만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

SELDI-TOF MS를 이용한 유방암 환자 진단을 위한 새로운 혈청 표지자의 개발

정용식,김호승,윤태일,전미선,윤용달,이용성,이기환,김혜진,김명욱,박희붕 한국유방암학회 2004 한국유방암학회지 Vol.7 No.1

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

어머니의 경제활동이 중학생의 식습관 및 식생활 태도에 미치는 영향

선윤정;이순희;박용순 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.2

The study was conducted to investigate the effect of mother's employment status on dietary habits and behaviors in 258 middle school students(114 boys and 144 girls). The percentage of employed mother was higher (57.0%) than that of non-employed mother (43.0%), and there was significantly more boys than girls in group of employed mother. Students with employed mother ate breakfast alone significantly more than those with non-employed mothers. Students with employed mother eat significantly more delivered foods (including dining out) for dinner than those with non-employed mothers. Students with employed mother bought snacks and liked junk food (fast food, instant food) significantly more than those with non-employed mothers. In addition, students with employed mother watched TV while having meals and drunk more soft drink than those with non-employed. mothers. In conclusion, mother’s employment status was the most important factor influencing dietary habits and behaviors of students. Therefore, students with employed mother's may required special attention for nutrition education.

異功散이 마우스 黑色腫의 肺轉移 抑制에 미치는 抗癌 및 免疫作用에 關한 硏究

李膳求,河智容 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1

종양은 그 발생원인과 성장기전이 자세히 밝혀져 있지 않는 질병으로 최근 성인사망의 제 1원인으로 급격히 발생빈도가 증가하고 있다. 종양환자의 수는 점점 증가하는 추세이며, 그에 따른 사망자의 수도 늘고 있다. 종양을 치료하는 방법으로 수술요법·방사선요법·화학약물요법·골수이식·면역요법·호르몬요법 등이 사용되어 왔으나 최근에 천연물 특히 전통적인 한약재를 이용한 종양파괴 및 종양에 있어 성장을 억제하는 약재의 연구가 시도되어 왔다. 한의학의 특정 약재 및 처방의 항암효과가 경험적으로 알려져 왔으며, 과학적이고 객관적인 병태를 통하여 이러한 약재의 효능을 검증하려는 실험이 최근에 시도되고 있다. 이에 본 연구는 補眞氣虛弱 및 治 久嗽不己 脾胃虛弱 등의 효능이 있는 異功散을 이용하여 B16세포의 전이억제능, 흑색종의 증식억제 및 면역능에 대하여 연구하고자 하였다. 본 연구에서는 시험관내 세포독성능을 알아보기 위하여 MTT법으로 각 농도별로 처리된 이공산을 B16세포에 적정농도로 처리하여 생존율 및 IC50을 측정하였다. 또한 생쥐를 이용한 동물실험으로써 흑색종을 폐에 전이시켜 이공산 투여후 흑색종의 집략수를 측정하였다. 동시에 항암효과와 면역능과의 관련성을 알아보기 위하여, Interleukin-2생산능과 NK-Activity를 측정하였다. 이공산의 생쥐에 대한 폐전이 흑색종의 억제효능과 면역반응에 미치는 영향을 알아보기 위한 실험에서 시험관내 세포독성 측정에서는 2㎍/well의 농도로부터 2배 희석시켜 MTT법으로 측정한 결과 유의성있는 억제를 보였으며 2,2124㎍/well의 IC50을 얻었다. 흑색종의 억제능을 측정한 결과 7일과 14일째에 유의성있는 억제를 보였고, 21일째는 흑색종이 폐의 전면에 분포되어 측정되지 않았다. 이 공산 투여후 생쥐의 IL-2의 생산능을 측정한 결과 이공산 투여군에 있어 투여 7일, 14일, 21일째에 모두 유의성있는 증가를 보였다. 그리고 NK-Activity를 측정한 결과 이공산 투여군이 대조군과 비교하여 유의한 차이는 보이지 못하였다. 이상의 결과를 종합하여 볼 때 이공산이 B16세포에 대하여 직접 세포독성능을 나타내며 보조 T 세포를 자극하여 IL-2의 생산능을 증가시켜 흑색종의 전이 및 증식을 억제하는 것으로 추정된다. 따라서 전이억제의 기전과 면역반응에 관련된 연구가 더욱 진행되어야 할것으로 사료된다. Herbal medicine as a candidate for effective cancer treatment recently gain positive concerns in field of therapeutic oncology. that is why some oriental medicine has been empirically safer in toxicity than anticancer drugs used in western medicine, and to show excellent therapeutic efficacy in human trial. Thus, these effects by clinically applied-herbs have not yet fully demonstrated in experimental tumor model. This study was initiated to evaluate antitumor effect of Ikongsan as candidate of antitumor-hebal agent against B16 melanoma metastasized into murine lung, and to examine association between immune parameter an anti-metastasis effect by Ikongsan. In experiment to test whether Ikongsan can directly kill cancer cells in vitro or not, Ikongsan showed direct killng action in concentration or higher against B16 melanoma cells using MTT assay. And also, in another experiment to know whether Ikongsan can inhibit growth and metastasis of cancer cell or not, Ikongsan significantly inhibited lung metastasis induced by intravenous injected-melanoma in inbred C57BL/6 mouse. When we quatiated interleukin-2 production, we could obtain results that in Ikongsan-treated group(7th, 14th, 21th), IL-2 production was significantly increased, But, NK activity in Ikongsan-treated group was not in significantly difference as compared to that of Ikongsan-nontreated group. These results show that Ikongsan can inhibit growth of B16 melanoma cells through biological mechanisms.

