Microstructure and solar-blind photo-detection performance of β-Ga₂O₃ thin films prepared by radio-frequency magnetron sputtering with different sputtering powers

Min Zhang,Pai Zhang,Yingnan Zhang,Jingchang Sun,Mengke Li,Yuxin Wang 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

One-Step Fabrication of Fluorescent Carbon Dots for Selective and Sensitive Detection of Cr (VI) in Living Cells

Dan Zhang,Yingnan Jiang,CHUANXI WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.1

A one-step facile method of synthesizing fluorescent carbon dots (CDs) has been demonstrated, whereby fluorescent CDs are produced through hydrothermal treatment of glucose in the presence of H3BO3 with a fluorescence quantum yield of 14.5%. It is found that spherical CDs have an average size of 3.7 nm as well as good monodispersion in aqueous solution. The added Cr (VI) selectively leads to the inner filter effect (IFE)-based fluorescence quenching of the CDs. Such fluorescence responses can be used for well quantifying Cr (VI) in the range of 0.05–200 µM. Significantly, the CDs possess negligible cytotoxicity, excellent biocompatibility and high selectivity. All these features are favorable for label-free monitoring of Cr (VI) in complex biological samples. It was then successfully applied for the fluorescence imaging of intracellular Cr (VI). As an efficient chemosensor, the CDs hold great promise in broadening their applications in biological systems.

The Role of Neutrophil-to-Lymphocyte Ratio in Predicting Pathological Response for Resectable Non–Small Cell Lung Cancer Treated with Neoadjuvant Chemotherapy Combined with PD-1 Checkpoint Inhibitors

Xiaoyan Sun,Yingnan Feng,Bin Zhang,Wuhao Huang,Xiaoliang Zhao,Hua Zhang,Dongsheng Yue,Changli Wang 대한암학회 2022 Cancer Research and Treatment Vol.54 No.4

Purpose The aim of our study was to investigate the value of baseline and preoperative neutrophil-to-lymphocyte ratio (NLR) in predicting the pathological response and disease-free survival (DFS) of neoadjuvant chemotherapy alone or combined with programmed cell death-1 (PD-1) checkpoint inhibitors in patients with resectable non–small cell lung cancer (NSCLC). Materials and Methods Resectable NSCLC patients who underwent neoadjuvant chemotherapy alone or combined with PD-1 checkpoint inhibitors between January 2018 and January 2020 were included. Peripheral venous blood samples of the patients were collected within 3 days prior to the first neoadjuvant treatment and within 3 days prior to surgery. Results A total of 79 patients in neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group and 89 patients in neoadjuvant chemotherapy alone group were included. Thirty-five point four percent of the patients achieved pathological complete response (pCR) in neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group, whereas only 9.0% reached pCR in the group of neoadjuvant chemotherapy. High NLR level were correlated with poor pathological response and DFS in neoadjuvant chemotherapy or combined with PD-1 checkpoint inhibitors group. Multivariate analysis revealed that baseline NLR could independently predict pathological response and DFS in the neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group. Conclusion High NLR level were correlated with poor pathological response and shorter DFS in patients with NSCLC undergoing neoadjuvant chemotherapy or combined with PD-1 checkpoint inhibitors. Meanwhile, baseline NLR could independently predict response to pathological response and DFS, revealing its potential as a screening tool in NSCLC patients who received neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors.

Apple residues derived porous carbon nanosheets synthesized with FeCl3 assisted hydrothermal carbonization for supercapacitors with high rate performance

Li Qiqi,Zhang Yingnan,Song Ya,Yang Huawei,Yang Lixia,Bai Liangjiu,Wei Donglei,Wang Wenxiang,Liang Ying,Chen Hou 한국탄소학회 2023 Carbon Letters Vol.33 No.2

Biomass carbon materials with high rate capacity have great potential to boost supercapacitors with cost effective, fast charging–discharging performance and high safety requirements, yet currently suffers from a lack of targeted preparation methods. Here we propose a facile FeCl3 assisted hydrothermal carbonization strategy to prepare ultra-high rate biomass carbon from apple residues (ARs). In the preparation process, ARs were first hydrothermally carbonized into a porous precursor which embedded by Fe species, and then synchronously graphitized and activated to form biocarbon with a large special surface area (2159.3 m2 g−1) and high degree of graphitization. The material exhibited a considerable specific capacitance of 297.5 F g−1 at 0.5 A g−1 and outstanding capacitance retention of 85.7% at 10 A g−1 in 6 M KOH, and moreover, achieved an energy density of 16.2 Wh kg−1 with the power density of 350.3 W kg−1. After 8000 cycles, an initial capacitance of 95.2% was maintained. Our findings provide a new idea for boosting the rate capacity of carbon-based electrode materials.

