흰쥐에서 사염화탄소에 의해 유도된 간 상해에 미치는 키토산 올리고당의 영향

이영돈,박승림,강소영,김세재,박지권,고영환 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-

Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. We reported recently that water soluble chitooligosaccharides have hepatoprotective effect on ethanol induced liver injury in the mouse. The current study examined the effect of water soluble chitooligosaccharides on CC1₄-induced liver injury in rats. Male Sprague-Dawley rats were orally treated with CC1₄without or with administration of 5% chitooligosaccharides. After 5 weeks after CC1₄treatment, the histological sections and the expression of mRNA of interleukin-12(IL-12), hepatocyte growth factor(HGF), and tumor necrosis factor(TNF- ) were examined. The liver section of rats supplemented with chitooligosaccharides showed attenuated effects of the necrosis, steatosis, cirrhosis compared with those of non-supplemented rats. The level of TNF- mRNA in CC1₄-treated rats were higher than those in the rats supplemented with chitooligosaccharides, while the levels of IL-12 and HGF mRNA were higher in the rats supplemented with chitooligosaccharides than those of in CC1₄-treated rats. These findings suggested that water soluble chitooligosaccharides may have a hepatoprotective activity against CCl₄-induced liver injury in rats.

Trigger point를 利用한 口眼괘斜 患者 10例에 대한 臨床的 考察

鄭榮敦,李浚龜,金永一,朴泰均,辛泳一,黃載然,李賢,李秉烈 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2

From July 1th 2001 to October 31th 2001, the Clinical investigation studies were carried out 10 cases of patient with Bell's palsy using Trigger point treatment group, who had been treated in Han-seung Oriental Medical Clinic. The results were like below : 1. The distribution of sex : Male were 4cases, female were 6case and the female to male ratio was 1.5 : 1. 2. The distribution of contributing factor : Unknown reason was most predominant 4 cases, and then were revealed to labor too hard, menttal stress(3 cases), trauma·common cold(1 case) in turn. 3. The distribution of perid to fall ill : Under a week was the most number 6cases, and then were revealed a week under two weeks(3 cases), over two weeks(1 case) in turn. 4. About period of treatment : The Trigger point treatment group is shorter than the Acupuncture treatment group. 5. The distribution of grade on admission in descending order : GrⅠ was the most number and then GrⅡ, GrⅢ in turn. 6. The distribution of clinical symptoms on adimission : Mastoid pain was the most number 9 cases and then lacrimal gland disorder 8 cases, dysgeusia 4 cases, hyperacusis 2 cases, the others 2 cases in turn. 7. About effect of treatment : The Trigger point treatment group is more excellent than the Acupuncture treatment group. 8. The more patient age is young, the more effect of treatment was excellent, had nothing to do with both groups. 9. The more perid to fall ill is short, the more effect of treatment was excellent, had nothing to do with both groups. 10. About period of improved frontal belly : The Trigger point treatment group is more excellent than the Acupuncture treatment group.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

청소년 도덕적 동기화 검사 도구 개정 연구(2차년도)

전종희 ( Jong Hee Jeon ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),윤영돈 ( Young Don Yoon ),류숙희 ( Sook Hee Ryue ),홍성훈 ( Seong Hoon Hong ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 J. Rest의 4구성요소 모형을 바탕으로 1차년도(2011년)에 개발된 도덕적 동기화 검사를 보다 신뢰롭고 타당한 도구로 개정하는 것이다. 따라서 선행연구를 보완하여 도덕 동기화의 구성 요소를 도덕지향성과 도덕적 정서귀인 등 두 항목으로 재설정하고, 스토리와 문항을 수정하였다. 개발된 세 개의 스토리(과제, 놀이공원, 작품) 별로 신뢰도를 분석한 결과, 전반적으로 .90 내외의 높고 수치를 보였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사를 위해서는 전국 중학교 2학년생 409명을 대상으로 했고, 본조사를 위해서는 전국 6,216명의 중학교 2학년생을 대상으로 실시하였다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 검증하기 위하여 요인분석을 실시한 결과, 과제 스토리와 놀이공원 스토리의 일부 문항이 가정한 요인으로 잘 묶이지 않았는데 이 문항들을 제거하고 요인분석을 다시 실시해본 결과 기대하는 바를 충족했다. 그리하여 2차년도 연구를 통해 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 9개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 28개 문항으로 확정되었다. 본 연구를 통해 수정 확정된 도덕적 동기화 검사도구는 상당히 안정적인 신뢰도와 타당도를 확보하였기에, 향후 우리나라 청소년의 도덕적 동기화 능력을 측정하기 위한 검사도구로 활용되기에 적절할 것으로 판단된다. The study aims to revise Moral Motivation Test I which was set for adolescents based on Rest`s four component model in 2011 and make standardized final morality test. In theory, this study is based on 4 components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The 4 components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral motivation. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral motivation, research team used moral orientation, moral emotion attributions. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral motivation, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “homework inspect”and “on going to park”, the factor analysis shows a little bit limitation result. Eliminated those questions, the result of factor analysis was more stable and reliable. Through these processes, to test moral motivation, this study shows 3 stories and 28 questions. And this recommends that just one simple story might be developed for one component(moral motivation).

