Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성

김성옥,이소영,김성규,손광희,김영국,문석식,복성해 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

Candida albicans의 효모형태에 대해 활성을 나타내는 항진균 물질의 탐색 중에 Aspergillus candidus F1484 균주의 발효액으로부터 항진균 화합물 F1484를 단리하고 ethyl acetate 추출, silica gel column chromatography, ODS column chromatography 및 preparative HPLC를 행하여 분리정제하였다. F1484 화합물은 EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC 및 HMBC에 의한 구조분석을 행한 결과 이 화합물은 항진균 물질인 chloroflavonin과 동일한 구조를 나타내었으며 효모형태의 Candida albicans에 대한 항진균 활성뿐만 아니라 여러 종류의 인체 종양 세포주에 대해서도 세포독성을 나타내었다. In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.

증기발생기 세관 와전류 탐상 신호해석을 위한 주성분 분석

김영환,송성진,김의래,임창재,김기복,최영환 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

증기발생기(SG) 세관은 그 가동 특성상 결함이 발생할 가능성이 매우 높으며 이들의 건전성 확보는 원자력 발전소의 안전을 위해서는 필수적이다. 이들의 가동중검사에는 ECT가 널리 사용되고 있다. 본 연구에서는 bobbin coil probe를 사용한 원전 SG 세관 ECT신호를 해석하기 위해서 신경회로망을 이용하였다. ECT의 특징을 추출하였고, 이들 중에서 단일특징 분류성능을 분석하여 유용한 특징을 선택하였으며, 또한 주성분분석을 이용하여 유용한 특징들을 정의하였다. 이와 같이 정의된 특징들로 정의된 신경회로망을 학습시키고, 학습된 신경회로망으로 미지의 결함신호에 대해서 결함의 분류와 크기 산정을 수행하였다. 수치해석으로 만들어진 모사 ECT신호에 대해서 적용한 결과, 주성분분석으로 정의된 특징들을 사용하는 경우에 보다 적은 수의 특징을 사용함에도 불구하고 신호해석의 성능이 향상되었다. 따라서, 주성분 분석은 ECT신호와 같은 다변량 데이터를 처리하는데 매우 유용함을 알 수 있었다.

대학생의 건강증진 프로그램 참여의사에 영향을 미치는 주요 요인에 관한 연구

김영복,하은희,김주영,윤영옥 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.1

This study purposed to examine the participative intention for health promotion program in a university and to find out the factors to associate with the participative intention. The data were based on the self-reported questionnaires from 746 women who study in E university, and this survey performed May, 1998. This study performed to analyze the participative intention for health promotion programs and the factors associate with health promotion program using x2-test and trend test by the PC-SAS 6.12. The major findings were as fellows: 1. The tendency of participative intention for health promotion programs showed that Influenza preventive program was the highest among the health promotion programs, and the next were Weight control program, Rubella preventive program, Fitness program. On the other hand, Smoking preventive program and Non-drinking program were lower than the other program. 2. The four significant factors on participative intention for health promotion programs were grade, concern for health, and behavior change experience through the health education. On the other hand, the cognitive level for health, experience for health education were not the significant factors associate with the participative intention for health promotion programs. 3. The relationship between factors and each health promotion program showedthat Rubella preventive program, Influenza preventive program, Weight control program, Smoking cessation program and Non-drinking program were associated with the grade or the health concern. And Chronic diseases preventive program was associated with the grade and the concern for health. Fitness program and Sex education program were associated with the concern for health and the behavior change experience through health education.

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

Oxidation of Titanium Matrix Composites Reinforced with (TiB + TiC) Particulates

Young‑Jig Kim,Poonam Yadav,Junhee Hahn,Xiao Xiao,Dong Bok Lee 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3

Titanium matrix composites reinforced with (5, 10, 20) vol% (TiB + TiC) particulates were in situ synthesized using melting-investment casting method by reacting Ti with B4Cpowder. Their oxidation behavior was studied at 800–1000 °C inair. Formed scales consisted of transient TiO3and stable rutile-TiO2. More dispersed (TiB + TiC) particulates had higheroxidation resistance due to strong Ti–B and Ti–C bonding which required higher activation energy for oxidation comparedto Ti–Ti bonding in the matrix. However, such increment in oxidation resistance was limited by the formation of semiprotectivetitanium oxides, volatile B2O3,and CO2gas. With increment of (TiB + TiC), scales progressively became thinner,thus improving scale adherence.

溫室保溫커튼의 材料特性에 따른 保溫效果分析

金榮福,金容換,李昇揆,金成泰,羅又禎,閔永鳳,朴重春,崔東烈 慶尙大學校 1991 論文集 Vol.30 No.2

The effects of the material properties of thermal curtains upon reduction of the greenhouse heat loss were studied. A theoretical analysis procedure with equations and computer programs was developed to estimate them by using energy balance principles. Curtain effectiveness for every three kinds pf value level of the material properties were studied and compared. The results of this study would be useful for the developent and management of greenhouse thermal curtains.

