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전라이(Jeon Ra-Ei),전현우(Jeon Hyun-Woo),유용신(Yu Yong-Sin),정인수(Jung In-Su),권춘안(Kwon Choon-An),이찬식(Lee Chansik) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)
The Regulations related Asbestos management were strengthened, while knowing harmful to the human. But it meet the legal requirement. This study extracted 29 asbestos management factors and used IPA Analysis for selecting the factors which need to improve preferentially. As a result, this study confirmed need for improving 13 management factors. This finding will be used as basic data for development of the asbestos management manual.
Role of food and clay particles in toxicity of copper and diazinon using <i>Daphnia magna</i>
Jeon, Junho,Sung Ra, Jin,Hong Lee, Sun,Lee, Myun J.,Yu, Seung H.,Don Kim, Sang Elsevier 2010 Ecotoxicology and environmental safety Vol.73 No.3
<P><B>Abstract</B></P><P>Toxicity changes in copper and diazinon were investigated in the presence of food, clay, and their mixture by using <I>Daphnia magna.</I> In sorption equilibrium experiments, copper was significantly attracted (>34% sorbed) to food, clay, and food–clay mixture due to their negative zeta potential, while diazinon was less sorbed (<11%). In the exposure test with food and clay particles, it was revealed that copper was remarkably reduced in the presence of clay particles indicating the change in bioavailability of copper by sorption to clay. This was considered as the primary mechanism for toxicity reduction whereas diazinon toxicity was food dependent in the analysis of toxicity using toxicity change index (TCI). It was also shown that certain foods could not only act as a sorbent to copper and diazinon, but also as a material of energy source to alleviate the toxic damage. Meanwhile, clay can be considered as a prominent sorbent to copper but not to diazinon and can inhibit the sorption interaction between foodstuffs and toxicants through the aggregation and sedimentation processes. Furthermore, clay particles, as shown in TCI analysis, may be a potentially risky material as a physiological stressor or a toxicant carrier in contaminated environments.</P>
다이버의 일회성 저수온 노출이 혈중 FGF21, Irisin 및 T3에 미치는 영향
전유나 ( Yu Nah Jeon ),라승구 ( Seung Goo Ra ),김창근 ( Chang Keun Kim ) 한국운동생리학회 2015 운동과학 Vol.24 No.3
PURPOSE: It has been understood that brown fat or beige adipose tissues can facilitate heat production through non-shivering thermogenesis. FGF21, irisin, or T3 hormones are believed to enhance brown fat activation and increase in cold environment and exercise. The purpose of this study was to determine the changes of circulating FGF21, irisin, T3 hormone concentrations during the acute diving activity in divers who have been undergone long-term intermittent cold exposure. METHODS: Seven SCUBA divers who have been diving at least for 5 years with 50 to 100 diving records per year participated in this study. A bout of acute diving was performed in the east sea (13-14 ℃) for 30 min. Blood samples were obtained from arm vein at pre- and post-diving, and after an hour recovery. Serum FGF21, Plasma irisin and serum T3, TG and FFA were assayed. RESULTS: Serum FGF21 level was increased after 30 min of diving (p=.043, 138%) compared to pre-diving and after one hour of recovery to pre-diving level (p=.018, 65%). However, plasma irisin, T3 , FFA, TG levels were unchanged both after post-diving and one hour recovery (p>.05). CONCLUSIONS: It is concluded that heat generation through non-shivering thermogenesis may play a major role during the acute diving activity in divers who have been undergone long-term intermittent cold exposure.
( A Ra Shim ),( Yu Im Hwang ),( Kyung Jin Lim ),( Young Mi Choi ),( Young Eun Jeon ),( Seok Kyo Seo ),( Si Hyun Cho ),( Young Sik Choi ),( Byung Seok Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.11
Objective To evaluate the clinical, hormonal and metabolic characteristics according to luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in women with polycystic ovary syndrome (PCOS). Methods A total of 225 women with PCOS were included in this study. They were divided into two groups according to LH/FSH ratio; group A (LH/FSH < 2, n=160) and group B (LH/FSH > 2, n=65). We compared clinical, hormonal and metabolic characteristics including age at menarche, body mass index (BMI), blood pressures, ovarian volume, and serum androgen levels between the two groups. Serum glucose and insulin levels, fasting glucose/insulin ratio, homeostatic model assessment of insulin resistance (HOMA-IR), and lipid profi les were also compared between the two groups. Pearson correlation coeffi cients were used to evaluate correlation between the LH/FSH ratio and various parameters. Results Age of menarche in the group B was signifi cantly later than that in the group A. BMI, waist-hip ratio and blood pressures were signifi cantly lower in the group B compared to those of the group A. Ovarian volume and serum levels of LH, estradiol, total testosterone, sex-hormone binding globulin, 17-hydroxyprogesterone (OHP), and high density lipoprotein were signifi cantly higher in the group B. Postprandial 2 hours glucose, insulin and HOMA-IR were signifi cantly higher in the group A. After adjustment of BMI, the LH/FSH ratio was signifi cantly positively correlated with age at menarche, ovarian volume, total testosterone levels, and 17-OHP levels. Conclusion The inappropriate gonadotropin secretion may be negatively correlated with BMI, and positively with age of menarche and increased ovarian androgen production irrespective of BMI in women with PCOS. However, it may not be associated with metabolic characteristics.