청소년 도덕적 품성화 검사 도구 개정 연구(2차년도)

류숙희 ( Sook Hee Ryue ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),홍성훈 ( Seong Hoon Hong ),전종희 ( Jong Hee Jeon ),윤영돈 ( Young Don Yoon ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 한국 청소년들의 도덕적 품성화 능력을 측정하기 위한 검사 도구를 개발하기 위한 것으로 2011년도에 개발된 검사 도구를 수정 및 보완한 것이다. 즉, J. Rest가 주장한 도덕성의 제4요소인 도덕적 품성화에 관한 선행연구들을 체계적으로 분석하여 도덕적 품성화의 개념을 보다 명확히 하였고, 1차년도에 설정한 도덕적 품성화의 구성 요소를 개인품성과 관계품성의 두 항목으로 재설정하였다. 또한 검사의 신뢰도와 타당도를 높이기 위해 기존의 스토리와 문항을 수정하였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사는 전국 중학교 2학년생 409명을 대상으로 실시되었고, 본조사는 전국 6,216명의 중학교 2학년생을 대상으로 실시되었다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 확보하기 위해 요인분석을 실시했는데, 도덕적 품성화 능력 검사는 1개 문항을 제외하고 모든 문항이 예정된 요인으로 묶였다. 그리하여 2차년도 연구를 통한 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 10개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 29개 문항으로 확정되었다. 2차년도 연구결과 개정된 검사 도구는 2011년 검사 도구에 비해 더 안정된 검사도구로서 향후 청소년의 도덕적 품성화 측정을 위한 연구와 실무에 활용될 수 있을 것이다. The study aims to revise Moral Character Test I which was set for adolescents based on Rest`s four components model in 2011 and make standardized final morality test. In theory, this study is based on the four components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The four components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral character. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral character, research team used personal character and interpersonal character. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral character, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “on going to park”, the factor analysis shows a little bit limitation result. Even though, 1st and 2nd researches have common weak point which is highly dependent upon not factor but story. Through these processes, to test moral motivation, this study shows 3 stories and 29 questions. And this recommends that just one simple story might be developed for one component(moral character).

후추(Piper nigrum) 열매의 Alkaloids

박일권,이학주,이상길,신상철,박지두,최돈하,안용준 한국목재공학회 2003 목재공학 Vol.31 No.5

후추 열매의 MeOH추출물로부터 silica gel 및 preparative HPLC 칼럼 크로마토그라피를 이용하여 5종의 알카로이드 화합물을 단리하였으며, NMR, MS 등의 기기분석 결과, N-isobutyl amide alkaloids인 pellitorin (Ⅰ)를 비롯하여, quineensine (Ⅱ), pipercide (Ⅲ), retrofractamide A (Ⅳ)과 piperidine alkaloid인 Pipeline (Ⅴ)으로 각각 동정하였다. Five amide alkaloids were isolated from the fruits of Piper nigrum. The structures were determined as : pellitorin(Ⅰ), quineensine(Ⅱ), pipercide(Ⅲ), retrofractamide A(Ⅳ), and piperine(Ⅴ) respectively on the baiss of spectrosopic data.

다기관 기능부전을 초래한 치명적인 삼일열 말라리아 증례

박상원,김동우,박주원,이순일,신영학,김의종,오명돈,최강원 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

삼일열 말라리아는 국내에서 재유행하고 있는 감염질환으로, 일반적으로 양성의 임상경과를 거친다. 저자들은 특이한 질병력이 없이 건강하였던 젊은 성인이 국내에서 삼일열 말라리아에 걸린 후 다기관기능부전과 폐출혈으로 사망한 증례를 경험하였다. 환자의 중증 임상경과를 설명할 만한 특이한 인자가 발견되지 않았다. Vivax malaria is a re-emerging infectious disease in Korea with cumulating 19,416 cases as of December 2003 since 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there are only small number of case reports on severe complications. We experienced a fatal vivax malaria in a previously healthy young adult with severe multi-organ failure and fatal massive pulmonary hemorrhage. The patient presented with abdominal pain and shock. There were splenic hemorrhage, disseminated intravascular coagulation, oliguric acute renal failure requiring dialysis, and pulmonary hemorrhage leading the patient finally to death. The initial parasitemia was 2,046/μL. Thin smear and PCR revealed only Plasmodium Vivax. There was no explainable cause of death except for the only serological suggestion of Mycoplasma pneumoniae infection without correlating clinical evidence. This is a first case of fatal vivax malaria in Korea since its re-emergence in 1993. Further case monitoring is needed to define whether this is a index case or an isolated one.

