CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area

Yang, Hong Yu,Fu, Yan,Jang, Moon-Sun,Li, Yi,Yin, Wen Ping,Ahn, Tae Kyu,Lee, Jung Hee,Chae, Heeyeop,Lee, Doo Sung Elsevier 2017 Colloids and surfaces. B, Biointerfaces Vol.155 No.-

<P><B>Abstract</B></P> <P>High photoluminescence (PL) quantum yield (QY), photostability CdSe@ZnS/ZnS core/multishell quantum dots (CM-QDs) were first applied for bioimaging. The solubility, stability and biocompatible of the fluorescence imaging probes were constructed by self-assembly of CM-QDs and pH-responsive methoxy poly(ethylene glycol)-poly(β-amino ester/amidoamine)-dodecylamine (mPEG-PAEA-DDA) multiblock copolymers. The resulting CM-QDs-loaded mPEG-PAEA-DDA micelles (CM-QDs-PEG-PAEA-DDA) exhibited lower cell cytotoxicity and higher fluorescence intensity than the core/shell CdSe@ZnS QDs-encapsulated mPEG-PAEA-DDA micelles (CS-QDs-PEG-PAEA-DDA). Moreover, the in vivo fluorescence imaging ability confirmed that the CM-QDs-PEG-PAEA-DDA can be employed as a pH-triggerable targeting imaging probe for detection of a rat bearing cerebral ischemia disease. Therefore, we believed that the CM-QDs-PEG-PAEA-DDA may be the next generation of fluorescence imaging probes for targeted diagnosis acidic pathological areas, using pH as a stimulus.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CdSe@ZnS/ZnS QDs are synthesized and first applied for bioimaging. </LI> <LI> mPEG-PAEA-DDA copolymer showed pH-responsive property and the hydrolysis stability. </LI> <LI> CM-QDs-PEG-PAEA-DDA exhibited lower toxicity and higher fluorescent intensity. </LI> <LI> CM-QDs-PEG-PAEA-DDA has ability to target image for acidic brain ischemic area. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Truncated Mitochondrial atpA Gene is Uniquely Present in a New orf220-type Cytoplasmic Male-Sterile Line of Stem Mustard (Brassica juncea Coss. Tumida Tsen et Lee)

Yang Jing-Hua,Zhang Ming-Fang,Yu Jing-Quan,Yang Jia-Fu,Li Yi,Rao Li-Bing 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

Yi Yang,Hong Wang,Ming Zhang,Mengxue Shi,Cailing Yang,Qiang Ni,Qi Wang,Jing Li,Xuemei Wang,Chen Zhang,Zhi Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

Background: In physical activity or labor, the human body is in a state of high intensity stress, and allparts or physiological functions of the body respond positively to maintain or balance the need formovement. The human body has many physiological changes in the process of movement, and fatigue isthe external manifestation of various complex changes inside the human body. Fatigue is also a physiologicalmechanism of self-protection after the body reaches a certain level of activity, which can preventthe occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complexprocess, and its mechanism has not been concluded yet. Therefore, it is an important work to search andscreen the effective components of natural plants that have anti-fatigue effect and to explore theirmechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110subjects who passed physical examination were included according to the scheme design, and randomlydivided into a test group which was given KRG and a placebo control group. The calculation is carried outaccording to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. AfterKRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acidcontent is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significantlower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful onrelieving physical fatigue.

Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

Preparation of Covalent and Solvent-resistance Colored Latex Particles and Its Application on Cotton Fabric

Yi Yang,Min Li,Aijun Tang,Yayun Liu,Zhen Li,Shaohai Fu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8

Conventional colored latex particles have poor solvent resistance due to the absence of chemical bonds betweenthe dye and polymer component, resulting in staining and greatly restricting its application. In this research, the disperse dyewas chemically bonded to the polymer to prepare covalent and solvent-resistance colored latex particles. Firstly, C.I. DisperseRed 60, as a common disperse dye in industry, was modified by acryloyl chloride (amidation reaction) for the purpose ofintroducing the C=C bonds. The structure of modified C.I. Disperse Red 60 was confirmed by 1HNMR, FTIR and elementalanalysis and its spectral property was also evaluated. Then the covalent colored latex particles were synthesized via miniemulsioncopolymerization of styrene (St) and ethyl acrylate (EA) in presence of modified C.I. Disperse Red 60 monomer. Results of FTIR, TG, DSC and TEM indicated that the covalent colored latex particles were successfully prepared. By usingUV-spectroscopy, the solvent resistance of the colored latex membranes in petroleum ether, hexane, cyclohexane, and ethanolwas monitored, respectively. Slight change of the absorption was detected for 10 days, which verified the excellent solventresistance of covalent colored latex membranes. Finally, the prepared colored latex particles were applied on cotton printingin the absence of binder. The results showed that the colored latex particles printed fabric had superior rubbing fastness andsoft hand feel.

A fry counting arithmetic based on culmination eroding

Yi Yang,Li-quan Ma,Ming-xia Li 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-

In fry image, overlapping fries make counting inaccurate. Former "worm eating leaf' arithmetic [3] can not distinguish overlapping fry's image. Therefore, this paper put forward a new eroding arithmetic to analyze overlapping fry's images and count them. This arithmetic, which is based on white and black image, by eroding some pixels, creates several pixels that only in one direction joint the fry object, and I call these pixels culmination. The arithmetic transforms the identification of the overlapping fry images to the statistic of the culmination amount and count fish. In theory it provides a new way to count overlapping object and enhance accuracy.

