REVIEWS : What we know about nonsteroidal anti-inflammatory drug hypersensitivity

( Duy Le Pham ),( Ji Hye Kim ),( Tu Hoang Kim Trinh ),( Hae Sim Park ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.3

Nonsteroidal anti-inf lammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammatory diseases, but their use is frequently related to hypersensitivity reactions. This review outlines our current knowledge of NSAID hypersensitivity (NHS) with regard to its pathogenic, molecular, and genetic mechanisms, as well as diagnosis and treatment. The presentation of NHS varies from a local (skin and/or airways) reaction to systemic reactions, including anaphylaxis. At the molecular level, NHS reactions can be classified as cross-reactive (mediated by cyclooxygenase inhibition) or selective (specific activation of immunoglobulin E antibodies or T cells). Genetic polymorphisms and epigenetic factors have been shown to be closely associated with NHS, and may be useful as predictive markers. To diagnose NHS, inhalation or oral challenge tests are applied, with the exclusion of any cross-reactive NSAIDs. For patients diagnosed with NHS, absolute avoidance of NSAIDs/aspirin is essential, and pharmacological treatment, including biologics, is often used to control their respiratory and cutaneous symptoms. Finally, desensitization is recommended only for selected patients with NHS. However, further research is required to develop new diagnostic methods and more effective treatments against NHS.

Distributed Interference Management in Two-Tier CDMA Femtocell Networks

Duy Trong Ngo,Long Bao Le,Le-Ngoc, T.,Hossain, E.,Dong In Kim IEEE 2012 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.11 No.3

<P>This paper proposes distributed joint power and admission control algorithms for the management of interference in two-tier femtocell networks, where the newly-deployed femtocell users (FUEs) share the same frequency band with the existing macrocell users (MUEs) using code-division multiple access (CDMA). As the owner of the licensed radio spectrum, the MUEs possess strictly higher access priority over the FUEs; thus, their quality-of-service (QoS) performance, expressed in terms of the prescribed minimum signal-to-interference-plus-noise ratio (SINR), must be maintained at all times. For the lower-tier FUEs, we explicitly consider two different design objectives, namely, throughput-power tradeoff optimization and soft QoS provisioning. With an effective dynamic pricing scheme combined with admission control to indirectly manage the cross-tier interference, the proposed schemes lend themselves to distributed algorithms that mainly require local information to offer maximized net utility of individual users. The approach employed in this work is particularly attractive, especially in view of practical implementation under the limited backhaul network capacity available for femtocells. It is shown that the proposed algorithms robustly support all the prioritized MUEs with guaranteed QoS requirements whenever feasible, while allowing the FUEs to optimally exploit the remaining network capacity. The convergence of the developed solutions is rigorously analyzed, and extensive numerical results are presented to illustrate their potential advantages.</P>

Synchronization algorithm for controlling 3-R planar parallel pneumatic artificial muscle robot

Le Duy KHOA,Kyoung Kwan AHN 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10

The aim of this paper is to design a 3-R planar parallel robot and develop a synchronization controller in order to synchronize the operation of the robot actuators. By other means, the proposed controller compensates errors between the actuators and enforces them to cooperate harmonically with each other regardless external disturbance caused by outside environment or geometrical constraints of the closed-loop structure. Due to the high adaptability, the Adaptive neuro-fuzzy algorithm was modified and applied as the main strategy of the synchronization controller. Practical experiments on a scaled parallel robot were carried out to evaluate the designed controller. The results showed that by applying the proposed technique, the working errors of the component actuators converged quickly to zero almost at the same time. Subsequently, the performance of the common platform was significantly improved in comparison with the performance when applying a non synchronization controller. The proposed method is effective in controlling systems which require collaborations between the sub-agents.

High Performance Three-Dimensional Chemical Sensor Platform Using Reduced Graphene Oxide Formed on High Aspect-Ratio Micro-Pillars

Le Thai Duy,Duck-Jin Kim,Vinh Quang Dang,Bo-Yeong Kim,Hock Key Moon,Nae-Eung Lee 한국진공학회 2015 한국진공학회 학술발표회초록집 Vol.2015 No.2

A Stretchable Gas Sensor Using Multilayered Fiber Network of Reduced Graphene Oxide/Polyurethane Nanohybrids

Le Thai Duy,Tran Quang Trung,Adeela Hanif,Eun Roh,Wonil Lee,Nae-Eung Lee 한국진공학회 2017 한국진공학회 학술발표회초록집 Vol.2017 No.2

