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부유대역 용융응고법으로 제조된 YBa_2Cu_3O_x 산화물초전도체의 미세구조와 전기적 특성
노태형,송정환,장규철,한이섭,김소정,구본급,김호기 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
The YBa_2Cu_3O_x-20 wt% Y_2BaCuO_5 composition designed in YBCO system was synthesized by solid state reaction method. The optimum condition of hot zone temperature and growth rate in floating-zone melt were 1080 ℃ and 2.5 mm/hour, respectively. In samples growth as these condition, the low angel boundaries in grain direction and small amount of amorphous phase known as decreasing characteristics of superconducting materials between grain boundaries in microstructure are investigated by polarized light microscopy on the whole. The critical current density(Jc) at 77k of sample using powder fabricated with no CeO_2 and doped 5 wt%CeO_2 were 8,000 A/㎠(Jc : 561A) and 12,000 A/㎠(Jc: 826A) at 0 T by direct current transport method, respectively.
<i>Artemisia asiatica</i> ethanol extract exhibits anti-photoaging activity
Jeong, Deok,Lee, Jongsung,Jeong, Seong-Gu,Hong, Yo Han,Yoo, Sulgi,Han, Sang Yun,Kim, Ji Hye,Kim, Sunggyu,Kim, Jin Sic,Chung, Young Soo,Kim, Jong-Hoon,Yi, Young-Su,Cho, Jae Youl Elsevier 2018 Journal of Ethnopharmacology Vol.220 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Artemisia asiatica</I> Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies.</P> <P><B>Aim of the study</B></P> <P>In this study, traditionally known skin-protective activity of <I>Artemisia asiatica</I> Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells.</P> <P><B>Materials and methods</B></P> <P>Effects of Aa-EE on cell viability, photocytotoxicity, and expression of matrix metalloproteinases (MMPs), cyclooxygenase (COX)-2, and moisturizing factors were measured in B16F10, HEK293, NIH3T3, and HaCaT cells under untreated and ultraviolet B (UVB)-irradiation conditions. Anti-melanogenic effect of Aa-EE was also examined by measuring both melanin content in B16F10 cells and tyrosinase activity. Anti-photoaging mechanism of Aa-EE was explored by determining the activation levels of signaling molecules by immunoblotting analysis.</P> <P><B>Results</B></P> <P>Aa-EE protected HaCaT cells from UVB irradiation-induced death. Aa-EE increased the expression of a type 1 pro-collagen gene and decreased the expression of matrix metalloproteinases, and COX-2 in NIH3T3 cells induced by UVB. Aa-EE increased the expression of transglutamase-1, hyaluronic acid synthase (HAS)-2, and HAS-3 in HaCaT cells and decreased the production of melanin in α-melanocyte-stimulating hormone-stimulated B16F10 cells by suppressing tyrosinase activity and the expression of tyrosinase, microphthalmia-associated transcription factor, tyrosinase-related protein (TRP)-1 and TRP-2.</P> <P><B>Conclusion</B></P> <P>The results suggest that Aa-EE could be skin-protective remedy with anti-photoaging, anti-apoptotic, skin remodeling, moisturizing, and anti-melanogenesis properties.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet
Han, So-Ra,Oh, Ki-Sook,Yoon, Yoo-Sik,Park, Jeong-Su,Park, Yun-Sun,Han, Jeong-Hye,Jeong, Ae-Lee,Lee, Sun-Yi,Park, Mi-Young,Choi, Yeon-A,Lim, Jong-Seok,Yang, Young The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such as hyperlipidemia, atherosclerosis, and hypertension. One component of these two herbs has been reported to have anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. However, there have been no reports about the effects of the mixed extract of these two herbs on metabolic diseases. In this study, we investigated the metabolic effects of THI using a diet-induced obesity (DIO) mouse model. High-fat diet (HFD) mice were orally administered daily with 250 mg/kg of THI. After 10 weeks of treatment, the THI-administered HFD mice showed reduction of body weights and epididymal white adipose tissue weights as well as improved glucose tolerance. In addition, the level of total cholesterol in the serum was markedly reduced. To elucidate the molecular mechanism of the metabolic effects of THI in vitro, 3T3-L1 cells were treated with THI, after which the mRNA levels of adipogenic transcription factors, including C/$EBP{\alpha}$ and $PPAR{\gamma}$, were measured. The results show that the expression of these two transcription factors was down regulated by THI in a dose-dependent manner. We also examined the combinatorial effects of THI and swimming exercise on metabolic status. THI administration simultaneously accompanied by swimming exercise had a synergistic effect on serum cholesterol levels. These findings suggest that THI could be developed as a supplement for improving metabolic status.