갱년기 장애에서 인태반 추출물 주사제의 효과 및 안전성에 대한 평가
박유란 ( Yu Ran Park ),김소라 ( So Ra Kim ),전균호 ( Gyun Ho Jeon ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),서창석 ( Chang Suk Suh ),이병석 ( Byung Soek Lee ),최훈 ( Hoon Choi ),박형무 ( Hyoung 대한폐경학회 2009 대한폐경학회지 Vol.15 No.3
연구목적: 현재 인태반추출물은 간 기능 개선 및 갱년기 증상 개선제로 허가되어 시판되고 있다. 하지만 아직까지는 각각의 효능에 대한 객관적인 검증이 거의 이루어지지 않았고 또한 이에 대한 기전 및 부작용 등에 대해 연구가 부족한 실정이다. 따라서 본 연구에서는 현재 널리 이용되고 있는 인태반 추출물 주사제의 갱년기 장애 증상 호전 효과를 평가하고 주사제의 유효성 및 안전성을 검증하고자 하였다. 연구재료 및 방법: 서울의 5개 기관을 방문한 만40세 이상의 여성 중 폐경이 확인되고 열성 홍조 증상을 호소하는 지원자를 모집하였다. 총 130명의 지원자를 대상으로 하여 이중 맹검법을 이용하여 무작위로 시험군과 대조군으로 나누었다. 이후 이중 맹검법을 이용하여 2주간 방문하여 시험군에는 인태반 추출물을 대조군에는 위약을 피하조직에 총 6회를 시행하였다. 이후 KI (Kupperman Index)점수, 열성 홍조 점수 개선 정도를 비교, 측정하도록 하였고 이에 대한 결과를 비교하였다. 이후 객관적인 수치의 비교를 위해 투약 전후의 E2, FSH 농도를 측정하여 이를 비교 하였다. 또한 인태반 추출물의 안정성을 평가하기 위해 투약 후 이상반응, 활력 징후 등을 WHOART 기준에 의해 측정하여 이상반응을 평가하였다. 결과: 주관적인 지표인 KI 점수는 유의하게 호전(P=0.0013) 되었으나 그 외 열성 홍조 변화량(P=0.8044)이나 객관적인 지표인 E2, FSH 농도는 변화가 없었다 (E2 농도, P=0.7665, FSH 농도, P=0.3577). 또한 투약 후 유의한 이상반응은 관찰되지 않았다 (χ2-test, P=0.7037). 결론: KI 점수의 경우 두 그룹간에 유의한 차이를 보였으나 열성 홍조 점수는 차이를 보이지 않았다. E2, FSH 농도도 또한 두 그룹간에 차이를 보이지 않았다. 인태반 추출물 사용시 의미 있는 부작용은 관찰되지 않았다. Objectives: In Korea, human placental extract (HPE) has been approved as a therapeutic agents for chronic liver diseases and menopause syndrome. However evidence-based studies about the effectiveness, mechanism of action, and side effects of HPE are incomplete. The aim of this study was to examine the effects of HPE on menopausal symptoms, and safety in middle-aged Korean women in a double-blind randomized controlled trial. Methods: Korean women >40 years of age, with menopausal symptoms and hot flushes were recruited as participants in 5 university hospitals in Seoul, Korea. The 130 women were randomly assigned as followed to a double blind test: the HPE group (n=66) received 6 subcutaneous injections of HPE for 2 weeks; the placebo group (n=64) received normal saline. The KI (Kupperman index) score, severity of hot flushes were and concentrations of E2 and FSH in serum were measured. The side effects of HPE were assessed. Results: The KI score was decreased significantly after 2 weeks of HPE treatment compared with the placebo group (P=0.0013); however, the severity of the hot flushes were not different between the two groups (P=0.8044). The E2 and FSH levels of the HPE group were not significantly increased at 2 weeks after HPE treatment compared with of the placebo group (E2 level, P=0.7665, FSH level, P=0.3577). No evidence of side effects were observed in either group (χ2-test, P=0.7037). Conclusion: The KI score in middle-aged Korean women improved after 2 weeks of HPE treatment, whereas the difference in hot flushes, and E2 and FSH levels did not change during the study period. No evidence of significant side effects were observed in patients treated with HPE. (J Korean Soc Menopause 2009;15:178-185)