Single-port and two-port Laparoscopic hysterectomy and adenxal surgery(초)

박유란 ( Yu Ran Park ),( Jeong Yeol Park ),( Dae Yeon Kim ),( Jong Hyeok Kim ),( Yong Man Kim ),( Young Tak Kim ),( Joo Hyun Nam ) 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-

일반부인과학

박유란 ( Yu Ran Park ),( Shin Wha Lee ),( Yeongsin Kim ),( In Young Bae ),( Hong-kyu Kim ),( Jaewon Choe ),( Yong-man Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: To assess the clinical usefulness and diagnostic accuracy of ultrasonographic measurement of endometrial thickness (ET) in women with endometrial hyperplasia or cancer (EH+). Methods: This retrospective cohort study included 29,995 consecutive women who underwent transvaginal ultrasonography (TVS) for an incidental finding of a thickened endometrium at the health screening and promotion center at Asan Medical Center between 2006 and 2010. Among 959 patients with endometrial abnormalities, 92 patients were included in this study. A total of 867 patients were excluded: 416 were lost to follow-up; 263 did not undergo endometrial biopsy; 155 had endometrial polyps; 17 had submucosal myomas; and 16 had insufficient tissue samples. Endometrial histology was the reference standard for calculating accuracy. Results: Of the 92 patients, 78 (84.8%) had normal pathology, while 14 (15.2%) had endometrial pathology (EH+), including 5 patients (35.7%) with simple hyperplasia without atypia, 3 (21.4%) with complex hyperplasia, and 6 (42.9%) with endometrial carcinoma, all stage Ia. The area under the receiver-operating characteristic curve was 0.75 (95% confidence interval [CI], 0.593-0.906). The cut-off value for ET was 8 mm, indicating that TVS ET had a fair accuracy in diagnosing carcinoma, had a sensitivity of 100% (95% CI, 62.9-100.0%) and a specificity of 24.3% (95% CI, 15.2-36.3%). Conclusion: TVS is useful for detecting EH+, with a cut-off value for ET of 8 mm having a high sensitivity for detecting endometrial pathologies and the ability to identify women highly unlikely to have EH+, thereby avoiding more invasive endometrial biopsy.

The effect of urban air particulate matters (PM2.5) on human tracheal epithelial cell in vitro

Yu-Ran Park(박유란),Hyeung-Uk-Yoo(유형욱),Seung-Min Oh(오승민),Kyu-Hyuck Chung(정규혁) 환경독성보건학회 2007 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

Role of free radicals in the genotoxicity of airborne fine particulate matter (PM2.5)

Yu-Ran Park(박유란),Hyun-Ji Oh(오현지),Yong-Joo Park(박용주),Seung-Min Oh(오승민),Kyu-Hyuck Chung(정규혁) 환경독성보건학회 2007 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

갱년기 장애에서 인태반 추출물 주사제의 효과 및 안전성에 대한 평가

박유란 ( Yu Ran Park ),김소라 ( So Ra Kim ),전균호 ( Gyun Ho Jeon ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),서창석 ( Chang Suk Suh ),이병석 ( Byung Soek Lee ),최훈 ( Hoon Choi ),박형무 ( Hyoung 대한폐경학회 2009 대한폐경학회지 Vol.15 No.3

