Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

씨름선수에서 체중 감량과 회복기의 Leptin과 PAI-1 변화

김용운,도경오,권태동,박덕일,장응찬,박소영,김종연,이석강 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Obesity which is defined as accumulation of excess body fat, is central factor of insulin resistance syndrome. Recently, it is revealed tat adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body, those are leptin and plasminogen activator inhibitor-1(PAI-1). Therefore, leptin and PAI-1 are increased in the obese state. Leptin regulates energy homeostasis and satiety and PAI-1 regulates fibrinolytic system. For these reasons, elevated levels of leptin and PAI-1 are considered as link factors between obesity and insulin resistance syndrome. However, the exact regulating mechanism for serum levels of leptin and PAI-1 is not fully understood yet. In this study, to evaluate the regulating mechanisms of serum levels of leptin and PAI-1 according to the weight changes, we measured leptin, PAI-1, physical, metabolic, and endocrine parameters during 10 days of weight reduction and 10 days of regain period in 7 young athletes. The mean body weight change was -4.7 kg(5.0%) in the weight reduction period and -2.4 kg(2.5%) in the weight regain period compared to baseline value. Baseline level of leptin in athletes was 1.7±0.66 ng/ml, which was significantly correlated with body weight, BMI, percent body fat, body fat mass, triglyceride, insulin, and PAI-1. Baseline level of PAI-1 in athletes was 16.6±5.26 ng/ml, which was significantly correlated with body weight, BMI, triglyceride, insulin, and leptin. Leptin was decreased to 0.7±0.39(44% of the basaline value) in the weight reduction period, and increased to 1.9±0.64(119% of the baseline value) in the regain period. PAI-1 was decreased to 7.4±2.72(44% of the basaline value) in the weight reduction period, and increased to 22.8±7.33(138% of the baseline value) in the regain period. The changes of leptin during weight reduction period were significantly correlated with the changes of insulin(r=0.890, P<0.01) and triglycerides(r=0.874, P<0.01). The changes of PAI-1 during weight reduction period were significantly correlated with the changes of FFA(r=0.889, P<0.01) and triglycerides(r=0.869, P<0.05). The changes of both leptin and AAI-1 during weight regain period were significantly correlated with the changes of insulin(r=0.755 and 0.849, P<0.05, respectively). In summary, these results suggest that serum levels of leptin and PAI-1 were affected by weight cycling, the percentages of change were more greater than that of weight change, and rebound phenomena were occurred during weight regain period.

연령대별 요추 추간판탈출증 환자의 요근과 척추주위근 단면적에 대한 분석

공덕현 ( Deok Hyun Kong ),배광호 ( Kwang Ho Bae ),고호연 ( Ho Yeon Go ),강명진 ( Myung Jin Kang ),김준수 ( Jun Su Kim ),양기영 ( Kee Young Yang ),이재훈 ( Jae Hoon Lee ),은영준 ( Young Jun Eun ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :This study was designed to evaluate the correlation of the cross-sectional areas(CSA) of paraspinalis(iliocostalis lumborum, multifidus, longissimus thoracis parts lumborum) and psoas muscle and sex, age, change of the VAS(visual analogue scale) and past history of chronic low back pain in patients suffering from HIVD(herniation of intervertebral disc). Methods :Medical records of 140 subjects with HIVD were retrospectively reviewed. The MRI(magnetic resonance imaging) findings on the patients were scanned and analyzed by PiView program to find the paraspinal and psoas muscle CSA and were evaluated by the correlation of sex, age, change of the VAS, and past history of chronic low back pain. Results :There was significant difference between groups in male and female, young-adults age and middle age, middle age and old age, young-adults age and old age. But the correlation of the paraspinal and psoas muscle CSA and past history of chronic low back pain were partially significant. On the other hand, the correlation of the paraspinal and psoas muscle CSA and change of the VAS were not significant. Conclusions :These results suggest that the cross-sectional areas(CSA) of paraspinalis and psoas muscle have relevance to sex and age.

뿜칠시공에 의한 단면복구재의 시공성 및 공학적 특성에 관한 실험적 연구

조봉석,김영선,장재봉,김용로,김경덕,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

These days, serious concerns of reinforced concrete have been raised recently over steel-bar corrosion, cracking, the deterioration of durability and structural stress resistance and so on, all due to the effects of exterior factors. Such being the case, in domestic, various repair materials and method systems to keep up with these reinforced concrete deteriorated due to salt damage, carbonation, chemical decay et. developed and applied. However, on-site quality control of various repair materials and method systems isn't achieved desirably because it is depend completely on a men of experience' opinions above all else regardless of various on - site environments. In this background, mock up test with due regard to real on-site environments was performed to secure fundamental data for establishment of desirable on-site quality control. Mock up test using repair mortar analyzed from angles of construction methods, mechanical spraying pressures, W 1M. Construction methods were designed manpower method and spraying method, spraying pressures were designed 32, 42, 52 psi, W/M were designed 14.4, 15.4, 16.4 %. And compressive strength, Chloride ion diffusion coefficient, bond strength, SEM of mock up test specimens were evaluated. In conclusion, we confirmed excellency of mechanical spraying pressures, fined extremely excellency of condition of spraying pressure 42 ps, W/M 14.4% within this study. therefore the results of this study will be useful to provide fundamental data for establishment of desirable on-site quality control.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

거푸집 일체형 외단열 갱폼시스템의 전단내력실험

김호수,정희범,김소연,박영석,원종덕 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

The shear capacity is evaluated for the structural safety security of integrated gang form system for outer insulation. Therefore, this study presents the composition types of outer insulation system and evaluates the shear capacity for the several design cases. Through the results, we find out the influencing factors that affect the shear capacity.