化學펄프 製造에 微生物의 應用 可能性

李宣鎬,尹炳虎,李元用 江原大學校 森林科學硏究所 1997 Journal of Forest Science Vol.13 No.-

要 約 백색부후균인 Fomes pini (Thore) Lloyd에 의해 처리된 chip을 anthraquinone(AQ)을 첨가하여 화학 펄프화를 실시하여 얻은 결과를 미처리재의 것과 비교하였다. 균처리함에 의해 카파값 20에서의 H factor는 소다와 크라프트 증해에서 각각 17%와 15%가 감소되었다. 이러한 결과는 목재를 백색부후균으로 처리함으로 인해 탈리그닌이 용이해졌음을 나타내는 것이다. 비페놀성 β-0-4 화합물인 veratrylglycerol-β-guaiacyl ether(I)와 페놀성 β-0-4 화합물인 syringylglycerol-β-syringyl ether(III)에 백색부후균을 작용시키면 반응생물로서 각각 α-guaiacoxy-β -hydroxypropioveratrone(II)과 α-syringyloxy- β -hydroxypropiosyringone (IV)이 생성됨이 밝혀겼다. 따라서 목재에 균처리를 함으로서 카르보닐기가 리그넌의 측쇄 α위에 도입되어 그로 인해 탈리그닌이 용이하게 된 것으로 여겨진다. ABSTRACT The decayed wood by Fomes pini (Thore) Lloyd required a smaller H factor than the sound wood for pulping to permanganate number 20. The H factors for the wood pulping by the kraft and soda processes were reduced by 15% and 17%. respectively. in the presence of 1% anthraquinone. The wood components degraded by fungi are normally more readily solubilized in alkali than the corresponding components in sound wood. The nonphenolic β-0-4 type lignin model compound. veratrylglycerol-β-guaiacyl ether(I), and phenolic model compound, syringlglycerol-β-syringyl ether(III). were degraded by the white-rot fungi to yield α-guaiacoxy-β-hydroxypropioveratrone(II) from the former and α-syringyloxy-β-hydroxypropiosyringone(IV) from the latter. Structures of the degradation products indicated that C r-oxidation could occur with wilite-rot fungi. It has been shown that the alkaline cleavage of β -aryl ether bonds in the lignin units is accelerated by the presence of α-carbonyl groups.

SHS법으로 TiAl 금속간 화합물의 제조시 첨가원소에 따른 기계적 성질에 관한 연구

宣炅杓,李龍鎬 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

TiAl intermetallic compounds are very attractive for high temperature structural applications because of their high specific strength, high temperature oxidation resistance, and superior creep characteristics. In this study, processing of TiAl using self-propagating high temperature synthesis was investigated. The effects of processing varibles including holding temperature and pressure, and alloying element on the microstructure, mechanical properties of TiAl were studied. It was demonstrated that the SHS process could yield TiAls with properties comparable with those of TiAl produced via the ingot metallurgy route.

Wakeman 式 樹形에서의 補助 鐵線이 S.(Seibel) 9110 葡萄나무 新梢의 自然誘引, 切損, 生長 및 果實의 品質에 미치는 影響

李英喆,崔東龍,金圭來,金善圭,李鎬珍 충북대학교 농업과학기술연구소 1990 農業科學硏究 Vol.8 No.1

Influence of supplemental wiring to standard Wakeman's training system on self-training, breakage, and growth of shoots, and fruit quality of Seibel 9110(S.9110, Verdelet) grapevines was studied. 1.Supplemental wiring increased the rate of self-training of shoots, and 2 to 4 wires were more effective than single wire. 2.Shoot breakage was decreased by the supplemental wiring. 3.Shoot growth tended to increase by the supplememntal wiring, and increase in the number of internodes was recognized only with 1W-15 and 2W-15 treatments. 4.Shoot diameter increased by the supplemental wiring. Pruning weight also was increased with supplemental wiring, especially by 2W-15 and 4W-15-30 treatments. 5.Cluster weight was greatly affected by supplemental wiring, and the effect was enhanced by 2W-15 and 4W-15-30 treatments. Brix degrees(°Bx) tended to increase by supplemental wiring but the effect was noted only by 2W-15 treatment.

CFD 해석을 이용한 막여과 공정 밸브의 개폐시간에 따른 유동 특성

정선용, 이계복 충북대학교 산업과학기술연구소 2018 산업과학기술연구 논문집 Vol.32 No.2

본문 참조

우측 대장에 발생한 연소성 용종 1예

이준식,박성한,홍현진,안광순,김지연,배용목,이은영,박선자 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Juvenile polyp, also known as a retention polyp because they contain mucin cysts, is a relatively common hamartomatous lesion in chlidhood. It occurs in 1-2% of children and young adults; however it is uncommon in adulthood. Juvenile polyp is rare in the first year of life and is thus presumed to be acquired and not congenital. It is pedunculated, 2-3 cm in size, red-tan in colour, smooth and always shows fluid filled cystic spaces on cut surface. Histologically, Juvenile polyps are hamartomatous with distended, mucus-filled glands, often with cystic dilatation and edematous lamina propria containing abundant vasculature. The most common manifestation is rectal bleeding produced by auto-amputation of the polyp. Juvenile polyp has been considered not to be at increased risk of developing carcinoma. However, atypical epithelium is observed in some lesions, especially in larger polyps, which may give rise to adenoma and subsequent malignant transformation. Therefore the diagnosis of solitary juvenile polyp should not be made only with colonoscopy and biopsy, but should be totally resected endoscopically for pathologic evaluation. About 90% of the lesions are solitary and localized within 20cm from anal verge. In Korea, there are some reports of juvenile polyps located in the rectosigmoid colon. We report one case of juvenile polyp in adolescent that presented as a hematochezia & abdominal pain, which is located at right colon.