Efficacy of Frozen-Thawed ET in Patients with Old Age or Non-Pregnant in Fresh ET Cycles

최수진,이선희,송인옥,궁미경,강인수,전진현,Choi, Su Jin,Lee, Sun Hee,Song, In Ok,Koong, Mi Kyoung,Kang, Inn Soo,Jun, Jin Hyun The Korean Society for Reproductive Medicine 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.4

목 적: 동결-융해 배아이식은 보조생식술에서 환자들에게 보다 많은 임신의 기회를 제공해줄 수 있는 방법으로 이용되고 있다. 본 연구에서는 예후가 좋지 않은 환자들에서 동결-융해 배아이식의 효용성을 알아보고자 하였다. 연구방법: 나이가 많은 고령 환자군 (38~44세)과 신선주기 배아이식에서 임신 실패군을 연구대상으로 하였다. 과배란 유도를 통해 채취한 난자를 일반적인 체외수정 또는 세포질내 정자주입술을 시행하여 수정을 유도하고, 잉여의 전핵 또는 난할 시기의 배아를 완만동결법으로 동결하였다. 동결보관 배아는 급속융해법으로 융해하여 호르몬요법을 시행한 환자의 자궁에 이식하였다. 신선 배아이식과 동결-융해 배아이식 과정에서의 배아 상태, 임신율, 착상률 등을 통계적인 방법으로 분석하였다. 결 과: 나이가 많은 고령군에서 신선 배아이식을 시행한 환자들과 동결-융해 배아이식을 시행한 환자들의 평균 연령은 $40.0{\pm}1.8$세 (n=206)와 $39.9{\pm}1.9$세 (n=69)로 통계적으로 유의한 차이가 없었으나, 임상적인 임신율과 착상률은 동결-융해 배아이식에서 29.0%와 11.2%로 신선 배아이식의 16.5%와 7.0%에 비해 통계적으로 유의하게 높게 나타났다. (p<0.05). 첫 번째 신선 배아이식에서 임신 실패군의 연속되는 신선 배아이식 환자군 ($31.2{\pm}2.3$, n=40)과 동결-융해 배아이식 환자군 ($31.9{\pm}3.1$, n=119)에서의 평균 연령은 차이가 없었으며, 임상적 임신율 (42.5% vs 40.3%)과 착상률 (22.6% vs 18.8%)도 유사하였다. 결 론: 본 연구에서는 동결-융해 배아이식이 고령 환자들에서 효과적으로 임신율과 착상률을 높일 수 있음을 보여주고 있다. 이러한 결과는 과배란 유도에 따른 자궁의 착상 환경 변화가 고령 환자들에서 임신율과 착상률을 저하시키는 것과 관련이 있을 것으로 생각된다. Objective: The aim of this study was to evaluate the efficacy of frozen-thawed ET in poor prognosis patients such as the old age (38~44 years; OA group) and the patients who did not achieve clinical pregnancy with the first fresh ET cycle (non-pregnant patients; NP group). Methods: Laboratory and clinical data were collected from fresh and frozen-thawed ET cycles of OA and NP group. Controlled ovarian hyperstimulation (COH) and conventional insemination or ICSI, in vitro culture and ET were performed by routine procedures. Supernumerary embryos were frozen by the slow freezing method, and frozen embryos were thawed by the rapid thawing method. Embryo development, pregnancy and implantation rates were statistically analyzed by Student t-test and chi square test Results: Mean ages were similar between fresh ET ($40.0{\pm}1.8$ years, n=206) and frozen-thawed ET ($39.9{\pm}1.9$ years, n=69) cycles in OA group. However, the clinical pregnancy and implantation rate of subsequent frozen-thawed ET significantly higher than those of fresh ET cycles (29.0% and 11.2% vs. 16.5% and 7.0%, p<0.05). In NP group, there was no difference in the mean age between fresh ET ($31.2{\pm}2.3$ years, n=40) and frozen-thawed ET ($31.9{\pm}3.1$ years, n=119) in subsequent cycles. The clinical pregnancy and implantation rates were similar between the subsequent fresh ET (42.5% and 22.6%) and the frozen-thawed ET (40.3% and 18.8%). Conclusion: In old age patients, higher pregnancy rate of frozen-thawed ET compared to fresh ET cycles in this study. It may be related that better uterine environments for implantation in frozen-thawed ET cycles than that of non-physiological hormonal condition in uterus of fresh COH cycles.

SCV 가솔린 엔진의 운전조건에 따른 희박연소 특성

최수진,전충환,장영준,Choi, Su-Jin,Jeon, Chung-Hwan,Chang, Young-June 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.2

Lean combustion in a SI engine is one of the best solution for the improvement of fuel economy and reduction of pollutant emission. In order to access a lean combustion engine, stable combustion at lean AlF ratio is needed. In this paper, the effect of fuel injection timing on lean misfire limit has been investigated in an MPI engine. To investigate the interaction of injection timing and intake flow characteristics, three different swirl generating SCV(swirl control valve) configurations were considered, and investigated their effects on lean misfire limit and torque at full load operation. Also the effects of spark timing on lean combustion has been investigated. Lean combustion has been examined and the results are reported in this paper. SCV B has been developed to satisfy the requirements of sufficient swirl generation to improve lean combustion and stable performance. It is found that injection timing, spark timing and intake air motion govern the stable lean combustion.