A Design of New Surface Gradient Coil and Its Application to MR Computerized Tomography
Yi, Jeong-Han,Cho, Zang-Hee The Korean Society of Medical and Biological Engin 1992 의공학회지 Vol.13 No.3
A new three-channel surface gradient coil obtained by using numerical optimization and its application to MR computerized nomography are presented. The new surface gradient coil pro aided linear field gradient region more than twice wider compared with the t'irst surface gradi encl coil, removed torque and field offset, and reduced coupling between the surface gradient coil and combined surface rf coil. We realized the new surface gradient coil set with $30{\times}60{cm^2}$2 size, which generated more tharl 4G/cm with 100 amperes over a $4{\times}4{\times}4{cm^3}$ region with good linearity. The optimal geometries of the three-channel surface gradient coil and volun teer's high-resolution in wiuo spinal cord Images obtained by using the optimized surface gradi ent coil set are presented.
오정한(Jeong Han Oh),주일한(Il-Han Joo),공동의(Dong-Yi Kong),최충혁(Choong-Hyeok Choi) 대한정형외과학회 2018 대한정형외과학회지 Vol.53 No.6
목적: 고정형 슬관절 단일 구획 치환술의 5년 추시 결과로 임상적 및 방사선적 결과, 합병증 발생 빈도를 알아보고자 하였다. 대상 및 방법: 2003년 5월부터 2011년 8월까지 고정형 슬관절 단일 구획 치환술을 시행한 25명, 26예를 대상으로 하였다. 평균 연령은 63.5세였으며 남자가 3명(3예), 여자가 22명(23예)이었으며 술 전 진단은 골관절염 23예, 골괴사 3예였다. 평균 추시 기간은 평균 67개월(60-149개월)이었다. 임상적으로 술 전과 술 후의 미국슬관절학회 슬관절 점수 및 기능점수, 관절 운동 범위를 조사하였고, 방사선적으로 슬관절 기립 전후방 사진과 측면 사진, 투시기 촬영을 통하여 술 후의 정렬상태와 골용해 여부를 조사하였다. 결과: 임상적 결과로 슬관절 점수는 평균 42.0점에서 87.9점으로, 기능점수는 57.5점에서 85.0점으로 향상되었다(p<0.001). 술 전 관절 운동 범위는 평균 132.9°에서 술 후 132.5°로 큰 차이를 보이지 않았다. 방사선적 결과로 대퇴경골각은 술 전 평균 내반 0.5°에서 술 후 외반 2.2°로 측정되었다. 방사선 투과성 선(radiolucent line)이 관찰되는 경우가 2예 발견되었으며 그 중 1예는 삽입물이 안정적이었으나 다른 1예는 단일 구획 치환술 시 대퇴슬개관절의 관절염을 확인하였고, 추시상 슬관절 내측 관절선의 동통 및 슬관절의 미만성 통증이 있어 슬관절 전치환술을 권유하였다. 그 외 골용해, 감염, 술 후 강직, 탈구 등의 합병증은 없었다. 결론: 고정형 슬관절 단일 구획 치환술의 중기 추시 결과는 임상적 및 방사선적으로 만족스러운 결과를 보였다. Purpose: To evaluate the clinical and radiological outcomes, and the complications of unicompartmental knee arthroplasty (UKA) using a fixed bearing prosthesis after 5-year follow-up. Materials and Methods: Twenty-six knees (25 patients) that underwent fixed bearing UKA between May 2003 and August 2011 were included. The subjects were 3 males (3 knees) and 22 females (23 knees), and the average age was 63.5 years. The preoperative diagnosis was osteoarthritis (23 knees) and osteonecrosis (3 knees). The mean follow-up duration was 67 months (from 60 to 149 months). The clinical evaluation included pre- and postoperative American knee society knee and function score, and range of motion. The radiology evaluation included standing antero-posterior, lateral view, and fluoroscopic film to analyze the postoperative alignment and osteolysis. Results: The mean American Knee Society knee score and function score were improved from 42.0 and 57.5 to 87.9 and 85.0, respectively (p<0.001). The mean preoperative and postoperative range of motion was 132.9° and 132.5°, respectively. The mean femorotibial angle were varus 0.5° preoperatively and valgus 2.2° postoperatively. A radiolucent line was observed in 2 knees; one knee had a stable implant, while in the other knee, patellofemoral arthritis was identified during UKA. Diffuse pain of the knee joint with tenderness of the medial joint line was identified at the follow-up, so conversion to total knee arthroplasty was recommended. No other complications, such as osteolysis, infections, postoperative stiffness, and dislocation, were encountered. Conclusion: The midterm results of fixed bearing UKA were clinically and radiologically satisfactory.