Slide Session : OS-ALG-04 ; Allergy : Association of Autophagy Related Gene Polymorphisms with Neutrophilic Asthma Phenotype in Korean Adult Asthmatics

( Le Duy Pham ),( Seung Hyun Kim ),( Purevsuren Losol ),( Eun Mi Yang ),( Yoo Seob Shin ),( Young Min Ye ),( Hae Sim Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Role of autophagy in neutrophil function and the association of autophagy and autophagy related gene (ATG) polymorphisms with asthma susceptibility were suggested. In this study, we investigated the association of ATG5 and ATG7 polymorphisms with asthma risk, severity and neutrophilic phenotype of asthma. Methods: We recruited 408 asthma patients and 201 healthy controls (NC). Sputum neutrophil counts were determined by H&E staining. Serum IL-8 levels were measured by ELISA. ATG5 gene polymorphisms (-769T>C, -335G>A and 8830C>T) and ATG7 gene polymorphisms (-100A>G and 25108G>C) were genotyped. The functional activities of ATG5 -769T>C and -335G>A variants were investigated by luciferase reporter assays. Results: No associations of ATG5 and ATG7 gene polymorphisms with asthma susceptibility and severity were found. ATG5 -769T>C and -335G>A were in complete linkage disequilibrium. In the asthma group, GA/AA genotypes at ATG5 -335G>A were associated with higher neutrophil counts in sputum (P<0.05); CC/TT genotype at ATG5 8830C>T associated with lower % FEV1 predicted value (P<0.05). DNA fragments containing ATG5 -769T and -335G alleles had higher promoter activities compared to those with -769C and -335A in both human airway epithelial cells (A549, P<0.01) and human mast cell (HMC-1, P<0.001). GG and CC genotype at ATG7 -100A>G and 25108G>C were significantly associated with high serum levels of IL-8 (P<0.05 for both variants). Conclusions: Polymorphisms of ATG5 and ATG7 genes could contribute to neutrophilic phenotype in the pathogenesis of adult asthma.

Efficacy of RinskorTM (florpyrauxifen-benzyl ester) on Herbicide Resistant Barnyardgrass (Echinochloa crus-galli) in Rice Fields of Mekong Delta, Vietnam

Le Duy,Nguyen M. Chon,Richard K. Mann,Bobba V. N. Kumar,Mauricio A. Morell 한국작물학회 2018 Journal of crop science and biotechnology Vol.21 No.1

Barnyardgrass (Echinochloa crus-galli) seed samples were collected in rice fields in different locations at Mekong delta in Vietnam for herbicide resistance tests. The ALS-resistant and synthetic auxin-resistant E. crus-galli were confirmed at several locations in the Mekong Delta. The average LD90 value of bispyribac, penoxsulam and quinclorac for assessed weed populations was 33.1, 15.1 and 550.2 g a.i.ha-1 respectively. There were cross resistant barnyardgrass populations to bispyribac and penoxsulam, the LD90 value of the two ALS inhibitors for E. crus-galli was positively correlated at R2=0.39, the cross resistant population was 33.3% of total sample. The correlation analysis was not useful to evaluate the multiple resistance between quinclorac and the two ALS inhibitors, the R2 value was lower than 0.05, however, the percentage of multiple resistance weed was 36.2% of population. There was no cross resistance or multiple resistance among the 3 tested herbicides and the new synthetic auxin herbicide RinskorTM. All tested weed samples, including quinclorac-resistant populations, were effectively controlled by RinskorTM. There was no difference between control from RinskorTM in the different herbicide resistant populations. Average LD90 value of RinskorTM in all tested barnyardgrass was 17.1 g a.i ha-1.

What Influences Decision on Seasoned Equity Offerings of Listed Vietnamese Companies?

