암센서용 TiO2/Au/CNT 나노복합물의 전기화학적 검출

홍성미, 김홍일, 김한주, Wang, Xuemei, 박수길 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

Demand of rapid detection for cancer, it is necessary that high sensitivity, specificity, low cost, and simple method. CNT and metal nano materials are widely used to elecate efficient. CNT have various advantage, and can be composed with metal nano materials. Especially, Titanium oxide and gold nano particles are focused on sensor for detection of cancer, it can elecate electron transition feeiciency between electrode surface and target materials, and biological functionalization of CNT. It means that nano material is composed each other. In this study, electrodes are considered materialsd and their chracteristic for cancer sensor.

Improved Image Denoising Based on 3D Collaborative Filtering

Xuemei Wang,Dengyin Zhang,Min Zhu,Yingtian Ji,Jin Wang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.4

As the state-of-art denoising method, BM3D is capable of achieving good denoising performance by exploiting both the non-local characteristics and sparsity prior knowledge of images. Nevertheless, experimental results show that the dissimilarity measurement defined in BM3D sometimes results in grouping patches with distinct structure. Inspired by the fact about the different impact of noise on patches with various structures, we propose a structure-adaptive image denoising method with 3D collaborative filtering by optimizing the block matching procedure. In our method, the similarity in the variance between patches is incorporated in block matching procedure. Besides, based on the prior knowledge of correlation among patches in the same neighborhood, the spatial distance between the reference patch and the candidate is also taken into account when measuring patches’ dissimilarity. Several numerical experiments demonstrate that the proposed approach achieve better results in PSNR and visual effect than original BM3D.

The Application of Atmospheric Plasma for Cotton Fabric Desizing

Xuemei Wang,Hongmei Zhao,Fuxing Chen,Xin Ning,Shaojuan Chen,Qunli Guan,Shouxiang Jiang,Dagang Miao 한국섬유공학회 2019 Fibers and polymers Vol.20 No.11

Production process of cotton fabric involves numerous water and chemical consumptions, causing serious energywaste and environmental problem. In this study, a waterless atmospheric plasma treatment (APT) was applied on cottonfabric to desize the starch coated in the weaving process. Plasma parameters, i.e., plasma voltage, plasma duty cycle andoxygen flow rate, are varied in order to systematically evaluate their influence on fabric physical properties such as theimpurity removal, whiteness, capillary effect, tensile strength and breaking elongation of fabric. Optimal plasma parametersfor oxygen APT were determined, with plasma voltage of 320 V, plasma duty cycle of 60 % and oxygen flow rate of 1000 l/h. The APT desizing method attained comparable fabric performances with the traditional amylase desizing method. The resultswere further supported by the scanning electron microscope (SEM) and Fourier transfer infrared spectroscopy (FTIR)investigations.

한국기업의 對베트남 해외직접투자 특징에 관한 연구

왕설매(Xuemei Wang),정진섭(Jin-Sup Jung),왕정상(Zhengxiang Wang) 한국산업경영학회 2012 경영연구 Vol.27 No.2

본 연구의 목적은 한국기업의 對베트남 해외직접투자의 특징을 도출하고, 실증분석을 통해 성공적인 해외투자 진출을 위한 전략적 시사점을 제시하고자 한다. 먼저 기존 연구의 탐색을 통해 對베트남 해외직접투자와 관련하여 투자시기, 투자방식, 투자동기, 투자업종, 투자규모, 입지선택등 주요 특징적 요인들을 찾았다. 그리고 이러한 특징을 중심으로 다음과 같은 세부 결과를 도출하였다. 첫째, 한국의 對베트남 해외직접투자는 진입 시기에 따라 경영성과가 달리 나타났다. 특히 2006년 베트남의 WTO 가입 후, 한국기업의 對베트남 해외직접투자 성과가 높게 나타났다. 둘째, 단독투자가 합자투자보다 그 비율이 높게 나타나고 있는데, 이는 한국기업들이 단독투자가 합작투자보다 성공가능성이 높다고 판단하고 있음을 시사하고 있다. 셋째, 최근 한국의 對베트남 해외직접투자의 동기로서 현지시장 개척을 위한 투자동기가 현지 자원개발이나 저임금활용을 위한 투자보다 부각되고 있다. 이는 이제 베트남이 단순 제조업 공장으로서의 역할뿐 아니라 소비시장으로서 부상하고 있음 을 시사한다. 넷째, 본 연구의 실증분석 결과, 제조업보다 서비스업의 매출신장률이 높게 나타났다. 이는 베트남 진출 시 제조업뿐 아니라 서비스업도 점차 중요하게 고려해야 함을 시사하고 있다. 다섯째, 투자규모에 따른 분석에서는 50명 미만의 소규모 종업원 기업들의 경영성과가 비교적 높게 나타났으나, 투자규모에 따른 그룹별 경영성과의 차이는 나타나지는 않았다. 여섯째, 입지선택 측면에서 입지우위가 세부적인 투자 장소의 결정에 영향을 미쳤다. 예를 들어, 베트남에 투자한 한국기업의 경우, 인프라가 잘 갖추어진 호치민을 하노이보다 더 선호하였으며, 호치민에 투자한 기업들이 더 나은 경영성과를 보였다. The goal of this study is to identify the characteristics of outward foreign direct investment (FDI) by Korean firms in Vietnam: timing, method, motivation, industry, size, and location. Meaningful results were obtained as follows. First, Korean firms' performance with regard to outward FDI in Vietnam differed according to the timing of their entry into Vietnam. In particular, their performance increased after 2006, following Vietnam's adhesion to the World Trade Organization (WTO). Second, wholly-owned subsidiaries (WOS) and joint ventures (JV) show few significant differences statistically speaking. However, recently, WOSs' performance has increased more rapidly than that of JVs. Third, Korean firms' motivation for outward FDI in Vietnam has switched from the resource-seeking/efficiency-seeking paradigm to the market-seeking paradigm. Fourth, the performance of the service industry was found to be higher than that of the manufacturing industry, so the outward FDI of the Korean service industry should be considered seriously. Fifth, when the size of a firm is based on the number of employees, the performance of small and medium-sized firms is a little better than that of large size firms. However, when considering the size of a firm according to the amount of investment, there are no differences between the various groups. Finally, certain locational advantages have affected the performance of outward FDI in Vietnam. Therefore, Ho Chi Minh, which is well equipped in terms of infrastructure, was preferred to Hanoi by Korean firms.