LncRNA AIRN infl uences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination

Huajie Cai,Yihu Zheng,Zhengde Wen,Yingnan Yang,Shouzhang Yang,Qiyu Zhang 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4

Long non-coding RNAs (LncRNAs) havebeen implicated in the pathogenesis of various human diseases. In this study, we probed into the role and potentialmechanisms of the antisense of IGF2R non-protein codingRNA (LncRNA AIRN) in the progression of hepatocellularcarcinoma (HCC). Using a quantitative real-timepolymerase chain reaction, we corroborated that LncRNAAIRN expression was raised in the HCC tissues and cells. The bioinformatic analysis revealed that a potential interactionbetween LncRNA AIRN and STAT1, which wasverifi ed by the RNA pull-down and RNA immunoprecipitation. In the cycloheximide-chase assay, the knockdown ofLncRNA AIRN enhanced the stability of STAT1 protein. Inthe immunoprecipitation assay, the knockdown of LncRNAAIRN restrained the cullin 4A (CUL4A)-mediated ubiquitinationof STAT1 protein. The cell transfection, MTT andfl ow cytometry assays expounded that the LncRNA AIRN/STAT1 axis was bound up with the regulation of the proliferationand apoptosis of HCC cells. The in vivo experimentscorroborated that the knockdown of LncRNA AIRNrestrained the tumor growth of HCC. Our data expoundedthat the knockdown of LncRNA AIRN restrained HCC cellproliferation and boosted cell apoptosis by restraining theCUL4A-mediated ubiquitination of STAT1 protein.

Deep-blue organic light-emitting diodes based on multi-tert-butyl modified naphthylene

Bin Wei,Hanfei Xu,Ning Zhao,Xicun Gao,Yiteng Ye,Yingnan Wang,Dengli Yao,Xiao-Wen Zhang,Xiujuan Liu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.102 No.-

Six tert-butyls modified naphthyl derivative (2,6-di-tert-butyl-1,5-bis-(3,5-di-tert-butyl-phenyl)-naphthalene (N(dtb)4) was synthesized and tested for host and guest materials in organic light-emittingdiodes (OLEDs). Blue OLED using N(dtb)4 as a host and an emitter DSA-PH as a guest reaches an efficiencyof 11.52 cd A 1 (maximum external quantum efficiency 7.8 % and maximum power efficiency10.33 lm W 1). In addition, for the OLED with N(dtb)4 being a guest, we find that the concentrations ofN(dtb)4 will also affect the performance of the OLED, among which ADN: 5 wt.% N(dtb)4 has higher efficiency,and the maximum current efficiency, external quantum efficiency (EQE) and power efficiency ofthe device reach 3.75 cd A 1, 3.93 % and 3.36 lm W 1, respectively. We also investigated the pure N(dtb)4-based ultraviolet OLED (UV-OLED), and achieved the maximum EQE of the device is 1.12 %. These resultsindicate that N(dtb)4, a novel synthesized fluorescent organic material, has great potential applications inOLEDs and accordingly advancing lightings and displays.

Characteristics of Ground Surface Settlement of Double-Line Adjacent Metro Construction in Sandy Cobble Stratum: A Case Study of Beijing Airport Line

Xianjie Hao,Zhuowen Sun,Yixin Zhao,Yiqiang Kang,Qian Zhang,Jinguo Cheng,Yingnan Wei,Zeyu Chen 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.11

As a long-term urban transportation infrastructure, the stability of metro construction is very important. With the continuous expansion of urban metro network, metro adjacent construction is more and more frequently encountered. In this paper, taking the double-line adjacent construction problems encountered during excavation of Beijing New Airport Line metro in sandy cobble stratum as an example, the surface settlement caused by excavation of single-line metro and double-line adjacent metro is studied by computed tomography scan, electron microscope scanning, laboratory mechanical tests, orthogonal inversion and numerical simulation and other methods. The results show that 1) the sandy cobble particle size and sandy cobble distribution of Beijing sandy cobble samples are relatively dispersed, and the sandy cobble particle size is from 3 to 20 cm, of which the largest proportion is the sandy cobble particle size from 5 to 8 cm. 2) The internal friction angle of Beijing sandy cobble samples with different moisture content is from 27° to 40°, which is much larger than that of other soil samples. Even at the post-peak stage, the shear stress of some sandy cobble samples does not gradually tend to be gentle, but continuously increases or has secondary peaks. 3) For the excavation of double-line adjacent metro, the maximum settlement difference and the impact range of excavation are proposed as indicators to investigate the degree of interaction of the adjacent metro. 4) The results of numerical orthogonal analysis show that the width of surface settlement zone increases significantly with the increase of tunnel diameter and spacing when excavating adjacent metro in sandy cobble stratum, but the rate of increase with tunnel diameter (from 6 m to 14 m) almost reaches 2 times of the rate of increase with the spacing (from 3 m to 15 m). 5) The maximum settlement value of sandy cobble stratum increases with the increase of tunnel diameter and decreases with the increase of spacing. The orthogonal linear analysis shows that the influence of tunnel diameter on the maximum settlement value is much greater than the spacing. The maximum settlement increases with the increase of tunnel diameter, which is about 3.6 times of that with the decrease of spacing.