Electrical Properties of MgxZn1−xO Thin Films Deposited by using RF Magnetron Co-sputtering with ZnO and Mg0.3Zn0.7O Targets

Li Li Yue,Yi Da Yang,김홍승,Nak-Won Jang,윤영 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.5

We successfully deposited hexagonal wurtzite MgxZn1−xO (0 x 0.18) films on Si substrates by using RF magnetron co-sputtering with ZnO and Mg0.3Zn0.7O targets. The Mg content was varied by controlling the RF power of the Mg0.3Zn0.7O target while the RF power of the ZnO target was fixed at 100 W. The electrical properties of the MgxZn1−xO films were investigated by using a transmission line model (TLM) with Ti/Au electrode and Hall effect measurements. The X-ray diffraction (XRD) results demonstrate that some Zn atoms can be replaced by Mg atoms in the MgxZn1−xO films. As the Mg content was increased from 0 at.% to 18 at.%, the resistivity of MgxZn1−xO films increased and the carrier concentration decreased from 1.17 × 1019 cm−3 to 1.17 × 1017 cm−3, which indicates a decrease in the number of oxygen vacancies. Meanwhile, the Hall mobility increased to 15.3 cm2/Vs. The electrical properties of MgxZn1−xO films were tuned by using the Mg content.

Finite Element Analysis on Mechanical Behaviour of Yungui Railway Tunnel in Shallow and Unsymmetrical Strata

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10

Triaxial compression tests had been performed to determine the properties of the surrounding rock. The displacement and stress of surrounding rock had been analyzed according to Silin 2 at Yungui railway under three kinds of conditions: the initial state, excavation without supporting , and supporting after excavation. Plane strain FEM was established to analyze the stability of the surrounding rock. Contrasted the monitor measuring data, the results showed that the most unfavorable position in the tunnel was found at the ridge side of the arch, and the implementation of support afforded to ensure the stability of surrounding rock, and the design of the early support approach had the ability to meet the safety requirements. The results had certain significance for understanding the mechanical behavior of shallow tunnel in unsymmetrical strata. tunnel, mechanical behaviour, numerical simulation, deformation, stability.

Tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods for combined chemo- and photothermal cancer therapy

Li, Yi,Duy Le, Thai Minh,Nam Bui, Quang,Yang, Hong Yu,Lee, Doo Sung Elsevier 2019 Carbohydrate polymers Vol.226 No.-

<P><B>Abstract</B></P> <P>In this work, tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods (AuNRs) are investigated for combined chemo- and photothermal cancer therapy. Low molecular weight hyaluronic acid (LMWHA) is conjugated with pH-sensitive groups for pH-induced aggregation and lipoic acid for coating of AuNRs. By changing pH-sensitive groups with different pKa values, pH-sensitivity of modified LMWHA can be tuned. After coating modified LMWHA onto AuNRs, biocompatibility of the AuNRs is significantly improved. These LMWHA-coated AuNRs can gradually aggregate under slightly acidic conditions, making them favorable for accumulation at acidic tumor sites. Surface LMWHA allows the nanocomposites to be selectively uptaken by CD44-expressing cancer cells, and AuNRs endows the nanocomposites with excellent photothermal ability. Loading of doxorubicin, a chemical drug, provides the LMWHA-coated AuNRs synergistic cancer cell-killing (<I>in vitro</I>) and tumor growth inhibiting (<I>in vivo</I>) ability. Taken together, these results demonstrate that this multifunctional nanosystem with pH-induced aggregation and CD44 targeting has potential for combined chemo- and photothermal cancer therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Conjugation of pH-sensitive groups induces acidity-triggered aggregation. </LI> <LI> Surface coating of hyaluronic acid allows selective tumor targeting of nanoparticles. </LI> <LI> Co-delivery of chemical drugs and gold nanorods enables combined cancer therapy. </LI> </UL> </P>

Advances in plant-derived natural products for antitumor immunotherapy

Yi Yang,Qinying Liu,Xianai Shi,Qiuhong Zheng,Li Chen,Yang Sun 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11

In recent years, immunotherapy has emergedas a novel antitumor strategy in addition to traditional surgery,radiotherapy and chemotherapy. It uniquely focuses onimmune cells and immunomodulators in the tumor microenvironmentand helps eliminate tumors at the root by rebuildingthe immune system. Despite remarkable breakthroughs,cancer immunotherapy still faces many challenges: lack ofpredictable and prognostic biomarkers, adverse side eff ects,acquired treatment resistance, high costs, etc. Therefore,more effi cacious and effi cient, safer and cheaper antitumorimmunomodulatory drugs have become an urgent requirement. For decades, plant-derived natural products obtainedfrom land and sea have provided the most important sourcefor the development of antitumor drugs. Currently, moreattention is being paid to the discovery of potential cancerimmunotherapy modulators from plant-derived naturalproducts, such as polysaccharides, phenols, terpenoids, quinonesand alkaloids. Some of these agents have outstandingadvantages of multitargeting and low side eff ects and lowcost compared to conventional immunotherapeutic agents.