Streptococcus pneumoniae aminopeptidase N contributes to bacterial virulence and elicits a strong innate immune response through MAPK and PI3K/AKT signaling

Ling Wang,Xuemei Zhang,Guangying Wu,Yuhong Qi,Jinghui Zhang,Jing Yang,Hong Wang,Wenchun Xu 한국미생물학회 2020 The journal of microbiology Vol.58 No.4

Streptococcus pneumoniae is a Gram-positive pathogen with high morbidity and mortality globally but some of its pathogenesis remains unknown. Previous research has provided evidence that aminopeptidase N (PepN) is most likely a virulence factor of S. pneumoniae. However, its role in S. pneumoniae virulence and its interaction with the host remains to be confirmed. We generated a pepN gene deficient mutant strain and found that its virulence for mice was significantly attenuated as were in vitro adhesion and invasion of host cells. The PepN protein could induce a strong innate immune response in vivo and in vitro and induced secretion of IL-6 and TNF-α by primary peritoneal macrophages via the rapid phosphorylation of MAPK and PI3K/AKT signaling pathways and this was confirmed using specific pathway inhibitors. In conclusion, PepN is a novel virulence factor that is essential for the virulence of S. pneumoniae and induces host innate immunity via MAPK and PI3K/AKT signaling.

Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

Yi Yang,Hong Wang,Ming Zhang,Mengxue Shi,Cailing Yang,Qiang Ni,Qi Wang,Jing Li,Xuemei Wang,Chen Zhang,Zhi Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

Background: In physical activity or labor, the human body is in a state of high intensity stress, and allparts or physiological functions of the body respond positively to maintain or balance the need formovement. The human body has many physiological changes in the process of movement, and fatigue isthe external manifestation of various complex changes inside the human body. Fatigue is also a physiologicalmechanism of self-protection after the body reaches a certain level of activity, which can preventthe occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complexprocess, and its mechanism has not been concluded yet. Therefore, it is an important work to search andscreen the effective components of natural plants that have anti-fatigue effect and to explore theirmechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110subjects who passed physical examination were included according to the scheme design, and randomlydivided into a test group which was given KRG and a placebo control group. The calculation is carried outaccording to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. AfterKRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acidcontent is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significantlower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful onrelieving physical fatigue.

Calculating Wind Variability Costs with Considering Ramping Costs of Conventional Power Plants

Xuemei Dai,Kaifeng Zhang,Jian Geng,Ying Wang,Kun Yuan 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3

Due to the variability of the wind power, conventional power plants are required to ramp more frequently to mitigate the imbalance of generation and supply, which increase the total cost of power systems. The increase of the cost is termed the “variability cost” of wind power. Generally, it includes the additional ramping cost, reserve cost and fuel cost of conventional plants. In this paper, we propose an alternative scenario construction method to calculate the “variability cost” of wind power from the viewpoint of the power system schedule. Firstly, in the alternative scenario, a new energy proxy with zero wind variability costs is constructed. Then, a unit commitment optimization model considering ramping costs is developed. The operation costs of power systems under two scenarios (alternative one and real one) are calculated and the diff erence between two costs is the variability cost. Furthermore, we apply the proposed method to calculate the variability costs of the wind farm cluster. The simulations show that the variability cost increases with higher penetration and higher variability of wind power. Meanwhile, it is found that the variability cost of the wind farm cluster as a whole is lower than the sum of variability costs of each wind farm.