휠체어 검도 경기를 위한 경기규정에 관한 연구

김영학,공병덕,이병기 龍仁大學校 武道硏究所 2002 武道硏究所誌 Vol.13 No.1

The purpose of this study was to build revised game rules for wheelchair Kumdo for the physically challenged confined to wheelchair, after teaching 10 people how to play Wheelchair Kumdo. It's ultimately intended to determine whether or not the revised game regulations were appropriate and workable and ultimately to promote Wheelchair Kumdo. There Kumdo trainees of the 4th, 5th and 6th grades respectively and three physically different people were coached to draft game rules in three phases, and they were finalized through an advice of a specialist. And then five disabled Kumdo trainees, who included three of the 3rd grade and two of the 2nd grade, learned the regulations for a month to find out their adequacy. As a result of interviewing them and analysing the collected data, the following findings were given: First, the stadium should have a flat floor, by using proper materials such as wood or concrete, to guarantee the smooth operation of wheelchair. It should be in a square form and 11 meter or higher in length. The starting lines should bo marked 'T' on both sides from the central line, and the upper parts of the marks should face each other. There should be 1.7m distance between the central and starting lines and 2 meter or higher extra spaces in the external sides. Second, the bamboo sword should be redesigned to be 114cm in length and 370g in weight to fit in wheelchair Kumdo. Third, among Kumdo equipment, Homyun(護面, Headgear), part of HoKu(Protection-equipment, 護具), should be made of lighter materials, thicker in the head part, and easy to wear. Gab(甲, Chest-guard) should have a sort of shock absorber in it, and a remodeled Hoku that has no wings on both sides should be used. To prevent wheelchair from shock and ensure its safety, a Quickie All Court model should be selected, and each contestant should wear a suit of different color that has his or her name on the shoulder portion. Fourth, each game should run four minutes, constituted by two periods, and a break time should be given. The judgment should be made without no extra time, and a contestant who hits one of the due points ahead of the other should be a winner. Fifth, as for Yuhyo-Geokja(有效擊刺, Point), action against the head, wrist or waist should be considered Geokja(擊刺, Strike), and one against the chest part should be regarded as Jabu(刺部, Stab). Based on the above-mentioned findings, there are some suggestions about wheelchair Kumdo games: First, as games could be held out in the field, outdoor programs should be attempted. Second, every game is divided into the first and second periods, and coaches need to develop programs suitable for the two-part competition to give better guidance. Third, general Kumdo equipment isn't suitable for wheelchair Kumdo, and a lot of research efforts should urgently be dedicated to developing separate equipment for that.

가정용 레인지 후드의 소음저감 설계에 관한 연구

김덕한,송화영,이동훈 서울産業大學校 2005 논문집 Vol.54 No.1

This paper introduces a study for the noise reduction design of a range hood for household. Generally, range hoods have a built-in sirocco fan from which squawky noises are generated. Though the squawky noises have low noise level, these kinds of noises make most of the users nervous. For the purpose of noise reduction, in this study, a perforated panel system is installed in the fan housing of range hood. From the experimental results, it is confirmed that the noise level emitted from the range hood is decreased above 2dBA in all frequency regions.

쇄골하정맥을 통하여 중심정맥도관 삽입 실패 후 나타난 혈흉 1예

김대영,김대우,손희원,박상진,이덕희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Central venous catheterization via an internal jugular vein or subclavian vein has become a common procedure in monitonng CVP and managing severely ill patients. However, there have beennumerous reports of complications associated with central venous catheterization. These include vessel injury, pneumothorax, hemothorax, nerve injury, arrhythmias, artriovenous thrombosis, pulmonary embolism, and infection at the insertion site. We report a case of hemothorax after subclavian vein catheterization failure, along with successful treatment.

光州·木浦圈 落後地域의 均衡發展에 관한 硏究 : 羅州市를 中心으로 Focused on Naju-city

金在國,丁英德 東新大學校 工業技術硏究所 2000 工業技術硏究 Vol.6 No.-

As capital circle and Busan region have been extensively developed with economic growth centered policies, population and industries were concentrated at these regions and then urban problems in housing, traffic and environment and unbalanced development among regions have been seriously raised. Therefore great-sphere development project circles are designated at eight regions with the surrounding areas of metropolitans and new industrial areas and their development projects are established for the activation of local economy through the induction of balanced regional development and the active altraction of privale capital. However, great-sphere development project also shows biased regional development remarkably and it is considered that the research for solution of such a problem is urgent. Also industrial and SOC are biased only on Kwangju and Mokpo regions within Kwangju - Mokpo great-sphere development project of Kwangju and Mokpo circle established in 1998 and it resulted in regional polarization. Especially, Naju is located geographically in the center of Kwangju - Mokpo great-sphere development circle and is also the traffic center and although it played the important roles as the capital and was the center of commercial activities, its development as the urban area was dull because of the development of industry, traffic and communication. Accordingly, this study is to suggest the methods for seeking the companion growth among Kwangju, Naju and Mokpo within the same circle by solving the problems due to the bias of industrial and SOC facilities, extending the urban spatial structure for developing Naju-city, a backward region and expanding SOC facilities with the cultivation of distinctive industries.