+)-chromen derivative (SLC-G005, 92.0%), introduced 3,4-dihydroxycinnamoyl group, showed potent inhibitory activity, not as much as GCK062 (99.5%).
( Yun Bin Lee ),( Jeong-hoon Lee ),( Hyeki Cho ),( Young Youn Cho ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jong In Kim ),( Jong Hun Im ),( Jung Hwan Lee ),( Eun Ju Oh ),( Jung-hwan Yoon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Aptamers are short synthetic oligomers that bind to protein targets on cancer cells. The human melanoma antigen-1 (MAGE-1), a member of MAGE gene family which encode tumor-specific antigens for autologous cytotoxic T cell recognition, is highly expressed in hepatocellular carcinoma (HCC) suggesting the possibility as a novel therapeutic target. We generated aptamers targeting MAGE-1 and assessed those therapeutic potentials in the treatment of HCC. Methods: MAGE-1 expression on the surface of HCC cells (SNU-761, Huh7, and SNU-3058) was assessed by immunofluorescence staining. Flow cytometry was performed to determine the binding affinity of the MAGE-1 aptamers, which were synthesized through systematic evolution of ligands by exponential enrichment (SELEX) method, to HCC cells. Cell proliferation was analyzed using the MTS assay. Results: MAGE-1 was highly expressed on the surface of SNU-761, Huh7, and SNU-3058 cells. Ten SELEX-derived MAGE-1 aptamers (representative aptamer; K<sub>d</sub>=0.01 nM, B<sub>max</sub>=0.28) were evaluated by flow cytometry for selection of high-affinity aptamers to HCC cells. Among MAGE-1 aptamers analyzed, one which showed high affinity to SNU-3058 cells (~34.6%) was selected for MTS assay. MAGE-1 aptamer treatment suppressed HCC cell growth under both normoxia and hypoxia compared to control aptamer. In a microarray, PFKFB4 gene expression was significantly reduced by MAGE-1 aptamer treatment with a -1.77-fold change in SNU-3058 cells, which were derived from hypovascular HCC. PFKFB4 encodes an enzyme, 6-phosphofructo- 2-kinase/fructose-2,6-biphosphatase 4, which is known to be overexpressed in cancer cells and induced under hypoxic condition. Real-time polymerase chain reaction analysis confirmed that the expression of PFKFB4 was decreased after MAGE-1 aptamer treatment in SNU-3058 cells. Conclusions: We demonstrated that newly developed MAGE-1 ap-tamer can bind to HCC cells with high affinity and inhibit HCC cell proliferation via PFKFB4 gene suppression. Further investigation of MAGE-1 aptamer as a novel targeted therapy for HCC is needed.
Yu Jin Jung,Boo Min Yun,Hyun Ji Kim,Yong Gu Cho,Ill Sup Noh,Kwon Kyoo Kang 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
UDP-glucose 4-epimerase (UGE; EC 5.1.3.2) is an enzyme that plays an essential role in the interconverts UDP-D-glucose (UDP-Glc) and UDP-Dgalactose (UDP-Gal). Five members of the Chinese cabbage (Brassica rapa) UDP-glucose 4-epimerase gene family, designated BrUGE1 to BrUGE5, have been cloned and characterized. Quantitative PCR shows that the BrUGE1and BrUGE4 mRNA are most abundant among other BrUGE genes, accounting for more than 55% of total BrUGE transcripts in most of the tissues examined. All genes showed organ specific expression pattern, two of which (BrUGE1 and 4) actively responded after Pectobacterium carotovorum subsp. carotovorum infection, while four genes (BrUGE-1, -3, -4 and -5)were shown to respond considerably against salt, drought and abscisic acid (ABA) treatments. To better understand the function of the UGE gene, we constructed a recombinant pART vector carrying the BrUGE1 gene under the control of the CaMV 35S promoter and nos terminator and transformed using Agrobacterium tumefaciens. We then investigated BrUGE1 overexpressing rice lines at the physiological and molecular levels under biotic and abiotic stress conditions. Bioassay of T3 progeny lines of the transgenic plants in Yoshida solution containing 120 mM Nacl for 2 weeks, confirmed that the BrUGE1 enhances salt tolerance to transgenic rice plants. Also T3 progeny lines of the transgenic plants, when exposed to infection caused by Xanthomonas oryzae pv oryzae, showed tolerance to bacterial blight. These results showed that BrUGE1 can be used as potential genetic resource for engineering Brassica with multiple stress resistance.