유형별 스포츠 마사지 처치가 심폐기능에 미치는 영향

김영빈,김용남,윤영복 圓光大學校 附設 體力科學硏究所 2001 體力科學硏究 Vol.24 No.-

The purpose of this study is to review and analyze the effects of sports massage treatments by kinds on the function of cardiac and lung system, on the maximum performance capacity during the stable period. In order to confirm the effects of sports massage on the function of cardiac and lung system. The objects of the test were 18 male students enrolled at W university, divided in 3 groups ; guoup A(effleurage), group B(petrissage), and group C(friction), each assigned with 6 students. The outcomes of this test are as follows. First, during the stable period, the function of cardiac and lung system was improved by the treatment of sports massage by kind. Among the groups, friction showed mere signficant(p< .05) improvement than effleurage and petrissage Second, the treatment of sports massage by kind enhanced the maximum performance capacity. The friction increased significantly(p<.05) in the maximum performance capacity of all groups. Form the outcomes summed up as above, it may be concluded that the treatment of sports massage is expected to bring warming up effect to increasing the function of cardiac and lung system as well as the maximum performance capacity during the stable period. As to the types of sports massage, friction may be most effective among other groups. It is, therefore, thought desirable to employ much more diverse and systematic approaches than before to detect thoroughly the effects of the sports massage treatment.

A LONG-TERM FIELD TEST OF A LARGE VOLUME IONIZATION CHAMBER BASED AREA RADIATION MONITORING SYSTEM DEVELOPED AT KAERI

Kim, Han-Soo,Ha, Jang-Ho,Park, Se-Hwan,Kim, Jung-Bok,Kim, Young-Kyun,Jin, Hyung-Ho The Korean Association for Radiation Protection 2009 방사선방어학회지 Vol.34 No.2

An Area Radiation Monitoring System (ARMS) ionization chamber, which had an 11.8 L active volume, was fabricated and performance-tested at KAERI. Low leakage currents, linearities at low and high dose rates were achieved from performance tests. The correlation coefficients between the ionization currents and the dose rates are 1 at high dose rate and 0.99 at low dose rate. In this study, an integration-type ARMS ionization chamber was tested over a year for an evaluation of its long-term stability at a radioisotope (RI) repository of the Young-gwang nuclear power plant. The standard deviation of dose rate of 1 day data and over a 100-days mean value were 6.2 $\mu$R/h and 2.9 $\mu$R/h, respectively. The fabricated ARMS ionization chamber showed stable performance from the results of the long-term tests. Design and performance characteristics of the fabricated ionization chamber for the ARMS from performance-tests are also addressed.

^(7)Li, ^(87)Rb과 ^(27)Al NMR을 이용한 (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6)와 K_(2)SnCl_(6):Al^(3+)의 상전이 근처에서의 결정 동력학 연구

김복수,김영훈,강재필,백아영,차유정,김민경,서용문,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

K_(2)SnCl_(6)는 antifluoride계에 속하는 결정으로서 K_(2)SnCl_(6)에 Li^(+)를 첨가하여 ^(7)Li 핵자기공명(NMR)을 측정하여 동형(isomorphic) 혼합결정(K_(1-x)Rb_(x))_(2)SnCl_(6)와 비동형(nonisomorphic) 혼합결정 K_(2)SnCl_(6):Al^(3+)에서의 핵자기공명(NMR), ^(87)Rb NMR과 ^(27)Al NMR의 측정값과 비교하였다. Rb^(+) 이온은 K_(2)SnCl_(6)의 K^(+)이온을 대신해 동형 결정을 이루며, Al^(3+)이온은 Sn^(4+)이온을 대치하면서 비동형 결정을 이루는데 Li^(+)이온 또한 K^(+)이온을 대신하는 동형 혼합결정과 유사한 결과 값을 얻을 수 있었다. 이 연구 결과는 종래의 Cl-NQR 연구 결과와 비교함으로서 K_(2)SnCl_(6)의 동력학적 특성과 구조 상전이 근처에서의 임계현상을 새로운 관점에서 볼 수 있는 가능성을 보여주었다. ^(7)Li, ^(87)Rb and ^(27)Al NMR have been investigated in the isomorphic and nonisomorphic impurity doped crystals (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6) and K_(2)SnCl_(6):Al^(3+) as a supplementary to the previous Cl NQR studies in these crystals. The results yielded that the features of NMR spectra for both types of crystals are roughly in line with the systematic trends shown in the Cl NQR in these crystals, though the outstanding characteristics exhibited in the Cl NQR become in the case of the NMR of the doped impurities in crystals somewhat weakend. This is due to the degradation of the role of the local field from the main hamiltonian in NQR to the subsidiary in NMR. Each NMR result of the iso/nonisomorphic crystals has been analyzed in terms of the 'impurity induced dynamic lattice defects' for K_(2)SnCl_(6):Al^(3+) and the 'static primary impurity effects' for (K_(1-x)Rb_(x))_(2)SnCl_(6) and (K_(1-x)Li_(x))_(2)SnCl_(6) respectlvely.

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.