Human Chorionic Gonadotropin(HCG)에 의한 넙치, Paralichthys olivaceus의 배정효과

박인석,김형배,최희정,이영돈,손진기 제주대학교 해양연구소 1992 해양자원연구소연구보고 Vol.16 No.-

For the evaluation of hormonal control of sperm in cultured fish a method to quantify the spermiation response of mature flatfish to hormonal therapy is described. Spermatocrit was determined after 30 min. in centrifuge condition of 12,000rpm. Sperm density was estimated by a standard hemacytometer method. However, sperm density can be predicted from spermatocrit since their relationship is linear as described by the re-gression equation. Y=1.14X-0.04 (r=0.91. P<0.0001. n=50), where Y is spermatocrit and X is sperm density. Sperm density levels ranged from 21.5 to 98.4×10^(4) spermatozoa per ㎕ milt corresponding to spermatocrit values of 12 to 95%. Milt production by mature flatfish was highest (7.4ml per kg body weight) at 24h after injection of 1,000IU of human chorionic gonadotropin(HCG) per kg body weight and coincided with low spermatocrit (63%) and sperm density (67.4×10^(4) spermatozoa per ㎕ milt) levels. No significant differences was appeared in milt production, spermatocrit and sperm density between control and HCG-treated fish at 48h after HCG injection. These results demonstrate that spermiation in mature flatfish can be reliably evaluated by a spermatocrit method and that HCG is effective in stimulating of spermiation in this species.

독가시치류의 일종 Siganus canaliculatus(PARK)의 산란기 생식소와 난발생

박무억,이영돈,노섬 제주대학교 해양연구소 1992 해양자원연구소연구보고 Vol.16 No.-

Mature adults of Rabbit fish, Siganus canaliculatus. which is generally known to be distributed up to the southern costal waters of Korean peninsula, were captured in Ham-duck, northeast of Cheju on August 2. 1992. Gonad of the Rabbit fish was investigated histologically on the view point of gonadal development. Pale yellow ovaries are consisted of the mature oocyte groups and early growing oocyte groups, while Yellowish red ovaries consisted of the ripe oocyte groups and early oocyte group. Milky white testis is mostly filled with spermatozoa in the lobular cavity. The eggs and sperm were stripped and fertilized by the wet method on the laboratory. The fertilized egg diameter varied from 0. 57mm to 0.61mm. The water temperature throughout incubation ranged from 26℃ to 27℃. The hatching took place in 32 hour after fertilization. The newly hatched larvae are averagely 1.94mm in TL, possessing yolk sac.

황해 동남 해역의 수괴지표성 요각류 및 모악류의 분포와 수괴특성

박주석,이삼석,강영실,이병돈,허성회 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1

Distribution of indicator species of copepods and chaetognaths were studied as an indicator species of water mass in the southeastern area of the Yellow Sea. Undinula darwini, Lucicutia flavicornis, Pleuromamma gracilis, Euchaeta resselli, Euchaeta plana and Sagitta enflata were found to be reliable indicator species for determining warm water mass. Of these species, E. plana and E. russelli have a weak tolerance on the low temperature. Sagitta crassa was indicator species of neritic waters: Sagitta bedoti was that of mixing waters. Centropages agdominalis represented neritic cold waters. In February U. darwini, L. flavicornis, P. gracilis, E. russelli, E. plana and S. enflata occurred in the western waters of Cheju-Do where warm waters over 14℃ occupied. Centropages abdominalis occurred in the northern area beyond Chindo with water temperature less than 10℃. E. plana, E. russelli and S. bedoti were found at the regions between Cheju-Do and Chindo where the water temperature was 12∼14℃ corresponding to the mixing waters. Based on cluster analysis and T-S diagram in February three different water masses were identified from the south to the north. In August, water masses were analyzed at two different layers, 0∼20m and 20m∼bottom layers, separated by thermocline depth. In 0∼20m layer, E plana and E. russelli were found from the western waters of Cheju-Do to Daehuksando. In 20m∼bottom layer, E. russelli and E. plana occurred at the northwestern waters of Cheju-Do with the water temperature warmer than 12℃. C. abdominalis was found at the northern area beyond Chindo. Based on the cluster analysis and T-S diagram in August three different water masses at 0∼20m and 20m∼bottom layers were identified from the coast to the offshore. C. abdominalis was found at the adjacent water of Chindo at 0∼20m layer and the northern area beyond Chindo at 20m∼bottom layer. This fact suggested that the cold water mass existed at the adjacent waters of Chindo in summer.