http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Seungmee Lee ),( Se Jeong Kim ),( Maria Lee ),( Hee Seung Kim ),( Keewon Kim ),( Seung-bum Ryoo ),( Jeong-hwa Seo ),( Sang Youn Kim ),( Ji Won Park ),( Kyoung Sup Hong ),( Hak Jae Kim ),( Chang Wook 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Although nerve-sparing surgery has been introduced for female patients with the pelvic tumors, its efficacy is still controversial because of no consensus of the surgical technique and a lack of the physiologic understanding of the pelvic autonomic nerves. Thus, we developed a female animal model for anatomical and functional assessment of the pelvic autonomic nerves in women. 방법: We used female domestic swine, weighing 25 to 30 kg. All procedures were performed under sterile conditions, and anesthetic procedure was induced with ketamine and maintained with enflurane inhalation through intubation. We sacrificed three swine for the anatomical assessment, and eight swine for the functional assessment of the pelvic autonomic nerves. Moreover, we developed a new stimulation system using a bipolar instrument and peripheral nerve stimulator, and made a new monitoring system for evaluating contraction of bladder, vagina and rectum. 결과: Like human, we found bilateral sympathetic trunk and ganglions run beside aorta and inferior vena cava, and thin fibers from sympathetic ganglions joins together to become the superior hypogastric nerve on the aortic bifurcation, which runs bilaterally as the inferior hypogastric nerves. Moreover, we found parasympathetic nerves from S2-S4, which join together with inferior hypogastric nerves and form the pelvic plexus. Then, we found the rectal, vesical and uterine branches of the pelvic plexus. For the functional assessment, we simulated the pelvic parasympathetic nerves, and then found regular contraction in bladder and rectum. On the other hand, sympathetic nerve stimulation decreased the contraction. However, vaginal contraction was different. These results were similar to those from five patients with cervical cancer whose functions of the pelvic autonomic nerves were evaluated during surgery. 결론: The female swine model may be adequate for the anatomical and functional assessment of the pelvic autonomic nerves in women.
Segmental serosectomy of the rectosigmoid colon during optimal debulking surgery for ovarian cancer
( Seungmee Lee ),( Maria Lee ),( Hee Seung Kim ),( Hyun Hoon Chung ),( Jae Weon Kim ),( Noh Hyun Park ),( Yong Sang Song ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Demonstrate a new instrument, technique or procedure. 방법: We performed segmental serosectomy of the rectosigmoid colon in 19 patients with primary or recurrent ovarian cancer between July 2014 and December 2016. The inclusion criteria was as follows: epithelial ovarian cancer; primary or recurrent disease, high probability of optimal debulking surgery in intraoperative evaluation; tumor between cul-de-sac and the rectosimoid junction. We evaluated surgical time, maximal length of serosectomy, postoperative leakage and postoperative change of defecation. 결과: Among all patients, four (21.1%), two (10.5%), one (5.3%), five (26.3%) and six patients (31.5%) showed stage IIB, IIIA, IIIB, IIIC and IV disease, whereas one (5.3%) showed recurrent disease. After debulking surgery, we found no gross residual disease, residual tumor <5 mm and <10 mm in 16 (84.2%), two (10.5%) and one patients (5.3%), respectively. The median value of surgical time was 42 min (range, 32-85 min), and the median value of length of serosectomy was 10 cm (range, 8-15 cm). There was no patient showing postoperative leakage, and nobody did not complain of frequent defecation after the surgery. 결론: In selected patients with ovarian cancer, segmental serosectomy of the rectosigmoid colon may be feasible and safe without frequent defecation during postoperative period.
( Seungmee Lee ),( Maria Lee ),( Hee Seung Kim ),( Hyun Hoon Chung ),( Jae Weon Kim ),( Noh Hyun Park ),( Yong Sang Song ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Pegylated liposomal doxorubicin (PLD) is already used to treat ovarian cancer patients widely with single agent or combination with carboplatin/ bevacizumab. But in Korea, PLD supplied since Dec 2014., and there is lack of clinical data of patient who treated with PLD in Korean population. The aim of present study is to evaluate clinical outcomes and adverse effect of PLD in Korean patient with ovarian cancer. 방법: Between 2014 and 2015, 76 patients who were treated with PLD in our institution was evaluated retrospectively. 결과: The stage distribution at diagnosis was stage I in 4.4%, stage II in 7.4 %, stage III in 64.7% and stage IV in 23.5%. 45 patients were treated with PLD single agent, 28 patients with PLD and carboplatin, and 3 patients with PLD and bevacizumab combination therapy. In patient group with platinum- resistant recurrence (total 48 patients), 33 patients (68.7%) were progressed, 12 patients (25%) were stable disease and 1 patient showed partial response. But in patient group with platinum- sensitive recurrence (total 28 patients), 7 patient (25%) were progressed, 16 patients (57.1%) were stable disease and 4 patients (14.2%) showed partial reaponse. 6 patients (7.9%) had adverse effect and 1 patient discontinued treatment and changed chemotherapy regimen due to adverse effect. Identified adverse effect include hand foot syndrome (3.9%), oral mucositis (2.6%). 결론: PLD could be chosen for recurrent ovarian cancer patients with relatively mild adverse effects. But continuous data collection for Patient treated with PLD is needed to determine outcome and adverse effect in Korean patients.
