그라인더(grinder) 사용에 의한 Hand-Arm Vibration Syndrome(HAVS)의 6예

임상혁,김록호,양길승,양정인,김상섭,전형준,박시복 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 수지증상이 있는 진동공구 작업자 8명에 대해 객관적이고 체계화된 진단방법을 이용하여 수지진동 증후군을 진단하고자 시행하였다. 방 법 : 과거병력, 가족력 등의 문진과 혈액 및 소변, 방사선 검사를 통해 다른 원인에 의한 레이노씨병을 배제하였고, 공구 측정 결과를 이용하여 작업과의 관련성을 보았으며, 냉수 침지검사와 근전도 검사를 통하여 수지진동 증후군을 진단하고자 하였다. 결 과 : 수지증상이 있는 진동공구 작업자 8명에 대해 과거병력, 가족력, 약물복용 및 과거 직업력 등 레이노씨병을 유발하는 요인에 대하여 조사하였고 특이점은 발견하지 못하였다. 다른 원인에 의한 레이노씨병을 배제하기 위해 혈액 및 소변, 방사선 검사를 하였고 8명 모두에서 특이 소견을 발견하지 못하였다. 위의 문진과 검사결과로 다른 원인에 의한 레이노씨병을 배제할 수 있었다. 해당사업장의 진동 공구 측정결과를 근거로 피검자의 공구가 ISO의 허용기준을 초과함을 알 수 있었다. 냉수 침지검사와 근전도 검사를 이용하여 피검자 8명중 6명이 말초 혈액순환 장해와 말초 신경염이 있는 것으로 진단되었다. 위의 내용을 근거로 6명은 진동에 의한 수지 진동 증후군으로 진단할 수 있었다. 결 론 : 수지증상이 있는 진동공구 작업자 8명에 대해 객관적이고 체계화된 진단방법을 이용하여 수지진동 증후군을 진단하였다. 해당 사업장의 진동 공구 작업자의 진동에 대한 검진이 필요할 것으로 생각된다. Objectives : To confirm the HAVS In workers exposed to hand-arm vibration with using the objective diagnostic methods. Methods : Several tests were used to help substantiate a clinical diagnosis of HAVS. Some other diseases were excluded by a medical interview, hematologic assessment, urinalysis, X-rays. The hand-arm vibration acceleration level of the grinder was evaluated for considering HAVS. Peripheral vascular changes were examined by a cold provocation test. An electromyography was implemented to ascertain the peripheral neural changes. Results : 8 workers with symptoms in hands & fingers, exposed to hand-arm vibration were examined. Some other diseases (primary Raynaud's disease, secondary Raynaud's disease in not occupational origin) were excluded by a medical interview, hematologic assessment, urinalysis, X-rays. The hand-arm vibration acceleration level of the grinder was 7.9 m/sec2. The recovery time of a skin temperature followed finger cooling was significantly prolonged in 6 workers with HAVS. The nerve conduction velocity was reduced in 6 workers with HAVS. Conclusions : So we report 6 cases of HAVS in grinding workers exposed to hand-arm vibration diagnosed objectively by an exclusion of some other disease, hand- arm vibration acceleration level, cold provocation test, electromyography.

Finite Element Analysis on Mechanical Behaviour of Yungui Railway Tunnel in Shallow and Unsymmetrical Strata

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10

Triaxial compression tests had been performed to determine the properties of the surrounding rock. The displacement and stress of surrounding rock had been analyzed according to Silin 2 at Yungui railway under three kinds of conditions: the initial state, excavation without supporting , and supporting after excavation. Plane strain FEM was established to analyze the stability of the surrounding rock. Contrasted the monitor measuring data, the results showed that the most unfavorable position in the tunnel was found at the ridge side of the arch, and the implementation of support afforded to ensure the stability of surrounding rock, and the design of the early support approach had the ability to meet the safety requirements. The results had certain significance for understanding the mechanical behavior of shallow tunnel in unsymmetrical strata. tunnel, mechanical behaviour, numerical simulation, deformation, stability.

Fluid Solid Coupling Analysis of Large Underground Oil Storage Caverns in Containment of Groundwater

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

Triaxial compression tests had been performed to determine the properties of the rock mass around unlining underground crude oil a storage cavern which was the first one in China. The execution situation of the tunnel project and the seepage law of groundwater were taken into account. The stress and the seepage field around the tunnel in different working states were simulated by applying Comsol around a underground crude oil storage caverns. According to the test results, it was found that the excavation process may arise the local damage. The extension of the loose zone induced by excavation ranged from 0 to 15.6 m, depending on the buried depth of the caverns. According to numerical simulation results, the crown settlement and stress concentration was depended on the buried depth and the water pressure distribution after excavation of the main cavity. This research results can provide the reference for analysis on the stability of the underground cavities under low stress level and on the water sealed underground petroleum storage rock caverns.

