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Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
Yu-Jin Hwang,Hye-Im Woo,Inhye Kim,Dong-Sik Park,Jaehyun Kim,Ae-Son Om,Kyung-A Hwang 경상대학교 농업생명과학연구원 2011 농업생명과학연구 Vol.45 No.5
We investigated the inhibitory effects of solvent extracts from Ailanthus altissima in A549 human lung cancer cell. A. altissima has been recognized as a traditional healthy food due to its various biological activities against hypertension, strokes, fever, pain, neuralgia, inflammation, and cancer effects. Recently, it has been reported that the extracts of various wild vegetables show strong anti-cancer properties by induction of apoptosis. However, the mechanisms of their cytotoxicity in human lung cancer cells have been poorly understood. The present study was investigated the effects of solvent extracts from A. altissima on cell growth and apoptosis on A549 human lung cancer cells. A treatment of A. altissima inhibited the growth of A549 cells in a dose-dependent manner by inducing apoptosis. Especially, the chloroform fraction showed the highest anti-cancer effect among five kinds of fractions. And also, induction of apoptosis by chloroform fraction were associated with down-regulation of Bcl-2, and up-regulation of pro-apoptotic Bax expression. From these results, A. altissima may have a therapeutic potential in human lung cancer cells and as a functional food.
Immunomodulatory Effect of Petasites japonicas on Murine Splenocytes
Yu-Jin Hwang,Hye-Im Woo,Dong-Sik Park,Jaehyun Kim,엄애선,Kyung-A Hwang 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.4
Recently, people are stepping up their efforts to prevent a disease and keep optimum health. Especially,the modulation of the immune responses to alleviate the diseases has been of interest for many years. Although Petasites japonicas have been used as one of the traditional remedies as well as food sources,few studies on their immunomodulating effects have been reported. The result indicated that the extract was able to increase the proliferation B, T lymphocytes compared to no mitogen group. Additionally,we measured several cytokines such as IL-2, IL-4, IFNγ and TNFα which were related with immunoregulation. The result of this study suggest that Petasites japonicas water extract could regulate the immune function by increasing the splenocyte proliferation. (Cancer Prev Res 16, 311-317, 2011)
Hwang, Yu Im,Sung, Na Young,Koo, Hwa Seon,Cha, Sun Hwa,Park, Chan Woo,Kim, Jin Yeong,Yang, Kwang Moon,Song, In Ok,Koong, Mi Kyoung,Kang, Inn Soo,Kim, Hye Ok The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.3
Objective: To evaluate correlations between serum anti-M${\ddot{u}}$llerian hormone (AMH) levels, phenotypes of polycystic ovary syndrome (PCOS), obesity, and metabolic parameters in patients with PCOS. Methods: A total of 175 patients with PCOS were diagnosed according to the Rotterdam Consensus were included. Exclusion criteria were age over 40, FSH>25 mIU/mL, and 17a-OHP>1.5 ng/mL. The Phenotypes of PCOS were divided into a severe form (oligo-anovulation, ANOV/hyperandrogenism/polycystic ovary morphology [PCOM]; n=59) and a mild form without HA (ANOV/PCOM, n=105). The serum AMH levels were classified into 3 groups (<5 vs. 5-10 vs. >10 ng/mL). Obesity was defined as body mass index (BMI) ${\geq}25kg/m^2$ (n=34). Results: The mean age was $25.9{\pm}5.7$ year and mean AMH level was $10.1{\pm}5.4$ ng/mL. The BMI ($kg/m^2$) was higher in group 1 ($24.2{\pm}6.3$) than in group 2 ($21.9{\pm}4.3$, p=0.046) or group 3 ($21.6{\pm}3.3$, p=0.019). There was no difference among the three groups in age, menstrual interval, antral follicle counts, androgens, or other metabolic parameters. The obesity group showed significantly lower AMH ($7.7{\pm}3.9$ ng/mL vs. $10.7{\pm}5.6$ ng/mL), p=0.004) and low-density lipoprotein levels ($93.1{\pm}21.2$ mg/dL vs. $107.5{\pm}39.3$ mg/dL, p=0.031), and showed higher total T ($0.74{\pm}0.59$ L vs. $0.47{\pm}0.36$ ng/mL, p=0.001), free T ($2.01{\pm}1.9$ vs. $1.04{\pm}0.8$ pg/mL, p=0.0001), and free androgen index ($6.2{\pm}7.9$ vs. $3.5{\pm}3.0$, p=0.003). After controlling for age factors and BMI, the serum AMH levles did not show any significant correlations with other hormonal or metabolic parmeters. Conclusion: For PCOS patients under the age 40, serum AMH is not negatively correlated with age. High serum AMH levels can not predict the phenotype of PCOS and metabolic disturbances in PCOS patients in the non-obese group. Further study might be needed to define the relation more clearly.