유동 강화형 밸브의 형상에 따른 정상 유동 특성

최수진,류기현,전충환,장영준,Choi, Su-Jin,Ryoo, Ki-Hyun,Jeon, Chung-Hwan,Chang, Young-June 대한기계학회 1999 大韓機械學會論文集B Vol.23 No.2

The flow characteristics of 2-valve and 4-valve cylinder heads with various blocked-valve were experimentally investigated in a steady flow rig. Effects of the blocked-valve configurations on flow coefficient, swirl and tumble intensity are studied. Compared to the conventional valve, the blocked valve in both cylinder heads have the much lower flow coefficient and the much higher intensity of swirl and tumble. Under the same size of blockage, the value of flow coefficient and swirl(or tumble) intensity were varied according to the position of blockage. Throughout these steady flow test the optimized positions of blockage in both cylinder heads were determined.

생쥐 난자의 효율적인 냉동보존 방법 확립을 위한 연구

최수진,김수경,김지선,조재원,전진현,변혜경,Choi, Su-Jin,Kim, Soo-Kyung,Kim, Ji-Sun,Cho, Jae-Won,Jun, Jin-Hyun,Byun, Hye-Kyung 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.1

Objective: The purpose of this study was to evaluate the efficacy and effect of various cryopreservation method on the survival and the cytoskeletal stability of metaphase II mouse oocyte. Methods: Mouse ovulated oocytes were collected and cryopreserved by a modified slow-freezing method with 1.5 M 1, 2-propanediol (PrOH)+0.1 M sucrose or by vitrification using cryo loop and EM grid with 40% ethylene glycol+0.6 M sucrose. Four hours after thawing, intact oocytes were fixed and stained with fluorescein isothiocyanate (FITC)-conjugated monoclonal anti-$\beta$-tubulin antibody to visualize spindle and propidium iodide (PI) to visualize chromosome. Spindle morphology was classified as follows: normal (barrel-shaped), slightly and absolute abnormal (multipolar or absent). Results: Survival rate of the frozen-thawed oocytes in vitrification group was significantly higher than that of slow-freezing group (62.7% vs. 24.4%, p<0.01). Vitrification with cryo loop showed significantly higher survival rate than that with EM grid (67.7% vs. 53.5%, p<0.05). On the other hand, proportion of normal spindle and chromosome configurations of the frozen-thawed oocytes between two vitrification group was not significantly different. Conclusion: For mouse ovulated oocytes, vitrification with cryo loop may be a preferable procedure compared to slow-freezing method. Further study should be needed to investigate developmental competency of frozen-thawed mouse oocytes.

특수교사가 인식하는 자폐범주성장애 아동의 식행동 및 식품기호도와 영양교육 요구도

최수진,오지은,김유리,김유리,Choi, Su Jin,Oh, Ji Eun,Kim, Yu-Ri,Kim, Yuri 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.1

The purpose of this study was to provide basic information on the development of nutrition education programs to improve the mealtime behavior of children with autism spectrum disorder (ASD) by investigating the mealtime behavior and food preferences of children with ASD through the perception of special education teachers. Surveys were given to 108 special education teachers in special education schools in Korea regarding the demographic characteristics, nutrition education support needs, mealtime behavior, and food preferences of children with ASD. Most of the special education teachers responded that nutrition education in special schools had not been conducted properly and nutrition education for ASD children is necessary. Mealtime behavior analysis classified the behavior into three clusters: cluster 1, 'less problematic mealtime behavior'; cluster 2, 'general feature of autism'; cluster 3, 'difficulty in self-directed diet'. The age, eating habits, and food preferences were different according to each mealtime behavior cluster. Therefore, it will be necessary to develop a nutrition education program based on the characteristics of mealtime behavior.

달 궤도 진입 목표값 변화에 따른 궤도요소 변화 연구

최수진,김인규,문상만,민승용,류동영,Choi, Su-Jin,Kim, In-Kyu,Moon, Sang-Man,Min, SeungYong,Rew, Dong-Young 항공우주시스템공학회 2015 항공우주시스템공학회지 Vol.9 No.4

Korea Aerospace Research Institute(here after KARI) has a plan to launch experimental lunar orbiter in 2018, and lunar orbiter and lander in 2020. There are several ways to go to the moon. Which one is direct transfer trajectory and another one is phasing loop transfer trajectory and the other one is WSB trajectory. Regardless of the transfer trajectories, LOI maneuver is the most important maneuver of all mission sequences because if this burn is failed, it is too difficult to get into the lunar orbit in the future. This paper describes first LOI target value of foreign lunar orbiters and analyzes orbital variations of experimental lunar orbiter according to various target values. By analyzing the variation of orbiter parameter after first LOI, proper orbital period for LOI target value are recommended to meet the inclination, apoapsis and periapsis altitude constraints.