Effect of Ni Addition on Toughness and Microstructure Evolution in Coarse Grain Heat Affected Zone

Yang You,Chengjia Shang,Sundaresa Subramanian 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.4

A Gleeble simulation was performed on low carbon steels to investigate the effect of Ni addition ontoughness and microstructure evolution in coarse grain heat affected zone from low heat input welding. Ni additionincreased the impact toughness at -20 °C and the prior austenite grain size.Microstructures of the lowNi and high Ni steel show noticeable differences in crystallography. Lath-structures in the two can be definedas crystallographic packet. In low Ni steel the packet consisting of acicular ferrite and lower bainite has allthe three Bain groups uniformly distributed; in high Ni steel the packet consisting of only lower bainitehas a dominant Bain group within it, making the other two groups subsidiary. The closely linked M/A particleswere found only in low Ni steel by tracking the orientation information. It is able to facilitate the fracturethrough the link-up of the micro-cracks initiated by each M/A particle. In the going direction of the link-upthere is no high angle boundary which can deflect the propagation of crack, thereby in this case the high angleboundary in low Ni steel is relatively ineffective. The mechanism of the toughness improvement brought by Niaddition should be ascribed to the relatively uniform transformation to final microstructure, which reducesthe appearance of closely linked M/A.

New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng

Shang, Jia-Huan,Sun, Wen-Jie,Zhu, Hong-Tao,Wang, Dong,Yang, Chong-Ren,Zhang, Ying-Jun The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.3

Background: Root rot is a serious destructive disease of Panax notoginseng, a famous cultivated araliaceous herb called Sanqi or Tianqi in Southwest China. Methods: The chemical substances of Sanqi rot roots were explored by chromatographic techniques. MS, 1D/2D-NMR, and single crystal X-ray diffraction were applied to determine the structures. Murine macrophage RAW264.7 and five human cancer cell lines were used separately for evaluating the antiinflammatory and cytotoxic activities. Results and Conclusion: Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6α,12β,20-triol (2), 20(S)-dammar-12-oxo-23-ene-25-hydroperoxyl-3β,6α,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12β,20-diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6α-hydroxy-22,23,24,25,26,27-hexanordammar-3,12,20-trione (7), are new compounds. In addition, 12 known ones (12-16 and 19-25) were reported in Sanqi for the first time. The new Compound 1 showed comparable antiinflammatory activity on inhibition of NO production to the positive control, whereas the known compounds 9, 12, 13, and 16 displayed moderate cytotoxicities against five human cancer cell lines. The results will provide scientific basis for understanding the chemical constituents of Sanqi rot roots and new candidates for searching antiinflammatory and antitumor agents.

Joint FrFT‐FFT basis compressed sensing and adaptive iterative optimization for countering suppressive jamming

Yang Zhao,Chaoxuan Shang,Zhuangzhi Han,Yuanwei Yin,Ning Han,Hui Xie 한국전자통신연구원 2019 ETRI Journal Vol.41 No.3

Accurate suppressive jamming is a prominent problem faced by radar equipment. It is difficult to solve signal detection problems for extremely low signal to noise ratios using traditional signal processing methods. In this study, a joint sensing dictionary based compressed sensing and adaptive iterative optimization algorithm is proposed to counter suppressive jamming in information domain. Prior information of the linear frequency modulation (LFM) and suppressive jamming signals are fully used by constructing a joint sensing dictionary. The jamming sensing dictionary is further adaptively optimized to perfectly match actual jamming signals. Finally, through the precise reconstruction of the jamming signal, high detection precision of the original LFM signal is realized. The construction of sensing dictionary adopts the Pei type fast fractional Fourier decomposition method, which serves as an efficient basis for the LFM signal. The proposed adaptive iterative optimization algorithm can solve grid mismatch problems brought on by undetermined signals and quickly achieve higher detection precision. The simulation results clearly show the effectiveness of the method.