단일기관 부인과 환자의 산과력을 토대로 살펴본 한국여성의 유산율
황유임 ( Yu Im Hwang ),심아라 ( A Ra Shim ),이마리아 ( Maria Lee ),남은지 ( Eun Ji Nam ),김성훈 ( Sung Hoon Kim ),김영태 ( Young Tae Kim ),박용원 ( Yong Won Park ),김상운 ( Sang Wun Kim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2
목적: 우리나라의 인공임신중절의 수준이나 특성 등에 대한 파악이 필요한 현시점에서 세브란스병원에 입원한 부인과 환자들의 산과력을 파악하여 우리나라 여성들의 유산력과 인공임신중절의 실태를 이해하는데 도움을 얻고자 하였다. 연구방법: 2005년 11월부터 2011년 4월 현재까지 본원에 입원하였던 부인과 환자 10,601명의 입원기록내 산과력을 토대로 연령에 따른 산과력의 경향을 파악하고, 연령에 따른 총 임신력에 대한 유산력의 분율 및 총 유산력에서 인공임신중절이 차지하는 분율 등을 비교하였다. 결과: 환자들의 평균 연령은 43.1세(범위, 10-90세)였고, 평균 임신력은 2.65±2.31회, 평균 출산력과 유산력은 각각 1.47 ± 1.34과 1.18 ± 1.50회였다. 출산력과 임신력은 높은 연령군일수록 횟수가 증가하는 양의 상관관계를 보였고, 인공임신중절은 60-69세와 70-79세 두 연령군에서 모두 1.8회로 가장 높았다. 총 임신력에 대한 유산력의 분율은 젊은 연령층일수록 증가하였고(10-19세, 0.95; 20-29세, 0.80), 총 임신 중 유산된 분율은 0.44로 나타났다. 또한 총 유산력에 대한 인공임신중절의 분율은 0.84이었고, 10-19세 연령군에서 0.95로 가장 높았고 30-39세 연령군에서는 0.72로 가장 낮았다. 결론: 부인과 환자들의 산과력을 토대로 파악한 이러한 자료는 우리나라 여성 전체의 산과력에 있어서의 경향과 인공임신중절의 실태를 이해하는데 도움이 될 것으로 생각되며, 이는 더 나아가 보다 현실적인 모자보건법 개정을 위한 중요한 정보를 제공할 것이다. Objective: This study aimed to help to understand the Korean women`s obstetrical history, especially abortion history, based on the medical records of gynecologic patients admitted to Severance Hospital. Methods: We identified the tendency of the obstetrical history and investigated the proportion of abortion to gravidity and the proportion of induced abortion to total abortion according to the age group, based on the obstetrical history on admission note of 10,601 patients, who were admitted to our hospital from November 2005 to April 2011. Results: The mean age of the patients was 43.1 years (range, 10 to 90 years) and the mean gravidity was 2.65 (±2.31). The mean parity and abortion number was 1.47 (±1.34) and 1.18 (±1.50), respectively. The higher age groups tended to have increased number of gravidity and parity. Number of induced abortion was highest in the age group 60-69 and 70-79 years (1.80±1.99 and 1.80±2.35, respectively). The total abortion proportion was 0.44 and the proportion of total abortion to gravidity tended to increase in the younger age groups (age group 10-19: 0.95 and 20-29: 0.80). The proportion of induced abortion to total abortion was 0.84 in total. The proportion was highest in the age group 10-19 years (0.95) and lowest in the age group 30-39 years (0.72). Conclusion: This data based on the medical records of gynecologic patients will provide important information for the amendment of the new law on abortion.
황유임 ( Yu Im Hwang ),손가현 ( Ga Hyun Son ),김영한 ( Young Han Kim ),권자영 ( Ja Young Kwon ),박용원 ( Yong Won Park ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1
폐분리증은 기관지폐 앞창자 기형의 드문 형태로 정상적인 기관-기관지 나무로부터 분리되어 있어 기능을 하지 못하는 폐실질 조직으로 정의하며 체순환으로부터 혈액공급을 받는 특징을 가진다. 폐분리증은 초음파상에서 초음파 반향이 증가된 종괴로 관찰되며, 도플러상에서 대동맥에서 종괴로 가는 혈액공급을 확인하게 되는 경우 폐분리증의 진단이 용이해 진다. 저자들은 임신 21주에 산전초음파상 종격동 종괴로 관찰되었으며, 출생 이후 흉강경을 이용한 종괴 절제술을 통해 병리학적으로 종격동에 위치한 폐분리증으로 확진된 1예를 경험하였기에 간단한 문헌고찰과 함께 국내에서 최초로 보고하는 바이다. Pulmonary sequestration is a developmental anomaly of broncho-pulmonary foregut with nonfunctioning parenchymal tissue, which usually supplied by systemic circulation. Pulmonary sequestration is detected by ultrasonography as a homogeneous echogenic mass and also by Doppler blood flow from systemic circulation to the mass. Pulmonary sequestration is classified into intralobar type and extralobar type. Extralobar type accounts for only 15~25% of the cases and it is subdivided into intrathoracic forms, which are most commonly found and extrathoracic type, which includes intraabdominal, retroperitoneal, or mediastinal masses. We report a rare case of prenatal detection of mediastinal mass with a brief review of literatures, which was confirmed to be a pulmonary sequestration by surgical mass excision after birth.
Anti-allergic Effect of Sword Bean Pod (Canavalia gladiata) in IgE-Sensitized RBL-2H3 Cells
Kyung-A Hwang,Hye-Jeong Hwang,Yu-Jin Hwang,Jeong Yeon Im 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Recently, the incidence of allergic diseases such as asthma and rhinitis is increasing due to changes in living environments such as fine dust and pollen. As allergic diseases increase, the treatment of allergic diseases is also being constantly developed, but long-term use of drug is accompanied by side effects such as cataracts and skin rashes. Therefore, we are focusing on discovering treatments made from natural products that are safe for the body and maximize the effect. Sword Bean Pod(SBP; Canavalia gladiata), which was recently registered as a food ingredient, has been reported to be effective in improving inflammatory diseases, but there is still no scientific basis for its anti-allergic effect. Therefore, in this study, we investigated the anti-allergic effect of SBP. As a result, SBP were decreased the gene expression levels of pro- and anti-inflammatory cytokines when the IgE-sensitized RBL-2H3 cells. Furthermore, by regulating the protein expression of cytokines and IgE receptor related factors, SBP was confirmed to be effective in anti-allergy. These findings may have a potential clinical implication in not only prevention but also treatment of allergic diseases.