니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

복강경담낭절제술에서 수술전 간담도신티그라피와 경구담낭조영술의 의의

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),한동복(Dong Bok Han),박철민(Cheol Min Park),이문규(Moon Gyu Lee),박광민(Kwang Min Park),이승규(Sung Gyu Lee) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.1

N/A 131I-6β-iodomethyl-19-norcholesterol(NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenral disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 case of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

遼末女眞社會의 構成 (Ⅰ) : 黑水와 黑水靺鞨 Focused on River Hei-shui˘(黑水) and Hei-shui˘-mo-he (黑水靺鞨)

李東馥 淸州大學校 1984 論文集 Vol.17 No.1

The people who founded Chin (金) dynasty were Sheng-nuzhens (生女眞). The main part of Sheng-nuzhens were Hei-shui-mo-he-rens (黑水靺鞨人) who had been living on the lower part of River Song-hua(松花江) in the east side of I-lan (依蘭) ever since both the period of Sui (隋) and Tang (唐) dynasty. The reason why the people were called Hei-shui-mo-he was due to the fact they lived around River Hei-shul(黑水). River Hei-shui has customarily been recognized as River Hei-long(黑龍江) of today, but in fact it indicates the lower areas of River Song-hua in the east part of I-lan. In the early 10th century, when Bo-hdi(渤海) dynasty had been declined, Hei-shuimo-he-rens, who had lived in the lower areas of River Song-hua at that time, expanded their power and pushed into Manchuria(滿洲). Their expansion of influence was much active around the time when Bo-hai dynasty was to be declined. When the Hei-shui-mo-he-rens advanced into the whole areas of Manchuria in the late period of Liao dynasty, they became the essential and major part of the people who founded the Sheng-nuzhen society.

한국인 태아 췌장도 발육에 관한 면역조직화학적 연구

이원복,김동창 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.4

The pancreases of Korean human fetuses aged from 13 to 40 weeks were studied immunohistochemically to observe the development of the pancreatic islet, frequency of single endocrine cell and composition of pancreatic islet. 1. The volume fractions of endocrine tissue of the fetal pancreas were higher value(from 7 to 8%). However, the relative values of the endocrine tissues that obtained from 5 to 10 month old fetuses were constant. 2. The exocrine tissue were slowly increased during the intrauterine life. On the other hand, the connective tissue were gradually decreased in the same time. 3. At the mid-term, the number of single alpha cells were similar to that of delta cells. The number of beta cell decreased in comparison with that of non-beta cells(p<0.01). At the term, the number of single alpha, beta and delta cells were not significant. These data indicated that the epithelial cells of pancreatic duct were budding during intrauterine life. 4. At the mid-term, the pancreatic islets were composed of about 36% of alpha and beta cells respectively and 28% of delta cells. At the term the pancreatic were composed of 33% of alpha cells, 41% of beta cells and 26% of delta cells, respectively. The fetal panreatic islet showed numerous delta cells but the beta cells occupied one half of the adult islets. 5. The mantle islet was one of the typical features of fetal pancreatic islet. It was composed of the central core of beta cells and peripheral zone of alpha and delta cells interposed with a few of beta cells.

LCD 제조 및 검사공정을 위한 자기부상 전송장치 개발

李斗馥,金東遠 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-

A magnetic levitation is suitable for moving materials in such a clean environment which must be kept free from even microscopic dust motes, for example, in a super clean room in LCD(Liquid Crystal Display) manufacturing plants and PDP(Plasma Display Panel) or biochemical plants, delicate medical machines, because friction can be disappeared or reduced. In addition to this, another advantage of levitation is that the manipulator can operate as a rigid body rather than using joints parts. In this work, the magnetic levitation is applied to transport a several liquid crystal display classes between LCD fabrication process modules in clean rooms because it can eliminate particles and oil contamination that normally exits in conventional transport systems due to contact motions of mechanical component. The transport system consists of a carrier, levitation track, and propelling system. Levitation is achieved by using antagonistic forces produced between electromagnet tracks and permanent magnets. Stabilization is achieved by using a simple feedback control. The continuous propelling force is obtained by sending specific current patterns to the propulsion coils.

열처리에 따른 Zircaloy-4 Tube의 부식특성에 관한 연구

이동복,최송천 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

열처리에 따른 Zircaloy-4 tube의 부식 특성을 조사하기 위하여 pilger된 시편, 수냉된 시편, 열처리된 시편에 대해, 500℃, 102 기압의 증기하에서의 부식 시험을 실시하였다. 주어진 시험조건하에서 수냉된 시편과 pilger된 시편은 좋은 nodular 부식 저항을 보였으나, 열처리된 시편은 나쁜 nodular 부식 저항을 가졌다. To investigate the effect of heat treatment on the corrosion behavior of water-quenched, heat -treated, and as-pilgered Zircaloy-4 tubes, corrosion testing was conducted at 500℃ in 102 atm of steam atmosphere. Under these given conditions, water-quenched and as-pilgered and the grains become bigger and equiaxed. Heat treated specimens exhibited improved resistance to nodular corroson, while heat- treated specimens had poor nodular corrosion resistance.

대기 및 CO₂/O₂분위기 하에서의 저탄소강의 산화

이동복 대한금속ᆞ재료학회 2006 대한금속·재료학회지 Vol.44 No.3

金代의 牛具稅에 대하여

李東馥 淸州大學校 1977 論文集 Vol.10 No.1

金代 猛安謀克地의 變貌에 대하여

李東馥 淸州大學校 1974 論文集 Vol.8 No.1