Effects of low dietary cation-anion difference induced by ruminal ammonium chloride infusion on performance, serum, and urine metabolites of lactating dairy cows

Wang, Kun,Nan, Xuemei,Zhao, Puyi,Liu, Wei,Drackley, James K.,Liu, Shijie,Zhang, Kaizhan,Bu, Dengpan Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.5

Objective: The objective of the present study was to determine ammonium chloride tolerance of lactating dairy cows, by examining effects of negative dietary cation anion difference (DCAD) induced by ruminal ammonium chloride infusion on performance, serum and urine minerals, serum metabolites and enzymes of lactating dairy cows. Methods: Four primiparous lactating Chinese Holstein cows fitted with ruminal cannulas were infused with increasing amounts (0, 150, 300, or 450 g/d) of ammonium chloride in a crossover design. The DCAD of the base diet was 279 mEq/kg dry matter (DM) using the DCAD formula (Na + K - Cl - S)/kg of DM. Ammonium chloride infusion added the equivalent of 0, 128, 330, and 536 mEq/kg DM of Cl in treatments. According to the different dry matter intakes (DMI), the resulting actual DCAD of the four treatments was 279, 151, -51, and -257 mEq/kg DM, respectively. Results: DMI decreased linearly as DCAD decreased. Yields of milk, 4% fat-corrected milk, energy-corrected milk, milk fat, and milk protein decreased linearly as DCAD decreased. Concentrations of milk protein and milk urea nitrogen increased linearly with decreasing DCAD. Concentration of Cl- in serum increased linearly and concentration of PO43- in serum increased quadratically as DCAD decreased. Urine pH decreased linearly and calculated urine volume increased linearly with decreasing DCAD. Linear increases in daily urinary excretion of $Cl^-$, $Ca^{2+}$, $PO_4{^{3-}}$, urea N, and ammonium were observed as DCAD decreased. Activities of alanine aminotransferase, aspartate aminotransferase, and ${\gamma}-glutamyl$ transferase in serum and urea N concentration in serum increased linearly as DCAD decreased. Conclusion: In conclusion, negative DCAD induced by ruminal ammonium chloride infusion resulted in a metabolic acidosis, had a negative influence on performance, and increased serum enzymes indicating potential liver and kidney damage in lactating dairy cows. Daily ammonium chloride intake by lactating dairy cows should not exceed 300 g, and 150 g/d per cow may be better.

Cloning of Chicken Microsomal Glutathione S-transferase 1 Gene (MGST1) and Identification of Its Different Splice Variants

Wang, X.-T.,Zhang, H.,Zhao, C.-J.,Li, J.-Y.,Xu, G.-Y.,Lian, L.-S.,Wu, C.-X.,Deng, Xuemei Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.2

Mammal microsomal glutathione transferase 1 (MGST1) can conjugate many toxic or carcinogenic substances and depress oxidative stress. In this study, Chicken MGST1 and its variants were cloned for the first time and were composed of 956 or 944 nucleotides. The 12 nt deletion in the exon 2 did not alter the GT-AG rule and the ORFs for the two MGST1 variants were the same, which both comprised 465 nucletides and encoded a peptide with 155 amino acids. It was found that the two different splice variants identified using RT-PCR expressed in all three organs investigated of Dwarf Brown Chicken, namely liver, spleen and shell gland. Moreover, the expression level of MGST1 mRNA in the liver of Dwarf Brown chickens was the highest (p<0.01), and there were no significant differences between the spleen and the shell gland. These results provide a base for studying the biological function of Chicken MGST1.

BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts

Xuemei Zhang,Hongya Hei,Jianjun Gao,Jibin Dong,Jie Tao,Lulu Tian,Wanma Pan,Hongyu Wang 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.7

Large conductance calcium-activated potassium (BK) channels participate in many important physiological functions in excitable tissues such as neurons, cardiac and smooth muscles, whereas the knowledge of BK channels in bone tissues and osteoblasts remains elusive. To investigate the role of BK channels in osteoblasts, we used transcription activator-like effector nuclease (TALEN) to establish a BK knockout cell line on rat ROS17/2.8 osteoblast, and detected the proliferation and mineralization of the BK-knockout cells. Our study found that the BK-knockout cells significantly decreased the ability of proliferation and mineralization as osteoblasts, compared to the wild type cells. The overall expression of osteoblast differentiation marker genes in the BK-knockout cells was significantly lower than that in wild type osteoblast cells. The BK-knockout osteoblast cell line in our study displays a phenotype decrease in osteoblast function which can mimic the pathological state of osteoblast and thus provide a working cell line as a tool for study of osteoblast function and bone related diseases.