White light emitting diodes(LEDs) with good color rendering indices(CRI) and high luminous efficiencies by the encapsulation of mixed and double-deck phosphors

Shang-Hui Yang,Jian-Shian Lin,Fuh-Shyang Juang,Ding-Chin Chou,Ming-Hua Chung,Chen-Ming Chen,Lung-Chang Liu 한국물리학회 2013 Current Applied Physics Vol.13 No.5

In this paper, white light emitting diodes (LEDs) with good color rendering indices (CRI) and high luminous efficiencies have been fabricated by the encapsulation of mixed and double-deck phosphors. Experimental results revealed that white LEDs with the encapsulation of double-deck phosphors exhibited better CRI and higher luminous efficiencies than those with the encapsulation of mixed phosphors because no secondary excitation took place. The hue, CRI, and luminous efficiencies of white LEDs with double-deck phosphors under 200 mA were CIEx,y =(0.357, 0.348), 90, and 62.3 lm/W,respectively while the hue, CRI, and luminous efficiencies of white LEDs with mixed phosphors under 200 mA were CIEx,y = (0.366, 0.354), 89, and 56.5 lm/W, respectively.

Direct comparison of biopsy techniques for hepatic malignancies

( Shang-chin Huang ),( Ja-der Liang ),( Shih-jer Hsu ),( Tzu-chan Hong ),( Hung-chih Yang ),( Jia-horng Kao ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.2

Background/Aims: The core needle biopsy (CNB), fine needle aspiration cytology (FNAC) and touch imprint cytology (TIC) are commonly used tools for the diagnosis of hepatic malignancies. However, little is known about the benefits and criteria for selecting appropriate technique among them in clinical practice. We aimed to compare the sensitivity of ultrasound-guided CNB, FNAC, TIC as well as combinations for the diagnosis of hepatic malignancies, and to determine the factors associated with better sensitivity in each technique. Methods: From January 2018 to December 2019, a total of 634 consecutive patients who received ultrasound-guided liver biopsies at the National Taiwan University Hospital was collected, of whom 235 with confirmed malignant hepatic lesions receiving CNB, FNAC and TIC simultaneously were enrolled for analysis. The clinical and procedural data were compared. Results: The sensitivity of CNB, FNAC and TIC for the diagnosis of malignant hepatic lesions were 93.6%, 71.9%, and 85.1%, respectively. Add-on use of FNAC or TIC to CNB provided additional sensitivity of 2.1% and 0.4%, respectively. FNAC exhibited a significantly higher diagnostic rate in the metastatic cancers (P=0.011), hyperechoic lesions on ultrasound (P=0.028), and those with depth less than 4.5 cm from the site of needle insertion (P=0.036). Conclusions: The sensitivity of CNB is superior to that of FNAC and TIC for the diagnosis of hepatic malignancies. Nevertheless, for shallow (depth <4.5 cm) and hyperechoic lesions not typical for primary liver cancers, FNAC alone provides excellent sensitivity. (Clin Mol Hepatol 2021;27:305-312)

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

Yang, Xiaoyan,Park, Seong-Hoon,Chang, Hsiang-Chun,Shapiro, Jason S.,Vassilopoulos, Athanasios,Sawicki, Konrad T.,Chen, Chunlei,Shang, Meng,Burridge, Paul W.,Epting, Conrad L. American Society for Clinical Investigation 2017 The Journal of clinical investigation Vol.127 No.4

Cloning, Expression, and Characterization of a Cold-Adapted and Surfactant-Stable Alginate Lyase from Marine Bacterium Agarivorans sp. L11

( Shang Yong Li ),( Xue Mei Yang ),( Lan Zhang ),( Wen Gong Yu ),( Feng Han ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5

The purpose of this study was to find a cold-adapted and surfactant-stable alginate lyase as a candidate for biotechnological and industrial applications. The gene for a new alginate lyase, AlyL1, from Agarivorans sp. L11 was cloned and expressed in Escherichia coli. The recombinant AlyL1 was most active at 40ºC (1,370 U/mg). It was a cold-adapted alginate lyase, which showed 54.5% and 72.1% of maximum activity at 15ºC and 20ºC, respectively. AlyL1 was an alkaliphilic enzyme and most active at pH 8.6. In addition, it showed high stability in the presence of various surfactants at a high concentration (from 0.1% to 1% (w/v)). AlyL1 was an endo-type alginate lyase that degraded both polyM and polyG blocks, yielding disaccharides and trisaccharides as the main products. This is the first report of the cloning and functional expression of a cold-adapted and surfactant-stable alginate lyase. AlyL1 might be an interesting candidate for biotechnological and industrial applications.