Effect of Temperature and Solvents on Enzymatic Synthesis of Naringin Acetate
Seungmee LEE,Yesol BAEK,Jemin SON,Kyeonga KIM,Hyeseon LEE,Hah Young YOO,Jong-Min OH,Chulhwan PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Flavonoids are antioxidants found in nature, and naringin, a type of flavonoid, has strong antioxidant, antibacterial, and anticancer effects. However, the application of naringin to living organisms has difficulty due to its low solubility and stability in hydrophobic environments. These problems can be overcome by the acylation of naringin. This study aimed to synthesize naringin acetate by acylation of naringin and acyl donor using lipase and to obtain a high conversion through optimization of a synthesis reaction. To optimize the synthesis reaction, parameters that affect synthesis (enzyme type, enzyme concentration, acyl donors, ㏖ar ratio (naringin:acyl donor), reaction temperature, and the solvent) were analyzed with one factor at a time (OFAT) method. Under optimal synthesis conditions, the conversion was obtained over 95%. This study suggested efficient synthesis methods that can obtain higher conversion in a shorter reaction time.
( Seungmee Lee ),( Hyewon Chung ),( Tae-kyu Jang ),( Sang-hoon Kwon ),( Chi-heum Cho ),( Sojin Shin ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To determine the clinical role of p16 immunostaining in young women with moderate cervical dysplasia. Methods: The medical record of 160 patients who diagnosed moderate cervical dysplasia via cervical punch biopsy between 2018 and 2021 at Keimyung University Dongsan Hospital were reviewed retrospectively. All pathologic review was undergone with p16 immunostaining. Results: Of 160 patients who diagnosed moderated dysplasia by punch biopsy, 67.9% of patients underwent conization, 4.9% of patients hysterectomy, and 25.9% of patients regular follow-up test without additional treatment such as conization. Median age of each group is 41, 64 and 32, respectively. In young women, our institution preferred to avoid conization. In young age (19-35) group, the higher P16 expression in the immunostaining results of punch biopsy and conization.. The degree of expression of P16 in punch biopsy was not correlated with the severity of cervical dysplasia after conization. In addition, HPV type 16, 18, and 52 were most associated with the occurrence of severe dysplasia and squamous cell carcinoma in situ. Conclusion: P16 could be putative biomarker for cervical dysplasia and useful to predict prognosis of moderate dysplasia in young women.
( Seungmee Lee ),( Tae-kyu Jang ),( Hyewon Chung ),( So-jin Shin ),( Sang-hoon Kwon ),( Chi-heum Cho ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: This article is to introduce our initial experience of lower para-aortic lymph node dissection (PALND) using robotic single-site platform in patients with early stage gynecological cancer. Methods: Total 9 patients with a preoperative diagnosis of endometrial cancer stage IB and locally advanced cervical cancer stage IB1 underwent robotic single-site operation with PALND. At the beginning of the surgery after cervical injection of indocyanine green (ICG) dye using 1 mL (0.5 mL superficial and deep, respectively) into 3 and 9 oclock of the cervix submucosally, the patient was tilted to the left for PALND. Through a single multichannel port, PALND was performed using the Da Vinci Si Surgical System (Intutitive Surgical, Sunnyvale, CA) which was docked to patients right side. For detection of sentinel node Firefly fluorescence imaging is employed with ICG dye. After full PALND, the patient was tilted to back to the Trendelenburg position with Da Vinci Si Surgical System docked toward the patients between legs. Then we performed robotic single-site operation including total radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. Results: The operation was performed successfully without any intraoperative complication. The total operation time was reasonable including average 18 minutes of lower para-aortic lymphadenectomy, and the mean estimated blood loss was 50 mL. The mean hospital days were 4.7 days and the patients were discharged without any postoperative complication. However, there was one patient who was admitted in the hospital for 10 days due to lymphocele. Conclusion: Lower para-aortic lymph node dissection using robotic single site platform in early stage gynecological cancer may be the next step in minimally invasive approach for gynecological malignancy. With Firefly Technology the node dissection in early stage gynecological cancer by robot singe site platform will give enhanced visualization and potentially improves the surgical and clinical outcomes.
Trends in Robotic Surgery in Korean Gynecology
( Seungmee Lee ),( Mee-ran Kim ),( Seok Ju Seong ),( Jiheum Paek ),( Yoon S Lee ),( Eun Ji Nam ),( Yong-man Kim ),( Young-han Park ),( Tae Joong Kim ),( Yong Beom Kim ),( Tae Jin Kim ),( San-hui Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: The objective of this study is to discover the trends of robotic surgery in gynecology since the introduction of robotic surgery platforms in Korea. Methods: : Data for the use of robotic surgery in gynecologic diseases were collected from the 14 hospitals that perform most of the robotic gynecologic surgeries in Korea. Records of robotic surgeries from between 2006 and 2019 were selected (n = 12,405), and data including diagnoses, approach methods, and names of surgical procedures were obtained. Statistical analysis was performed, including a trend test. Results: Overall, robotic surgery in gynecology showed an increasing trend (p < 0.001). The common cases in which robotic surgery was used for benign diseases were uterine leiomyoma, adnexal tumors, and adenomyosis, which accounted for 68%, 17%, and 9% of benign cases, respectively. Common malignant diseases were cervical cancer, endometrial cancer, and ovarian cancer, accounting for 55%, 35%, and 5% of malignant cases, respectively. This increasing trend was significantly evident in uterine leiomyoma, both single-site and multiport approaches. Conclusion: Since robotic surgical platforms were introduced in Korea, the number of gynecologic robotic surgeries has grown rapidly. Considering these data, the use of robotic surgery is expected to grow continuously for both benign and malignant gynecological diseases. A large amount of minimal invasive surgeries are expected to be replaced with robotic surgeries.