LE, Long Hau,NGUYEN, Thi Binh Nhi,PHAM, Xuan Quynh,VUONG, Quoc Duy,LE, Tan Nghiem Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.5

This paper investigates the determinants on decision to conduct seasoned equity offerings (SEOs) of listed companies on the Ho Chi Minh Stock Exchange in Vietnam. Seasoned equity offerings (SEOs) are defined as the issue of more stocks by a firm to raise more capital after a primary issue. Using panel data collected from audited financial statements of 99 listed companies on the Ho Chi Minh Stock Exchange during 2014-2018, the study employs a logit regression model by fixed effects method to examine factors that affect the decision to implement seasoned equity offerings of those companies. The findings of this study show that profit, revenue growth and company's size have a positively significant impact on the decision, while dividend pay-out ratio negatively significantly influences the equity issuing decision. Furthermore, these results are robust after controlling for the forms of equity offerings, i.e. bonus stocks, stock dividends and rights to buy shares. These findings are consistent with economic theories such as agency theory, pecking order theory, and growth opportunity theory, and also could be explained by the real situations of the Vietnamese stock exchange. This study has important implications for corporate managers, policy makers and investors.

Genetic diversity and herbicide resistance of 15 Echinochloa crus-galli populations to quinclorac in Mekong Delta of Vietnam and Arkansas of United States

Le, Duy,Nguyen, Chon M.,Mann, Richard K.,Yerkes, Carla N.,Kumar, Bobba V.N. The Korean Society of Plant Biotechnology 2017 식물생명공학회지 Vol.44 No.4

Barnyardgrass (Echinochloa crus-galli) is one of the worst weeds in rice (Oryza sativa), but there are few reports about the genetic diversity and herbicide resistance of barnyardgrass in Vietnam. In this study, we used random amplified polymorphic DNA (RAPD) analysis and greenhouse testing to study the genetic diversity and quinclorac resistance levels of 15 Echinochloa crus-galli populations in the Mekong Delta, Vietnam, and the state of Arkansas, U.S. The quinclorac resistance of Echinochloa crus-galli populations in Vietnam was confirmed; 9 populations were resistant to quinclorac with R/S ratios ranging from 1.9 to 6.3. Six oligonucleotide primers produced a total of 55 repeatable bands of which 46 were polymorphic (83.3% average) among the 15 populations. Genetic distance was calculated, and cluster analysis separated the 15 populations into 2 main clusters with the genetic distances within the clusters ranging from 0.09 to 0.39. The two main clusters were divided into 7 subclusters, and the quinclorac resistant and susceptible populations were located randomly within each subcluster. Six out of 13 weed populations from Vietnam belonged to one cluster and a single Echinochloa species. The remaining 7 populations were identified as potentially different species in the Echinochloa genus. Nine Echinochloa populations from Vietnam were tested and identified as quinclorac resistant. The connection between quinclorac resistance levels and weed groups defined by RAPD analysis in the study is unclear; the quinclorac resistance of each resistant population could have evolved individually, regardless of differences in genetic diversity and location of the sampled populations.

Genetic diversity and herbicide resistance of 15 Echinochloa crus-galli populations to quinclorac in Mekong Delta of Vietnam and Arkansas of United States

Duy Le,Chon M. Nguyen,Richard K. Mann,Carla N. Yerkes,Bobba V. N. Kumar 한국식물생명공학회 2017 JOURNAL OF PLANT BIOTECHNOLOGY Vol.44 No.4

Barnyardgrass (Echinochloa crus-galli) is one of the worst weeds in rice (Oryza sativa), but there are few reports about the genetic diversity and herbicide resistance of barnyardgrass in Vietnam. In this study, we used random amplified polymorphic DNA (RAPD) analysis and greenhouse testing to study the genetic diversity and quinclorac resistance levels of 15 Echinochloa crus-galli populations in the Mekong Delta, Vietnam, and the state of Arkansas, U.S. The quinclorac resistance of Echinochloa crus-galli populations in Vietnam was confirmed; 9 populations were resistant to quinclorac with R/S ratios ranging from 1.9 to 6.3. Six oligonucleotide primers produced a total of 55 repeatable bands of which 46 were polymorphic (83.3% average) among the 15 populations. Genetic distance was calculated, and cluster analysis separated the 15 populations into 2 main clusters with the genetic distances within the clusters ranging from 0.09 to 0.39. The two main clusters were divided into 7 subclusters, and the quinclorac resistant and susceptible populations were located randomly within each subcluster. Six out of 13 weed populations from Vietnam belonged to one cluster and a single Echinochloa species. The remaining 7 populations were identified as potentially different species in the Echinochloa genus. Nine Echinochloa populations from Vietnam were tested and identified as quinclorac resistant. The connection between quinclorac resistance levels and weed groups defined by RAPD analysis in the study is unclear; the quinclorac resistance of each resistant population could have evolved individually, regardless of differences in genetic diversity and location of the sampled populations.