연구목적: 현재 인태반추출물은 간 기능 개선 및 갱년기 증상 개선제로 허가되어 시판되고 있다. 하지만 아직까지는 각각의 효능에 대한 객관적인 검증이 거의 이루어지지 않았고 또한 이에 대한 기전 및 부작용 등에 대해 연구가 부족한 실정이다. 따라서 본 연구에서는 현재 널리 이용되고 있는 인태반 추출물 주사제의 갱년기 장애 증상 호전 효과를 평가하고 주사제의 유효성 및 안전성을 검증하고자 하였다. 연구재료 및 방법: 서울의 5개 기관을 방문한 만40세 이상의 여성 중 폐경이 확인되고 열성 홍조 증상을 호소하는 지원자를 모집하였다. 총 130명의 지원자를 대상으로 하여 이중 맹검법을 이용하여 무작위로 시험군과 대조군으로 나누었다. 이후 이중 맹검법을 이용하여 2주간 방문하여 시험군에는 인태반 추출물을 대조군에는 위약을 피하조직에 총 6회를 시행하였다. 이후 KI (Kupperman Index)점수, 열성 홍조 점수 개선 정도를 비교, 측정하도록 하였고 이에 대한 결과를 비교하였다. 이후 객관적인 수치의 비교를 위해 투약 전후의 E2, FSH 농도를 측정하여 이를 비교 하였다. 또한 인태반 추출물의 안정성을 평가하기 위해 투약 후 이상반응, 활력 징후 등을 WHOART 기준에 의해 측정하여 이상반응을 평가하였다. 결과: 주관적인 지표인 KI 점수는 유의하게 호전(P=0.0013) 되었으나 그 외 열성 홍조 변화량(P=0.8044)이나 객관적인 지표인 E2, FSH 농도는 변화가 없었다 (E2 농도, P=0.7665, FSH 농도, P=0.3577). 또한 투약 후 유의한 이상반응은 관찰되지 않았다 (χ2-test, P=0.7037). 결론: KI 점수의 경우 두 그룹간에 유의한 차이를 보였으나 열성 홍조 점수는 차이를 보이지 않았다. E2, FSH 농도도 또한 두 그룹간에 차이를 보이지 않았다. 인태반 추출물 사용시 의미 있는 부작용은 관찰되지 않았다. Objectives: In Korea, human placental extract (HPE) has been approved as a therapeutic agents for chronic liver diseases and menopause syndrome. However evidence-based studies about the effectiveness, mechanism of action, and side effects of HPE are incomplete. The aim of this study was to examine the effects of HPE on menopausal symptoms, and safety in middle-aged Korean women in a double-blind randomized controlled trial. Methods: Korean women >40 years of age, with menopausal symptoms and hot flushes were recruited as participants in 5 university hospitals in Seoul, Korea. The 130 women were randomly assigned as followed to a double blind test: the HPE group (n=66) received 6 subcutaneous injections of HPE for 2 weeks; the placebo group (n=64) received normal saline. The KI (Kupperman index) score, severity of hot flushes were and concentrations of E2 and FSH in serum were measured. The side effects of HPE were assessed. Results: The KI score was decreased significantly after 2 weeks of HPE treatment compared with the placebo group (P=0.0013); however, the severity of the hot flushes were not different between the two groups (P=0.8044). The E2 and FSH levels of the HPE group were not significantly increased at 2 weeks after HPE treatment compared with of the placebo group (E2 level, P=0.7665, FSH level, P=0.3577). No evidence of side effects were observed in either group (χ2-test, P=0.7037). Conclusion: The KI score in middle-aged Korean women improved after 2 weeks of HPE treatment, whereas the difference in hot flushes, and E2 and FSH levels did not change during the study period. No evidence of significant side effects were observed in patients treated with HPE. (J Korean Soc Menopause 2009;15:178-185)

20대 여성의 유방 부피 계측치에 따른 브래지어 컵의 분류

박유신,김선미,김은란,Park, Yu-Sin,Kim, Seon-Mi,Kim, Eun-Ran 대한인간공학회 2004 大韓人間工學會誌 Vol.23 No.2

The research subjects of this study were 30 unmarried Korean women from 20 to 29 who had never had an operation on their breast. Measurement method using plaster breast mold was used for measuring their volume of breast. The correlation between their breast volume and the methods to set up brassiere cups with the existing method and with their circumference of breast was analyzed using KendalI's Coefficient. which was to figure out a method which had a bigger correlation with the volume of breast between the method to set up brassiere cups using the existing method and the method using the circumference of breast. The results analyzed showed that the coefficient of correlation between the existing method and the volume of breast was .12 and the significance level was .45. They didn't have any correlation. On the other hand. the coefficient of correlation between the circumference of breast and the volume of breast was .82. which was very high values and the significance level was very high .0001. Therefore. it turned out that it was difficult to set up brassiere cups by using the existing method and it was easier and more reliable to set up the cups by using the circumference of breast.

발리우드를 활용한 체감형 콘솔게임의 콘텐츠 개발에 대한 연구

강효순,박유란,Kang, Hyo-Soon,Park, Yu-Ran 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.6

체감형 콘솔게임의 현황과 문제점을 닌텐도사의 '위(Wii)'를 중심으로 분석한다. 이 중 스포츠분야에 편향되고 다양하지 못한 콘텐츠의 한계를 글로컬한 문화콘텐츠로 한 단계 발전시켜 개발하기 위해 뮤지컬 형식이 주를 이루는 발리우드를 활용한 해결방안을 제시한다. 인도의 빼놓을 수 없는 문화코드인 '발리우드'는 국내를 비롯한 제3국에서는 이국적 신선함으로 소비자의 구매욕을 자극할 수 있고, 11억 인도시장으로의 진출에는 그들에게 익숙하면서도 새로운 형태의 게임문화를 판매할 수 있을 것이다. 본 연구를 위하여 발리우드가 포함된 문화콘텐츠 문화코드 이외에 인도의 정치적, 사회적, 경제적 문화코드까지 전반에 걸쳐 살펴봄으로써 그들의 문화에 이질적이지 않은 콘텐츠를 개발할 수 있을 것으로 기대한다. The current situation and problems of sensory console games was analyzed focusing on the Nintendo 'Wii.' In order to develop the limitation of contents that lean strongly towards sports and fail to offer diversity one step further into glocal cultural contents, a solution of applying 'Bollywood', which has a main musical format, is presented. Bollywood is a unique cultural code of India which can stimulate the purchase desires of consumers with its exotic freshness in third countries, and can be used to lead sales of a new form of game culture that is familiar yet in a new format in the 1.1 billion population Indian market. The political, social and economic codes of Bollywood are examined in this study in addition to cultural contents and codes that include Bollywood to develop contents that are not foreign to their culture.