국내 제주도에서 수집된 Propolis의 특성 및 생리활성

최수진(Su Jin Choi),박선일(Sun-Il Park),안목련(Mok-Ryeon Ahn) 한국양봉학회 2011 韓國養蜂學會誌 Vol.26 No.4

Propolis is a resinous substance honeybees forage from the buds and exudates of certain trees and plants which is then stored inside the beehives. Jeju is a southern island of Korea with a subtropical climate. The aim of this study is to examine the amount of total polyphenol and flavonoid contents and the antioxidant activity of the ethanol extracts of propolis (EEP) from Jeju Island. EEP were evaluated for antioxidant activities by β-carotene bleaching, 1,1-diphenyl-2-picylhydrazyl (DPPH) free radicalscavenging, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization, ferric reducing ability of plasma (FRAP) and inhibiting ability of soybean oil assays. Furthermore, we investigated the antibacterial and antifungal activities of propolis collected on Jeju Island. As a result, the amount of total polyphenol and flavonoid contents in Jeju Island propolis varied widely, ranging from 59.7 to 126.8mg/g of EEP and from 42.1 to 108.8mg/g of EEP, respectively. EEP samples were o bserved fifteen flavonoid and phenolic acid bands on high performance thin-layer chromatography (HPTLC) plate. Propolis from Bukjeju Nohyeung (J2) had relatively strong antioxidant activity accompanied by high total polyphenol, but that from Bukjeju Hallim (J5) had weak that. All EEP samples were more effective against gram-positive bateria than gram-negative ones and molds.

대장 스텐트 삽입 부위 염증에 의한 패혈증 환자에서 발생한 간문맥 혈전증

최수진 ( Su Jin Choi ),민지원 ( Ji Won Min ),윤종민 ( Jong Min Yun ),안혜신 ( Hye Shin Ahn ),한덕재 ( Deok Jae Han ),이현정 ( Hyeon Jeong Lee ),김영옥 ( Young Ok Kim ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.5

Portal vein thrombosis is an uncommon but an important cause of portal hypertension. The most common etiological factors of portal vein thrombosis are liver cirrhosis and malignancy. Albeit rare, portal vein thrombosis can also occur in the presence of local infection and inflammation such as pancreatitis or cholecystitis. A 52-year-old male was admitted because of general weakness and poor oral intake. He had an operation for colon cancer 18 months ago. However, colonic stent had to be inserted afterwards because stricture developed at anastomosis site. Computed tomography taken at admission revealed portal vein thrombosis and inflammation at colonic stent insertion site. Blood culture was positive for Escherichia coli. After antibiotic therapy, portal vein thrombosis resolved. Herein, we report a case of portal vein thrombosis with sepsis caused by inflammation at colonic stent insertion site which was successfully treated with antibiotics. (Korean J Gastroenterol 2015;65:316-320)

가시화엔진을 이용한 연소 및 라디칼 특성에 관한 연구

최수진(Su-Jin Choi),장영준(Young-June Chang),전충환(Chung-Hwan Jeon) 한국연소학회 1999 한국연소학회지 Vol.4 No.1

소형 액체상단을 이용한 달 탐사선 임무 예비설계

최수진(Su-Jin Choi),이훈희(Hoonhee Lee),이상일(Sang-Il Lee),임석희(Seok-Hee Lee),이기주(Keejoo Lee) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.11

달 탐사에서 발사체 상단은 주로 저궤도에 투입된 탐사선을 38만km의 거리에 위치한 달까지 투입해주는 역할을 한다. 해외의 경우 상단(Upper Stage)은 달 탐사선을 지구-달 전이궤적에 투입 후 탐사선과 분리되고, 달 탐사선은 그 이후 자체 추진제를 이용하여 중간 경로 수정 기동 및 달 궤도 진입을 수행한다. 본 연구는 새롭게 제시되는 소형 액체상단의 성능을 기술하였다. 습질량이 총 2.9 톤인 소형액체상단을 이용할 경우 달 탐사선을 지구-달 전이궤적 투입뿐만 아니라 달 궤도 진입까지 수행할 수 있다. 본 연구는 나로 우주센터에서 발사할 경우를 기준으로 허용 가능한 달 탐사선의 질량 범위를 도출하고, 탐사선의 허용 가능한 임무 범위도 다양하게 기술하고자 한다. Upper stage of launch vehicle has been mainly used for inject a lunar explorer from low earth orbit to the moon located 380,000 km away in lunar mission. In overseas cases, the upper stage is separated from the lunar explorer after the lunar explorer is injected into the earth-moon transfer trajectory, and the lunar explorer is performed mid-course correction maneuvers and lunar orbit insertion maneuvers by using on-board fuel. This study describes the performance of a upper stage mentioned newly proposed small liquid upper stage. For the small liquid upper stage that wet mass is 2.9 ton, this upper stage not only can inject earth-moon transfer trajectory but also can perform lunar orbit insertion. This study provides acceptable mass range of the lunar explorer and describes various acceptable mission range based on the launch from Naro Space Center.