뮐러관 기형 환자에 대한 임상적 고찰: 서울아산병원 20년 (1990~2009년) 간의 경험

전균호 ( Gyun Ho Jeon ),박유란 ( Yu Ran Park ),신유정 ( You Jung Shin ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.7

목적: 뮐러관 기형 환자의 임상양상과 생식력에 대하여 알아보고자 하였다. 연구 방법: 1990년부터 2009년까지 20년간 서울아산병원에서 뮐러관 기형으로 진단받은 186명의 환자들의 임상적 특징과 생식력을 분석하였다. 결과: 뮐러관 기형은 1,326환자당 1명 (0.075%)의 빈도로 대부분 성인기에 발견되었고, 청소년기와 소아기에 발견된 경우는 15.1%에 불과하였다. 약 40% 이상의 환자들은 증상이 없이 우연히 발견되었지만, 그 외 상당수의 환자들은 무월경, 생리통, 이상 생리 등의 증상을 호소하였다. 본 연구에서 자궁 기형 중 가장 흔한 유형은 쌍자궁 (30.6%)이었고, 다음으로 두뿔 자궁(19.4%), Mayer-Rokitansky-Kuster-Hauser 증후군, 중격 자궁, 단각 자궁의 순이었다. 이들 환자들에서 확인된 251예의 임신의 예후는 자연 유산과 조산이 55.8%로 매우 흔하였고, 총 생존아 출산율은 48.6%였다. 각 자궁 기형별로 분석하였을 때 궁상자궁과 쌍자궁의 생존아 출산률이 각각 60.0%, 58.0%였고, 단각 자궁과 두뿔 자궁은 각각 42.1%, 46.7%로 비슷하게 나타난 반면, 중격 자궁은 32.4%로 상대적으로 낮은 생존아 출산율을 보였다. 결론: 대부분의 뮐러관 기형은 성인기에 발견되지만 많은 수의 환자들은 청소년기 이후부터 생리 이상, 생리통 등의 증상을 보일 수 있다. 본 연구에서 중격 자궁 환자들의 생식력에 대한 예후는 궁상 자궁과 쌍자궁 환자들에 비해 나쁜 것으로 나타났다. Objective: To investigate the clinical characteristics and reproductive outcomes of women with Mullerian anomalies. Methods: One hundred and eighty-six patients were diagnosed with Mullerian anomalies at the Asan Medical Center from 1990 to 2009 and their clinical characteristics and reproductive outcomes were analyzed. Mullerian anomalies were categorized according to the classification by the American Fertility Society (1988). Results: Mullerian anomaly was noticed in 1 in 1,326 patients (0.075%). Most cases were found in adulthood (84.9%) whereas only 15.1% cases in adolescent or pediatric period. More than 40% of cases were asymptomatic and found incidentally but others suffered from amenorrhea (12.4%), dysmenorrhea (10.8%), abnormal menstruation (10.2%), etc. Most common type of uterine anomalies was uterine didelphys (30.6%), followed by bicornuate uterus (19.4%), Mayer-Rokitansky-Kuster-Hauser syndrome (10.8%), septate uterus (9.1%) and unicornuate uterus (8.6%). On the reproductive outcomes of 251 pregnancies identified, spontaneous miscarriages and preterm labor were quite common (55.8%), and the overall live birth rate was 48.6%. When each anomaly was individually analyzed, the live birth rate was 60.0% in the arcuate uterus and 58.0% in the uterine didelphys. The unicornuate and bicornuate uterus presented a similar chance of having a living child (42.1%, 46.7%), while the septate uterus showed a relatively lower live birth rate (32.4%). Conclusion: Although most cases of Mullerian anomalies are diagnosed in adulthood, many patients may suffer from menstrual abnormalities, dysmenorrhea or recurrent miscarriages since adolescence. The reproductive outcomes of the arcuate uterus and uterine didelphys were better, while those of septate uterus were poor in our study.